Prof. Dr. Eva Medina

Goldmann O., Lang J.C., Rohde M., May T., Molinari G., Medina E. (2024)

Alpha-hemolysin promotes internalization of Staphylococcus aureus into human lung epithelial cells via caveolin-1- and cholesterol-rich lipid rafts

Cell.Mol.Life Sci., 81 (1)

DOI: 10.1007/s00018-024-05472-0 HZI-Repositorium PubMed

Ohm M., Hosseini S., Lonnemann N., He W., More T., Goldmann O., Medina E., ... , Hiller K., Korte M. (2024)

The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain

Journal of Neuroinflammation, 21 (1)

DOI: 10.1186/s12974-024-03188-3 HZI-Repositorium PubMed

Rox K., Medina E. (2024)

Aerosolized delivery of ESKAPE pathogens for murine pneumonia models

Scientific Reports, 14 (1)

DOI: 10.1038/s41598-024-52958-9 HZI-Repositorium PubMed

Goldmann O., Nwofor O.V., Chen Q., Medina E. (2024)

Mechanisms underlying immunosuppression by regulatory cells

Front Immunol., 15

DOI: 10.3389/fimmu.2024.1328193 HZI-Repositorium PubMed

Goldmann O., Medina E. (2023)

Myeloid-derived suppressor cells impair CD4+ T cell responses during chronic Staphylococcus aureus infection via lactate metabolism

Cell.Mol.Life Sci., 80 (8)

DOI: 10.1007/s00018-023-04875-9 HZI-Repositorium PubMed

Papaxenopoulou L.A., Zhao G., Khailaie S., Katsoulis-Dimitriou K., Schmitz I., Medina E., ... , Hatzikirou H., Meyer-Hermann M. (2022)

In silico predicted therapy against chronic Staphylococcus aureus infection leads to bacterial clearance in vivo

iScience, 25 (12)

DOI: 10.1016/j.isci.2022.105522 HZI-Repositorium PubMed

Lang J.C., Seiß E.A., Moldovan A., Müsken M., Sauerwein T., Fraunholz M., Müller A.J., ... , Goldmann O., Medina E. (2022)

A Photoconvertible Reporter System for Bacterial Metabolic Activity Reveals That Staphylococcus aureus Enters a Dormant-Like State to Persist within Macrophages

MBio.

DOI: 10.1128/mbio.02316-22 HZI-Repositorium PubMed

Heinz A., Nonnenmacher Y., Henne A., Khalil M.A., Bejkollari K., Dostert C., Hosseini S., Goldmann O., He W., Palorini R., Verschueren C., Korte M., Chiaradonna F., Medina E., ... , Brenner D., Hiller K. (2022)

Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2

Biochim.Biophys.Acta Mol.Basis.Dis., 1868 (12)

DOI: 10.1016/j.bbadis.2022.166530 HZI-Repositorium PubMed

He W., Henne A., Lauterbach M., Geißmar E., Nikolka F., Kho C., Heinz A., Dostert C., Grusdat M., Cordes T., Härm J., Goldmann O., Ewen A., Verschueren C., Blay-Cadanet J., Geffers R., Garritsen H., Kneiling M., Holm C.K., Metallo C.M., Medina E., Abdullah Z., Latz E., ... , Brenner D., Hiller K. (2022)

Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages

Nat.Metab, 4 (5)

DOI: 10.1038/s42255-022-00565-1 HZI-Repositorium PubMed

Goldmann O., Sauerwein T., Molinari G., Rohde M., Förstner K.U., Medina E. (2022)

Cytosolic Sensing of Intracellular Staphylococcus aureus by Mast Cells Elicits a Type I IFN Response That Enhances Cell-Autonomous Immunity

J Immunol, 208 (7)

DOI: 10.4049/jimmunol.2100622 HZI-Repositorium PubMed

Junca H., Pieper D.H., Medina E. (2022)

The emerging potential of microbiome transplantation on human health interventions

Comput.Struct.Biotechnol.J., 20 (January 2022)

DOI: 10.1016/j.csbj.2022.01.009 HZI-Repositorium PubMed

Dietrich O., Heinz A., Goldmann O., Geffers R., Beineke A., Hiller K., ... , Saliba A.E., Medina E. (2021)

Dysregulated Immunometabolism Is Associated with the Generation of Myeloid-Derived Suppressor Cells in Staphylococcus aureus Chronic Infection

J.Innate.Immun.

