Dr Lothar Gröbe

Dr Lothar Gröbe
Research Group Leader
+49 531 6181-3073

Dr Lothar Gröbe

Lothar Gröbe studied biology at the University of Braunschweig. He worked as PhD student at the GBF, the ancestor of the HZI, and received his PhD about the „Interaction of the ActA protein of Listeria monocytogenes with the cytoskeleton of the host cell“. 

As a postdoc at the GBF he established the high-speed cell sorter MoFlo. After working as application specialist for Cytomation, he returned to the GBF and continued to be in charge of the cell sorters at the HZI. 

Lothar Gröbe is a member of the department Experimental Immunology and since 2010 he is head of the cytometry platform of the HZI.

Publications
Seffer M.T., Weinert M., Molinari G., Rohde M., Gröbe L., ... , Kielstein J.T., Engelmann S. (2023)
Staphylococcus aureus binding to Seraph- â
PLoS ONE, 18 (3)
DOI: 10.1371/journal.pone.0283304 HZI-Repositorium PubMed
Alpers K., Vatareck E., Gröbe L., Müsken M., Scharfe M., ... , Häußler S., Tomasch J. (2023)
Transcriptome Dynamics of Pseudomonas aeruginosa during Transition from Overlapping To Non-Overlapping Cell Cycles
mSystems.
DOI: 10.1128/msystems.01130-22 HZI-Repositorium PubMed
Tegge W., Guerra G., Höltke A., Schiller L., Beutling U., Harmrolfs K., Gröbe L., Wullenkord H., Xu C., ... , Weich H., Brönstrup M. (2021)
Selective bacterial targeting and infection-triggered release of antibiotic colistin conjugates
Angew.Chem.Int.Ed Engl., 60 (33)
DOI: 10.1002/anie.202104921 HZI-Repositorium PubMed
Voigt J., Malone D.F.G., Dias J., Leeansyah E., Björkstrom N.K., Ljunggren H.G., Gröbe L., Klawonn F., Heyner M., ... , Sandberg J.K., Jänsch L. (2018)
Proteome analysis of human CD56(neg) NK cells reveals a homogeneous phenotype surprisingly similar to CD56(dim) NK cells
Eur.J.Immunol., 48 (9)
DOI: 10.1002/eji.201747450
Van Ham M., Teich R., Philipsen L., Niemz J., Amsberg N., Wissing J., Nimtz M., Grobe L., Kliche S., Thiel N., Klawonn F., Hubo M., Jonuleit H., Reichardt P., Muller A.J., ... , Hühn J., Jänsch L. (2017)
TCR signalling network organization at the immunological synapses of murine regulatory T cells
Eur.J.Immunol., 47 (12)
DOI: 10.1002/eji.201747041 HZI-Repositorium PubMed
Yang B.H., Flöß S., Hagemann S., Deyneko I.V., Gröbe L., Pezoldt J., Sparwasser T., ... , Lochner M., Hühn J. (2015)
Development of a unique epigenetic signature during in vivo Th17 differentiation
Nucleic Acids Res, 43 (3)
DOI: 10.1093/nar/gkv014 HZI-Repositorium PubMed
Patzelt D., Wang H., Buchholz I., Rohde M., Gröbe L., Pradella S., Neumann A., Schulz S., Heyber S., Munch K., Munch R., Jahn D., ... , Wagner-Döbler I., Tomasch J. (2013)
You are what you talk: quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae
ISME Journal, 7 (12)
DOI: 10.1038/ismej.2013.107
Scheiter Maxi, Lau Ulrike, van Ham Marco, Bulitta Björn, Gröbe Lothar, Garritsen H., Klawonn Frank, ... , Konig S., Jänsch Lothar (2013)
Proteome analysis of distinct developmental stages of human natural killer (NK) cells
Molecular and Cellular Proteomics, 12 (5)
DOI: 10.1074/mcp.M112.024596 HZI-Repositorium PubMed
Kahlisch L., Henne K., Gröbe Lothar*, Brettar I., Höfle Manfred G.* (2011)
Assessing the Viability of Bacterial Species in Drinking Water by Combined Cellular and Molecular Analyses3526
Microbial Ecology, 63 (2)
DOI: 10.1007/s00248-011-9918-4
