Prof Dr Dunja Bruder

Head of Research Group

Prof. Dunja Bruder

Dunja Bruder studied biotechnology at the Technical University of Braunschweig and passed her diploma in 1996. She already showed a high interest in immunology during her studies and analyzed immune responses against bacterial toxins during her PhD thesis at the Helmholtz Centre for Infection Research (1996-1999).

In the following years, Dunja Bruder worked as a postdoc in the junior group “Mucosal Immunity” and established upon others a transgenic mouse model for the investigation of T cell-mediated lung inflammation which she intensively used to study the immunological functions of alveolar epithelial cells.

During several scientific stays abroad, for example at the Harvard Medical School in Boston and the Yale University School of Medicine in New Haven, she deepened her immunological knowledge and learned how to perform influenza A virus infection in mice. Her successful research activity was rewarded with the Young Investigator Award of the Society of Mucosal Immunology in 2005.

Since October 2006 Dunja Bruder leads the research group “Immune Regulation” at the HZI and was rewarded as the “Supervisor of the year 2008” for her exemplary education of PhD students. In December 2009 she completed her habilitation in immunology at the Hanover Medical School. Since August 2011 Dunja Bruder has a professorship for Infections Immunology at the Institute of Medical Microbiology and Hospital Hygiene at the Otto-von-Guericke-University in Magdeburg and since this time she is leading research groups at both places. In 2014 she became advisory board member of the SFB 854 in frame of which researches from Magdeburg together with among others scientists from the HZI and the TU Braunschweig study the molecular organization of the communication within the immune system. Also since 2014 Dunja Bruder is the coordinator of the SFB 854 integrated graduate school MGK 854. Since 2017 she is spokesperson of Module 3 („Immunosenescence: Infection and immunity in the context of aging“) of the international graduate school ABINEP (Analysis, Imaging, and Modelling of Neuronal and Inflammatory Processes). Within this module clinicians of the University Hospital of the OVGU Magdeburg are working together with HZI scientists on translational projects in the area of infection research.

Publications

Booth J.S., Wahid R., Bruder D., Salerno-Goncalves R. (2024)

Editorial: The synthesis of secretory immunoglobulin A in mucosal tissue: mucosal-associated invariant T, T follicular helper, and B cells

Front Immunol., 15

DOI: 10.3389/fimmu.2024.1504432 HZI-Repositorium PubMed

Franz T., Stegemann-Koniszewski S., Schreiber J., Müller A., Bruder D., Dudeck A., ... , Boehme J.D., Kahlfuss S. (2024)

Metabolic and ionic control of T cells in asthma endotypes

Am.J.Physiol Cell Physiol, 327 (5)

DOI: 10.1152/ajpcell.00474.2024 PubMed

Röwekamp I., Maschirow L., Rabes A., Fiocca Vernengo F., Hamann L., Heinz G.A., Mashreghi M.F., Caesar S., Milek M., Fagundes Fonseca A.C., Wienhold S.M., Nouailles G., Yao L., Mousavi S., Bruder D., Boehme J.D., Puzianowska-Kuznicka M., Beule D., Witzenrath M., CAPNETZ Study Group, Löning M., Klose C.S.N., Heimesaat M.M., ... , Diefenbach A., Opitz B. (2024)

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

Proceedings of the National Academy of Sciences of the United States of America, 121 (22)

DOI: 10.1073/pnas.2310864121 HZI-Repositorium PubMed

Camp B., Jorde I., Sittel F., Pausder A., Jeron A., Bruder D., ... , Schreiber J., Stegemann-Koniszewski S. (2024)

Comprehensive analysis of lung macrophages and dendritic cells in two murine models of allergic airway inflammation reveals model- and subset-specific accumulation and phenotypic alterations

Front.Immunol., 15

DOI: 10.3389/fimmu.2024.1374670 HZI-Repositorium PubMed

Brandt S., Bernhardt A., Häberer S., Wolters K., Gehringer F., Reichardt C., Krause A., Geffers R., Kahlfuß S., Jeron A., Bruder D., Lindquist J.A., ... , Isermann B., Mertens P.R. (2024)

Comparative Analysis of Acute Kidney Injury Models and Related Fibrogenic Responses: Convergence on Methylation Patterns Regulated by Cold Shock Protein

Cells, 13 (5)

DOI: 10.3390/cells13050367 HZI-Repositorium PubMed

Dogra T., Pelz L., Boehme J.D., Kuechler J., Kershaw O., Marichal-Gallardo P., Baelkner M., Hein M.D., Gruber A.D., Benndorf D., Genzel Y., Bruder D., ... , Kupke S.Y., Reichl U. (2023)

Generation of "OP7 chimera" defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice

Sci.Rep., 13 (1)

DOI: 10.1038/s41598-023-47547-1 HZI-Repositorium PubMed

Vogel K., Arra A., Lingel H., Bretschneider D., Prätsch F., Schanze D., Zenker M., Balk S., Bruder D., Geffers R., Hachenberg T., ... , Arens C., Brunner-Weinzierl M.C. (2023)

Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood

Nat.Commun., 14 (1)

DOI: 10.1038/s41467-023-41630-x HZI-Repositorium PubMed

Brauns S., Marquardt I., Thon C., Frentzel S., Jakob J., Färber J., Philipsen L., Jänsch L., ... , Link A., Bruder D. (2023)

Mucosal-associated invariant T (MAIT) cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity

Int.Immunol.