DOI: 10.1159/000519306 HZI-Repositorium PubMed

Groma M., Horst S.A., Das S., Huettel B., Klepsch M., Rudel T., ... , Medina E., Fraunholz M. (2020)

Identification of a Novel LysR-Type Transcriptional Regulator in Staphylococcus aureus That Is Crucial for Secondary Tissue Colonization during Metastatic Bloodstream Infection

MBio., 11 (4)

DOI: 10.1128/mBio.01646-20 HZI-Repositorium PubMed

Bonifacius A., Goldmann O., Floess S., Holtfreter S., Robert P.A., Nordengrün M., Kruse F., Lochner M., Falk C.S., Schmitz I., Bröker B.M., ... , Medina E., Hühn J. (2020)

Staphylococcus aureus Alpha-Toxin Limits Type 1 While Fostering Type 3 Immune Responses

Front Immunol., 11

DOI: 10.3389/fimmu.2020.01579 HZI-Repositorium PubMed

Le P., Kunold E., Macsics R., Rox K., Jennings M.C., Ugur I., Reinecke M., Chaves-Moreno D., Hackl M.W., Fetzer C., Mandl F.A.M., Lehmann J., Korotkov V.S., Hacker S.M., Kuster B., Antes I., Pieper D.H., Rohde M., Wuest W.M., ... , Medina E., Sieber S.A. (2020)

Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms

Nat.Chem., 12 (2)

DOI: 10.1038/s41557-019-0378-7 HZI-Repositorium PubMed

Goldmann O., Cern A., Müsken M., Rohde M., Weiss W., ... , Barenholz Y., Medina E. (2019)

Liposomal mupirocin holds promise for systemic treatment of invasive Staphylococcus aureus infections

J.Control Release, 316

DOI: 10.1016/j.jconrel.2019.11.007 PubMed

Thänert R., Itzek A., Hossmann J., Hamisch D., Madsen M.B., Hyldegaard O., Skrede S., Bruun T., Norrby-Teglund A., ... , Medina E., Pieper D.H. (2019)

Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

Nat.Commun., 10 (1)

DOI: 10.1038/s41467-019-11722-8 HZI-Repositorium PubMed

Zhao W., Cross A.R., Crowe-McAuliffe C., Weigert-Munoz A., Csatary E.E., Solinski A.E., Krysiak J., Goldberg J.B., Wilson D.N., Medina E., ... , Wuest W.M., Sieber S.A. (2019)

The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa

Angew.Chem.Int.Ed., 58 (25)

DOI: 10.1002/anie.201903472 HZI-Repositorium PubMed

Seiß E.A., Krone A., Formaglio P., Goldmann O., Engelmann S., Schraven B., ... , Medina E., Müller A.J. (2019)

Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils

Sci.Rep., 9 (1)

DOI: 10.1038/s41598-019-42129-6 HZI-Repositorium PubMed

Jayachandran R., Gumienny A., Bolinger B., Ruehl S., Lang M.J., Fucile G., Mazumder S., Tchang V., Woischnig A.K., Stiess M., Kunz G., Claudi B., Schmaler M., Siegmund K., Li J., Dertschnig S., Holländer G., Medina E., Karrer U., Moshous D., Bumann D., Khanna N., ... , Rossi S.W., Pieters J. (2019)

Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity

Immunity., 50 (1)

