Prof. Dr. Klemens Rottner

Sharafutdinov I., Friedrich B., Rottner K., Backert S., Tegtmeyer N. (2024)

Cortactin: A major cellular target of viral, protozoal, and fungal pathogens

Mol.Microbiol.

DOI: 10.1111/mmi.15284 HZI-Repositorium PubMed

Jackson J., Hoffmann C., Scifo E., Wang H., Wischhof L., Piazzesi A., Mondal M., Shields H., Zhou X., Mondin M., Ryan E.B., Döring H., Prehn J.H.M., Rottner K., Giannone G., Nicotera P., Ehninger D., ... , Milovanovic D., Bano D. (2024)

Actin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology

Cell Death and Disease, 15 (4)

DOI: 10.1038/s41419-024-06686-7 HZI-Repositorium PubMed

Rottner K., Bieling P. (2024)

Illuminating cortactin structure and function at actin filament branches

Nature Structural and Molecular Biology, 31 (5)

DOI: 10.1038/s41594-024-01297-4 PubMed

De Cicco T., Pezinski M., Wojcicka O., Pradhan B.S., Jablonska M., ... , Rottner K., Proszynski T.J. (2024)

Cortactin interacts with a[alpha]Dystrobrevin-1 and regulates murine neuromuscular junction morphology

European Journal of Cell Biology, 103 (2)

DOI: 10.1016/j.ejcb.2024.151409 HZI-Repositorium PubMed

Sharafutdinov I., Harrer A., Müsken M., Rottner K., Sticht H., Täger C., Naumann M., ... , Tegtmeyer N., Backert S. (2024)

Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection

Cell Insight, 3 (3)

DOI: 10.1016/j.cellin.2024.100161 HZI-Repositorium PubMed

Kumar R., Rottner K., Rao G.N. (2024)

Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin in Retinal Neovascularization and Vascular Leakage

Arterioscler.Thromb.Vasc.Biol.

DOI: 10.1161/ATVBAHA.123.320279 PubMed

Kirchenwitz M., Halfen J., von Peinen K., Prettin S., Kollasser J., Zur Lage S., Blankenfeldt W., Brakebusch C., Rottner K., ... , Steffen A., Stradal T.E.B. (2023)

RhoB promotes Salmonella survival by regulating autophagy

Eur.J.Cell Biol., 102 (4)

DOI: 10.1016/j.ejcb.2023.151358 HZI-Repositorium PubMed

Lambert C., Schmidt K., Karger M., Stadler M., Stradal T.E.B., Rottner K. (2023)

Cytochalasans and Their Impact on Actin Filament Remodeling

Biomolecules., 13 (8)

DOI: 10.3390/biom13081247 HZI-Repositorium PubMed

Gautreau A., Lappalainen P., Rottner K. (2023)

Editorial -

European Journal of Cell Biology

DOI: 10.1016/j.ejcb.2023.151306 HZI-Repositorium PubMed

Lambert C., Shao L., Zeng H., Surup F., Saetang P., Aime M.C., Husbands D.R., Rottner K., ... , Stradal T.E.B., Stadler M. (2023)

Cytochalasans produced by Xylaria karyophthora and their biological activities

Mycologia

DOI: 10.1080/00275514.2023.2188868 HZI-Repositorium PubMed

Bieling P., Rottner K. (2023)

From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly

Curr.Opin.Cell Biol., 80

DOI: 10.1016/j.ceb.2023.102156 PubMed

Castellanos-Martinez R., Leon-Vega I.I., Guerrero-Fonseca I.M., Vargas-Robles H., Jimenez-Camacho K.E., Hernandez-Galicia G., Ortiz-Navarrete V.F., Rottner K., ... , Medina-Contreras O., Schnoor M. (2023)

T cell functions and organ infiltration by leukemic T cells require cortactin

J.Leukoc.Biol

DOI: 10.1093/jleuko/qiad001 HZI-Repositorium PubMed

Fäßler F., Javoor M.G., Datler J., Döring H., Hofer F.W., Dimchev G., Hodirnau V.-V., Faix J., ... , Rottner K., Schur F.K.M. (2023)

ArpC5 isoforms regulate Arp2/3 complex-dependent protrusion through differential Ena/VASP positioning

Science advances, 9 (3)

DOI: 10.1126/sciadv.add6495 HZI-Repositorium PubMed

Yang S., Tang Y., Liu Y., Brown A.J., Schaks M., Ding B., Kramer D.A., Mietkowska M., Ding L., Alekhina O., Billadeau D.D., Chowdhury S., Wang J., ... , Rottner K., Chen B. (2022)