DOI: 10.1093/intimm/dxad032 PubMed

Stegemann-Koniszewski S., Frentzel S., Bruder D. (2023)

Good and bad outcomes of respiratory viral infections-influenza A virus trains sustained antitumor immunity of macrophages in the lung

Cellular and Molecular Immunology

DOI: 10.1038/s41423-023-01015-y HZI-Repositorium PubMed

Jakob J., Kröger A., Klawonn F., Bruder D., J+ñnsch L. (2023)

Translatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes

Front.Immunol., 14

DOI: 10.3389/fimmu.2023.1091837 HZI-Repositorium PubMed

Metzdorf K., Jacobsen H., Greweling-Pils M.C., Hoffmann M., Lüddecke T., Miller F., Melcher L., Kempf A.M., Nehlmeier I., Bruder D., Widera M., Ciesek S., ... , Pöhlmann S., Cicin-Sain L. (2023)

TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection

Viruses, 15 (2)

DOI: 10.3390/v15020271 HZI-Repositorium PubMed

Frentzel S., Jeron A., Pausder A., Kershaw O., Volckmar J., ... , Schmitz I., Bruder D. (2022)

I k

Front.Immunol., 13

DOI: 10.3389/fimmu.2022.1028789 HZI-Repositorium PubMed

Abdi Sarabi M., Shiri A., Aghapour M., Reichardt C., Brandt S., Mertens P.R., Medunjanin S., Bruder D., ... , Braun-Dullaeus R.C., Weinert S. (2022)

Normoxic HIF-1 a

Cells, 11 (23)

DOI: 10.3390/cells11233878 HZI-Repositorium PubMed

Jhutty S.S., Boehme J.D., Jeron A., Volckmar J., Schultz K., Schreiber J., Schughart K., Zhou K., Steinheimer J., Stöcker H., Stegemann-Koniszewski S., ... , Bruder D., Hernandez-Vargas E.A. (2022)

Predicting Influenza A Virus Infection in the Lung from Hematological Data with Machine Learning

mSystems.

DOI: 10.1128/msystems.00459-22 HZI-Repositorium PubMed

Wenzek C., Steinbach P., Wirsdörfer F., Sutter K., Boehme J.D., Geffers R., Klopfleisch R., Bruder D., Jendrossek V., Buer J., ... , Westendorf A.M., Knuschke T. (2022)

CD47 restricts antiviral function of alveolar macrophages during influenza virus infection

iScience, 25 (12)

DOI: 10.1016/j.isci.2022.105540 HZI-Repositorium PubMed

Pausder A., Mras P., Hoenicke L., Waldburg N., Lesker T.R., Schreiber J., Strowig T., ... , Boehme J.D., Bruder D. (2022)

Altered nasal microbiota in asthmatic patients is not related to changes in secretory immunity in the nasopharynx

Clin.Exp.Allergy

DOI: 10.1111/cea.14200 HZI-Repositorium PubMed

Cammann C., Israel N., Frentzel S., Jeron A., Topfstedt E., ler T., Simeoni L., Zenker M., Fehling H.J., Schraven B., ... , Bruder D., Seifert U. (2022)

T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation

Front Immunol, 13

DOI: 10.3389/fimmu.2022.958616 HZI-Repositorium PubMed

Gelmez E., Lehr K., Kershaw O., Frentzel S., Vilchez-Vargas R., Bank U., Link A., Schüler T., ... , Jeron A., Bruder D. (2022)

Characterization of Maladaptive Processes in Acute, Chronic and Remission Phases of Experimental Colitis in C57BL/6 Mice

Biomedicines., 10 (8)

DOI: 10.3390/biomedicines10081903 HZI-Repositorium PubMed

Volckmar J., Melcher L., Bruder D. (2022)

Route, origin & valence matter: towards sophisticated next-generation vaccines to cope with the COVID-19 pandemic

Signal.Transduct.Target Ther., 7 (1)

DOI: 10.1038/s41392-022-01053-4. HZI-Repositorium PubMed

Aghapour M., Tulen C.B.M., Abdi Sarabi M., Weinert S., Müsken M., Relja B., van Schooten F.J., Jeron A., Braun-Dullaeus R., ... , Remels A.H., Bruder D. (2022)

Cigarette Smoke Extract Disturbs Mitochondria-Regulated Airway Epithelial Cell Responses to Pneumococci

Cells, 11 (11)

DOI: 10.3390/cells11111771 HZI-Repositorium PubMed

Hochnadel I., Hoenicke L., Petriv N., Neubert L., Reinhard E., Hirsch T., Alfonso J.C.L., Suo H., Longerich T., Geffers R., Lichtinghagen R., Guzmán C.A., Wedemeyer H., Lenzen H., Manns M.P., ... , Bruder D., Yevsa T. (2022)

Correction: Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers (Oncogene, (2022), 41, 14, (2039-2053), 10.1038/s41388-022-02222-z)

Oncogene, 41 (19)

DOI: 10.1038/s41388-022-02261-6 HZI-Repositorium PubMed

Aghapour M., Surender S., Bruder D. (2022)

Beware the intruder: gasodermin A as molecular guardian preventing systemic dissemination of group A streptococci following local skin infection

Cell Mol.Immunol.

DOI: 10.1038/s41423-022-00863-4 HZI-Repositorium PubMed

Aghapour M., Ubags N.D., Bruder D., Hiemstra P.S., Sidhaye V., ... , Rezaee F., Heijink I.H. (2022)

Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD

Eur Respir Rev, 31 (163)

DOI: 10.1183/16000617.0112-2021 HZI-Repositorium PubMed

Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers

Oncogene

DOI: 10.1038/s41388-022-02222-z HZI-Repositorium PubMed

Gelmez E., Jeron A., Bruder D. (2022)

Negative elongation factor: a key factor in the maintenance of intestinal epithelial barrier integrity

Cell Mol.Immunol.

