Prof Dr Christian Sieben

Prof Dr Christian Sieben
Research Group Leader
+49531 6181-2950

Christian Sieben studied Biology at the TU Darmstadt with majors in physiology and cell biology. After graduating in plant cell biology, he moved to the Humboldt-Universität zu Berlin to start a PhD in single-cell virology. During this time, he developed microscopy approaches to decipher respiratory virus infection at the level of individual cells. He then moved to EPFL in Switzerland to study super-resolution microscopy techniques, which now allow him to study virus infection at the single protein level. In 2020, Christian started his group Nanoscale Infection Biology (NIBI) at HZI in Braunschweig.

Publications
Dobramysl U., Sieben C., Holcman D. (2024)
Mean time to infection by small diffusing droplets containing SARS-CoV-2 during close social contacts
Networks and Heterogeneous Media, 19 (1)
DOI: 10.3934/nhm.2024017 HZI-Repositorium
Menke L., Sieben C. (2024)
An Improved Workflow for the Quantification of Orthohantavirus Infection Using Automated Imaging and Flow Cytometry
Viruses., 16 (2)
DOI: 10.3390/v16020269 HZI-Repositorium PubMed
Feng J., Nie C., Xie E., Thongrom B., Reiter-Scherer V., Block S., Herrmann A., Quaas E., ... , Sieben C., Haag R. (2023)
Sulfated Polyglycerol-Modified Hydrogels for Binding HSV-1 and RSV
ACS Appl.Mater.Interfaces.
DOI: 10.1021/acsami.3c09553 PubMed
Xie E., Ahmad S., Smyth R.P., Sieben C. (2023)
Advanced fluorescence microscopy in respiratory virus cell biology
(116)
DOI: 10.1016/bs.aivir.2023.05.002 PubMed
Kastner M., Karner A., Zhu R., Huang Q., Geissner A., Sadewasser A., Lesch M., W+Ârmann X., Karlas A., Seeberger P.H., Wolff T., Hinterdorfer P., ... , Herrmann A., Sieben C. (2023)
Relevance of Host Cell Surface Glycan Structure for Cell Specificity of Influenza A Viruses
Viruses, 15 (7)
DOI: 10.3390/v15071507 HZI-Repositorium PubMed
Degen M., Santos J.C., Pluhackova K., Cebrero G., Ramos S., Jankevicius G., Hartenian E., Guillerm U., Mari S.A., Kohl B., Müller D.J., Schanda P., Maier T., Perez C., Sieben C., ... , Broz P., Hiller S. (2023)
Structural basis of NINJ1-mediated plasma membrane rupture in cell death
Nature
DOI: 10.1038/s41586-023-05991-z HZI-Repositorium PubMed
Menke L., Sperber H.S., Aji A.K., Chiantia S., Schwarzer R., Sieben C. (2023)
Advances in fluorescence microscopy for orthohantavirus research
Microscopy.(Oxf)
DOI: 10.1093/jmicro/dfac075 HZI-Repositorium PubMed
Blundell B., Sieben C., Manley S., Rosten E., Ch'ng Q., Cox S. (2021)
3D Structure From 2D Microscopy Images Using Deep Learning
Front Bioinform., 1
DOI: 10.3389/fbinf.2021.740342 HZI-Repositorium PubMed
Kirchenwitz M., Stahnke S., Prettin S., Borowiak M., Menke L., Sieben C., Birchmeier C., Rottner K., ... , Stradal T.E.B., Steffen A. (2022)
SMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta
Cells, 11 (10)
DOI: 10.3390/cells11101648 HZI-Repositorium PubMed
Welke R.W., Sperber H.S., Bergmann R., Koikkarah A., Menke L., Sieben C., Krüger D.H., Chiantia S., ... , Herrmann A., Schwarzer R. (2022)
Characterization of Hantavirus N Protein Intracellular Dynamics and Localization
Viruses, 14 (3)
DOI: 10.3390/v14030457 HZI-Repositorium PubMed
Wang B., Lin Y.C., Vasquez-Rifo A., Jo J., Price-Whelan A., McDonald S.T., Brown L.M., ... , Sieben C., Dietrich L.E.P. (2021)
Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence
Nat.Commun., 12 (1)
DOI: 10.1038/s41467-021-24796-0 HZI-Repositorium PubMed
Touizer E., Sieben C., Henriques R., Marsh M., Laine R.F. (2021)
Application of Super-Resolution and Advanced Quantitative Microscopy to the Spatio-Temporal Analysis of Influenza Virus Replication
Viruses., 13 (2)
DOI: 10.3390/v13020233 HZI-Repositorium PubMed

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