[Translate to English:] Prof. Dr. Carlos A. Guzmán

Petriv N., Suo H., Hochnadel I., Timrott K., Bondarenko N., Neubert L., Reinhard E., Jedicke N., Kaufhold P., Guzman C.A., Lichtinghagen R., Manns M.P., ... , Bantel H., Yevsa T. (2024)

Essential roles of B cell subsets in the progression of MASLD and HCC

JHEP Reports, 6 (12)

DOI: 10.1016/j.jhepr.2024.101189 HZI-Repositorium PubMed

Kumar S., Zoodsma M., Nguyen N., Pedroso R., Trittel S., Riese P., Botey-Bataller J., Zhou L., Alaswad A., Arshad H., Netea M.G., Xu C.J., Pessler F., Guzman C.A., ... , Graca L., Li Y. (2024)

Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population

Sci.Adv., 10 (39)

DOI: 10.1126/sciadv.adq7006 HZI-Repositorium PubMed

Uno N., Ebensen T., Guzman C.A., Ross T.M. (2024)

Intranasal administration of octavalent next-generation influenza vaccine elicits protective immune responses against seasonal and pre-pandemic viruses

J.Virol., 98 (9)

DOI: 10.1128/jvi.00354-24 HZI-Repositorium PubMed

Valdes I., Suzarte E., Lazo L., Cobas K., Cabrales A., Perez Y., Garateix R., Silva J.A., Aguilar J.C., ... , Guzman C.A., Guillen G. (2024)

Addition of nucleotide adjuvants enhances the immunogenicity of a recombinant subunit vaccine against the Zika virus in BALB/c mice

Vaccine, 42 (25)

DOI: 10.1016/j.vaccine.2024.126213 PubMed

Demoulins T., Techakriengkrai N., Ebensen T., Schulze K., Liniger M., Gerber M., Nedumpun T., McCullough K.C., Guzman C.A., ... , Suradhat S., Ruggli N. (2024)

New Generation Self-Replicating RNA Vaccines Derived from Pestivirus Genome

Methods Mol.Biol., 2. edition

DOI: 10.1007/978-1-0716-3770-8_4 PubMed

Schulze K., Weber U., Schuy C., Durante M., Guzman C.A. (2024)

Influenza Virus Inactivated by Heavy Ion Beam Irradiation Stimulates Antigen-Specific Immune Responses

Pharmaceutics, 16 (4)

DOI: 10.3390/pharmaceutics16040465 HZI-Repositorium PubMed

Hillenbrand M., Esslinger C., Seidenberg J., Weber M., Zingg A., Townsend C., Eicher B., Rutkauskaite J., Riese P., Guzman C.A., ... , Fischer K., Schmitt S. (2024)

Fast-Track Discovery of SARS-CoV-2-Neutralizing Antibodies from Human B Cells by Direct Functional Screening

Viruses., 16 (3)

DOI: 10.3390/v16030339 HZI-Repositorium PubMed

Jungbluth S., Martin W., Slezak M., Depraetere H., Guzman C.A., Ussi A., Morrow D., van Heuverswyn F., Arnouts S., Carrondo M.J.T., Olesen O., Ottenhoff T.H.M., Dockrell H.M., Ho M.M., Dobly A., Christensen D., Segales J., Laurent F., Lantier F., Stockhofe-Zurwieden N., Morelli F., Langermans J.A.M., Verreck F.A.W., Le Grand R., Sloots A., Medaglini D., ... , Lawrenz M., Collin N. (2023)

Potential business model for a European vaccine R&D infrastructure and its estimated socio-economic impact

F1000Research, 12

DOI: 10.12688/f1000research.141399.1 HZI-Repositorium PubMed

Mendez Y., Vasco A.V., Ebensen T., Schulze K., Yousefi M., Davari M., Wessjohann L.A., Guzman C.A., ... , Rivera D.G., Westermann B. (2023)

Diversification of a Novel a[alpha]-Galactosyl Ceramide Hotspot Boosts the Adjuvant Properties in Parenteral and Mucosal Vaccines

Angew.Chem.Int.Ed Engl.

DOI: 10.1002/anie.202310983 HZI-Repositorium PubMed

Lopez-Serrano S., Mahmmod Y.S., Christensen D., Ebensen T., Guzman C.A., Rodriguez F., ... , Segales J., Aragon V. (2023)

Immune responses following neonatal vaccination with conserved F4 fragment of VtaA proteins from virulent Glaesserella parasuis adjuvanted with CAF®01 or CDA

Vaccine X., 14

DOI: 10.1016/j.jvacx.2023.100330 HZI-Repositorium PubMed

Paschold L., Gottschick C., Langer S., Klee B., Diexer S., Aksentijevich I., Schultheiß C., Purschke O., Riese P., Trittel S., Haase R., Dressler F., Eberl W., Hübner J., Strowig T., Guzman C.A., ... , Mikolajczyk R., Binder M. (2023)

T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort

Sci.Rep., 13 (1)

DOI: 10.1038/s41598-023-36144-x HZI-Repositorium

Ebensen T., Arntz A., Schulze K., Hanefeld A., Guzman C.A., Scherließ R. (2023)

Pulmonary Application of Novel Antigen-Loaded Chitosan Nano-Particles Co-Administered with the Mucosal Adjuvant C-Di-AMP Resulted in Enhanced Immune Stimulation and Dose Sparing Capacity

Pharmaceutics., 15 (4)

DOI: 10.3390/pharmaceutics15041238 HZI-Repositorium PubMed

Demuth L., Ohm M., Michaelsen-Preusse K., Schulze K., Riese P., Guzman C.A., ... , Korte M., Hosseini S. (2023)

Influenza vaccine is able to prevent neuroinflammation triggered by H7N7 IAV infection

Frontiers in Pharmacology, 14

DOI: 10.3389/fphar.2023.1142639 HZI-Repositorium PubMed

Sanchez M.V., Ebensen T., Schulze K., Cargnelutti D.E., Scodeller E.A., Guzmán C.A. (2023)

Protective Efficacy of a Mucosal Influenza Vaccine Formulation Based on the Recombinant Nucleoprotein Co-Administered with a TLR2/6 Agonist BPPcysMPEG

Pharmaceutics., 15 (3)

DOI: 10.3390/pharmaceutics15030912 HZI-Repositorium PubMed

Zayed A.R., Bitar D.M., Steinert M., Lück C., Spröer C., Brettar I., ... , Höfle M.G., Bunk B. (2023)

Comparative Genomics of Legionella pneumophila Isolates from the West Bank and Germany Support Molecular Epidemiology of Legionnaires' Disease

Microorganisms., 11 (2)

DOI: 10.3390/microorganisms11020449 HZI-Repositorium PubMed

Demoulins T., Schulze K., Ebensen T., Techakriengkrai N., Nedumpun T., Englezou P.C., Gerber M., Hlushchuk R., Toledo D., Djonov V., von Gunten S., McCullough K.C., Liniger M., Guzmán C.A., ... , Suradhat S., Ruggli N. (2023)

Coatsome-replicon vehicles: Self-replicating RNA vaccines against infectious diseases

Nanomedicine.

DOI: 10.1016/j.nano.2023.102655 HZI-Repositorium PubMed

Ramponi F., Aerts C., Sartor P., Pinazo M.J., Freilij H., Guzmán C.A., ... , Malchiodi E., Sicuri E. (2022)

Development of vaccines for Chagas disease (CRUZIVAX): stakeholders' preferences and potential impacts on healthcare

Gaceta Sanit., 37

DOI: 10.1016/j.gaceta.2022.102275 HZI-Repositorium PubMed

Riese P., Trittel S., Akmatov M.K., May M., Prokein J., Illig T., Schindler C., Sawitzki B., Elfaki Y., Floess S., Huehn J., Blazejewski A.J., Strowig T., Hernandez-Vargas E.A., Geffers R., Zhang B., Li Y., ... , Pessler F., Guzmán C.A. (2022)

Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Nat.Commun., 13 (1)

DOI: 10.1038/s41467-022-34487-z HZI-Repositorium PubMed

Wagner A.K., Kadri N., Tibbitt C., van de Ven K., Bagawath-Singh S., Oliinyk D., LeGresley E., Campbell N., Trittel S., Riese P., Ribacke U., Sandalova T., Achour A., ... , Kärre K., Chambers B.J. (2022)

PD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype

iScience, 25 (10)

DOI: 10.1016/j.isci.2022.105137 HZI-Repositorium PubMed

Fernandes B., Sousa M., Castro R., Schäfer A., Hauser J., Schulze K., Amacker M., Tamborrini M., Pluschke G., Alves P.M., ... , Fleury S., Roldáo A. (2022)

Scalable Process for High-Yield Production of PfCyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate

Front Bioeng.Biotechnol., 10

DOI: 10.3389/fbioe.2022.879078 HZI-Repositorium PubMed

Hochnadel I., Hoenicke L., Petriv N., Neubert L., Reinhard E., Hirsch T., Alfonso J.C.L., Suo H., Longerich T., Geffers R., Lichtinghagen R., Guzmán C.A., Wedemeyer H., Lenzen H., Manns M.P., ... , Bruder D., Yevsa T. (2022)

Correction: Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers (Oncogene, (2022), 41, 14, (2039-2053), 10.1038/s41388-022-02222-z)

Oncogene, 41 (19)

DOI: 10.1038/s41388-022-02261-6 HZI-Repositorium PubMed

Caputo A., Guzmán C.A., Palmer C.S., Nicoli F. (2022)

Editorial: The Role of Systemic and Cellular Metabolism on Susceptibility to Infections and Responsiveness to Vaccination

Front Cell Infect Microbiol, 12

DOI: 10.3389/fcimb.2022.854241 HZI-Repositorium PubMed

Hochnadel I., Hoenicke L., Petriv N., Neubert L., Reinhard E., Hirsch T., Alfonso J.C.L., Suo H., Longerich T., Geffers R., Lichtinghagen R., Guzmán C.A., Wedemeyer H., Lenzen H., Manns M.P., ... , Bruder D., Yevsa T. (2022)

Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers

Oncogene

DOI: 10.1038/s41388-022-02222-z HZI-Repositorium PubMed

Kim Y., Zheng X., Eschke K., Chaudhry M.Z., Bertoglio F., Tomic A., Krmpotic A., Hoffmann M., Bar-On Y., Boehme J., Bruder D., Ebensen T., Brunotte L., Ludwig S., Messerle M., Guzmán C., Mandelboim O., Hust M., Pöhlmann S., ... , Jonjic S., Cicin-Sain L. (2022)

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

Cell Mol.Immunol., 19 (2)

DOI: 10.1038/s41423-021-00814-5 HZI-Repositorium PubMed

Langer S., Horn J., Gottschick C., Klee B., Purschke O., Caputo M., Dorendorf E., Meyer-Schlinkmann K.M., Raupach-Rosin H., Karch A., Rübsamen N., Aydogdu M., Buhles M., Dressler F., Eberl W., von Koch F.E., Frambach T., Franz H., Guthmann F., Guzmán C.A., Haase R., Hansen G., Heselich V., Hübner J., Koch H.G., Oberhoff C., Riese P., Schild R., Seeger S., Tchirikov M., Trittel S., ... , Von Kaisenberg C., Mikolajczyk R. (2022)

Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life - Results from the LoewenKIDS Cohort

Microorg., 10 (1)

DOI: 10.3390/microorganisms10010111 HZI-Repositorium PubMed

Sohail A., Iqbal A.A., Sahini N., Chen F., Tantawy M., Waqas F., Winterhoff M., Ebensen T., Schultz K., Geffers R., Schughart K., Preusse M., Shehata M., Bähre H., Pils M.C., Guzmán C.A., Mostafa A., Pleschka S., Falk C., ... , Michelucci A., Pessler F. (2022)

Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection

PLoS Pathog., 18 (1)

DOI: 10.1371/journal.ppat.1010219 HZI-Repositorium PubMed

Lopez-Serrano S., Cordoba L., Perez-Maillo M., Pleguezuelos P., Remarque E.J., Ebensen T., Guzmán C.A., Christensen D., ... , Segales J., Darji A. (2021)

Immune responses to pandemic h1n1 influenza virus infection in pigs vaccinated with a conserved hemagglutinin HA1 peptide adjuvanted with CAF-®01 or CDA/ a

Vaccines, 9 (7)

DOI: 10.3390/vaccines9070751 HZI-Repositorium PubMed

Lanfermann C., Wintgens S., Ebensen T., Kohn M., Laudeley R., Schulze K., Rheinheimer C., Hegemann J.H., ... , Guzmán C.A., Klos A. (2021)

Prophylactic multi-subunit vaccine against chlamydia trachomatis: In vivo evaluation in mice

Vaccines, 9 (6)

DOI: 10.3390/vaccines9060609 HZI-Repositorium PubMed

Graalmann T., Borst K., Manchanda H., Vaas L., Bruhn M., Graalmann L., Köster M., Verboom M., Hallensleben M., Guzmán C.A., Sutter G., Schmidt R.E., ... , Witte T., Kalinke U. (2021)

B cell depletion impairs vaccination-induced CD8+T cell responses in a type i interferon-dependent manner

Annals of the Rheumatic Diseases

DOI: 10.1136/annrheumdis-2021-220435 HZI-Repositorium PubMed

Shukla D., Patidar A., Sarma U., Chauhan P., Pandey S.P., Chandel H.S., Bodhale N., Ghosh S.K., Guzmán C.A., Ebensen T., Silvestre R., Sarkar A., ... , Saha B., Bhattacharjee S. (2021)

Interdependencies between Toll-like receptors in Leishmania infection

Immunology, 164 (1)

DOI: 10.1111/imm.13364 HZI-Repositorium PubMed

Sharma A., Sanduja P., Anand A., Mahajan P., Guzmán C.A., Yadav P., Awasthi A., Hanski E., ... , Dua M., Johri A.K. (2021)

Advanced strategies for development of vaccines against human bacterial pathogens

World J.Microbiol.Biotechnol., 37 (4)

DOI: 10.1007/s11274-021-03021-6 HZI-Repositorium PubMed

Lirussi D., Weissmann S.F., Ebensen T., Nitsche-Gloy U., Franz H.B.G., Guzmán C.A. (2021)

Cyclic di-adenosine monophosphate: A promising adjuvant candidate for the development of neonatal vaccines

Pharmaceutics, 13 (2)

DOI: 10.3390/pharmaceutics13020188 HZI-Repositorium PubMed

Demoulins T., Ruggli N., Gerber M., Thomann-Harwood L.J., Ebensen T., Schulze K., ... , Guzmán C.A., McCullough K.C. (2021)

Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs

Front Immunol., 11

DOI: 10.3389/fimmu.2020.622385 HZI-Repositorium PubMed

Francis Z., Incerti S., Zein S.A., Lampe N., Guzmán C.A., Durante M. (2021)

Monte Carlo Simulation of SARS-CoV-2 Radiation-Induced Inactivation for Vaccine Development

Radiat.Res., 195 (3)

DOI: 10.1667/RADE-20-00241.1 HZI-Repositorium PubMed

Durante M., Schulze K., Incerti S., Francis Z., Zein S., Guzmán C.A. (2020)

Virus Irradiation and COVID-19 Disease

Front.Phys., 8

DOI: 10.3389/fphy.2020.565861 HZI-Repositorium

Pogozhykh D., Eicke D., Gryshkov O., Wolkers W.F., Schulze K., Guzmán C.A., ... , Blasczyk R., Figueiredo C. (2020)

Towards Reduction or Substitution of Cytotoxic DMSO in Biobanking of Functional Bioengineered Megakaryocytes

Int.J.Mol.Sci., 21 (20)

DOI: 10.3390/ijms21207654 HZI-Repositorium PubMed

Guzmán C.A. (2020)

Next Generation Influenza Vaccines: Looking into the Crystal Ball

Vaccines.(Basel), 8 (3)

DOI: 10.3390/vaccines8030464 HZI-Repositorium PubMed

Zeeb M., Kerrinnes T., Cicin-Sain L., Guzmán C.A., Puppe W., Schulz T.F., Peters A., Berger K., ... , Castell S., Karch A. (2020)

Seropositivity for pathogens associated with chronic infections is a risk factor for all-cause mortality in the elderly: findings from the Memory and Morbidity in Augsburg Elderly (MEMO) Study

Geroscience., 42 (5)

DOI: 10.1007/s11357-020-00216-x HZI-Repositorium PubMed

Montefusco-Pereira C.V., Horstmann J.C., Ebensen T., Beisswenger C., Bals R., Guzmán C.A., Schneider-Daum N., ... , Carvalho-Wodarz C.S., Lehr C.M. (2020)

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

J.Vis.Exp. (160)

DOI: 10.3791/61069 HZI-Repositorium PubMed

Riese P., Trittel S., Pathirana R.D., Klawonn F., Cox R.J., Guzmán C.A. (2020)

Responsiveness to influenza vaccination correlates with nkg2c-expression on nk cells

Vaccines.(Basel), 8 (2)

DOI: 10.3390/vaccines8020281 HZI-Repositorium PubMed

Patidar A., Selvaraj S., Chauhan P., Guzmán C.A., Ebenson T., Sarkar A., ... , Chattopadhyay D., Saha B. (2020)

Peptidoglycan-treated tumor antigen-pulsed dendritic cells impart complete resistance against tumor rechallenge

Clin.Exp.Immunol., 201 (3)

DOI: 10.1111/cei.13468 HZI-Repositorium PubMed

Freuer D., Linseisen J., Waterboer T., Pessler F., Guzmán C.A., Wawro N., ... , Peters A., Meisinger C. (2020)

Seropositivity of selected chronic infections and different measures of obesity

PLoS.ONE., 15 (4)

DOI: 10.1371/journal.pone.0231974 HZI-Repositorium PubMed

Bugatti A., Marsico S., Mazzuca P., Schulze K., Ebensen T., Giagulli C., Pena E., Badimón L., Slevin M., Caruso A., ... , Guzmán C.A., Caccuri F. (2020)

Role of autophagy in von willebrand factor secretion by endothelial cells and in the in vivo thrombin-antithrombin complex formation promoted by the hiv-1 matrix protein p17

Int.J.Mol.Sci., 21 (6)

DOI: 10.3390/ijms21062022 HZI-Repositorium PubMed

Sanchez Alberti A., Bivona A.E., Matos M.N., Cerny N., Schulze K., Weissmann S., Ebensen T., Gonzalez G., Morales C., Cardoso A.C., Cazorla S.I., ... , Guzmán C.A., Malchiodi E.L. (2020)

Mucosal Heterologous Prime/Boost Vaccination Induces Polyfunctional Systemic Immunity, Improving Protection Against Trypanosoma cruzi

Front Immunol., 11

DOI: 10.3389/fimmu.2020.00128 HZI-Repositorium PubMed

Böning M.A.L., Trittel S., Riese P., Van Ham M., Heyner M., Voss M., Parzmair G.P., Klawonn F., Jeron A., Guzmán C.A., Jänsch L., Schraven B., ... , Reinhold A., Bruder D. (2020)

ADAP Promotes Degranulation and Migration of NK Cells Primed During in vivo Listeria monocytogenes Infection in Mice

Front.Immunol., 10

DOI: 10.3389/fimmu.2019.03144 HZI-Repositorium PubMed

Ebensen T., Fuchs B., Schulze K., Guzmán C.A. (2019)

Infection prevention: oil- and lipid-containing products in vaccinology

(7)

DOI: 10.1007/978-3-319-72473-7_25-1

Michler T., Kosinska A.D., Festag J., Bunse T., Su J., Ringelhan M., Imhof H., Grimm D., Steiger K., Mogler C., Heikenwalder M., Michel M.L., Guzmán C.A., Milstein S., Sepp-Lorenzino L., ... , Knolle P., Protzer U. (2020)

Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-titer HBV Carrier Mice

Gastroenterology, 158 (6)

DOI: 10.1053/j.gastro.2020.01.032 HZI-Repositorium PubMed

Batyrova B., Luwaert F., Maravelia P., Miyabayashi Y., Vashist N., Stark J.M., Soori S.Y., Tibbitt C.A., Riese P., ... , Coquet J.M., Chambers B.J. (2020)

PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-?