Arf GTPase activates the WAVE regulatory complex through a distinct binding site

Sci.Adv., 8 (50)

DOI: 10.1126/sciadv.add1412 HZI-Repositorium PubMed

Pokrant T., Hein J.I., Körber S., Disanza A., Pich A., Scita G., ... , Rottner K., Faix J. (2023)

Ena/VASP clustering at microspike tips involves lamellipodin but not I-BAR proteins, and absolutely requires unconventional myosin-X

Proc Natl Acad Sci U S A, 120 (2)

DOI: 10.1073/pnas.2217437120 HZI-Repositorium PubMed

Sharafutdinov I., Knorr J., Rottner K., Backert S., Tegtmeyer N. (2022)

Cortactin: A universal host cytoskeletal target of Gram-negative and Gram-positive bacterial pathogens

Mol.Microbiol.

DOI: 10.1111/mmi.15002 HZI-Repositorium PubMed

Kirchenwitz M., Stahnke S., Grunau K., Melcher L., Van Ham M., Rottner K., ... , Steffen A., Stradal T.E.B. (2022)

The autophagy inducer SMER28 attenuates microtubule dynamics mediating neuroprotection

Sci.Rep., 12 (1)

DOI: 10.1038/s41598-022-20563-3 HZI-Repositorium PubMed

Ding B., Yang S., Schaks M., Liu Y., Brown A.J., Rottner K., ... , Chowdhury S., Chen B. (2022)

Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase

Nat.Commun., 13 (1)

DOI: 10.1038/s41467-022-33174-3 HZI-Repositorium PubMed

Kage F., Döring H., Mietkowska M., Schaks M., Grüner F., Stahnke S., Steffen A., Müsken M., ... , Stradal T.E.B., Rottner K. (2022)

Lamellipodia-like actin networks in cells lacking WAVE regulatory complex

J Cell Sci, 135 (15)

DOI: 10.1242/jcs.260364 HZI-Repositorium PubMed

Lartey N.L., Vargas-Robles H., Guerrero-Fonseca I.M., García-Ponce A., Salinas-Lara C., ... , Rottner K., Schnoor M. (2022)

The Actin-Binding Protein Cortactin Promotes Sepsis Severity by Supporting Excessive Neutrophil Infiltration into the Lung

Biomedicines, 10 (5)

DOI: 10.3390/biomedicines10051019 HZI-Repositorium PubMed

Kirchenwitz M., Stahnke S., Prettin S., Borowiak M., Menke L., Sieben C., Birchmeier C., Rottner K., ... , Stradal T.E.B., Steffen A. (2022)

SMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta

Cells, 11 (10)

DOI: 10.3390/cells11101648 HZI-Repositorium PubMed

Petersen L., Stroh S., Schöttelndreier D., Grassl G.A., Rottner K., Brakebusch C., ... , Fahrer J., Genth H. (2022)

The Essential Role of Rac1 Glucosylation in Clostridioides difficile Toxin B-Induced Arrest of G1-S Transition

Front Microbiol, 13

DOI: 10.3389/fmicb.2022.846215 HZI-Repositorium PubMed

Kummer D., Steinbacher T., Thölmann S., Schwietzer M.F., Hartmann C., Horenkamp S., Demuth S., Peddibhotla S.S.D., Brinkmann F., Kemper B., Schnekenburger J., Brandt M., Betz T., Liashkovich I., Kouzel I.U., Shahin V., Corvaia N., Rottner K., Tarbashevich K., Raz E., Greune L., Schmidt M.A., ... , Gerke V., Ebnet K. (2022)

A JAM-A-tetraspanin- anb

J Cell Biol., 221 (4)

DOI: 10.1083/jcb.202105147 HZI-Repositorium PubMed

Fung T.S., Chakrabarti R., Kollasser J., Rottner K., Stradal T.E.B., ... , Kage F., Higgs H.N. (2022)

Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria

Curr.Biol., 32 (7)

DOI: 10.1016/j.cub.2022.02.058 HZI-Repositorium PubMed

Faix J., Rottner K. (2022)

Ena/VASP proteins in cell edge protrusion, migration and adhesion

J Cell Sci, 135 (6)

DOI: 10.1242/jcs.259226 HZI-Repositorium PubMed

Rottner K., Stradal T.E.B. (2022)

WASP stings into matrix to lead immune cell migration

J.Cell Biol., 221 (2)

DOI: 10.1083/jcb.202112087 HZI-Repositorium PubMed

Mehidi A., Kage F., Karatas Z., Cercy M., Schaks M., Polesskaya A., Sainlos M., Gautreau A.M., Rossier O., ... , Rottner K., Giannone G. (2021)

Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration

Nature Cell Biology, 23 (11)

DOI: 10.1038/s41556-021-00786-8 PubMed

Funk J., Merino F., Schaks M., Rottner K., Raunser S., Bieling P. (2021)

A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks

Nat.Commun., 12 (1)

DOI: 10.1038/s41467-021-25682-5 HZI-Repositorium PubMed

Tegtmeyer N., Harrer A., Rottner K., Backert S. (2021)

Helicobacter pylori caga induces cortactin y-470 phosphorylation-dependent gastric epithelial cell scattering via abl, vav2 and rac1 activation

Cancers, 13 (16)

DOI: 10.3390/cancers13164241 HZI-Repositorium PubMed

Cornelius J., Rottner K., Korte M., Michaelsen-Preusse K. (2021)

Cortactin Contributes to Activity-Dependent Modulation of Spine Actin Dynamics and Spatial Memory Formation

Cells, 10 (7)

DOI: 10.3390/cells10071835 HZI-Repositorium PubMed

Knorr J., Sharafutdinov I., Fiedler F., Esmaeili D.S., Rohde M., Rottner K., ... , Backert S., Tegtmeyer N. (2021)

Cortactin is required for efficient fak, src and abl tyrosine kinase activation and phosphorylation of helicobacter pylori caga

Int.J.Mol.Sci., 22 (11)

DOI: 10.3390/ijms22116045 HZI-Repositorium PubMed

Walch P., Selkrig J., Knodler L.A., Rettel M., Stein F., Fernandez K., Viéitez C., Potel C.M., Scholzen K., Geyer M., Rottner K., Steele-Mortimer O., Savitski M.M., ... , Holden D.W., Typas A. (2021)

Global mapping of Salmonella enterica-host protein-protein interactions during infection

Cell Host.Microbe

DOI: 10.1016/j.chom.2021.06.004 HZI-Repositorium PubMed

Rottner K., Stradal T.E.B., Chen B. (2021)

WAVE regulatory complex

Curr.Biol., 31 (10)

DOI: 10.1016/j.cub.2021.01.086 HZI-Repositorium PubMed

Rottner K., Vicente-Manzanares M. (2021)

European Journal of Cell Biology - Editorial

Eur.J.Cell Biol., 100 (4)

DOI: 10.1016/j.ejcb.2021.151163 HZI-Repositorium PubMed

Stahnke S., Döring H., Kusch C., De Gorter D.J.J., Dütting S., Guledani A., Pleines I., Schnoor M., Sixt M., Geffers R., Rohde M., Müsken M., Kage F., Steffen A., Faix J., Nieswandt B., ... , Rottner K., Stradal T.E.B. (2021)

Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion

Curr.Biol., 31 (5 / May)

DOI: 10.1016/j.cub.2021.02.043 HZI-Repositorium PubMed

Dimchev V., Lahmann I., Koestler S.A., Kage F., Dimchev G., Steffen A., Stradal T.E.B., Vauti F., ... , Arnold H.H., Rottner K. (2021)

Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation

Front.Cell Dev.Biol., 9

DOI: 10.3389/fcell.2021.634708 HZI-Repositorium PubMed

Leithner A., Altenburger L.M., Hauschild R., Assen F.P., Rottner K., Stradal T.E.B., Diz-Munoz A., ... , Stein J.V., Sixt M. (2021)

Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse

J.Cell Biol., 220 (4)

DOI: 10.1083/jcb.202006081 HZI-Repositorium PubMed

Papalazarou V., Swaminathan K., Jaber-Hijazi F., Spence H., Lahmann I., Nixon C., Salmeron-Sanchez M., Arnold H.H., ... , Rottner K., Machesky L.M. (2020)

The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts

Development, 147 (22)

DOI: 10.1242/dev.194555 HZI-Repositorium PubMed

Wang C., Lambert C., Hauser M., Deuschmann A., Zeilinger C., Rottner K., Stradal T.E.B., Stadler M., ... , Skellam E.J., Cox R.J. (2020)

Diversely Functionalised Cytochalasins through Mutasynthesis and Semi-Synthesis

Chem.Eur.J., 26 (60)

DOI: 10.1002/chem.202002241 HZI-Repositorium PubMed

Singh S.P., Thomason P.A., Lilla S., Schaks M., Tang Q., Goode B.L., Machesky L.M., ... , Rottner K., Insall R.H. (2020)

Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

PLoS Biol, 18 (8)