DOI: 10.1016/j.immuni.2018.12.011 HZI-Repositorium PubMed

Dudeck A., Köberle M., Goldmann O., Meyer N., Dudeck J., Lemmens S., Rohde M., Roldan N.G., Dietze-Schwonberg K., Orinska Z., Medina E., Hendrix S., Metz M., Zenclussen A.C., ... , von Stebut E., Biedermann T. (2018)

Mast cells as protectors of health

J.Allergy Clin.Immunol., 144 (4)

DOI: 10.1016/j.jaci.2018.10.054 HZI-Repositorium PubMed

Heck J.G., Rox K., Lünsdorf H., Lückerath T., Klaassen N., Medina E., ... , Goldmann O., Feldmann C. (2018)

Zirconyl Clindamycinphosphate Antibiotic Nanocarriers for Targeting Intracellular Persisting Staphylococcus aureus

ACS Omega, 3 (8)

DOI: 10.1021/acsomega.8b00637 HZI-Repositorium

Medina E., Hartl D. (2018)

Myeloid-Derived Suppressor Cells in Infection: A General Overview

J.Innate.Immun., 10 (5-6)

DOI: 10.1159/000489830 HZI-Repositorium PubMed

Strehlitz A., Goldmann O., Pils M.C., Pessler F., Medina E. (2018)

An interferon signature discriminates pneumococcal from staphylococcal pneumonia

Front.Immunol., 9 (JUN)

DOI: 10.3389/fimmu.2018.01424 HZI-Repositorium PubMed

Ferrer-Navarro M., Strehlitz A., Medina E., Vila J. (2018)

Changed expression of cytoskeleton proteins during lung injury in a mouse model of Streptococcus pneumoniae infection

Front.Microbiol., 9 (MAY)

DOI: 10.3389/fmicb.2018.00928 HZI-Repositorium PubMed

Fetzer C., Korotkov V.S., Lee K.M., Neuenschwander M., von Kries J.P., Medina E. (2017)

A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus

Angew.Chem.Int.Ed., 56 (49)

DOI: 10.1002/anie.201708454 PubMed

Goldmann O., Beineke A., Medina E. (2017)

Identification of a novel subset of myeloid-derived suppressor cells during chronic staphylococcal infection that resembles immature eosinophils

J.Infect.Dis., 216 (11)

DOI: 10.1093/infdis/jix494 HZI-Repositorium

Goldmann O., Medina E. (2017)

Staphylococcus aureus strategies to evade the host acquired immune response

Int.J.Med.Microbiol. (9)

DOI: 10.1016/j.ijmm.2017.09.013 PubMed

Blaschke U., Beineke A., Klemens J., Medina E., Goldmann O. (2017)

Induction of Cyclooxygenase 2 by Streptococcus pyogenes Is Mediated by Cytolysins

J.Innate.Immun., 9 (6)

DOI: 10.1159/000479153 PubMed

Leech J.M., Lacey K.A., Mulcahy M.E., Medina E., McLoughlin R.M. (2017)

IL-10 plays opposing roles during staphylococcus aureus systemic and localized infections

J.Immunol., 198 (6)

DOI: 10.4049/jimmunol.1601018 HZI-Repositorium PubMed

Thänert R., Goldmann O., Beineke A., Medina E. (2017)

Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection

Nat.Commun., 8

DOI: 10.1038/ncomms14268 HZI-Repositorium PubMed

Deicke C., Chakrakodi B., Pils M.C., Dickneite G., Johansson L., ... , Medina E., Loof T.G. (2016)

Local activation of coagulation factor XIII reduces systemic complications and improves the survival of mice after Streptococcus pyogenes M1 skin infection

Int.J Med.Microbiol., 306 (7)

DOI: 10.1016/j.ijmm.2016.06.001 PubMed

Chaves-Moreno D., Wos-Oxley M.L., Jauregui R., Medina E., Oxley A.P., Pieper D.H. (2016)