Immun.Inflamm.Dis., 8 (1)

DOI: 10.1002/iid3.279 HZI-Repositorium PubMed

Trittel S., Chambers B.J., Heise U., Guzmán C.A., Riese P. (2019)

Key features and homing properties of NK cells in the liver are shaped by activated iNKT cells

Sci.Rep., 9 (1)

DOI: 10.1038/s41598-019-52666-9 HZI-Repositorium PubMed

Zheng X., Oduro J.D., Boehme J.D., Borkner L., Ebensen T., Heise U., Gereke M., Pils M.C., Krmpotic A., Guzmán C.A., ... , Bruder D., Cicin-Sain L. (2019)

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge

PLoS Pathog., 15 (9)

DOI: 10.1371/journal.ppat.1008036 HZI-Repositorium PubMed

Sharma-Chawla N., Stegemann-Koniszewski S., Christen H., Boehme J.D., Kershaw O., Schreiber J., Guzmán C.A., ... , Bruder D., Hernandez-Vargas E.A. (2019)

In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection

Front Immunol., 10

DOI: 10.3389/fimmu.2019.01864 HZI-Repositorium PubMed

Trittel S., Vashist N., Ebensen T., Chambers B.J., Guzmán C.A., Riese P. (2019)

Invariant NKT Cell-Mediated Modulation of ILC1s as a Tool for Mucosal Immune Intervention

Front Immunol., 10

DOI: 10.3389/fimmu.2019.01849 HZI-Repositorium PubMed

Gottschick C., Raupach-Rosin H., Langer S., Hassan L., Horn J., Dorendorf E., Caputo M., Bittner M., Beier L., Rübsamen N., Schlinkmann K., Zoch B., Guzmán C.A., Hansen G., Heselich V., Holzapfel E., Hübner J., Pietschmann T., Pieper D.H., Pletz M., Riese P., Schmidt-Pokrzywniak A., Hartwig S., Von Kaisenberg C., Aydogdu M., Buhles M., Dressler F., Eberl W., Haase R., von Koch F.E., Feidicker S., Frambach T., Franz H.G.B., Guthmann F., Koch H.G., Seeger S., Oberhoff C., Pauker W., Petry K.U., Schild R.L., Tchirikov M., Röhrig E., ... , Karch A., Mikolajczyk R. (2019)

Erratum: Cohort profile: The LoewenKIDS Study - Life-course perspective on infections, the microbiome and the development of the immune system in early childhood (International Journal of Epidemiology (2019) DOI: 10.1093/ije/dyz001)

Int.J.Epidemiol., 48 (4)

DOI: 10.1093/ije/dyz069 PubMed

Perche F., Clemencon R., Schulze K., Ebensen T., Guzmán C.A., Pichon C. (2019)

Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine

Mol.Ther.Nucl.Acids, 17 (September)

DOI: 10.1016/j.omtn.2019.07.014 HZI-Repositorium PubMed

Akmatov M.K., Riese P., Trittel S., May M., Prokein J., Illig T., Schindler C., ... , Guzmán C.A., Pessler F. (2019)

Self-reported diabetes and herpes zoster are associated with a weak humoral response to the seasonal influenza A H1N1 vaccine antigen among the elderly

BMC Infect.Dis., 19 (1)

DOI: 10.1186/s12879-019-4214-x HZI-Repositorium PubMed

Volckmar J., Knop L., Stegemann-Koniszewski S., Schulze K., Ebensen T., ... , Guzmán C.A., Bruder D. (2019)

The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly(I:C)/CpG after subcutaneous vaccination with soluble protein antigen or DEC-205-mediated antigen targeting to dendritic cells

Vaccine, 37 (35)

DOI: 10.1016/j.vaccine.2019.07.019 HZI-Repositorium PubMed

de Groot C., Müsken M., Bleckmann M., Ebensen T., Guzmán C.A., Müller-Goymann C.C. (2019)

Novel colloidal associations of soyasaponins and lipid components (DPPC, cholesterol) as potential adjuvants for vaccines

Vaccine, 37 (35)

DOI: 10.1016/j.vaccine.2019.07.020 PubMed

Matthijs A.M.F., Auray G., Jakob V., Garcia-Nicolas O., Braun R.O., Keller I., Bruggman R., Devriendt B., Boyen F., Guzmán C.A., Michiels A., Haesebrouck F., Collin N., Barnier-Quer C., ... , Maes D., Summerfield A. (2019)

Systems Immunology Characterization of Novel Vaccine Formulations for Mycoplasma hyopneumoniae Bacterins

Front Immunol., 10 (May 2019)

DOI: 10.3389/fimmu.2019.01087 HZI-Repositorium PubMed

Ebensen T., Schulze K., Prochnow B., Guzmán C.A. (2018)

Preclinical Animal Models for Developing Vaccines Against Influenza Infection for the Young and the Elderly

(168-1)

DOI: 10.1007/978-3-319-64597-1_168-1 PubMed

Ebensen T., Delandre S., Prochnow B., Guzmán C.A., Schulze K. (2019)

The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and Qualitative Enhanced Immune Responses Post Immunization

Front Cell Infect Microbiol, 9 (February)

DOI: 10.3389/fcimb.2019.00031 HZI-Repositorium PubMed

Gottschick C., Raupach-Rosin H., Langer S., Hassan L., Horn J., Dorendorf E., Caputo M., Bittner M., Beier L., Rübsamen N., Schlinkmann K., Zoch B., Guzmán C.A., Hansen G., Heselich V., Holzapfel E., Hübner J., Pietschmann T., Pieper D.H., Pletz M., Riese P., Schmidt-Pokrzywniak A., Hartwig S., von Kaisenberg C., Aydogdu M., Buhles M., Dressler F., Eberl W., Haase R., Edler von Koch F., Feidicker S., Frambach T., Franz H.G.B., Guthmann F., Koch H.G., Seeger S., Oberhoff C., Pauker W., Petry K.U., Schild R.L., Tchirikov M., ... , Röhrig E., Mikolajczyk R. (2019)

Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood

Int.J.Epidemiol., 48 (4)

DOI: 10.1093/ije/dyz001 HZI-Repositorium PubMed

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Vashist N., Trittel S., Ebensen T., Chambers B.J., Guzmán C.A., Riese P. (2018)

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Front.Immunol., 8 (MAR)

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Dual dye in-vivo imaging of differentially charged PLGA carriers reveals antigen-depot effect, leading to improved immune responses in preclinical models

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Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection

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Superior immunogenicity of HCV envelope glycoproteins when adjuvanted with cyclic-di-AMP, a STING acitvator or archaeosomes

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In Silico Vaccine Strain Prediction for Human Influenza Viruses

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Bivalent mucosal peptide vaccines administered using the LCP carrier system stimulate protective immune responses against Streptococcus pyogenes infection

Nanomedicine., 13 (8)

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Follicular Drug Delivery: a Root to Success - delivering drugs through the skin without the use of needles has proven a significant challenge for the scientific community. But what about exploiting hair follicles?

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Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway

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Intranasal vaccination with an adjuvanted polyphosphazenes nanoparticle-based vaccine formulation stimulates protective immune responses in mice

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Role of autophagy in the HIV-1 matrix protein p17-driven lymphangiogenesis

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Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders-findings of a multicenter population-based study

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Gene expression driven by a strong viral promoter in MVA increases vaccination efficiency by enhancing antibody responses and unmasking CD8+ t cell Epitopes

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Towards intelligent vaccines: the VAC-CHIP.

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Blockade of Neutrophil's Chemokine Receptors CXCR1/2 Abrogate Liver Damage in Acute-on-Chronic Liver Failure

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Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population

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Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver

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A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects

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Motivations for (non)participation in population-based health studies among the elderly - comparison of participants and nonparticipants of a prospective study on influenza vaccination

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Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand

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The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages

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Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions

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Big Data in Vaccinology: Introduction and section summaries

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High individuality of respiratory bacterial communities in a large cohort of adult cystic fibrosis patients under continuous antibiotic treatment

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TRANSVAC research infrastructure - Results and lessons learned from the European network of vaccine research and development

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Use of S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy polyethylene glycol as adjuvant improved protective immunity associated with a DNA vaccine encoding Cu,Zn superoxide dismutase of Brucella abortus in mice

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Pegylated Bisacycloxypropylcysteine, a Diacylated Lipopeptide Ligand of TLR6, Plays a Host-Protective Role against Experimental Leishmania major Infection

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Oral Multicomponent DNA Vaccine Delivered by Attenuated Salmonella Elicited Immunoprotection against American Trypanosomiasis

Journal of Infectious Diseases, 211

Sanchez M.V., Ebensen T., Schulze K., Cargnelutti D., Blazejewska P., ... , Scodeller E.A., Guzmán C.A. (2014)

Intranasal Delivery of Influenza rNP Adjuvanted with c-di-AMP Induces Strong Humoral and Cellular Immune Responses and Provides Protection against Virus Challenge

PLoS ONE, 9 (8)

Dutruel C., Thole J., Geels M., Mollenkopf H.J., Ottenhoff T., Guzmán C.A., Fletcher H.A., ... , Leroy O., Kaufmann S.H. (2014)

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'How can big data help?'

