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Analysis of natural products using liquid chromatography.
News
Chemistry meets biology: access to new natural products
Natural products are among the most promising candidates for the development of new drugs. However, due to their structural complexity, they are often difficult to access. A team headed by Tobias Gulder from the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has now developed new synthetic strategies for the class of polycyclic tetramate macrolactams (PoTeMs), a group of natural products with a broad spectrum of biological activities. In addition to chemical synthesis, enzymatic catalysis and genetic engineering approaches were used. The strategies established in this way not only allow PoTeMs to be produced in large quantities, but also to modify their carbon structure and thus their pharmaceutical properties. The researchers published their results in the journal Angewandte Chemie International Edition, among others.
12.05.2025
HIPS
EM image
News
Viruses under the super microscope: How influenza viruses communicate with cells
Influenza viruses are among the most likely triggers of future pandemics. A research team from the Helmholtz Centre for Infection Research (HZI) and the Medical Center - University of Freiburg has developed a method that can be used to study the interaction of viruses with host cells in unprecedented detail. With the help of their new development, they have also analyzed how novel influenza viruses use alternative receptors to enter target cells. The results were recently published in two papers in the journal Nature Communications.
07.05.2025
HZI Campus
Poster Curiosity is Infectious
News
Doctoral studies at HZI: Exciting projects for tomorrow's top researchers
The Helmholtz Centre for Infection Research (HZI) has a lot to offer its doctoral candidates: Together with renowned partner institutions, the center has developed high-quality doctoral programs that impart in-depth expertise in innovative future disciplines and train the specialists of tomorrow. In addition to a first-class scientific education at one of the leading health research institutions, young scientists at HZI have the opportunity to expand their interdisciplinary knowledge and gain valuable additional skills in areas such as management and soft skills.
30.04.2025
HZI Campus
CiiM
HIRI
TWINCORE
HIPS
Portrait Rolf Müller
News
Award for outstanding achievements in natural product research
Every two years, the MDPI Sustainability Foundation presents the Tu Youyou Award for outstanding achievements in the fields of natural product and medicinal chemistry. This year, Rolf Müller is one of two researchers to receive the award for his work on developing new antibiotics based on microbial natural products. The prize was established in 2016 in honor of Chinese Nobel Prize winner Tu Youyou and comes with a total prize money of 100,000 Swiss francs.
30.04.2025
HIPS
Electron microscope image of Fusobacteria.
News
An unexpected bacterial blocker
Fusobacteria, which are part of the oral microbiome, are suspected of playing a role in cancer progression. Scientists at the Helmholtz Institute for RNA-based Infection Research (HIRI) are working on innovative strategies to inhibit the spread of these bacteria. Antisense molecules, which could serve as programmable, targeted antibiotics, show great promise. In a recent study, a research team led by Jörg Vogel identified a compound that effectively halts the growth of five Fusobacterium species. The findings were published today in the journal mBio.
29.04.2025
HIRI
Dr. Arnaud Carpentier and Frauke Lange in the lab
News
Better insights into the hepatitis D virus
Hepatitis D virus (HDV) infects the liver and causes severe inflammation. According to WHO estimates, 12 million people worldwide are infected with HDV. Currently, there are only a few treatment options. A team of researchers from TWINCORE, the Centre for Experimental and Clinical Infection Research in Hannover, has developed a stem cell-based infection model for HDV and has used it to discover a possible target for an attack on the virus. They are now publishing their results in the scientific journal JHEP Reports. The TWINCORE is a joint institution of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and Hannover Medical School (MHH).
25.04.2025
TWINCORE

HZI in the media

DGP 2026: Schlüssel für die Medizin der Zukunft ist die richtige Balance zwischen Technik und Zuwendung

... beschäftigt sich daneben unter dem Dach des Helmholtz Institutes für Pharmazeu­tische Forschung Saarland (HIPS) ...

18.03.2026
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Biermann Medizin
Start-up AveThera erwirbt Fraunhofer-Standort für Biologika-Produktion

... Ausbau von Produktions- und Vermarktungskapazitäten.

 

Das Helmholtz-Zentrum für Infektionsforschung HZI begrüßt den Erhalt der GMP- ...

18.03.2026
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Bionity.COM
Gesucht: Optimierte Wirkstoffe gegen RSV

... der Universität zu Lübeck, des Helmholtz-Zentrums für Infektionsforschung (HZI) in Braunschweig, der Medizinischen Hochschule Hannover ...

17.03.2026
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Biermann Medizin
Pandemien

Vorsorge Das Coronavirus hält die Welt nicht mehr in Atem. Doch was, wenn ein ­anderer gefährlicher Erreger auftaucht? So wappnet sich unser Gesundheitssystem

16.03.2026
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Apotheken Umschau
Kommt die Superkeim-Pandemie? - 42 - Die Antwort auf fast alles | Video der Sendung vom 12.10.2025 03:00 Uhr mit Untertitel

... stumpfen ab“, erklärt Marc Brönstrup vom Helmholtz-Zentrum für Infektionsforschung in Braunschweig. Neue Antibiotika sind dringend ...

14.03.2026
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ARD Mediathek
RSV: Neue Wirkstoffe?

... der Medizinischen Hochschule Hannover und dem Helmholtz-Zentrum für Infektionsforschung (HZI) in Braunschweig neue Wirkstoffe ...

13.03.2026
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MTA Dialog
Universität des Saarlandes Wirkstoff-Forscher als Transport-Unternehmer

... späten 1990ern hob sie der am Saarbrücker Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS) tätige ...

08.03.2026
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Saarbrücker Zeitung
CRISPR Discovery Could Enable Single Test for COVID, Flu, RSV

European institutions, including Germany’s Helmholtz Institute for RNA-based Infection Research, Helmholtz Center for Infection Research,

06.03.2026
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Clinical Lab Products
Immunzellen als Therapie gegen Autoimmunerkrankungen und Organabstoßung

Die Zellen kontrollieren die Reaktion des Immunsystems und verhindern Schäden durch Selbstangriffe. Forschende arbeiten daran, sie zur Therapie einzusetzen.

05.03.2026
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NDR Norddeutscher Rundfunk
Schleim als Virus-Barriere: Wie Grippeviren Menschen und Tiere infizieren

Nachwuchsgruppe „Nanoinfektionsbiologie“ am HZI. Diese Lücke soll das Projekt ONEMUC (Respiratorischer Mukus als One Health-Schnittstelle) ...

03.03.2026
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DeutschesGesundheitsPortal
PSC: Suche nach neuen Behandlungsansätzen im Projekt StopPSC

Hochschule Hannover (MHH) und des Helmholz-Zentrums für Infektionsforschung (HZI) erforschen im Rahmen des Projektes StopPSC ( ...

03.03.2026
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Biermann Medizin
Neue Nachwuchsgruppen zur Infektionsforschung in Braunschweig

Mdisk, stock.adobe.com

 

Braunschweig – Das Helmholtz-Zentrum für Infektionsforschung ( HZI ) in Braunschweig erhält für sein ...

03.03.2026
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Deutsches Ärzteblatt

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