DOI: 10.1038/s41423-021-00817-2 HZI-Repositorium PubMed

Marquardt I., Jakob J., Scheibel J., Hofmann J.D., Klawonn F., Neumann-Schaal M., Gerhard R., ... , Bruder D., Jänsch L. (2021)

Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells

Front Microbiol., 12

DOI: 10.3389/fmicb.2021.752549 HZI-Repositorium PubMed

Kim Y., Zheng X., Eschke K., Chaudhry M.Z., Bertoglio F., Tomic A., Krmpotic A., Hoffmann M., Bar-On Y., Boehme J., Bruder D., Ebensen T., Brunotte L., Ludwig S., Messerle M., Guzmán C., Mandelboim O., Hust M., Pöhlmann S., ... , Jonjic S., Cicin-Sain L. (2022)

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

Cell Mol.Immunol., 19 (2)

DOI: 10.1038/s41423-021-00814-5 HZI-Repositorium PubMed

Pausder A., Fricke J., Schughart K., Schreiber J., Strowig T., ... , Bruder D., Boehme J.D. (2021)

Exogenous and Endogenous Triggers Differentially Stimulate Pigr Expression and Antibacterial Secretory Immunity in the Murine Respiratory Tract

Lung

DOI: 10.1007/s00408-021-00498-8 HZI-Repositorium PubMed

Düsedau H.P., Steffen J., Figueiredo C.A., Boehme J.D., Schultz K., Erck C., Korte M., Faber-Zuschratter H., Smalla K.H., Dieterich D., Kröger A., ... , Bruder D., Dunay I.R. (2021)

Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic Transmission

MBio., 12 (5)

DOI: 10.1128/mBio.01776-21 HZI-Repositorium PubMed

Böning M.A.L., Parzmair G.P., Jeron A., Düsedau H.P., Kershaw O., Xu B., Relja B., Schlüter D., Dunay I.R., Reinhold A., ... , Schraven B., Bruder D. (2021)

Enhanced Susceptibility of ADAP-Deficient Mice to Listeria monocytogenes Infection Is Associated With an Altered Phagocyte Phenotype and Function

Frontiers in Immunology, 12

DOI: 10.3389/fimmu.2021.724855 HZI-Repositorium PubMed

Ruhnau J., Grote V., Juarez-Osorio M., Bruder D., Mahour R., Rapp E., ... , Rexer T.F.T., Reichl U. (2021)

Cell-Free Glycoengineering of the Recombinant SARS-CoV-2 Spike Glycoprotein

Front.Bioeng.Biotechnol., 9

DOI: 10.3389/fbioe.2021.699025 HZI-Repositorium PubMed

Rand U., Kupke S.Y., Shkarlet H., Hein M.D., Hirsch T., Marichal-Gallardo P., Cicin-Sain L., ... , Reichl U., Bruder D. (2021)

Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity

Cells, 10 (7)

DOI: 10.3390/cells10071756 HZI-Repositorium PubMed

Elfaki Y., Yang J., Boehme J., Schultz K., Bruder D., Falk C.S., ... , Hühn J., Floess S. (2021)

Tbx21 and foxp3 are epigenetically stabilized in t-bet+ tregs that transiently accumulate in influenza a virus-infected lungs

Int.J.Mol.Sci., 22 (14)

DOI: 10.3390/ijms22147522 HZI-Repositorium PubMed

Hoang Q.T.M., Nguyen V.K., Oberacher H., Fuchs D., Hernandez-Vargas E.A., Borucki K., Waldburg N., Wippermann J., Schreiber J., ... , Bruder D., Veluswamy P. (2021)

Serum Concentration of the Phytohormone Abscisic Acid Is Associated With Immune-Regulatory Mediators and Is a Potential Biomarker of Disease Severity in Chronic Obstructive Pulmonary Disease

Frontiers in Medicine, 8

DOI: 10.3389/fmed.2021.676058 HZI-Repositorium PubMed

Bruder D. (2020)

Influenza - Prävalenz, Bedeutung und Implikationen für die Prävention und Gesundheitsförderung

(68-1)

DOI: 10.1007/978-3-662-55793-8_68-1 PubMed

Volckmar J., Knop L., Hirsch T., Frentzel S., Erck C., Van Ham M., ... , Stegemann-Koniszewski S., Bruder D. (2021)

Chemical conjugation of a purified dec-205-directed antibody with full-length protein for targeting mouse dendritic cells in vitro and in vivo

J.Visualized Exp., 2021 (168)

DOI: 10.3791/62018 HZI-Repositorium PubMed

Roth S., Cao J., Singh V., Tiedt S., Hundeshagen G., Li T., Boehme J.D., Chauhan D., Zhu J., Ricci A., Gorka O., Asare Y., Yang J., Lopez M.S., Rehberg M., Bruder D., Zhang S., Groß O., Dichgans M., ... , Hornung V., Liesz A. (2021)

Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade

Immunity., 54 (4)

DOI: 10.1016/j.immuni.2021.02.004 HZI-Repositorium PubMed

Elfaki Y., Robert P.A., Binz C., Falk C.S., Bruder D., Prinz I., Floess S., ... , Meyer-Hermann M., Hühn J. (2021)

Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice

Eur.J.Immunol.