Vaccine, 32 (35)

DOI: 10.1016/j.vaccine.2014.06.014 HZI-Repositorium PubMed

Matos M.N., Cazorla S.I., Bivona A.E., Morales C., Guzmán C.A., Malchiodi E.L. (2014)

Tc52 Amino Terminal Domain DNA Carried by Attenuated Salmonella Induce Protection against a Trypanosoma cruzi Lethal Challenge

Infection and Immunity, 82 (10)

Salguero G., Daenthanasanmak A., Münz C., Raykova A., Guzmán C.A., Riese P., Figueiredo C., Länger F., Schneider A., Macke L., Sundarasetty B.S., Witte T., ... , Ganser A., Stripecke R. (2014)

Dendritic cell-mediated immune humanization of mice: Implications for allogeneic and xenogeneic stem cell transplantation

Journal of Immunology, 192 (10)

Neuhaus V., Chichester J.A., Ebensen Thomas, Schwarz K., Hartman C.E., Shoji Y., Guzmán Carlos A., Yusibov V., ... , Sewald K., Braun A. (2014)

A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung

Vaccine, 32 (26)

DOI: 10.1016/j.vaccine.2014.04.011 HZI-Repositorium PubMed

Skrnjug I., Rueckert C., Libanova R., Lienenklaus S., Weiss S., Guzmán C.A. (2014)

The Mucosal Adjuvant Cyclic di-AMP Exerts Immune Stimulatory Effects on Dendritic Cells and Macrophages

PLoS ONE, 9 (4)

DOI: 10.1371/journal.pone.0095728 HZI-Repositorium PubMed

Caccuri F., Rueckert C., Giagulli C., Schulze K., Basta D., Zicari S., Marsico S., Cervi E., Fiorentini S., Slevin M., ... , Guzmán C.A., Caruso A. (2014)

HIV-1 matrix protein p17 promotes lymphangiogenesis and activates the endothelin-1/endothelin B receptor axis

Arteriosclerosis, Thrombosis, and Vascular Biology, 34 (4)

Gras C., Schulze K., Goudeva L., Guzmán C.A., Blasczyk R., Figueiredo C. (2013)

HLA-Universal Platelet Transfusions Prevent Platelet Refractoriness in a Mouse Model

Human gene therapy, 24 (12)

Mittal A., Raber A.S., Schaefer U.F., Weissmann S., Ebensen T., Schulze K., Guzmán C.A., ... , Hansen S., Lehr C.-M. (2013)

Transfollicular delivery of antigen using nanocarriers for non-invasive transcutaneous immunization

Controlled Release Society (CRS) Letters, 30

Svindland S.C., Pedersen G.K., Pathirana R.D., Bredholt G., Nostbakken J.K., Jul-Larsen A., Guzmán C.A., Montomoli E., Lapini G., Piccirella S., Jabbal-Gill I., ... , Hinchcliffe M., Cox R.J. (2013)

A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine1

Influenza and other Respiratory Viruses, 7 (6)

DOI: 10.1111/irv.12056 HZI-Repositorium PubMed

Gurramkonda C., Zahid M., Nemani S.K., Adnan A., Gudi S.K., Khanna N., Ebensen T., Lünsdorf H., ... , Guzmán C.A., Rinas U. (2013)

Purification of hepatitis B surface antigen virus-like particles from recombinant Pichia pastoris and in vivo analysis of their immunogenic properties

Journal of Chromatography B, 940C

DOI: 10.1016/j.jchromb.2013.09.030 HZI-Repositorium PubMed

Riese P., Schulze K., Ebensen T., Prochnow B., Guzmán C.A. (2013)

Vaccine Adjuvants: Key Tools For Innovative Vaccine Design

Current Topics in Medicinal Chemistry, 13 (20)

Gismondi M.I., Díaz Carrasco J.M., Valva P., Becker P.D., Guzmán C.A., ... , Campos R.H., Preciado M.V. (2013)

Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children

Virology, 447 (1-2)

DOI: 10.1016/j.virol.2013.09.002 HZI-Repositorium PubMed

Mittal A., Raber A.S., Schaefer U.F., Weissmann S., Ebensen T., Schulze K., Guzmán C.A., ... , Lehr C.-M., Hansen S. (2013)

Non-invasive delivery of nanoparticles to hair follicles: A perspective for transcutaneous immunization

Vaccine, 31 (34)

Roy B., Agarwal S., Brennecke A.-M., Krey M., Pabst O., ... , Düber S., Weiss S. (2013)

B-1 cell subpopulations contribute differently to gut immunity

European Journal of Immunology, 43 (8)

DOI: 10.1002/eji.201243070 HZI-Repositorium PubMed

Fiebig A., Pradella S., Petersen J., Päuker O., Michael V., Lünsdorf H., Göker M., ... , Klenk H.P., Wagner-Döbler I. (2013)

Genome of the R-body producing marine alphaproteobacterium Labrenzia alexandrii type strain (DFL-11T)

Standards in Genomic Sciences, 7 (3)

DOI: 10.4056/sigs.3456959 HZI-Repositorium PubMed

Ebermann L., Ruzsics Z., Guzmán C.A., Van Rooijen N., Casalegno-Garduno R., ... , Koszinowski U., Cicin-Sain L. (2012)

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient host

PLoS Pathogens, 8 (12)

DOI: 10.1371/journal.ppat.1003062 HZI-Repositorium PubMed

Rueckert C., Guzmán C.A. (2012)

Vaccines: from empirical development to rational design

PLoS Pathogens, 8 (11)

DOI: 10.1371/journal.ppat.1003001 HZI-Repositorium PubMed

Krishnaswamy J.K., Jirmo A.C., Baru A.M., Ebensen T., Guzmán C.A., ... , Sparwasser Tim, Behrens G.M. (2012)

Toll-like receptor-2 agonist-allergen coupling efficiently redirects th2 cell responses and inhibits allergic airway eosinophilia

American Journal of Respiratory Cell and Molecular Biology, 47 (6)

DOI: 10.1165/rcmb.2011-0414OC

Waern J.M., Yuan Q., Rudrich U., Becker P.D., Schulze K., Strick-Marchand H., Huntington N.D., Zacher B.J., Wursthorn K., DiSanto J.P., Guzmán C.A., Manns M.P., ... , Ott M., Bock M. (2012)

Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice

Hepatology, 56 (4)

DOI: 10.1002/hep.25816 HZI-Repositorium PubMed

Caccuri F., Giagulli C., Bugatti A., Benetti A., Alessandri G., Ribatti D., Marsico S., Apostoli P., Slevin M.A., Rusnati M., Guzmán C.A., ... , Fiorentini S., Caruso A. (2012)

HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2

Proceedings of the National Academy of Sciences USA, 109 (36)

Krawczyk-Bärsch E., Lünsdorf H., Pedersen K., Arnold T., Bok F., Steudtner R., ... , Lehtinen A., Brendler V. (2012)

Immobilization of uranium in biofilm microorganisms exposed to groundwater seeps over granitic rock tunnel walls in Olkiluoto, Finland

Geochimica et Cosmochimica Acta, 96

Mehner D., Osadnik H., Lünsdorf H., Bruser T. (2012)

The Tat System for Membrane Translocation of Folded Proteins Recruits the Membrane-stabilizing Psp Machinery in Escherichia coli

Journal of Biological Chemistry, 287 (33)

Nörder M., Gutierrez M.G., Zicari S., Cervi E., Caruso A., Guzmán C.A. (2012)

Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferation

FASEB journal, 26 (7)

Yevsa T., Ebensen T., Fuchs B., Zygmunt B., Libanova R., Gross R., ... , Schulze K., Guzmán C.A. (2013)

Development and characterization of attenuated metabolic mutants of Bordetella bronchiseptica for applications in vaccinology

Environmental Microbiology, 15 (1)

DOI: 10.1111/j.1462-2920.2012.02779.x HZI-Repositorium PubMed

Henne K., Kahlisch L., Brettar I., Höfle Manfred G. (2012)

Analysis of structure and composition of bacterial core communities in mature drinking water biofilms and bulk water of a citywide network in Germany

Applied and Environmental Microbiology, 78 (10)

DOI: 10.1128/AEM.06373-11 HZI-Repositorium PubMed

Fiege K., Lünsdorf H., Atarijabarzadeh S., Mischnick P. (2012)

Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles

Beilstein Journal of Organic Chemistry, 8

DOI: 10.3762/bjoc.8.63 HZI-Repositorium PubMed

Caro-Quintero A., Auchtung J., Deng J., Brettar I., Höfle Manfred, ... , Tiedje J.M., Konstantinidis K.T. (2012)

Genome sequencing of five Shewanella baltica strains recovered from the oxic-anoxic interface of the Baltic Sea

Journal of Bacteriology, 194 (5)

Libanova R., Becker P.D., Guzmán C.A. (2012)

Cyclic di-nucleotides: new era for small molecules as adjuvants

Microbial Biotechnology, 5 (2)

DOI: 10.1111/j.1751-7915.2011.00306.x HZI-Repositorium PubMed

Zygmunt B.M., Weissmann S.F., Guzmán C.A. (2012)

NKT Cell Stimulation with a[alpha]-galactosylceramide Results in a Block of Th17 Differentiation after Intranasal Immunization in Mice

PLoS ONE, 7 (1)

DOI: 10.1371/journal.pone.0030382 HZI-Repositorium PubMed

Kahlisch L., Henne K., Gröbe Lothar*, Brettar I., Höfle Manfred G.* (2011)

Assessing the Viability of Bacterial Species in Drinking Water by Combined Cellular and Molecular Analyses3526

Microbial Ecology, 63 (2)

DOI: 10.1007/s00248-011-9918-4

Garcia K., Gavilan R.G., Höfle Manfred G., Martinez-Urtaza J., Espejo R.T. (2012)

Microevolution of Pandemic Vibrio parahaemolyticus Assessed by the Number of Repeat Units in Short Sequence Tandem Repeat Regions

PLoS ONE, 7 (1)

DOI: 10.1371/journal.pone.0030823 HZI-Repositorium PubMed

Vezzulli L., Brettar I., Pezzati E., Reid P.C., Colwell R.R., ... , Höfle Manfred G., Pruzzo C. (2012)

Long-term effects of ocean warming on the prokaryotic community: evidence from the vibrios

ISME Journal, 6 (1)

DOI: 10.1038/ismej.2011.89 HZI-Repositorium PubMed

Brettar I., Christen R., Höfle Manfred G. (2012)

Analysis of bacterial core communities in the central Baltic by comparative RNA-DNA-based fingerprinting provides links to structure-function relationships

ISME Journal, 6 (1)

DOI: 10.10038/ismej.2011.80

Pedersen G.K., Ebensen T., Gjeraker I.H., Svindland S., Bredholt G., ... , Guzmán C.A., Cox R.J. (2011)

Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP

PLoS ONE, 6 (11)

DOI: 10.1371/journal.pone.0026973 HZI-Repositorium PubMed

Leidinger P., Popescu R., Gerthsen D., Lünsdorf H., Feldmann C. (2011)

Nanoscale copper sulfide hollow spheres with phase-engineered composition: covellite (CuS), digenite (Cu1.8S), chalcocite (Cu2S)

Nanoscale, 3 (6)

Brettar Ingrid*, Christen R., Höfle Manfred G.* (2011)