DOI: 10.1371/journal.pbio.3000774 HZI-Repositorium PubMed

Tang Q., Schaks M., Koundinya N., Yang C., Pollard L.W., Svitkina T.M., ... , Rottner K., Goode B.L. (2020)

WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge

Mol.Biol Cell, 31 (20)

DOI: 10.1091/mbc.E19-12-0705 HZI-Repositorium PubMed

Salzer E., Zoghi S., Kiss M.G., Kage F., Rashkova C., Stahnke S., Haimel M., Platzer R., Caldera M., Ardy R.C., Hoeger B., Block J., Medgyesi D., Sin C., Shahkarami S., Kain R., Ziaee V., Hammerl P., Bock C., Menche J., Dupré L., Huppa J.B., Sixt M., Lomakin A., Rottner K., Binder C.J., Stradal T.E.B., ... , Rezaei N., Boztug K. (2020)

The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity

Sci.Immunol., 5 (49)

DOI: 10.1126/sciimmunol.abc3979 HZI-Repositorium PubMed

Damiano-Guercio J., Kurzawa L., Mueller J., Dimchev G., Schaks M., Nemethova M., Pokrant T., Brühmann S., Linkner J., Blanchoin L., Sixt M., ... , Rottner K., Faix J. (2020)

Loss of ENA/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

eLife, 9

DOI: 10.7554/eLife.55351 HZI-Repositorium PubMed

Schaks M., Reinke M., Witke W., Rottner K. (2020)

Molecular Dissection of Neurodevelopmental Disorder-Causing Mutations in CYFIP2

Cells, 9 (6)

DOI: 10.3390/cells9061355 HZI-Repositorium PubMed

Dimchev G., Amiri B., Humphries A.C., Schaks M., Dimchev V., Stradal T.E.B., Faix J., Krause M., Way M., ... , Falcke M., Rottner K. (2020)

Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation

J.Cell Sci., 133 (7)

DOI: 10.1242/jcs.239020 HZI-Repositorium PubMed

Samus M., Li Y.T., Sorokin L., Rottner K., Vestweber D. (2020)

Actin-binding protein cortactin promotes pathogenesis of experimental autoimmune encephalomyelitis by supporting leukocyte infiltration into the central nervous system

J.Neurosci., 40 (7)

DOI: 10.1523/JNEUROSCI.1266-19.2019 HZI-Repositorium PubMed

Kage F., Steffen A., Ellinger A., Ranftler C., Gehre C., Brakebusch C., Pavelka M., ... , Stradal T., Rottner K. (2019)

Author Correction: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42

Sci Rep., 9 (1)

DOI: 10.1038/s41598-019-54630-z HZI-Repositorium PubMed

Rottner K., Schaks M. (2019)

N-WASP Guides Cancer Cells toward LPA

Dev.Cell, 51 (4)

DOI: 10.1016/j.devcel.2019.10.029 HZI-Repositorium PubMed

Taha M., Aldirawi M., März S., Seebach J., Odenthal-Schnittler M., Bondareva O., Bojovic V., Schmandra T., Wirth B., Mietkowska M., ... , Rottner K., Schnittler H. (2019)

EPLIN-a[alpha] and -b[beta] Isoforms Modulate Endothelial Cell Dynamics through a Spatiotemporally Differentiated Interaction with Actin

Cell Rep., 29 (4)

DOI: 10.1016/j.celrep.2019.09.043 HZI-Repositorium PubMed

Schaks M., Giannone G., Rottner K. (2019)

Actin dynamics in cell migration

Essays Biochem., 63 (5)

DOI: 10.1042/EBC20190015 HZI-Repositorium PubMed

Schaks M., Döring H., Kage F., Steffen A., Klünemann T., Blankenfeldt W., ... , Stradal T., Rottner K. (2021)

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding

Small Gtpases., 12 (2)

DOI: 10.1080/21541248.2019.1657755 HZI-Repositorium PubMed

Mehidi A., Rossier O., Schaks M., Chazeau A., Biname F., Remorino A., Coppey M., Karatas Z., Sibarita J.B., Rottner K., ... , Moreau V., Giannone G. (2019)

Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion

Curr.Biol., 29 (17)

DOI: 10.1016/j.cub.2019.07.035 HZI-Repositorium PubMed

Kunschmann T., Puder S., Fischer T., Steffen A., Rottner K., Mierke C.T. (2019)

The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices

Sci.Rep., 9 (1)

DOI: 10.1038/s41598-019-43975-0 HZI-Repositorium PubMed

Kugelmann D., Rotzer V., Walter E., Egu D.T., Fuchs M.T., Vielmuth F., Vargas-Robles H., Schnoor M., Hertl M., Eming R., Rottner K., Schmidt A., ... , Spindler V., Waschke J. (2019)

