Dr Torow, did you ever imagine becoming a researcher?
(laughs) Not necessarily, at least not in such a clear-cut way, but my interest in the natural sciences developed early on. During a year abroad in New York, I attended a public high school where I had the chance to take university-level courses in chemistry and math. I loved it! After high school, I decided to study biochemistry at the University of Hannover. Later, research stays in Boston and Stockholm, where I focused on microbiology and infection biology, solidified my passion for research. By then, it was clear: I absolutely wanted to pursue a career in research!
Today, you study the early-life immune system. How did you get there?
Even as a student, I was particularly fascinated by cell biology and immune cells. The complexity of the immune system has always been incredibly exciting to me! I completed my doctorate at Hannover Medical School, where I studied the development of the adaptive immune system in the neonatal gut. My doctoral research demonstrated that the recognition of gut bacteria by specific immune cells, known as T cells, remains actively suppressed for a long time after birth. This was my first step into my current research field. After earning my PhD, I moved to RWTH Aachen University, where I did my post doc and then took over a junior research group in 2021. My research there focused on identifying the factors that eventually trigger the adaptive immune system of newborns to start recognizing gut bacteria. We found that at a specific time, a particular type of epithelial cell forms in the intestine. These cells help train the immune system by providing immune cells with a carefully regulated doses of gut bacteria.
Why is it important to better understand the neonatal gut immune system?
The gut is one of the main entry points for pathogens and hosts one of the most complex immune systems in the body. This immune system must distinguish between beneficial gut bacteria and harmful pathogens. Before birth, the intestine is sterile, but within days after birth, a newborn’s gut becomes as densely colonized with bacteria as an adult's. During this period, the immune system undergoes a major transition. Initially, it is relatively inactive.