Exploring the transcriptome of Staphylococcus aureus in its natural niche

Sci Rep., 6

DOI: 10.1038/srep33174 HZI-Repositorium PubMed

Medina E., Pieper D.H. (2016)

Tackling Threats and Future Problems of Multidrug-Resistant Bacteria

Curr Top.Microbiol.Immunol., 398 (Part 1, chapter 1)

DOI: 10.1007/82_2016_492

Medina E. (2006)

Streptococcus pyogenes and host'genetics

Mod.Asp.Immunobiol., 18

DOI: -

Chaves-Moreno D., Wos-Oxley M.L., Jauregui R., Medina E., Oxley A.P., Pieper D.H. (2015)

Application of a Novel "Pan-Genome"-Based Strategy for Assigning RNAseq Transcript Reads to Staphylococcus aureus Strains

PLoS ONE, 10 (12)

DOI: 10.1371/journal.pone.0145861 HZI-Repositorium PubMed

Tuchscherr L., Kreis C.A., Hoerr V., Flint L., Hachmeister M., Geraci J., Bremer-Streck S., Kiehntopf M., Medina E., Kribus M., Raschke M., Pletz M., ... , Peters G., Löffler B. (2015)

Staphylococcus aureus develops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis

J Antimicrob.Chemother., 71 (2)

DOI: 10.1093/jac/dkv371 PubMed

Goldmann O., Tuchscherr L., Rohde M., Medina E. (2015)

a[alpha]-Hemolysin enhances Staphylococcus aureus internalization and survival within mast cells by modulating the expression of beta1 integrin

Cell Microbiol., 18 (6)

DOI: 10.1111/cmi.12550 PubMed

Tsatsaronis J.A., Ly D., Pupovac A., Goldmann O., Rohde M., Taylor J.M., Walker M.J., ... , Medina E., Sanderson-Smith M.L. (2015)

Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses

J.Innate Immun., 7 (6)

Horst S.A., Itzek A., Klos A., Beineke A., Medina E. (2015)

Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection

Pathogens, 4 (4)

DOI: 10.3390/pathogens4040722 HZI-Repositorium PubMed

Yuan D., Zhu Z., Tan X., Liang J., Zeng C., Zhang J., Chen J., Ma L., Dogan A., Brockmann G., Goldmann O., Medina E., Rice A.D., Moyer R.W., Man X., Yi K., Li Y., Lu Q., ... , Huang Y., Huang S. (2014)

Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms

Science China Life Sciences, 57

Loof T.G., Goldmann O., Naudin C., Mörgelin M., Neumann Y., Pils M.C., Foster S.J., ... , Medina E., Herwald H. (2015)

Staphylococcus aureus-induced clotting of plasma is an immune evasion mechanism for persistence within the fibrin network

Microbiology, 161 (3)

Szafranska A.K., Oxley A.P.A., Chaves-Moreno D., Horst S.A., Roßlenbroich S., Peters G., Goldmann O., Rohd M., Sinha B., Pieper D.H., Löffler B., Jauregui R., ... , Wos-Oxley M.L., Medina E. (2014)

High-resolution transcriptomic analysis of the adaptive response of staphylococcus aureus during acute and chronic phases of osteomyelitis

MBio, 5 (6)

DOI: 10.1128/mBio.01775-14 HZI-Repositorium PubMed

Tebartz C., Horst Sarah A., Sparwasser Tim, Hühn Jochen, Beineke A., ... , Peters G., Medina Eva (2014)

A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection

Journal of Immunology, 194 (3)

Loof Torsten G., Deicke Christin, Medina Eva (2014)

The role of coagulation/fibrinolysis during Streptococcus pyogenes infection

Frontiers in Cellular and Infection Microbiology, 4

DOI: 10.3389/fcimb.2014.00128 HZI-Repositorium PubMed

Mehraj J., Akmatov M.K., Strömpl J., Gatzemeier A., Layer F., Werner G., Pieper D.H., Medina E., Witte W., ... , Pessler F., Krause G. (2014)

Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Nasal Carriage in a Random Sample of Non-Hospitalized Adult Population in Northern Germany

PLoS ONE, 9 (9)

DOI: 10.1371/journal.pone.0107937 HZI-Repositorium PubMed

Horst S.A., Linner A., Beineke A., Lehne S., Höltje C., Hecht A., Norrby-Teglund A., ... , Medina E., Goldmann O. (2013)

Prognostic Value and Therapeutic Potential of TREM-1 in Streptococcus pyogenes- Induced Sepsis

Journal of Innate Immunology, 5 (6)

DOI: 10.1159/000348283 HZI-Repositorium PubMed

Ko Y.P., Freitag C.M., Kuipers A., Jongerius I., Medina Eva, van Rooijen W.J., Spaan A.N., van Kessel K.P.M., ... , Höök M., Rooijkkers S.H.M. (2013)

Phagocytosis escape by a bacterial protein that connects complement and coagulation proteins at the bacterial surface

PLoS Pathogens, 9 (12)

DOI: 10.1371/journal.ppat.1003816 HZI-Repositorium PubMed

Rosendahl A., Bergmann Silke, Hammerschmidt S., Goldmann O., Medina E. (2013)

Lung dendritic cells facilitate extrapulmonary bacterial dissemination during pneumococcal pneumonia

Frontiers in Cellular and Infection Microbiology, 3

DOI: 10.3389/fcimb.2013.00021 HZI-Repositorium PubMed

Michelucci A., Cordes T., Ghelfi J., Pailot A., Reiling N., Goldmann O., Binz T., Wegner A., Tallam A., Rausell A., Buttini M., Linster C.L., Medina Eva, ... , Balling R., Hiller K. (2013)

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Proceedings of the National Academy of Sciences USA, 110 (19)

DOI: 10.1073/pnas.1218599110 HZI-Repositorium PubMed

Goldmann O., Medina Eva* (2012)

The expanding world of extracellular traps: not only neutrophils but much more

Frontiers in Immunology, 3

DOI: 10.3389/fimmu.2012.00420 HZI-Repositorium PubMed

Schindler D., Gutierrez Maximiliano G., Beineke A., Rauter Y., Rohde Manfred, Foster S., ... , Goldmann O., Medina Eva (2012)

Dendritic Cells Are Central Coordinators of the Host Immune Response to Staphylococcus aureus

American Journal of Pathology, 181 (4)

Niemann S., Ehrhardt C., Medina Eva*, Warnking K., Tuchscherr L., Heitmann V., Ludwig S., ... , Peters G., Loffler B. (2012)

Combined Action of Influenza Virus and Staphylococcus aureus Panton-Valentine Leukocidin Provokes Severe Lung Epithelium Damage

Journal of Infectious Diseases, 206 (7)

Horst S.A., Hoerr V., Beineke A., Kreis C., Tuchscherr L., Kalinka J., Lehne S., Schleicher I., Kohler G., Fuchs T., Raschke M.J., Rohde Manfred*, Peters G., Faber C., ... , Loffler B., Medina Eva* (2012)

A Novel Mouse Model of Staphylococcus aureus Chronic Osteomyelitis That Closely Mimics the Human Infection: An Integrated View of Disease Pathogenesis

American Journal of Pathology, 181 (4)

DOI: 10.1016/j.ajpath.2012.07.005 PubMed

Wos-Oxley M., Bleich A., Oxley A.P., Kahl S., Janus L., Smoczek A., Nahrstedt H., Pils M., Taudien S., Platzer M., Hedrich H.J., ... , Medina Eva*, Pieper Dietmar* (2012)

Comparative evaluation of establishing a human gut microbial community within rodent models

Gut Microbes, 3 (3)

Ziegler C., Goldmann O., Hobeika E., Geffers Robert*, Peters G., Medina Eva* (2011)

The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen-reactivity to in vivo anergy