DOI: 10.1002/eji.202048981 HZI-Repositorium PubMed

Wu Q., Jorde I., Kershaw O., Jeron A., Bruder D., ... , Schreiber J., Stegemann-Koniszewski S. (2020)

Resolved influenza a virus infection has extended effects on lung homeostasis and attenuates allergic airway inflammation in a mouse model

Microorg., 8 (12)

DOI: 10.3390/microorganisms8121878 HZI-Repositorium PubMed

Luecke E., Jeron A., Kroeger A., Bruder D., Stegemann-Koniszewski S., Jechorek D., Borucki K., Reinhold D., Reinhold A., Foellner S., Walles T., ... , Hachenberg T., Schreiber J. (2021)

Eosinophilic pulmonary vasculitis as a manifestation of the hyperinflammatory phase of COVID-19

J Allergy Clin Immunol., 147 (1)

DOI: 10.1016/j.jaci.2020.09.026 HZI-Repositorium PubMed

Boehme J.D., Frentzel S., Bruder D. (2020)

NMP4: a nuclear driver of innate inflammatory responses during influenza A virus infection

Cell.Mol.Immunol, 17 (12)

DOI: 10.1038/s41423-020-0517-5 HZI-Repositorium PubMed

Sasaki K., Bruder D., Hernandez-Vargas E.A. (2020)

Topological data analysis to model the shape of immune responses during co-infections

Comm.Nonlinear Sci.Numer.Simul., 85 (June 2020)

DOI: 10.1016/j.cnsns.2020.105228 HZI-Repositorium PubMed

Böning M.A.L., Trittel S., Riese P., Van Ham M., Heyner M., Voss M., Parzmair G.P., Klawonn F., Jeron A., Guzmán C.A., Jänsch L., Schraven B., ... , Reinhold A., Bruder D. (2020)

ADAP Promotes Degranulation and Migration of NK Cells Primed During in vivo Listeria monocytogenes Infection in Mice

Front.Immunol., 10

DOI: 10.3389/fimmu.2019.03144 HZI-Repositorium PubMed

Aghapour M., Remels A.H.V., Pouwels S.D., Bruder D., Hiemstra P.S., ... , Cloonan S.M., Heijink I.H. (2020)

Mitochondria: At the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease

Am.J.Physiol.Lung Cell.Mol.Physiol., 318 (1)

DOI: 10.1152/ajplung.00329.2019 PubMed

Zheng X., Oduro J.D., Boehme J.D., Borkner L., Ebensen T., Heise U., Gereke M., Pils M.C., Krmpotic A., Guzmán C.A., ... , Bruder D., Cicin-Sain L. (2019)

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge

PLoS Pathog., 15 (9)

DOI: 10.1371/journal.ppat.1008036 HZI-Repositorium PubMed

Sharma-Chawla N., Stegemann-Koniszewski S., Christen H., Boehme J.D., Kershaw O., Schreiber J., Guzmán C.A., ... , Bruder D., Hernandez-Vargas E.A. (2019)

In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection

Front Immunol., 10

DOI: 10.3389/fimmu.2019.01864 HZI-Repositorium PubMed

Volckmar J., Knop L., Stegemann-Koniszewski S., Schulze K., Ebensen T., ... , Guzmán C.A., Bruder D. (2019)

The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly(I:C)/CpG after subcutaneous vaccination with soluble protein antigen or DEC-205-mediated antigen targeting to dendritic cells

Vaccine, 37 (35)

DOI: 10.1016/j.vaccine.2019.07.019 HZI-Repositorium PubMed

Frentzel S., Katsoulis-Dimitriou K., Jeron A., Schmitz I., Bruder D. (2019)

Essential role of IkappaBNS for in vivo CD4(+) T cell activation, proliferation and Th1 cell differentiation during Listeria monocytogenes infection in mice

Eur.J.Immunol., 49 (9)

DOI: 10.1002/eji.201847961 HZI-Repositorium PubMed

Schultz K., Grieger C., Li Y., Ruschel A., Minnich K., Bruder D., ... , Gereke M., Sechi A. (2018)

Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages

PLoS ONE, 13 (12)

DOI: 10.1371/journal.pone.0207358 HZI-Repositorium PubMed

Abdissa K., Nerlich A., Beineke A., Ruangkiattikul N., Pawar V., Heise U., Janze N., Falk C., Bruder D., Schleicher U., Bogdan C., ... , Weiss S., Goethe R. (2018)

Presence of infected Gr-1intCD11bhiCD11cintmonocytic myeloid derived suppressor cells subverts T cell response and is associated with impaired dendritic cell function in Mycobacterium avium-infected mice

Front.Immunol., 9 (OCT)

DOI: 10.3389/fimmu.2018.02317 HZI-Repositorium PubMed

Bernal I., Hofmann J.D., Bulitta B., Klawonn F., Michel A.M., Jahn D., Neumann-Schaal M., ... , Bruder D., Jänsch L. (2018)

Clostridioides difficile activates human mucosal-associated invariant t cells

Front.Microbiol., 9 (OCT)

DOI: 10.3389/fmicb.2018.02532 HZI-Repositorium PubMed

Liakopoulos V., Jeron A., Shah A., Bruder D., Mertens P.R., Gorny X. (2018)

Hemodialysis-related changes in phenotypical features of monocytes

Sci.Rep., 8 (1)

DOI: 10.1038/s41598-018-31889-2 HZI-Repositorium PubMed

Jeron A., Boehme J.D., Volckmar J., Gereke M., Yevsa T., Geffers R., Guzmán C.A., Schreiber J., ... , Stegemann-Koniszewski S., Bruder D. (2018)

