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Researchers at the Helmholtz Centre for Infection Research (HZI) have contributed to a study by the Medical Center Hamburg-Eppendorf (UKE) that has uncovered a new mechanism of neuron damage in the autoimmune disease multiple sclerosis (MS). Until now, it was unclear how inflammation in MS reduces protein degradation and leads to their harmful accumulation in neurons. A combination of new molecular biological, biochemical, and genetic methods enabled the international research team to identify a previously unknown mechanism of impaired protein degradation in inflamed neurons and its key regulator, the immunoproteasome.

18.06.2025

HZI Campus

Electron microscope image of Bacteroides thetaiotaomicron, illustrating the differences in the size of the bacterial cells.

News

Despite being genetically identical, bacteria can vary considerably in shape and size. Whether these variations affect bacterial function has remained an open question. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Chair of Microbiology of the Julius-Maximilians-Universität Würzburg (JMU) have now characterized the functional differences between various forms of the gut bacterium Bacteroides thetaiotaomicron. They demonstrated a link between cell type and metabolic function. These findings offer deeper insights into microbial gut diversity and pave the way for new possibilities in microbiome-based therapies. The study was recently published in the journal Cell Reports.

17.06.2025

HZI Campus

HIRI

Students and lecturers of the NOZGEKA Master program in Malawi

News

An efficient global pandemic preparedness and response requires experts who are trained to perform epidemiological studies and infectious disease modelling. The Helmholtz Centre for Infection Research (HZI) leads the consortium NOZGEKA with the aim of establishing a Master of Science in Public Health with a focus on infectious disease epidemiology in Malawi. The University of Münster and Medical Center - University of Freiburg, and University of Livingstonia (UNILIA) and Mzuzu University (MZUNI) in Malawi are collaborators in the consortium.

17.06.2025

HZI Campus

CiiM coordinator Jennifer Debarry presents the CiiM Founders's Award to Michael Manns

News

The CiiM Founders' Award was given to Prof. Michael Manns at the fifth meeting of the CiiM Directorate. The award, made from a concrete core and larch wood from the future CiiM building, honors his outstanding commitment to the founding and establishment of the Centre for Individualised Infection Medicine (CiiM). The CiiM is a joint institution of the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH).

16.06.2025

CiiM

News

Every year, the Controlled Release Society (CRS) honors outstanding individuals who have significantly advanced the field of drug delivery. This year, Prof. Claus-Michael Lehr has been awarded the CRS Distinguished Service Award for his long-standing commitment to the society and his influential contributions to pharmaceutical science.

12.06.2025

HIPS

Three intestinal organoids (gray) with spreading Shigella infection (green)

News

Thanks to lab-grown miniature intestines, researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg in collaboration with Uppsala University in Sweden have successfully mapped how aggressive Shigella bacteria infect the human gut. The study, published today in the journal Nature Genetics, opens the door to using cultured human mini-organs to investigate a wide range of other serious infections.

12.06.2025

HIRI

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HZI in the media

new antiviral medicines, says virologist Christian Sieben of the Helmholtz Centre for Infection Research in Germany.

Earlier in 2025, for

10.11.2025

The Press

Hochschule Hannover, die Universitätsmedizin Göttingen, das Helmholtz-Zentrum für Infektionsforschung in Braunschweig sowie die KI-

07.11.2025

Heise online

... , Leiter der Forschungsgruppe Mikrobielle Wirkstoffe am Helmholtz-Zentrum für Infektionsforschung, zu bedenken. Das erste ...

07.11.2025

Leipziger Volkszeitung (LVZ)

Quelle: Pressemitteilung

HZI-Helmholtz Zentrum für Infektionsforschung ...

04.11.2025

LaborPraxis

Forschende des Helmholtz-Zentrums für Infektionsforschung und der Universität Würzburg entwickeln derzeit einen Kaugummi, der Grippeviren

04.11.2025

Arbeitsmedizin-Sozialmedizin-Umweltmedizin

... Vakzinologie und angewandte Mikrobiologie am Helmholtz-Zentrum für Infektionsforschung. Die M2-Membranproteinhemmer verhindern ...

02.11.2025

Augsburger Allgemeine

... etwas dran ist“, erklärt Biologe Marc Stadler vom Helmholtz-Zentrum für Infektionsforschung gegenüber der Barmer-Krankenkasse. „Es ...

30.10.2025

bild der wissenschaft

could be reintroduced at any time. Epidemiologists at the Helmholtz Center for Infection Research (HZI) have now shown that many people do

23.10.2025

MSN.com

... eingeschleppt werden könnte. Epidemiolog:innen des Helmholtz-Zentrums für Infektionsforschung (HZI) haben nun gezeigt, dass ...

23.10.2025

innovations report

this development, a research team at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), in collaboration with the Swiss

22.10.2025

Phys.org

Malaria-Medikamentes ermöglichen könnte. Das HIPS ist ein Standort des Helmholtz-Zentrums für Infektionsforschung in Zusammenarbeit mit ...

22.10.2025

Verband Deutscher Biologen e.V.

(Bild: DOI: 10.1021/jacs.5c08354 / Hips / CC BY 4.0) Wissenschaftler am Hips entwickelten eine Plattform zur Produktion von Furanoliden, die effektiv gegen Bakterien und Krebszellen wirken können und vielversprechende Wirkstoffe darstellen.

21.10.2025

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