Portrait Natalia Torow
Dr Natalia Torow, Head of the Junior Research Group "Early Life Immunity" at the HZI
Interview

"Learning from mistakes, staying committed, and growing from the experience—this applies to both research and caregiving"

Dr Natalia Torow researches the immune system of newborns, seeking to understand how it responds to pathogens and vaccinations to better prevent early-life infections. Since 2024, she has led the junior research group "Early Life Immunity" at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, introducing a new research focus to the institution. In this interview, she discusses the neonatal immune system’s "silent mode," her goal of optimizing oral vaccines, and how she balances life as a researcher with family responsibilities.

Dr Torow, did you ever imagine becoming a researcher?

(laughs) Not necessarily, at least not in such a clear-cut way, but my interest in the natural sciences developed early on. During a year abroad in New York, I attended a public high school where I had the chance to take university-level courses in chemistry and math. I loved it! After high school, I decided to study biochemistry at the University of Hannover. Later, research stays in Boston and Stockholm, where I focused on microbiology and infection biology, solidified my passion for research. By then, it was clear: I absolutely wanted to pursue a career in research!

Today, you study the early-life immune system. How did you get there?

Even as a student, I was particularly fascinated by cell biology and immune cells. The complexity of the immune system has always been incredibly exciting to me! I completed my doctorate at Hannover Medical School, where I studied the development of the adaptive immune system in the neonatal gut. My doctoral research demonstrated that the recognition of gut bacteria by specific immune cells, known as T cells, remains actively suppressed for a long time after birth. This was my first step into my current research field. After earning my PhD, I moved to RWTH Aachen University, where I did my post doc and then took over a junior research group in 2021. My research there focused on identifying the factors that eventually trigger the adaptive immune system of newborns to start recognizing gut bacteria. We found that at a specific time, a particular type of epithelial cell forms in the intestine. These cells help train the immune system by providing immune cells with a carefully regulated doses of gut bacteria.

Why is it important to better understand the neonatal gut immune system?

The gut is one of the main entry points for pathogens and hosts one of the most complex immune systems in the body. This immune system must distinguish between beneficial gut bacteria and harmful pathogens. Before birth, the intestine is sterile, but within days after birth, a newborn’s gut becomes as densely colonized with bacteria as an adult's. During this period, the immune system undergoes a major transition. Initially, it is relatively inactive.

Oral vaccination of an infant
Oral vaccination of an infant

Is that a good thing or a bad thing?

It was once thought that the neonatal immune system was simply immature. However, recent studies suggest that this low-activity state is beneficial, possibly even essential. Strong immune responses can cause tissue damage, which could be detrimental to early development. Understanding the unique characteristics of the neonatal immune system is crucial. This knowledge can help us develop more effective vaccines specifically designed for neonatal immune system.

You joined HZI last summer and now lead the MICROSTAR junior research group "Early Life Immunity." What is the main goal of your research?

Together with my four-person team, I aim to investigate the unique properties of the neonatal gut immune system and, based on these insights, develop improved approaches for oral vaccines for newborns. We are particularly interested in how different known and novel vaccine adjuvants—substances that enhance immune responses—affect gut immune cells. Our research employs a combination of mouse models, genetic systems, and cutting-edge technologies, including next-generation single-cell analysis. This allows us to observe, in real time, how individual immune cells in the intestine respond to stimuli, such as vaccine adjuvants. In low-resource countries, infectious diseases still cause high morbidity and mortality among children. A well-designed oral vaccine tailored to the neonatal immune system could be a game-changer.

You have a family, with two children aged five and nine. How do you balance research and caregiving?

(laughs) I’m not sure if I manage it perfectly—balancing research and family is definitely a challenge! Right now, I’m experiencing the "rush hour of life" every single day. Research involves long working hours, and flexibility is essential—lab experiments take as long as they take. Mobility is also crucial, for example, to attend international conferences. However, I prioritize tasks and delegate responsibilities within my team to focus on the most critical aspects of my work. At home, my partner and I share caregiving duties. Having a reliable partnership is key!

What do you find particularly challenging?

Time is an extremely limited resource. Everything—daily routines, travel for conferences—has to be carefully planned. And then, of course, there are the unpredictable challenges, such as illness or daycare closures, which require immediate solutions. It can be exhausting and stressful. However, having strong family support helps. We are fortunate that the grandparents can step in when needed. I’m incredibly grateful for that.

How do you unwind in your free time?

Good question! (laughs) Weekends are dedicated to family. I try to stick to that because it’s essential for long-term sustainability in my career. I really enjoy weekends—we go on outings, play games, or watch movies together. That’s my way of recharging! There’s not much time for anything else right now. I do feel that personal time is limited, but at the same time, I have a fulfilling job that allows me to be creative, design new experiments, explore innovative research approaches, and work independently. That’s something I deeply appreciate. It’s truly rewarding!

Do you think role models are important for young female researchers?

Absolutely! Role models are incredibly important. Young women considering a research career need to see that it is possible to combine science and family life. We need visible examples—women and men who excel in research, hold leadership positions, and also share caregiving responsibilities. Seeing that it works, that the two can coexist, is both inspiring and empowering. Before I had children, I would have loved to see more role models ...

Despite the challenges, you pursued both research and family life and have clearly not regretted it. What advice do you have for young scientists?

The most important thing is to be truly passionate about your research! Just as crucial is finding the right environment—research is far more rewarding when you work in a place that supports and challenges you. Women should seek research environments that actively promote gender equality and career development. And, as a researcher, you must develop resilience. Science involves setbacks—experiments fail, hypotheses turn out to be incorrect, and research paths sometimes lead to dead ends. The key is to learn from mistakes, stay persistent, and grow from the experience. This applies to both research and caregiving!

Interview: Nicole Silbermann

Portrait Andreas Fischer

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Dr Andreas Fischer
Science Editor