Respiratory bordetella bronchiseptica carriage is associated with broad phenotypic alterations of peripheral CD4+CD25+ T cells and differentially affects immune responses to secondary non-infectious and infectious stimuli in mice

Int.J.Mol.Sci., 19 (9)

DOI: 10.3390/ijms19092602 HZI-Repositorium PubMed

Veluswamy P., Bruder D. (2018)

PD-1/PD-L1 pathway inhibition to restore effector functions in exhausted CD8+ T cells: Chances, limitations and potential risks

Transl.Cancer Res., 7 (Supplement 4 (April))

DOI: 10.21037/tcr.2018.04.04 HZI-Repositorium

Bulitta B., Zuschratter W., Bernal I., Bruder D., Klawonn F., von Bergen M., ... , Garritsen H.S.P., Jänsch L. (2018)

Proteomic definition of human mucosal-associated invariant T cells determines their unique molecular effector phenotype

Eur.J.Immunol., 48 (8)

DOI: 10.1002/eji.201747398

Stegemann-Koniszewski S., Behrens S., Boehme J.D., Hochnadel I., Riese P., Guzmán C.A., Kröger A., Schreiber J., ... , Gunzer M., Bruder D. (2018)

Respiratory influenza A virus infection triggers local and systemic natural killer cell activation via toll-like receptor 7

Front.Immunol., 9 (FEB)

DOI: 10.3389/fimmu.2018.00245 HZI-Repositorium PubMed

Frede A., Neuhaus B., Knuschke T., Wadwa M., Kollenda S., Klopfleisch R., Hansen W., Buer J., Bruder D., ... , Epple M., Westendorf A.M. (2017)

Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation

Nanomedicine., 13 (8)

DOI: 10.1016/j.nano.2017.08.001

Schuster M., Plaza-Sirvent C., Matthies A.M., Heise U., Jeron A., Bruder D., Visekruna A., ... , Hühn J., Schmitz I. (2017)

c-REL and IkappaBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors

J.Immunol., 199 (3)

DOI: 10.4049/jimmunol.1600877

Boehme J.D., Bruder D. (2017)

IL-33: a jack of all trades in the orchestration of respiratory antibacterial immunity

Cell Mol.Immunol., 14 (11)

DOI: 10.1038/cmi.2017.53 HZI-Repositorium

Boehme J.D., Stegemann-Koniszewski S., Autengruber A., Peters N., Wissing J., Jänsch L., ... , Jeron A., Bruder D. (2017)

Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance

Sci.Rep., 7 (1)

DOI: 10.1038/s41598-017-05212-4 PubMed

Mracsko E., Stegemann-Koniszewski S., Na S.Y., Dalpke A., Bruder D., ... , Lasitschka F., Veltkamp R. (2017)

A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with Streptococcus pneumoniae

Cerebrovasc.Dis., 43 (3-4)

DOI: 10.1159/000452136 PubMed

Volckmar J., Gereke M., Ebensen T., Riese P., Philipsen L., Lienenklaus S., Wohlleber D., Klopfleisch R., Stegemann-Koniszewski S., Muller A.J., Gruber A.D., Knolle P., ... , Guzmán C.A., Bruder D. (2017)

Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver

Sci Rep., 7 (Mar)

DOI: 10.1038/srep43985 HZI-Repositorium PubMed

Sharma-Chawla N., Sender V., Kershaw O., Gruber A.D., Volckmar J., Henriques-Normark B., ... , Stegemann-Koniszewski S., Bruder D. (2016)

Influenza A virus infection predisposes hosts to secondary infection with different Streptococcus pneumoniae serotypes with similar outcome but serotype-specific manifestation

Infect.Immun., 84 (12)

DOI: 10.1128/IAI.00422-16 HZI-Repositorium PubMed

Sakthivel P., Breithaupt A., Gereke M., Copland D.A., Schulz C., Gruber A.D., Dick A.D., ... , Schreiber J., Bruder D. (2016)

Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course

Lung, 159

DOI: 10.1007/s00408-016-9962-4 HZI-Repositorium PubMed

Duvigneau S., Sharma-Chawla N., Boianelli A., Stegemann-Koniszewski S., Nguyen V.K., ... , Bruder D., Hernandez-Vargas E.A. (2016)

Hierarchical effects of pro-inflammatory cytokines on the post-influenza susceptibility to pneumococcal coinfection

Sci Rep., 6

DOI: 10.1038/srep37045 HZI-Repositorium PubMed

Pieler M.M., Frentzel S., Bruder D., Wolff M.W., Reichl U. (2016)

A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection

Vaccine, 34 (50)

DOI: 10.1016/j.vaccine.2016.10.041 HZI-Repositorium PubMed

Sakthivel P., Bruder D. (2016)

Mechanism of granuloma formation in sarcoidosis

Curr Opin.Hematol., 24 (1)

DOI: 10.1097/MOH.0000000000000301 PubMed

Parzmair G.P., Gereke M., Haberkorn O., Annemann M., Podlasly L., Kliche S., Reinhold A., ... , Schraven B., Bruder D. (2016)

ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens

J Leukoc.Biol., 101 (2)

DOI: 10.1189/jlb.1A0216-090RR PubMed

Boianelli A., Sharma-Chawla N., Bruder D., Hernandez-Vargas E.A. (2016)

Oseltamivir PK/PD Modeling and Simulation to Evaluate Treatment Strategies against Influenza-Pneumococcus Coinfection