EMBO Molecular Medicine, 3 (11)

Abel J., Goldmann O., Ziegler C., Höltje C., Smeltzer M.S., Cheung A.L., Bruhn D., ... , Rohde Manfred*, Medina Eva* (2011)

Staphylococcus aureus evades the extracellular antimicrobial activity of mast cells by promoting its own uptake

Journal of Innate Immunity, 3 (5)

DOI: 10.1159/000327714 HZI-Repositorium PubMed

Medina Eva*, Goldmann O. (2011)

In vivo and ex vivo protocols for measuring the killing of extracellular pathogens by macrophages

Current Protocols in Immunology, Chapter 14

Medina Eva* (2010)

Murine model of polymicrobial septic peritonitis using cecal ligation and puncture (CLP)

Methods in Molecular Biology, 602

Medina Eva* (2010)

Murine model of pneumococcal pneumonia

Methods in Molecular Biology, 602

Tuchscherr L., Medina Eva*, Hussain M., Volker W., Heitmann V., Niemann S., Holzinger D., Roth J., Proctor R.A., Becker K., ... , Peters G., Loffler B. (2011)

Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection

EMBO Molecular Medicine, 3 (3)

DOI: 10.1002/emmm.201000115 HZI-Repositorium PubMed

Medina Eva* (2010)

Murine model of cutaneous infection with Streptococcus pyogenes

Methods in Molecular Biology, 602

Nippe N., Varga G., Holzinger D., Loffler B., Medina Eva*, Becker K., Roth J., ... , Ehrchen J.M., Sunderkotter C. (2011)

Subcutaneous Infection with S. aureus

Journal of Investigative Dermatology, 131 (1)

DOI: 10.1038/jid.2010.282 HZI-Repositorium PubMed

Loof T.G., Goldmann O., Gessner A., Herwald H., Medina Eva* (2010)

Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88

American Journal of Pathology, 176 (2)

Goldmann O., Hertzen E., Hecht A., Schmidt H., Lehne S., ... , Norrby-Teglund A., Medina Eva* (2010)

Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes

Journal of Immunology, 185 (4)

von Kockritz-Blickwede M., Konrad S., Foster S., Gessner J.E., Medina Eva* (2009)

Protective role of complement C5a in an experimental model of Staphylococcus aureus bacteremia

Journal of Innate Immunity, 2 (1)

Goldmann O., Lehne S., Medina Eva* (2010)

Age-related susceptibility to Streptococcus pyogenes infection in mice: underlying immune dysfunction and strategy to enhance immunity

Journal of Pathology, 220 (5)

DOI: 10.1002/path.2664 HZI-Repositorium PubMed

Goldmann O., Rohde Manfred*, Medina Eva* (2009)

Infection biology: Streptococcus pyogenes

Biospektrum, 15 (4)

Medina Eva* (2009)

Neutrophil Extracellular Traps: a strategic tactic to defeat pahtogens with potential consequences for the host

Journal of Innate Immunity, 1

Medina Eva* (2009)

Beyond the NETs

Journal of Innate Immunity, 1

Goldmann O., Sastalla I., Wos-Oxley M., Rohde Manfred*, Medina Eva* (2009)

Streptococcus pyogenes induces oncosis in macrophages through the activation of an inflammatory programmed cell death pathway

Cellular Microbiology, 11 (1)

von Kockritz-Blickwede M., Rohde Manfred*, Oehmcke S., Miller L.S., Cheung A.L., Herwald H., ... , Foster S., Medina Eva* (2008)

Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model

American Journal of Pathology, 173 (6)

Loof T.G., Goldmann O., Medina Eva* (2008)

Immune recognition of Streptococcus pyogenes

Infection and Immunity, 76 (6)

DOI: 10.1128/IAI.01680-07 HZI-Repositorium PubMed

Von Köckritz-Blickwede M., Goldmann O., Thulin P., Heinemann K., Norrby-Teglund A., ... , Rohde M., Medina E. (2008)

