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How do viruses and bacteria affect our cognitive abilities? What role do they play in neurodegenerative diseases like Alzheimer’s and dementia? And how can we protect our brain in the long term? In this episode of the HZI podcast InFact, Prof. Martin Korte, head of the research group “Neuroinflammation and Neurodegeneration” at the Helmholtz Centre for Infection Research (HZI), discusses the links between infections, the immune system, and the brain.

Not only does our body change with age, but so does our immune system. A recent study led by the Centre for Individualised Infection Medicine (CiiM) shows exactly how immune cells age and how infections and vaccinations can influence this process. The CiiM is a joint initiative of the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH). Using a big data approach, the researchers have developed a computer model called the “Single-Cell Immune Aging Clock”, which can be used to determine aging processes within individual immune cells. The scientists are making the innovative aging clock freely available for further research. They hope that it will serve as a useful tool to better understand the aging processes of the immune system, particularly with the context of infectious diseases and immune disorders. The study has been published in the journal Nature Aging.

Regarding the current reporting on the origin of the coronavirus SARS-CoV-2, Prof. Fabian Leendertz, Director of the Helmholtz Institute for One Health (HIOH), makes the following statement: “Based on the data published to date, it can be assumed that the transmission to humans took place via intermediate hosts (e.g. animal farms), as the contacts and risks are much higher there. This data has been published in various WHO reports and relevant peer-reviewed scientific publications. If there is now other and new data that supports an origin in the laboratory, then that is a different picture. We now have to wait until this data has been examined and reviewed by experts.”

In May 2022, alarming headlines emerged: A mysterious and deadly disease was spreading in Central Africa. Was this the beginning of a new pandemic? Today, we know that it was Mpox (formerly known as monkeypox), a viral disease that has once again been declared a public health emergency. In this episode of the HZI podcast Infact, Dr Julia Port, head of the research group “Laboratory of Transmission Immunology” at the Helmholtz Centre for Infection Research (HZI), discusses virus transmission and the role of the immune system. Her research bridges immunology, viral ecology, and global health.

Today, the Citizen Science project CiFly will enter its second year. This year, 9th and 10th grade students from the Alexander-von-Humboldt-Gymnasium will again have the opportunity to get to know the Helmholtz Institute for One Health (HIOH), but also the chance to explore the biobank of the University Medical Center and the Greifswald Zoo from the perspective of a researcher.

Infectious keratitis blinds 1.5 million people worldwide every year. This severe eye disease is often caused by the hospital germ Pseudomonas aeruginosa, which the World Health Organization considers one of the most dangerous bacteria of its kind. Now, scientists at Saarland University and the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) have found a way to combat this resilient pathogen. Their study has been published in Advanced Science. The HIPS is a site of the Helmholtz Centre for Infection Research (HZI) in collaboration with Saarland University.