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A recent study led by the Centre for Individualised Infection Medicine (CiiM) and the Radboud University Medical Center published in Genome Biology shows that BCG vaccination does more than fend off tuberculosis - it leaves enduring chemical marks on immune cells that boost responses to various pathogens. Researchers also uncover hormone‑immune crosstalk and sex‑specific effects that could guide next‑generation, individualised vaccine design.

10.07.2025

CiiM

Dr. Andreas Pavlou, first author of the study, in the lab

News

Infections in the brain can have serious consequences and are often fatal. The immune defense system works differently here than in the rest of the body. A team of researchers at TWINCORE – Centre for Experimental and Clinical Infection Research in Hanover – has now discovered, in collaboration with partners, which signaling pathways play a central role in communication between immune cells in the brain in their defense against viruses. The results have now been published in the Journal of Neuroinflammation. The TWINCORE is a joint institution of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and Hannover Medical School (MHH).

09.07.2025

TWINCORE

[Translate to English:] Empfangsschild des Arabuko-Sokoke-Nationalparks

Story

Natural substances are an important source of active ingredients used in medicine. However, the chemical diversity of fungi in particular has not yet been sufficiently researched. The EU project Mycobiomics, coordinated by Marc Stadler, Head of the Department “Microbial Drugs” at the Helmholtz Centre for Infection Research (HZI), is investigating the biodiversity of fungi in Europe, Asia and Africa in order to identify pharmaceutically valuable secondary metabolites. In May and June 2025, project participants met in Kenya and South Africa for an expedition and a subsequent symposium.

09.07.2025

HZI Campus

The One Health Surveillance team from HIOH receives the award for “Best Research Environment 2024”.

News

Excellent conditions for research, an inspiring atmosphere and fair cooperation: for all this, the research group “One Health Surveillance” (OHS) at the Helmholtz Institute for One Health (HIOH) has been awarded the “Best Research Environment 2024” prize by the Junge Akademie. Under the leadership of Dr. Fee Zimmermann, the OHS group is establishing health and environmental observatories, so-called “One Health Exploratories”, which collect long-term and systematic data on the health of humans, animals and the environment and integrate it into a big picture. The HIOH is a site of the Helmholtz Centre for Infection Research (HZI) in Braunschweig in cooperation with the University of Greifswald, the University Medicine Greifswald and the Friedrich-Loeffler-Institut.

09.07.2025

HIOH

Electron micrograph of coccal bacteria growing in chains

News

Influenza viruses can trigger epigenetic changes in the alveolar epithelium, the cell layer that lines the alveoli, permanent changes in gene activity without changing the DNA itself. These changes have a lasting effect on subsequent immune responses and result in the body no longer being able to react appropriately to the bacterial pathogens in the event of a subsequent infection with pneumococci. A research team at the Helmholtz Centre for Infection Research (HZI) and the University Hospital Magdeburg (UMMD) has published new findings on the long-term consequences of an influenza A infection in a mouse model in the journal Cell Communication and Signaling.

04.07.2025

HZI Campus

Preparing for historical specimen sampling

Story

From 4 to 6 June 2025, the Department “Pathogen Evolution” led by Prof. Dr. Sébastien Calvignac-Spencer at the Helmholtz Institute for One Health (HIOH) conducted a combined retreat and sampling mission at the Institute of Pathology of the University of Veterinary Medicine Vienna — a key collaboration partner for accessing and studying historical pathological specimens in veterinary medicine. HIOH is a site of the Helmholtz Centre for Infection Research (HZI). The visit focused on collecting around 60 historical tissue samples for molecular genetic analyses related to animal disease research, while also offering time for internal discussions on lab optimization, project development, and team building.

03.07.2025

HIOH

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HZI in the media

Quelle: Pressemitteilung

HZI-Helmholtz Zentrum für Infektionsforschung ...

04.11.2025

LaborPraxis

Forschende des Helmholtz-Zentrums für Infektionsforschung und der Universität Würzburg entwickeln derzeit einen Kaugummi, der Grippeviren

04.11.2025

Arbeitsmedizin-Sozialmedizin-Umweltmedizin

... Vakzinologie und angewandte Mikrobiologie am Helmholtz-Zentrum für Infektionsforschung. Die M2-Membranproteinhemmer verhindern ...

02.11.2025

Augsburger Allgemeine

... etwas dran ist“, erklärt Biologe Marc Stadler vom Helmholtz-Zentrum für Infektionsforschung gegenüber der Barmer-Krankenkasse. „Es ...

30.10.2025

bild der wissenschaft

could be reintroduced at any time. Epidemiologists at the Helmholtz Center for Infection Research (HZI) have now shown that many people do

23.10.2025

MSN.com

... eingeschleppt werden könnte. Epidemiolog:innen des Helmholtz-Zentrums für Infektionsforschung (HZI) haben nun gezeigt, dass ...

23.10.2025

innovations report

this development, a research team at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), in collaboration with the Swiss

22.10.2025

Phys.org

Malaria-Medikamentes ermöglichen könnte. Das HIPS ist ein Standort des Helmholtz-Zentrums für Infektionsforschung in Zusammenarbeit mit ...

22.10.2025

Verband Deutscher Biologen e.V.

(Bild: DOI: 10.1021/jacs.5c08354 / Hips / CC BY 4.0) Wissenschaftler am Hips entwickelten eine Plattform zur Produktion von Furanoliden, die effektiv gegen Bakterien und Krebszellen wirken können und vielversprechende Wirkstoffe darstellen.

21.10.2025

PROCESS

at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), in partnership with the Helmholtz Centre for Infection Research (HZI

20.10.2025

Bioengineer.org

their biological activity. HIPS is a site of the Helmholtz Center for Infection Research (HZI) in collaboration with Saarland University.

20.10.2025

Phys.org

... die Abteilung „Experimentelle Immunologie“ am Helmholtz-Zentrum für Infektionsforschung (HZI) in Braunschweig, lehrt als Professor an ...

17.10.2025

Deutsches Ärzteblatt

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