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

Blood

DOI: 10.1182/blood-2007-07-104018 HZI-Repositorium PubMed

Loof T.G., Rohde Manfred*, Chhatwal Gursharan S.*, Jung S., Medina Eva* (2007)

The contribution of dendritic cells to host defenses against Streptococcus pyogenes

Journal of Infectious Diseases, 196

Medina Eva* (2004)

Models of group A streptococcal diseases: a review of current status

Drug Discovery Today: Disease Models, 1

Schulze K., Goldmann O., Medina E., Guzmán C.A. (2008)

The FAI protein of group C streptococci acts as a mucosal adjuvant by the specific targeting and activation of B cells

International Journal of Medical Microbiology, 298 (1-2)

Klein C., Medina Eva*, Sander L., Roskams T., Müller Werner*, ... , Trautwein C., Goldmann O. (2007)

Contribution of IL-6/gp130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes

Journal of Infectious Diseases, 196 (5)

DOI: 10.1086/520090 HZI-Repositorium PubMed

Dinkla Kathrin*, Sastalla I., Godehardt A.W., Janze N., Chhatwal Gursharan S*., ... , Rohde Manfred*, Medina Eva* (2007)

Upregulation of capsule enables Streptococcus pyogenes

Microbes and Infection, 9 (8)

Goldmann O., von Kockritz-Blickwede M., Holtje C., Chhatwal G.S., Geffers R., Medina E. (2007)

Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes

Infection and Immunity, 75 (8)

DOI: 10.1128/IAI.00181-07 HZI-Repositorium PubMed

Medina Eva*, Ryan L., LaCourse R., North R.J. (2006)

Superior virulence of Mycobacterium bovis

Tuberculosis, 86 (1)

Siegert J., Sastalla I., Chhatwal Gursharan S*., Medina Eva* (2006)

Vaccination equally enables both genetically susceptible and resistant mice to control infection with group A streptococci

Microbes and Infection, 8 (2)

DOI: 10.1016/j.micinf.2005.06.024 HZI-Repositorium PubMed

Schulze K., Medina E., Guzmán C.A. (2006)

Intranasal immunization with serum opacity factor (SOF) of Streptococcus pyogenes

Vaccine, 24

DOI: 10.1016/j.vaccine.2005.06.039

Medina E., Lengeling A. (2005)

Genetic regulation of host responses to Group A Streptococcus in mice

Briefings in Functional Genomics & Proteomics, 4

Goldmann O., Lengeling A., Böse J., Blöcker H., Geffers R., ... , Chhatwal G.S., Medina E. (2005)

The role of the major histocompatibility complex on resistance to Group A Streptococci in mice

Journal of Immunology, 175

Goldmann O., Chhatwal G.S., Medina E. (2005)

Contribution of NK cells to the pathogenesis of septic shock induced by Streptococcus pyogenes in mice

Journal of Infectious Diseases, 191

Schulze K., Goldmann O., Toppel A., Medina E., Guzmán C.A. (2005)

The FAI protein of group C streptococci targets B cells and exhibits adjuvant activity

Vaccine, 23

Goldmann O., Chhatwal G.S., Medina E. (2004)

The role of host genetic factors in susceptibility to group A streptococcal infections

Indian Journal of Medical Research, 119

McArthur J., Medina E., Mueller A., Chin J., Currie B.J., Sriprakash K.S., Talay S.R., ... , Chhatwal G.S., Walker M.J. (2004)

Intranasal vaccination with streptococcal fibronectin binding protein, Sfb 1, fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model

Infection and Immunity, 72

DOI: 10.1128/IAI.72.12.7342-7345.2004 HZI-Repositorium PubMed

Goldmann O., Rohde M., Chhatwal G.S., Medina E. (2004)

Role of macrophages on host resistance to group A streptococci

Infection and Immunity, 72 (5)