Front Cell Infect.Microbiol., 6

DOI: 10.3389/fcimb.2016.00060 HZI-Repositorium PubMed

Sakthivel P., Sharma N., Klahn P., Gereke M., Bruder D. (2016)

Abscisic acid: A phytohormone and mammalian cytokine as novel pharmacon with potential for future development into clinical applications

Curr.Med.Chem., 23 (15)

DOI: 10.2174/0929867323666160405113129

Stegemann-Koniszewski S., Jeron A., Gereke M., Geffers R., Kroger A., ... , Gunzer M., Bruder D. (2016)

Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals

MBio., 7 (3)

DOI: 10.1128/mBio.00276-16 HZI-Repositorium PubMed

Bruder D., Probst-Kepper M., Westendorf A.M., Geffers R., Beissert S., Loser K., Von Boehmer H., ... , Buer J., Hansen W. (2004)

Erratum: Frontline: Neuropilin-1: A surface marker of regulatory T cells (European Journal of Immunology (2004) vol. 34 (3) (623-630) 10.1002/eji.200324799)

Eur.J.Immunol., 34 (5)

DOI: 10.1002/eji.200490008 PubMed

Rolle A.M., Hasenberg M., Thornton C.R., Solouk-Saran D., Weski J., Maurer A., Fischer E., Spycher P.R., Schibli R., Boschetti F., Stegemann-Koniszewski S., Bruder D., Severin G.W., Autenrieth S.E., Krappmann S., Davies G., ... , Pichler B.J., Gunzer M. (2016)

ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo

Proc.Natl.Acad.Sci.U.S.A., 113 (8)

DOI: 10.1073/pnas.1518836113 HZI-Repositorium PubMed

Petzold C., Steinbronn N., Gereke M., Strasser R.H., Sparwasser T., Bruder D., Geffers R., ... , Schallenberg S., Kretschmer K. (2014)

Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin

Eur.J.Immunol., 44 (12)

DOI: 10.1002/eji.201444750 HZI-Repositorium PubMed

Désiréé Boehme J., Pietkiewicz S., Lavrik I., Jeron A., Bruder D. (2015)

Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease

Lung, 193 (6)

DOI: 10.1007/s00408-015-9797-4 HZI-Repositorium PubMed

Boehme J.D., Pietkiewicz S., Lavrik I., Jeron A., Bruder D. (2015)

Erratum to: Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease

Lung, 193

DOI: 10.1007/s00408-015-9812-9 HZI-Repositorium PubMed

Boianelli A., Nguyen V.K., Ebensen T., Schulze K., Wilk E., Sharma N., Stegemann-Koniszewski S., Bruder D., Toapanta F.R., Guzmán C.A., ... , Meyer-Hermann M., Hernandez-Vargas E.A. (2015)

Modeling influenza virus infection: A roadmap for influenza research

Viruses, 7 (10)

DOI: 10.3390/v7102875 HZI-Repositorium PubMed

Sakthivel P., Grunewald J., Eklund A., Bruder D., Wahlstrom J. (2015)

Pulmonary sarcoidosis is associated with high-level ICOS expression on lung regulatory T cells - possible implications for the ICOS/ICOS-L axis in disease course and resolution

Clin.Exp.Immunol., 183

DOI: 10.1111/cei.12715 HZI-Repositorium PubMed

Yeruva S., Chodisetti G., Luo M., Chen M., Cinar A., Ludolph L., Lünnemann M., Goldstein J., Singh A.K., Riederer B., Bachmann O., Bleich A., Gereke M., Bruder D., Hagen S., He P., ... , Yun C., Seidler U. (2015)

Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H+ exchanger NHE3 dysfunction in human and murine colitis

Pflug.Arch.Eur.J.Physiol., 467 (8)

DOI: 10.1007/s00424-014-1608-x HZI-Repositorium PubMed

Biswas A., Bruder D., Wolf S.A., Jeron A., Mack M., ... , Heimesaat M.M., Dunay I.R. (2015)

Ly6Chigh monocytes control cerebral toxoplasmosis

J.Immunol., 194 (7)

Tschernig T., Hartwig C., Jeron A., Dinh Q.T., Gereke M., Bruder D. (2015)

First genomic analysis of dendritic cells from lung and draining lymph nodes in murine asthma

Int.J Genomics, 2015

DOI: 10.1155/2015/638032 HZI-Repositorium PubMed

Sakthivel P., Gereke M., Breithaupt A., Fuchs D., Gigliotti L., Gruber A.D., ... , Dianzani U., Bruder D. (2014)

Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells

PLoS ONE, 9 (7)

DOI: 10.1371/journal.pone.0100970 HZI-Repositorium PubMed

Nair Sharmila, Michaelsen-Preusse K., Finsterbusch Katja, Stegemann-Koniszewski Sabine, Bruder Dunja, Grashoff Martina, Korte Martin, Köster Mario, Kalinke Ulrich, ... , Hauser Hansjörg, Kröger Andrea (2014)

Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons

PLoS Pathogens, 10 (3)

DOI: 10.1371/journal.ppat.1003999 HZI-Repositorium PubMed

Kominsky D.J., Campbell E.L., Ehrentraut S.F., Wilson K.E., Kelly C.J., Glover L.E., Collins C.B., Bayless A.J., Saeedi B., Dobrinskikh E., Bowers B.E., Macmanus C.F., Muller W., ... , Colgan S.P., Bruder Dunja (2014)

IFN-gamma-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia

Journal of Immunology, 192 (3)

DOI: 10.4049/jimmunol.1301757 HZI-Repositorium PubMed

Sakthivel Priya, Gereke Marcus, Bruder Dunja (2012)