Genus IV. Belliella

, 2nd

Brettar Ingrid*, Christen R., Höfle Manfred G.* (2011)

Genus III. Aquiflexum

, 2nd

Duarte M., Ferreira-da-Silva F., Lünsdorf H., Junca H., Gales L., ... , Pieper D.H., Nunes O.C. (2011)

Gulosibacter molinativorax ON4T molinate hydrolase, a novel cobalt-dependent amidohydrolase

Journal of Bacteriology, 193 (20)

DOI: 10.1128/JB.05054-11 HZI-Repositorium PubMed

Danilov S.M., Gordon K., Nesterovitch A.B., Lünsdorf H., Chen Z., Castellon M., Popova I.A., Kalinin S., Mendonca E., Petukhov P.A., Schwartz D.E., ... , Minshall R.D., Sturrock E.D. (2011)

An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding

PLoS ONE, 6 (10)

Hedrich S., Lünsdorf H., Kleeberg R., Heide G., Seifert J., Schlomann M. (2011)

Schwertmannite Formation Adjacent to Bacterial Cells in a Mine Water Treatment Plant and in Pure Cultures of Ferrovum myxofaciens

Environmental Science and Technology, 45 (18)

TrehanPati N., Sukriti S., Geffers R., Hissar S., Riese P., Toepfer T., ... , Guzmán C.A., Sarin S.K. (2011)

Gene expression profiles of T cells from hepatitis E virus infected patients in acute and resolving phase

Journal of Clinical Immunology, 31 (3)

DOI: 10.1007/s10875-010-9506-210.1007/s10875-010-9506-2 HZI-Repositorium PubMed

Zygmunt B.M., Gröbe L., Guzmán C.A. (2011)

Peritoneal cavity is dominated by IFNgamma-secreting CXCR3+ Th1 cells

PLoS ONE, 6 (7)

DOI: 10.1371/journal.pone.0018032 HZI-Repositorium PubMed

Lünsdorf H., Gurramkonda C., Adnan A., Khanna N., Rinas U. (2011)

Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen

Microbial Cell Factories, 10

DOI: 10.1186/1475-2859-10-48 HZI-Repositorium PubMed

Becker P.D., Royo J.L., Guzmán C.A. (2010)

Based on the salicylate-dependent control circuit encompassing nahR/Psal::xylS2 for biotechnological applications

Bioengineered Bugs, 1 (4)

Ebensen T., Libanova R., Schulze K., Yevsa T., Morr M., Guzmán C.A. (2011)

Bis-(3',5')-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant

Vaccine, 29 (32)

Krawczyk-Barsch E., Lünsdorf H., Arnold T., Brendler V., Eisbein E., ... , Jenk U., Zimmermann U. (2011)

The influence of biofilms on the migration of uranium in acid mine drainage (AMD) waters

Science of the Total Environment, 409 (16)

Madhun A.S., Haaheim L.R., Nostbakken J.K., Ebensen T., Chichester J., Yusibov V., ... , Guzmán C.A., Cox R.J. (2011)

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4(+) cells and strong mucosal and systemic antibody responses in mice

Vaccine, 29 (31)

Knothe S., Mutschler V., Rochlitzer S., Winkler C., Ebensen T., Guzmán C.A., Hohlfeld J., ... , Braun A., Muller M. (2011)

The NKT cell ligand a[alpha]galactosylceramide suppresses allergic airway inflammation by induction of a Th1 response

Vaccine, 29 (25)

DOI: 10.1016/j.vaccine.2011.03.068 HZI-Repositorium PubMed

Sabirova J.S., Becker A., Lünsdorf H., Nicaud J.M., Timmis K.N., Golyshin P.N. (2011)

Transcriptional profiling of the marine oil-degrading bacterium Alcanivorax borkumensis during growth on n-alkanes

Fems Microbiology Letters, 319 (2)

DOI: 10.1111/j.1574-6968.2011.02279.x HZI-Repositorium PubMed

Huntington N.D., Alves N.L., Legrand N., Lim A., Strick-Marchand H., Mention J.J., Plet A., Weijer K., Jacques Y., Becker P.D., Guzmán C.A., Soussan P., Kremsdorf D., ... , Spits H., Di Santo J.P. (2011)

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo

Proceeding of the National Academy of Sciences USA, 108 (15)

Ebensen T., Libanova R., Guzmán Carlos A.* (2011)

Infection prevention: oil- and lipid-containing products in vaccinology

(74, Human-animal-plant health and physiology consequences of microbial interactions with hydrocarbons and lipids)

Caro-Quintero A., Deng J., Auchtung J., Brettar I., Höfle Manfred G.*, ... , Klappenbach J., Konstantinidis K.T. (2010)

Unprecedented levels of horizontal gene transfer among spatially co-occurring Shewanella bacteria from the Baltic Sea

ISME Journal, 5 (131)

Becker P.D., Royo J.L., Guzmán C.A. (2010)

Exploitation of prokaryotic expression systems based on the salicylate-dependent control circuit encompassing nahRPsal::xylS2 for biotechnological applications

Bioengineered Bugs, 1

DOI: 10.4161/bbug.1.4.11247 PubMed

Wang X., Lünsdorf H., Ehren I., Brauner A., Romling U. (2010)

Characteristics of Biofilms from Urinary Tract Catheters and Presence of Biofilm-Related Components in Escherichia coli

Current Microbiology, 60

Knothe S., Mutschler V., Rochlitzer S., Winkler C., Ebensen T., Guzmán C.A., Hohlfeld J., ... , Braun A., Muller M. (2011)

Local treatment with BPPcysMPEG reduces allergic airway inflammation in sensitized mice

Immunobiology, 216 (1-2)

DOI: 10.1016/j.imbio.2010.05.003 HZI-Repositorium PubMed

Roming M., Lünsdorf H., Dittmar K.E., Feldmann C. (2010)

ZrO(HPO(4))(1-x)(FMN)(x): quick and easy synthesis of a nanoscale luminescent biomarker

Angewandte Chemie International Edition, 49 (3)

Wurdemann D., Tindall B.J., Pukall R., Lünsdorf H., Strompl C., Namuth T., Nahrstedt H., Wos-Oxley M., Ott S., Schreiber S., ... , Timmis K.N., Oxley A.P. (2009)

Gordonibacter pamelaeae gen. nov., sp. nov., a new member of the Coriobacteriaceae isolated from a patient with Crohn's disease, and reclassification of Eggerthella hongkongensis Lau et al. 2006 as Paraeggerthella hongkongensis gen. nov., comb. nov

International Journal of Systematic and Evolutionary Microbiology, 59 (Pt 6)

Bjorkstrom N.K., Riese P., Heuts F., Andersson S., Fauriat C., Ivarsson M.A., Bjorklund A.T., Flodstrom-Tullberg M., Michaelsson J., Rottenberg M.E., Guzmán C.A., ... , Ljunggren H.G., Malmberg K.J. (2010)

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education

Blood, 116 (19)

Becker P.D., Legrand N., van Geelen C.M., Noerder M., Huntington N.D., Lim A., Yasuda E., Diehl S.A., Scheeren F.A., Ott M., Weijer K., Wedemeyer H., Di Santo J.P., Beaumont T., ... , Guzmán C.A., Spits H. (2010)

Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice

PLoS ONE, 5 (10)

DOI: 10.1371/journal.pone.0013137 HZI-Repositorium PubMed

Switalla S., Lauenstein L., Prenzler F., Knothe S., Forster C., Fieguth H.G., Pfennig O., Schaumann F., Martin C., Guzmán C.A., Ebensen T., Muller M., Hohlfeld J.M., Krug N., ... , Braun A., Sewald K. (2010)

Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices

Toxicology and Applied Pharmacology, 246 (3)

DOI: 10.1016/j.taap.2010.04.010 PubMed

Fritzer A., Senn B.M., Minh D.B., Hanner M., Gelbmann D., Noiges B., Henics T., Schulze K., Guzmán C.A., Goodacre J., von Gabain A., ... , Nagy E., Meinke A.L. (2010)

Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine

Infection and Immunity, 78 (9)

Kahlisch L., Henne K., Draheim J., Brettar I., Höfle Manfred G.* (2010)

High-resolution in situ genotyping of Legionella pneumophila populations in drinking water by multiple-locus variable-number tandem-repeat analysis using environmental DNA

Applied in Environmental Microbiology, 76 (18)

DOI: 10.1128/AEM.00416-10 HZI-Repositorium PubMed

Ebensen T., Guzmán C.A. (2009)

Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design

Advances in Experimental Medicine and Biology, 655

Nörder M., Becker P.D., Drexler I., Link C., Erfle V., Guzmán C.A. (2010)

Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model

PLoS ONE, 5 (6)

DOI: 10.1371/journal.pone.0011400 HZI-Repositorium PubMed

Chen H.L., Lünsdorf H., Hecht H.J., Tsai H. (2010)

Porcine pulmonary angiotensin I-converting enzyme-Biochemical characterization and spatial arrangement of the N- and C-domains by three-dimensional electron microscopic reconstruction

Micron, 41 (6)

DOI: 10.1016/j.micron.2010.01.005 HZI-Repositorium PubMed

Guzmán Carlos A.* (2009)

Optimizing rational vaccine design

Microbial Biotechnology, 2 (2 spec. iss.)