Wilke S., Gröbe Lothar*, Maffenbeier V., Jäger Volker*, Gossen M., Josewski J., Duda A., Polle L., Owens R.J., Wirth Dagmar*, Heinz Dirk* W., ... , van den Heuvel Joop*, Büssow Konrad* (2011)
Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development
PLoS ONE, 6 (12)
DOI: 10.1371/journal.pone.0027829 HZI-Repositorium PubMed
Zygmunt B.M., Gröbe L., Guzmán C.A. (2011)
Peritoneal cavity is dominated by IFNgamma-secreting CXCR3+ Th1 cells
PLoS ONE, 6 (7)
DOI: 10.1371/journal.pone.0018032 HZI-Repositorium PubMed
Lemme A., Grobe L., Reck M., Tomasch J., Wagner-Döbler Irene* (2011)
Subpopulation-Specific Transcriptome Analysis of Competence-Stimulating-Peptide-Induced Streptococcus mutans
Journal of Bacteriology, 193 (8)
DOI: 10.1128/JB.01363-10 HZI-Repositorium PubMed
Wilke S., Krausze J., Gossen M., Gröbe Lothar*, Jager V., Gherardi E., ... , van den Heuvel J., Bussow Konrad* (2010)
Glycoprotein production for structure analysis with stable, glycosylation mutant CHO cell lines established by fluorescence-activated cell sorting
Protein Science, 19 (6)
Kahlisch L., Henne K., Gröbe Lothar*, Draheim J., Höfle Manfred G.*, Brettar I. (2010)
Molecular analysis of the bacterial drinking water community with respect to live/dead status
Water Science and Technology, 61 (1)
DOI: 10.2166/wst.2010.773
Pils M.C., Pisano F., Fasnacht N., Heinrich J.M., Gröbe Lothar*, Schippers A., Rozell B., ... , Jack R.S., Muller W. (2010)
Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
European Journal of Immunology, 40 (2)
DOI: 10.1002/eji.200939592
Zygmunt B.M., Rharbaoui F., Gröbe L., Guzmán C.A. (2009)
Intranasal immunization promotes th17 immune responses
Journal of Immunology, 183 (11)
Westendorf A.M., Fleissner D., Gröbe Lothar*, Jung S., Gruber A.D., ... , Hansen W., Buer J. (2009)
CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells
GUT, 58 (2)
Gekara N.O., Gröbe Lothar*, Viegas N., Weiss Siegfried* (2008)
Listeria monocytogenes desensitizes immune cells to subsequent Ca
Infection and Immunity, 76 (2)
DOI: 10.1128/IAI.00622-07 HZI-Repositorium PubMed
Hansen W., Westendorf A.M., Reinwald S., Bruder Dunja*, Deppenmeier S., Gröbe Lothar*, Probst-Kepper Michael*, Gruber A.D., ... , Geffers Robert*, Buer Jan* (2007)
Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3 -
Journal of Immunology, 179
Gereke M., Gröbe L., Prettin S., Kasper M., Deppenmeier S., Gruber A.D., Enelow R.I., ... , Buer J., Bruder D. (2007)
Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation
Respiratory research, 8
DOI: 10.1186/1465-9921-8-47 HZI-Repositorium PubMed
Gekara N.O., Westphal K., Ma B., Rohde M., Gröbe L., Weiss S. (2007)
The multiple mechanisms of Ca 2+
Cellular Microbiology, 9 (8)
DOI: 10.1111/j.1462-5822.2007.00932.x HZI-Repositorium PubMed
Fleige A., Alberti S., Gröbe L., Frischmann U., Geffers R., Müller W., ... , Nordheim A., Schippers A. (2007)
Serum response factor contributes selectively to lymphocyte development
The Journal of Biological Chemistry, 282 (33)
DOI: 10.1074/jbc.M703119200 HZI-Repositorium PubMed
Pistor S., Grobe L., Sechi A.S., Domann E., Gerstel B., Machesky L.M., ... , Chakraborty T., Wehland J. (2000)
Mutations of arginine residues within the 146-KKRRK-150 motif of the ActA protein of Listeria monocytogenes abolish intracellular motility by interfering with the recruitment of the Arp2/3 complex
Journal of Cell Science, 113 (18)

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