Therapeutic intervention in cancer and chronic viral infections: antibody mediated manipulation of PD-1/PD-L1 interaction

Review on Recent Clinical Trials, 7 (1)

Jeron A., Hansen W., Ewert F., Buer J., Geffers R., Bruder D. (2012)

ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells

BMC GENOMICS, 13 (1)

DOI: 10.1186/1471-2164-13-705 HZI-Repositorium

Gereke Marcus, Autengruber A., Gröe Lothar, Jeron A., Bruder Dunja, Stegemann-Koniszewski S. (2012)

Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies

Journal of Visualized Experiments: JoVE (70)

DOI: 10.3791/4322

Telieps T., Ewald F., Gereke M., Annemann M., Rauter Y., Schuster M., Ueffing N., von Smolinski D., Gruber A.D., ... , Bruder D., Schmitz I. (2013)

Cellular-FLIP, Raji isoform (c-FLIPR) modulates cell death induction upon T-cell activation and infection

European Journal of Immunology, 43 (6)

Autengruber Andrea, Gereke Marcus, Hansen G., Hennig C., Bruder Dunja (2012)

Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function

European Journal of Microbiology and Immunology, 2 (2)

DOI: 10.1556/EuJMI.2.2012.2.3

Stegemann-Koniszewski S., Gereke M., Orrskog S., Lienenklaus S., Pasche B., Bader S.R., Gruber A.D., Akira S., Weiss Siegfried, Henriques-Normark B., ... , Bruder Dunja, Gunzer M. (2012)

TLR7 Contributes to the Rapid Progression but Not to the Overall Fatal Outcome of Secondary Pneumococcal Disease following Influenza A Virus Infection

Journal of Innate Immunity, 5 (1)

DOI: 10.1159/000345112 HZI-Repositorium PubMed

Tosiek M.J., Bader S.R., Gruber A.D., Buer J., Gereke M., Bruder Dunja (2012)

CD8+ T Cells Responding to Alveolar Self-Antigen Lack CD25 Expression and Fail to Precipitate Autoimmunity

American Journal of Respiratory Cell and Molecular Biology, 47 (6)

DOI: 10.1165/rcmb.2011-0387OC

Albrecht M., Arnhold M., Lingner S., Mahapatra S., Bruder Dunja, ... , Hansen G., Dittrich A.M. (2012)

IL-4 Attenuates Pulmonary Epithelial Cell-Mediated Suppression of T Cell Priming

PLoS ONE, 7 (9)

DOI: 10.1371/journal.pone.0045916 PubMed

Alberts R., Chen H., Pommerenke C., Smit A.B., Spijker S., Williams R.W., Geffers Robert*, ... , Bruder Dunja*, Schughart Klaus* (2011)

Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease1

BMC GENOMICS, 12

DOI: 10.1186/1471-2164-12-610 HZI-Repositorium

Kang T.W., Yevsa T., Woller N., Hoenicke L., Wuestefeld T., Dauch D., Hohmeyer A., Gereke M., Rudalska R., Potapova A., Iken M., Vucur M., Weiss Siegfried*, Heikenwalder M., Khan S., Gil J., Bruder Dunja*, Manns M., Schirmacher P., Tacke F., Ott M., Luedde T., Longerich T., ... , Kubicka S., Zender Lars* (2011)

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Nature, 479 (7374)

Cappuccini F., Eldh T., Bruder Dunja*, Gereke M., Jastrow H., Schulze-Osthoff K., Fischer U., Kohler D., ... , Stuschke M., Jendrossek V. (2011)

New insights into the molecular pathology of radiation-induced pneumopathy

Radiotherapy and Oncology, 101 (1)

DOI: 10.1016/j.radonc.2011.05.064 HZI-Repositorium PubMed

Ukena S.N., Velaga S., Geffers Robert*, Grosse J., Baron U., Buchholz S., Stadler M., Bruder Dunja*, ... , Ganser A., Franzke A. (2011)

Human regulatory T cells in allogeneic stem cell transplantation

Blood, 118 (13)

Tosiek M.J., Gruber A.D., Bader S., Hoymann H.G., Mauel S., Tschwernig T., Buer J., ... , Gereke M., Bruder Dunja* (2011)

CD4 +

Journal of Immunology, 186 (11)

Liesz A., Zhou W., Mracskó E., Karcher S., Doerr H., Schwarting S., Sun L., Bruder Dunja*, Stegemann S., Cerwenka A., Sommer C., ... , Dalpke A., Veltkamp R. (2011)

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

Brain, 134 (3)

Bar-On L., Birnberg T., Lewis K.L., Edelson B.T., Bruder D., Hildner K., Buer J., Murphy K.M., ... , Reizis B., Jung S. (2010)

CX3CR1+ CD8a[alpha]+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells

Proceedings of the National Acadamy of Sciences of the United States of America, 107 (33)

DOI: 10.1073/pnas.1001562107 HZI-Repositorium PubMed

Lienenklaus S., Cornitescu M., Zietara N., Lyszkiewicz M., Gekara N., Jablonska J., Edenhofer F., Rajewsky K., Bruder D., Hafner M., ... , Staeheli P., Weiss S. (2009)

Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo

Journal of Immunology, 183 (5)

DOI: 10.4049/jimmunol.0804277 PubMed

Jeron A., Pfoertner S., Bruder Dunja*, Geffers Robert*, Hammerer P., Hofmann R., ... , Buer J., Schrader A.J. (2009)

Frequency and Gene Expression Profile of Regulatory T Cells in Renal Cell Carcinoma