Cazorla S.I., Frank F.M., Becker P.D., Arnaiz M., Mirkin G.A., Corral R.S., ... , Guzmán C.A., Malchiodi E.L. (2010)

Redirection of the immune response to the functional catalytic domain of the cystein proteinase cruzipain improves protective immunity against Trypanosoma cruzi infection

Journal of Infectious Diseases, 202 (1)

DOI: 10.1086/652872 HZI-Repositorium PubMed

Libanova R., Ebensen T., Schulze K., Bruhn D., Nörder M., Yevsa T., ... , Morr M., Guzmán C.A. (2010)

Corrigendum to "The member of the cyclic di-nucleotide family bis- (3',5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant [Vaccine 28 (2010) 2249-2258]

Vaccine, 28 (20)

Prajeeth C.K., Jirmo A.C., Krishnaswamy J.K., Ebensen T., Guzmán C.A., Weiss S., Constabel H., ... , Schmidt R.E., Behrens G.M. (2010)

The synthetic TLR2 agonist BPPcysMPEG leads to efficient cross-priming against co-administered and linked antigens

European Journal of Immunology, 40 (5)

Stegmann K.A., Björkström N.K., Liermann H., Ciesek S., Riese P., Wiegand J., Hadem J., Suneetha P.V., Jaroszewicz J., Wang C., Schlaphoff V., Fytili P., Cornberg M., Manns M.P., Geffers R., Pietschmann T., Guzmán C.A., ... , Ljunggren H.-G., Wedemeyer H. (2010)

Interf alpha-induced TRAIL on human NK cells is associated with control of hepatitis C virus infection

Gastroenterology, 138 (5)

DOI: 10.1053/j.gastro.2010.01.051 PubMed

Kahlisch L., Henne K., Gröbe Lothar*, Draheim J., Höfle Manfred G.*, Brettar I. (2010)

Molecular analysis of the bacterial drinking water community with respect to live/dead status

Water Science and Technology, 61 (1)

DOI: 10.2166/wst.2010.773

Fuchs B., Knothe S., Rochlitzer S., Nassimi M., Greweling M., Lauenstein H.D., Nassenstein C., Muller M., Ebensen T., Dittrich A.M., Krug N., ... , Guzmán C.A., Braun A. (2009)

A Toll-Like Receptor 2/6 Agonist Reduces Allergic Airway Inflammation in Chronic Respiratory Sensitisation to Timothy Grass Pollen Antigens

International Archives of Allergy and Immunology, 152 (2)

DOI: 10.1159/000265534

Probst-Kepper M., Geffers R., Kroger A., Viegas N., Erck C., Hecht H.-J., Lünsdorf H., Roubin R., Moharregh-Khiabani D., Wagner K., Ocklenburg F., Jeron A., Garritsen H., Arstila T.P., Kekalainen E., Balling R., Hauser H., ... , Buer J., Weiss S. (2009)

GARP: a key receptor controlling FOXP3 in human regulatory T cells

Journal of Cellular and Molecular Medicine, 13 (9)

Hahn M.W., Lang E., Brandt U., Lünsdorf H., Wu Q.L., Stackebrandt E. (2010)

Polynucleobacter cosmopolitanus sp. nov., free-living planktonic bacteria inhabiting freshwater lakes and rivers

International Journal of Systematic and Evolutionary Microbiology, 60 (Pt 1)

Libanova R., Ebensen T., Schulze K., Bruhn D., Norder M., Yevsa T., ... , Morr M., Guzmán C.A. (2010)

The member of the cyclic di-nucleotide family bis-(3', 5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant

Vaccine, 28 (10)

Haridass D., Yuan Q., Becker P.D., Cantz T., Iken M., Rothe M., Narain N., Bock M., Norder M., Legrand N., Wedemeyer H., Weijer K., Spits H., Manns M.P., Cai J., Deng H., Di Santo J.P., ... , Guzmán C.A., Ott M. (2009)

Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice

American Journal of Pathology, 175 (4)

Zygmunt B.M., Rharbaoui F., Gröbe L., Guzmán C.A. (2009)

Intranasal immunization promotes th17 immune responses

Journal of Immunology, 183 (11)

Guzmán Carlos .A.* (2010)

Research needs in vaccinology

Ebensen T., Libanova R., Guzmán C.A. (2010)

Bis-(3',5')-cyclic di-GMP: promising adjuvant for vaccine design

(22)

DOI: 10.1128/9781555816667.ch22 PubMed

Ebensen T., Fuchs B., Schulze K., Guzmán C.A. (2009)

Infection prevention: oil- and lipid-containing products in vaccinology

(74)

DOI: 10.1007/978-3-540-77587-4_252

Golyshina O.V., Yakimov M.M., Lünsdorf H., Ferrer M., Nimtz M., Timmis K.N., Wray V., ... , Tindall B.J., Golyshin P.N. (2009)

Acidiplasma aeolicum gen. nov., sp. nov., a euryarchaeon of the family Ferroplasmaceae isolated from a hydrothermal pool, and transfer of Ferroplasma cupricumulans to Acidiplasma cupricumulans comb. nov

International Journal of Systematic and Evolutionary Microbiology, 59 (Pt 11)

DOI: 10.1099/ijs.0.009639-0 HZI-Repositorium PubMed

Osanjo G.O., Muthike E.W., Tsuma L., Okoth M.W., Bulimo W.D., Lünsdorf H., Abraham W.-R., Dion M., Timmis K.N., ... , Golyshin P.N., Mulaa F.J. (2009)

A salt lake extremophile, Paracoccus bogoriensis

African Journal of Microbiology Research, 3 (8)

Zharkouskay A., Lünsdorf H., Feldmann C. (2009)

Ionic liquid-based synthesis of luminescent YVO4:Eu and YVO4:Eu@YF3 nanocrystals

Journal of Materials Science, 44 (15)

Giagulli C., Noerder M., Avolio M., Becker P.D., Fiorentini S., ... , Guzmán C.A., Caruso A. (2009)

Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level

International Immunopharmacology, 9 (12)

DOI: 10.1016/j.intimp.2009.08.010 HZI-Repositorium PubMed

Legrand N., Ploss A., Balling Rudi*, Becker P.D., Borsotti C., Brezillon N., Debarry J., de Jong Y., Deng H., Di Santo J.P., Eisenbarth S., Eynon E., Flavell R.A., Guzmán C.A., Huntington N.D., Kremsdorf D., Manns M.P., Manz M.G., Mention J.J., Ott M., Rathinam C., Rice C.M., Rongvaux A., Stevens S., Spits H., Strick-Marchand H., Takizawa H., van Lent A.U., Wang C., Weijer K., ... , Willinger T., Ziegler P. (2009)

Humanized mice for modeling human infectious disease: challenges, progress, and outlook

Cell Host and Microbe, 6 (1)

DOI: 10.1016/j.chom.2009.06.006 HZI-Repositorium PubMed

Palma C., Iona E., Ebensen T., Guzmán C.A., Cassone A. (2009)

The toll-like receptor 2/6 ligand MALP-2 reduces the viability of Mycobacterium tuberculosis

Open Microbiology Journal, 3

Pati N.T., Geffers R., Sukriti Hissar S., Riese P., Toepfer T., Buer J., ... , Guzmán C.A., Sarin S.K. (2009)

Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B viral infection

Hepatology, 49 (3)

Harth-Chu E., Espejo R.T., Christen R., Guzmán C.A., Höfle M.G. (2009)

Multiple-locus variable-number tandem-repeat analysis for clonal identification of Vibrio parahaemolyticus isolates by using capillary electrophoresis

Applied in Environmental Microbiology, 75 (12)

Valva P., Becker P., Streitemberger P., Lombardi G.M., Rey G., ... , Guzmán C.A., Preciado M.V. (2009)

Germline TP53 mutations and single nucleotide polymorphisms in children

Medicina (B Aires), 69 (1/2)

Spring S., Lünsdorf H., Fuchs B.M., Tindall B.J. (2009)

The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov

PLoS ONE, 4 (3)

DOI: 10.1371/journal.pone.0004866 HZI-Repositorium PubMed

Gismondi M.I., Becker P.D., az Carrasco J.M., Guzmán C.A., Campos R.H., Preciado M.V. (2009)

Evolution of hepatitis C virus hypervariable region 1 in immunocompetent children born to HCV-infected mothers

Journal of Viral Hepatitis, 16 (5)

DOI: 10.1111/j.1365-2893.2009.01071.x HZI-Repositorium PubMed

Bosch V., Pfeiffer T., Devitt G., Allespach I., Ebensen T., Emerson V., ... , Guzmán C.A., Keppler O.T. (2009)

HIV pseudovirion vaccine exposing Env "fusion intermediates"-Response to immunisation in human CD4/CCR5-transgenic rats

Vaccine, 27 (16)

Gurramkonda C., Adnan A., Gabel T., Lünsdorf H., Ross A., Nemani S.K., Swaminathan S., ... , Khanna N., Rinas U. (2009)

Simple high-cell density fed-batch technique for high-level recombinant protein production with Pichia pastoris: Application to intracellular production of Hepatitis B surface antigen

Microbial Cell Factories, 8

DOI: 10.1186/1475-2859-8-13 HZI-Repositorium PubMed

Fiorentini S., Riboldi E., Facchetti F., Avolio M., Fabbri M., Tosti G., Becker P.D., Guzmán C.A., ... , Sozzani S., Caruso A. (2008)

HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype

Proceedings of the National Academy of Sciences of the United States of America, 105 (10)

Henne K., Kahlisch L., Draheim J., Brettar Ingrid*, Höfle Manfred* (2008)

Polyvalent fingerprint based molecular surveillance methods for drinking water supply systems

Water Science and Technology: Water Supply, 8 (5)

Gillen C.M., Courtney H.S., Schulze K., Rohde M., Wilson M.R., Timmer A.M., Guzmán C.A., Nizet V., ... , Chhatwal G.S., Walker M.J. (2008)

Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes

Journal of Biological Chemistry, 283

Schulze K., Staib C., Schatzl H.M., Ebensen T., Erfle V., Guzmán C.A. (2008)

A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus

Vaccine, 26 (51)

DOI: 10.1016/j.vaccine.2008.09.006 HZI-Repositorium PubMed

Hegermann J., Lünsdorf H., Overbeck J., Schrempf H. (2008)

Polyphosphate at the Streptomyces lividans cytoplasmic membrane is enhanced in the presence of the potassium channel KcsA

Journal of Microscopy, 229 (Pt 1)

Höfle Manfred G.*, Kirchman D.L., Christen R., Brettar Ingrid* (2008)

Molecular diversity of bacterioplankton: Link to a predictive biogeochemistry of pelagic ecosystems

Aquatic Microbial Ecology, 53 (1)

Gross R., Guzmán C.A., Sebaihia M., Martins dos Santos Vitor A.P.M.*, Pieper Dietmar H.*, Koebnik R., Lechner M., Bartels D., Buhrmester J., Choudhuri J.V., Ebensen T., Gaigalat L., Herrmann S., Khachane A.N., Larisch C., Link S., Linke B., Meyer F., Mormann S., Nakunst D., Ruckert C., Schneiker-Bekel S., Schulze K., Vorholter F.J., Yevsa T., Engle J.T., Goldman W.E., Puhler A., Gobel U.B., Goesmann A., Blöcker Helmut*, ... , Kaiser O., Martinez-Arias R. (2008)