DOI: 10.1128/IAI.72.5.2956-2963.2004 HZI-Repositorium

Medina E., Goldmann O., Toppel A., Rohde M., Chhatwal G.S. (2003)

Survival of Streptococcus pyogenes within host phagocytic cell: a pathogenic mechanism for persistence and systematic invasion

Journal of Infectious Diseases, 187

Goldmann O., Chhatwal G.S., Medina E. (2003)

Immune mechanisms underlying host susceptibility to group A streptococcal infections

Journal of Infectious Diseases, 187

Toppel A., Rasmussen M., Rohde M., Medina E., Chhatwal G.S. (2003)

Contribution of protein G-related Ü2-macroglobulin binding protein to bacterial virulence in a mouse skin model of group A streptococcal infection.

Journal of Infectious Diseases, 187

Schulze K., Medina E., Chhatwal G.S., Guzmán C.A. (2003)

Stimulation of long-lasting protection against Streptococcus pyogenes after intranasal vaccination with non adjuvanted fibronectin-binding domain of the SfbI protein.

Vaccine, 21 (17-18)

Medina E., Rohde M., Chhatwal G.S. (2003)

Intracellular survival of Streptococcus pyogenes in polymorphonuclear cells results in increased bacterial virulence.

Infection and Immunity, 71

DOI: 10.1128/IAI.71.9.5376-5380.2003 HZI-Repositorium PubMed

Schulze K., Medina E., Chhatwal G.S., Guzmán C.A. (2003)

Identification of B- and T-cell epitopes within the fibronectin-binding domain of the SfbI protein of Streptococcus pyogenes

Infection and Immunity, 71 (12)

Medina E., Anders D., Chhatwal G.S. (2002)

Induction of NF-6B nuclear translocation in human respiratory epithelial cells by group A streptococci

Microbial Pathogenesis, 33 (6)

Medina E., Chhatwal G.S. (2002)

The potential for vaccine development against rheumatic fever

Indian Heart Journal, 54 (1)

Goldmann O., Rohde M., Medina E. (2002)

Phagocytosis of bacille Calmette-Guerin-infected necrotic macrophages induces a maturation phenotype and evokes antigen-presentation functions in dendritic cells

Immunology, 107 (4)

Basso H., Rharbaoui F., Ständer L.H., Medina E., Garcia-Del Portillo F., Guzmán C.A. (2002)

Characterization of a novel intracellular activated gene from Salmonella enterica

Infection and Immunity, 70

Zimna K., Medina E., Jungnitz H., Guzmán C.A. (2001)

Role played by the response regulator ris in Bordetella bronchiseptica

Fems Microbiology Letters, 201 (2)

Schulze K., Medina E., Talay S.R., Towers R.J., Chhatwal G.S., Guzmán C.A. (2001)

Characterization of the domain of fibronectin-binding protein I of Streptococcus pyogenes

Infection and Immunity, 69 (1)

Medina E., Guzmán C.A. (2001)

Use of live bacterial vaccine vectors for antigen delivery: potential and limitations

Vaccine, 19 (13-14)

Medina E., Goldmann O., Rohde M., Lengeling A., Chhatwal G.S. (2001)

Genetic control of susceptibility to group A streptococcal infection in mice

Journal of Infectious Diseases, 184 (7)

Medina E., Guzmán C.A. (2000)

Modulation of immune responses following antigen administration by mucosal route

Fems Immunology and Medical Microbiology, 27 (4)

Medina E., Paglia P., Rohde M., Colombo M.P., Guzmán C.A. (2000)

Modulation of host immune responses stimulated by Salmonella vaccine carrier strains by using different promoters to drive the expression of the recombinant antigen

European Journal of Immunology, 30 (3)

Medina E., Schulze K., Chhatwal G.S., Guzmán C.A. (2000)

Nonimmune interaction of the SfbI protein of Streptococcus pyogenes with the immunoglobulin G F(ab')(2) fragment

Infection and immunity., 68 (8)

Prof Dr Eva Medina

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