Tumor Biology, 30 (3)

Gereke M., Jung S., Buer J., Bruder Dunja* (2009)

Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells

American Journal of Respiratory and Critical Care Medicine, 179 (5)

Stegemann S., Dahlberg S., Kroger A., Gereke M., Bruder Dunja*, ... , Henriques-Normark B., Gunzer Matthias* (2009)

Increased susceptibility for superinfection with Streptococcus pneumoniae

PLoS ONE, 4 (3)

DOI: 10.1371/journal.pone.0004840 HZI-Repositorium PubMed

Srivastava B., Blazejewska P., Hessmann M., Bruder D., Geffers Robert*, Mauel S., ... , Gruber A.D., Schughart Klaus* (2009)

Host genetic background strongly influences the response to influenza a virus infections

PLoS ONE, 4 (3)

DOI: 10.1371/journal.pone.0004857 HZI-Repositorium PubMed

Ukena S.N., Singh A., Dringenberg U., Engelhardt R., Seidler U., Hansen W., Bleich A., Bruder Dunja*, Franzke A., Rogler G., Suerbaum S., Buer Jan*, ... , Gunzer F., Westendorf Astrid .M.* (2007)

Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity

PLoS ONE, 2 (12)

DOI: 10.1371/journal.pone.0001308 HZI-Repositorium PubMed

Hansen W., Westendorf A.M., Reinwald S., Bruder Dunja*, Deppenmeier S., Gröbe Lothar*, Probst-Kepper Michael*, Gruber A.D., ... , Geffers Robert*, Buer Jan* (2007)

Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3 -

Journal of Immunology, 179

Gereke M., Gröbe L., Prettin S., Kasper M., Deppenmeier S., Gruber A.D., Enelow R.I., ... , Buer J., Bruder D. (2007)

Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation

Respiratory research, 8

DOI: 10.1186/1465-9921-8-47 HZI-Repositorium PubMed

Westendorf A.M., Bruder D., Hansen W., Buer J. (2006)

Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in a transgenic autoimmune mouse model

Annals of the New York Academy of Sciences, 1072

Westendorf A.M., Fleissner D., Deppenmeier S., Gruber A.D., Bruder D., Hansen H., ... , Liblau R., Buer J. (2006)

Autoimmune-mediated intestinal inflammation - impact and regulation of antigen specific CD8+ T cells

Gastroenterology, 131 (2)

Bruder Dunja*, Srikiatkhachorn A., Enelow R.I. (2006)

Cellular immunity and lung injury in respiratory virus infection

Viral Immunology, 26

Ramana C.V., Chintapalli J., Xu L., Alia C., Bruder Dunja*, Enelow R.I. (2006)

Lung epithelial Stat1 and NF- B signalling in response to CD8+ T cell antigen recognition

Journal of Interferon and Cytokine Research, 26

Hansen W., Loser K., Westendorf Astrid M.*, Bruder Dunja*, Pförtner S., Siewert C., Hühn J., ... , Beissert S., Buer Jan* (2006)

GPR83-overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo

Journal of Immunology, 177

Bruder Dunja*, Nussbaum A.K., Gakamsky D.M., Schirle M., Stevanovic S., Singh-Jasuja H., Darji A., Chakraborty T., Schild H., ... , Pecht I., Weiss Siegfried* (2006)

Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O

International immunology, 18

DOI: 10.1093/intimm/dxh352 HZI-Repositorium PubMed

Bruder D., Westendorf A.M., Hansen W., Prettin S., Gruber A.D., Qian Y., Von Boehmer H., ... , Mahnke K., Buer J. (2005)

On the edge of autoimmunity: T cell stimulation by steady state dendritic cells prevents autoimmune diabetes

Diabetes, 54

Westendorf A.M., Gunzer F., Deppenmeier S., Tapadar D., Hunger J.K., Schmidt M., ... , Buer J., Bruder D. (2005)

Intestinal immunity of E. coli

Fems Immunology and Medical Microbiology, 43 (3)

Rharbaoui F., Bruder D., Vidakovic M., Ebensen T., Buer J., Guzmán C.A. (2005)

Characterization of a B220+ lymphoid cell subpopulation with immune modulatory functions

Journal of Immunology, 174

Westendorf A.M., Templin M., Geffers R., Deppenmeier S., Gruber A.D., Probst-Kepper M., Hansen W., Liblau R.S., Gunzer F., ... , Bruder D., Buer J. (2005)

CD4+ T cell mediated instinal immunity: chronic inflammation versus immune regulation

GUT, 54

Bruder D., Westendorf A.M., Geffers R., Gruber A.D., Gereke M., ... , Enelow R.I., Buer J. (2004)

CD4 T cell mediated lung disease: steady state between pathological and tolerogenic immune reactions

American Journal of Respiratory and Critical Care Medicine, 170

Bruder D., Probst-Kepper M., Westendorf A.M., Geffes R., Beissert S., Loser K., Von Boehmer H., ... , Buer J., Hansen W. (2004)

Neuropilin-1: a surface marker of regulatory T cells

European Journal of Immunology, 34 (3)

Lechner O., Bruder D., Lauber J., Buer J. (2002)

Anerge T-Zellen: Immunregulatoren mit Potential für die Klinik!

Die gelben Hefte, 42

Lechner O., Bruder D., Lauber J., Buer J. (2002)

Anergic T-cells: immunregulators with clinical implications!

Biomedical Progress, 15

Research group

Immune Regulation

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HZI Campus

Prof Dr Dunja Bruder

Prof. Dunja Bruder

Research group

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