The missing link: Bordetella petrii

BMC GENOMICS, 9

DOI: 10.1186/1471-2164-9-449 HZI-Repositorium PubMed

Jordao L., Lengeling A., Bordat Y., Boudou F., Gicquel B., Neyrolles O., Becker P.D., Guzmán C.A., ... , Griffiths G., Anes E. (2008)

Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice

Microbes and Infection, 10 (12-13)

Cataldi A., Yevsa T., Vilte D.A., Schulze K., Castro-Parodi M., Larzabal M., Ibarra C., ... , Mercado E.C., Guzmán C.A. (2008)

Efficient immune responses against Intimin and EspB of enterohaemorragic Escherichia coli after intranasal vaccination using the TLR2/6 agonist MALP-2 as adjuvant

Vaccine, 26 (44)

DOI: 10.1016/j.vaccine.2008.07.027 PubMed

Standar K., Mehner D., Osadnik H., Berthelmann F., Hause G., ... , Lünsdorf H., Bruser T. (2008)

PspA can form large scaffolds in Escherichia coli

Febs Letters, 582 (25-26)

DOI: 10.1016/j.febslet.2008.09.002 HZI-Repositorium PubMed

Fiorentini S., Marsico S., Becker P.D., Iaria M.L., Bruno R., ... , Guzmán C.A., Caruso A. (2008)

Synthetic peptide AT20 coupled to KLH elicits antibodies against a conserved conformational epitope from a major functional area of the HIV-1 matrix protein p17

Vaccine, 26 (36)

Becker P.D., Nörder Miriam*, Guzmán C.A. (2008)

Genetic immunization: Bacteria as DNA vaccine delivery vehicles

Human Vaccines, 4 (3)

Vezzulli L., Guzmán C.A., Colwell R.R., Pruzzo C. (2008)

Dual role colonization factors connecting Vibrio cholerae's lifestyles in human and aquatic environments open new perspectives for combating infectious diseases

Current Opinion in Biotechnology, 19 (3)

Ebensen T., Guzmán C.A. (2008)

Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design

Human Vaccines, 4 (1)

HZI-Repositorium PubMed

Brettar Ingrid*, Höfle Manfred G.* (2008)

Molecular assessment of bacterial pathogens-a contribution to drinking water safety

Current Opinion in Biotechnology, 19 (3)

Mastini C., Becker P.D., Iezzi M., Curcio C., Musiani P., Forni G., ... , Cavallo F., Guzmán C.A. (2008)

Intramammary application of non-methylated-CpG oligodeoxynucleotides (CpG) inhibits both local and systemic mammary carcinogenesis in female BALB/c Her-2/neu transgenic mice

Current Cancer Drug Targets, 8 (3)

HZI-Repositorium PubMed

Cazorla S.I., Frank F.M., Becker P.D., Corral R.S., Guzmán C.A., Malchiodi E.L. (2008)

Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury an experimental Trypanosoma cruzi

Vaccine, 26

DOI: 10.1016/j.vaccine.2008.02.011 HZI-Repositorium PubMed

Gobert A.P., Coste A., Guzmán C.A., Hindré T., Girardeau P., Martin C. (2008)

Modulation of chemokine gene expression by Shiga-toxin producing Escherichia coli

Microbes and Infection, 10 (2)

DOI: 10.1016/j.micinf.2007.10.018 HZI-Repositorium PubMed

Marini E., Tiberio L., Fiorentini S., Caracciolo S., Tosti G., Guzmán C.A., Schiaffonati L., ... , Fiorentini S., Caruso A. (2008)

HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of the transcriptional factor AP-1

Cellular Microbiology, 10 (3)

Cazorla S.I., Becker P.D., Frank F.M., Ebensen T., Sartori M.J., Corral R.S., ... , Malchiodi E.L., Guzmán C.A. (2008)

Oral vaccination with Salmonella enterica

Infection and Immunity, 76 (1)

DOI: 10.1128/IAI.01163-07 HZI-Repositorium PubMed

Höfle Manfred G.*, Brettar Ingrid* (2007)

Ein molekularbiologischer Blick in unser Trinkwasser - Mikrobielle Diagnostik für Umweltproben

Bioforum, 3 (2)

Schulze K., Goldmann O., Medina E., Guzmán C.A. (2008)

The FAI protein of group C streptococci acts as a mucosal adjuvant by the specific targeting and activation of B cells

International Journal of Medical Microbiology, 298 (1-2)

Brettar I., Christen R., Bötel J., Lünsdorf H., Höfle M. (2007)

Anderseniella baltica gen. nov., sp. nov., a novel marine bacterium of the Alphaproteobacteria isolated from sediment in the central Baltic Sea

International Journal of Systematic and Evolutionary Microbiology, 57 (10)

DOI: 10.1099/ijs.0.65007-0 HZI-Repositorium PubMed

Royo J.L., Becker P.D., Camacho E.M., Cebolla A., Link C., ... , Santero E., Guzmán C.A. (2007)

In vivo gene regulation in Salmonella spp. by a salicylate-dependent control circuit

Nature Methods, 4 (11)

DOI: 10.1038/nmeth1107 HZI-Repositorium PubMed

Ebensen T., Schulze K., Riese P., Morr M., Guzmán C.A. (2007)

The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant

Clinical and Vaccine Immunology, 14 (8)

DOI: 10.1128/CVI.00119-07 HZI-Repositorium PubMed

Ebensen T., Link C., Riese P., Schulze K., Morr M., Guzmán C.A. (2007)

A pegylated derivative of alpha-galactosylceramide exhibits improved biological properties

Journal of Immunology (Baltimore, Md.: 1950), 179 (4)

DOI: 10.4049/jimmunol.179.4.2065 HZI-Repositorium PubMed

Fiorentini S., Marconi P., Avolio M., Marini E., Garrafa E., Caracciolo S., Rossi D., Bozac A., Becker P.D., Gentili F., Facchetti F., Guzmán C.A., ... , Manservigi R., Caruso A. (2007)

Replication-deficient mutant Herpes Simplex Virus-1 targets professional antigen presenting cells and induces efficient CD4+ T helper responses

Microbes and Infection, 9 (8)

DOI: 10.1016/j.micinf.2007.04.001 HZI-Repositorium PubMed

Brettar I., Guzmán C.A., Höfle M.G. (2007)

Human pathogenic micro-organisms in the marine environment - an ecological perspective

CIESM Reports, 31

Becker P.D., Nörder Miriam*, Guzmán C.A., Grinstein S. (2007)

Immune modulator adamantylamide dipeptide stimulates efficient Major Histocompatibility complex class I-restricted responses in mice

Clinical and Vaccine Immunology, 14

DOI: 10.1128/CVI.00316-06 HZI-Repositorium PubMed

Becker P.D., Bertot G.M., Souss D., Ebensen T., Guzmán C.A., Grinstein S. (2007)

Intranasal vaccination with recombinant outer membrane protein CD and adamantylamide dipeptide as the mucosal adjuvant enhances pulmonary clearance of Moraxella catarrhalis

Infection and Immunity, 75 (4)

DOI: 10.1128/IAI.01081-06 HZI-Repositorium PubMed

Gattinger A., Höfle Manfred G.*, Schloter M., Embacher A., Böhme F., ... , Munch J.C., Labrenz M. (2007)

Traditional cattle manure application determines abundance, diversity and activity of methanogenic Archaea

Environmental Microbiology, 9 (3)

DOI: 10.1111/j.1462-2920.2006.01181.x HZI-Repositorium PubMed

Becker P.D., Guzmán C.A. (2007)

Community-acquired pneumonia : paving the way towards new vaccination concepts

Olive C., Schulze K., Kuo Sun H., Ebensen T., Horváth A., ... , Toth I., Guzmán C.A. (2007)

Enhanced protection against Streptococcus pyogenes

Vaccine, 25 (10)

Ebensen T., Schulze K., Riese P., Link C., Morr M., Guzmán C.A. (2007)

The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties

Vaccine, 25 (8)

DOI: 10.1128/CVI.00119-07

Pfoertner S., Jeron A., Probst-Kepper M., Guzmán C.A., Hansen W., Westendorf A.M., Toepfer T., Schrader A.J., Franzke A., ... , Buer J., Geffers R. (2006)

Signatures of human regulatory T cells: an encounter with old friends and new players

Genome Biology, 7

DOI: 10.1186/gb-2006-7-7-r54 HZI-Repositorium PubMed

Hansen W., Loser K., Westendorf Astrid M.*, Bruder Dunja*, Pförtner S., Siewert C., Hühn J., ... , Beissert S., Buer Jan* (2006)

GPR83-overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo

Journal of Immunology, 177

Ocklenburg F., Moharregh-Khiabani D., Geffers Robert*, Janke V., Pfoertner S., Garritsen H., Groebe L., Klempnauer J., Dittmar Kurt E.J.*, Weiss Siegfried*, ... , Buer Jan*, Probst-Kepper M. (2006)

UBD, a down-stream element of Foxp3, leads to the identification of LGALS3, a new marker of human regulatory T cells

Laboratory Investigation, 86

Veldman C., Pahl A., Beissert S., Hansen W., Buer Jan*, Dieckmann D., ... , Schuler G., Hertl M. (2006)

Inhibition of the transcription factor Foxp3 converts desmoglein 3-specific type 1 regulatory T cells into Th 2-like cells

Journal of Immunology, 176

De Buhr M., Mähler M., Geffers Robert*, Hansen W., Westendorf Astrid M.*, Lauber J., Buer Jan*, Akira S., Schlegelberger B., ... , Hedrich H.J., Bleich A. (2006)

Cd14, Gbp1, and Pla2g2a: 3 major candidate genes for experimental IBD identified by combining QTL and microarray analyses

Physiological Genomics, 25

DOI: 10.1152/physiolgenomics.00022.2005 PubMed

Garbe A.I., Vermeer B., Gamrekelashivili J., von Wasielewski R., Greten F.R., Westendorf Astrid M.*, Buer Jan*, Schmid R.M., Manns M.P., ... , Korangy F., Greten T.F. (2006)

Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses

Cancer Research, 66

González-Escalona N., Romero J., Guzmán C.A., Espejo R.T. (2006)

Variation in the 16S-23S rRNA intergenic spacer regions in Vibrio parahaemolyticus

Fems Microbiology Letters, 256

Fiorentini S., Becker P.D., Marini E., Marconi P., Avolio M., Tosti G., Link C., Manservigi R., ... , Guzmán C.A., Caruso A. (2006)

HIV-1 matrix protein p17 modulates in vivo

Viral Immunology, 19

Gismondi M.I., Becker P.D., Valva P., Guzmán C.A., Preciado M.V. (2006)

Phylogenetic analysis of previously non-typeable hepatitis C virus isolates from Argentina

Journal of Clinical Microbiology, 44

DOI: 10.1128/JCM.02569-05 HZI-Repositorium PubMed

Link C., Ebensen T., Ständner L., Déjosez M., Reinhard E., ... , Rharbaoui F., Guzmán C.A. (2006)

An SopB-mediated immune escape mechanism of Salmonella enterica

Microbes and Infection, 8

DOI: 10.1016/j.micinf.2006.04.013 HZI-Repositorium PubMed

Schulze K., Olive C., Ebensen T., Guzmán C.A. (2006)

Intranasal vaccination with Sfbl or M protein-derived peptides conjugated to diphtheria toxoid confers protective immunity against a lethal challenge with S. pyogenes

Vaccine, 24

Becker P.D., Fiorentini S., Link C., Tosti G., Ebensen T., ... , Caruso A., Guzmán C.A. (2006)

The HIV-1 matrix protein p17 can be efficiently delivered by intranasal route in mice using the TLR 1/6 agonist MALP-2 as mucosal adjuvant

Vaccine, 24

DOI: 10.1016/j.vaccine.2005.11.008

Rharbaoui F., Guzmán C.A. (2005)

New generation of immune modulators based on toll-like receptor signaling

Current Immunology Review, 1 (2)

Borsutzky S., Ebensen T., Link C., Becker P.D., Fiorelli V., Cafaro A., ... , Ensoli B., Guzmán C.A. (2006)

Efficient systemic and mucosal responses against the HIV-1 Tat protein by Prime/Boost vaccination using the lipopeptide MALP-2 as adjuvant

Vaccine, 24

DOI: 10.1016./j.vaccine.2005.11.025

Schulze K., Medina E., Guzmán C.A. (2006)

Intranasal immunization with serum opacity factor (SOF) of Streptococcus pyogenes

Vaccine, 24

DOI: 10.1016/j.vaccine.2005.06.039

Guzman C.A., Borsutzky S., Griot-Wenk M., Metcalfe I.C., Pearman J., Collioud A., ... , Favre D., Dietrich G. (2006)

Vaccines against Typhoid fever

Vaccine, 24

DOI: 10.1016/J.vaccine.2005.07.111 HZI-Repositorium PubMed

Schulze K., Ebensen T., Link C., Guzmán C.A. (2005)

Mukosale versus systemische Vakzinierung: Neue Strategien zur Entwicklung effizienterer Impfstoffe

Deutsche Industrievereinigung Biotechnologie (DIB)

Ebensen T., Link C., Guzmán C.A. (2005)

Human and veterinary classical vaccines against bacterial diseases

, 2rd

Erfle V., Goebel F.D., Guzmán C.A., Le Grand R. (2005)

Vaccines based on Nef and on Nef/delta V2 Env

Microbes and Infection, 7

DOI: 10.1128/AEM.71.11.7301-7309.2005 HZI-Repositorium PubMed

Guzmán C.A., Cebolla A., Beltrametti F., Staendner L.H., de Lorenzo V. (2005)

Physiological stress of intracellular Shigella flexneri

Febs Letters, 579 (3)

Rharbaoui F., Bruder D., Vidakovic M., Ebensen T., Buer J., Guzmán C.A. (2005)

Characterization of a B220+ lymphoid cell subpopulation with immune modulatory functions

Journal of Immunology, 174

Schulze K., Goldmann O., Toppel A., Medina E., Guzmán C.A. (2005)

The FAI protein of group C streptococci targets B cells and exhibits adjuvant activity

Vaccine, 23

Ebensen T., Guzmán C.A., Schulze K. (2004)

Salmonellen - Feind, aber auch Freund

Labor Praxis, Oktober

Borsutzky S., Cazac B.B., Roes J., Guzmán C.A. (2004)

TGF-ß receptor signaling is critical for mucosal IgA responses

Journal of Immunology, 173

Guzmán C.A., Feuerstein G. (2004)

Pharmaceutical Biotechnology - Editorial Overview

Current Opinion in Biotechnology, 15

Rharbaoui F., Westendorf A., Link C., Felk S., Buer J., ... , Gunzer M., Guzmán C.A. (2004)

The mycoplasma-derived lipopeptide MALP-2 triggers a global immune activation on nasal associated lymphoid tissues

Infection and Immunity, 72

Becker P.D., Guzmán C.A. (2004)

Rational design of vaccination strategies to promote antigen entry into the MHC class I-restricted presentation pathway

Transfusion Medicine and Hemotherapy, 31

DOI: 10.1159/000082484

Ebensen T., Paukner S., Link C., Kudela P., de Domenico C., ... , Lubitz W., Guzmán C.A. (2004)

Bacterial ghosts are an efficient delivery system for DNA vaccines

Journal of Immunology, 172

Fey A., Eichler S., Flavier S., Christen R., Höfle M.G., Guzmán C.A. (2004)

Establishment of a real-time PCR-based approach for accurate quantification of bacterial RNA targets in water, using Salmonella as a model organism

Applied and Environmental Microbiology, 70 (6)

DOI: 10.1128/AEM.70.6.3618-3623.2004 HZI-Repositorium PubMed

McArthur J., Schulze K., Chin J., Currie B.J., Sriprakash K.S., Talay S.R., ... , Chhatwal G.S., Guzmán C.A. (2004)

Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice

Indian Journal of Medical Research, 119 (Suppl.)

Link C., Gavioli R., Ebensen T., Canella A., Reinhard E., Guzmán C.A. (2004)

The toll-like receptor ligand MALP-2 stimulates dendritic cell maturation and modulates proteasome composition and activity

European Journal of Immunology, 34 (3)

Gismondi M.I., Staendner L.H., Grinstein S., Guzmán C.A., Preciado M.V. (2004)

Hepatitis C virus isolates from Argentina disclose a novel genotype 1-associated restriction pattern

Journal of Clinical Microbiology, 42 (3)

DOI: 10.1128/JCM.42.3.1298-1301.2004 HZI-Repositorium PubMed

Bertot G.M., Becker P.D., Guzmán C.A., Grinstein S. (2004)

Intranasal vaccination with recombinant P6 protein and adamantylamide dipeptide as mucosal adjuvant confers efficient protection against Otitis media and lung infection by nontypeable Haemophilus influenzae

Journal of Infectious Diseases, 189 (7)

DOI: 10.1086/382508 HZI-Repositorium

Mcarthur J.D., West N.P., Cole J.N., Jungnitz H., Guzmán C.A., Chin J., Lehrbach P.R., ... , Djordjevic S.P., Walker M.J. (2003)

An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection

Fems Microbiology Letters, 221

Dietrich G., Spreng S., Favre D., Viret J.-F., Guzmán C.A. (2003)

Live attenuated bacteria as vectors to deliver plasmid DNA vaccines

Current opinion in molecular therapeutics, 5

Schulze K., Medina E., Chhatwal G.S., Guzmán C.A. (2003)

Stimulation of long-lasting protection against Streptococcus pyogenes after intranasal vaccination with non adjuvanted fibronectin-binding domain of the SfbI protein.

Vaccine, 21 (17-18)

Noguera-Obenza M., Ochoa T.J., Gomez H.F., Guerrero M.L., Herrera-Insua I., Morrow A.L., Ruiz-Palacios G., Pickering L.K., ... , Guzmán C.A., Cleary T.G. (2003)

Human milk secretory antibodies against attching and effacing Escherchia coli antigens.

Emerging Infectious Diseases, 9

Schulze K., Guzmán C.A. (2003)

Identification of the domains of the fibronectin-binding protein I of Streptococcus pyogenes responsible for adjuvanticity

Fems Immunology and Medical Microbiology, 37

Ebensen T., Link C., Guzmán C.A. (2003)

Classical bacterial vaccines

(11)

Buttó S., Fiorelli V., Tripiciano A., Ruiz-Alverez M.J., Scoglio A., Ensoli F., Ciccozzi M., Collacchi B., Sabbatucci M., Cafaro A., Guzmán C.A., Borsetti A., Caputo A., Vardas E., Colvin M., Lukwija M., Rezza G., ... , Ensoli B., and the Tat Multicentric Study Group (2003)

Sequence conservation and antibody cross-recognition of the Clade B HIV-1 Tat protein vaccine candidate in HIV-1-infected Italian, Ugandan and South African individuals.

Journal of Infectious Diseases., 188

Ochoa T.J., Noguera-Obenza M., Ebel F., Guzmán C.A., Gomez H.F., Cleary T.G. (2003)

Lactoferrin impairs Type III secretory system function in enteropathogenic Escherichia coli

Infection and Immunity, 71

Viret J.-F., Moser C., Rharbaoui F., Metcalfe I.C., Guzmán C.A. (2003)

Virosomal technology and mucosal adjuvants.

(10)

Schulze K., Medina E., Chhatwal G.S., Guzmán C.A. (2003)

Identification of B- and T-cell epitopes within the fibronectin-binding domain of the SfbI protein of Streptococcus pyogenes

Infection and Immunity, 71 (12)

Dietrich G., Spreng S., Favre D., Viret J.-F., Guzmán C.A. (2003)

Delivery of cancer DNA vaccines by live attenuated bacteria.

Enhancer-immunotherapy of cancer, 1

Beltrametti F., Kresse A.U., Guzmán C.A. (2000)

Transcriptional regulation of the pas pene of enterohemorrhagic Escherichia coli

Fems Microbiology Letters, 184 (1)

DOI: 10.1111/j.1574-6968.2000.tb09001.x HZI-Repositorium PubMed

Prof Dr Carlos A. Guzmán

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