Role of Src and Cortactin in Pemphigus Skin Blistering

Front Immunol, 10

DOI: 10.3389/fimmu.2019.00626 HZI-Repositorium PubMed

Litschko C., Brühmann S., Csiszar A., Stephan T., Dimchev V., Damiano-Guercio J., Junemann A., Körber S., Winterhoff M., Nordholz B., Ramalingam N., Peckham M., Rottner K., ... , Merkel R., Faix J. (2019)

Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins

Proc.Natl.Acad.Sci.U.S.A, 116 (9)

DOI: 10.1073/pnas.1821638116 PubMed

Velázquez-Avila M., Balandrán J.C., Ramirez-Ramirez D., Velázquez-Avila M., Sandoval A., Felipe-López A., Nava P., Alvarado-Moreno J.A., Dozal D., Prieto-Chávez J.L., Schaks M., Rottner K., Dorantes-Acosta E., López-Martinez B., ... , Schnoor M., Pelayo R. (2019)

High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse

Leukemia, 33 (6)

DOI: 10.1038/s41375-018-0333-4 HZI-Repositorium PubMed

Schaks M., Singh S.P., Kage F., Thomason P., Klünemann T., Steffen A., Blankenfeldt W., Stradal T.E., ... , Insall R.H., Rottner K. (2018)

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

Curr.Biol., 28 (11)

DOI: 10.1016/j.cub.2018.10.002 HZI-Repositorium PubMed

Rottner K., Schaks M. (2019)

Assembling actin filaments for protrusion

Curr.Opin.Cell Biol., 56 (Februar)

DOI: 10.1016/j.ceb.2018.09.004 HZI-Repositorium PubMed

Dolati S., Kage F., Mueller J., Müsken M., Kirchner M., Dittmar G., Sixt M., ... , Rottner K., Falcke M. (2018)

On the relation between filament density, force generation and protrusion rate in mesenchymal cell motility

Mol.Biol.Cell, 29 (22)

DOI: 10.1091/mbc.E18-02-0082 HZI-Repositorium PubMed

Beer L.A., Tatge H., Reich N., Tenspolde M., Olling A., Goy S., Rottner K., ... , Alekov A.K., Gerhard R. (2018)

Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate

Cell Microbiol., 20 (10)

DOI: 10.1111/cmi.12865 HZI-Repositorium

Ge J., Burnier L., Adamopoulou M., Kwa M.Q., Schaks M., ... , Rottner K., Brakebusch C. (2018)

RhoA, Rac1, and Cdc42 differentially regulate SMA and collagen i expression in mesenchymal stem cells

J.Biol.Chem., 293 (24)

DOI: 10.1074/jbc.RA117.001113 HZI-Repositorium PubMed

Dimchev G., Rottner K. (2018)

Micromanipulation Techniques Allowing Analysis of Morphogenetic Dynamics and Turnover of Cytoskeletal Regulators

J.Vis.Exp. (135)

DOI: 10.3791/57643 PubMed

Steffen A., Kage F., Rottner K. (2018)

Imaging the Molecular Machines That Power Cell Migration

Methods Mol.Biol., 1749 (19)

DOI: 10.1007/978-1-4939-7701-7_19

Rottner K., Kage F. (2017)

Actin Networks: Adapting to Load through Geometry

Curr.Biol., 27 (23)

DOI: 10.1016/j.cub.2017.10.042 HZI-Repositorium PubMed

Schnoor M., Stradal T.E., Rottner K. (2017)

Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein

Trends Cell Biol., 28 (2)

DOI: 10.1016/j.tcb.2017.10.009 PubMed

Rottner K., Faix J., Bogdan S., Linder S., Kerkhoff E. (2017)

Actin assembly mechanisms at a glance

J.Cell Sci., 130 (20)

DOI: 10.1242/jcs.206433 HZI-Repositorium

Böttcher R.T., Veelders M., Rombaut P., Faix J., Theodosiou M., Stradal T.E., Rottner K., Zent R., ... , Herzog F., Fassler R. (2017)

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading

J.Cell Biol., 216 (11)

DOI: 10.1083/jcb.201701176 HZI-Repositorium

Litschko C., Linkner J., Bruhmann S., Stradal T.E.B., Reinl T., Jänsch L., ... , Rottner K., Faix J. (2017)

Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes

Eur.J.Cell Biol., 96 (8)

DOI: 10.1016/j.ejcb.2017.08.003 PubMed

Steffen A., Stradal T.E., Rottner K. (2017)

Signalling Pathways Controlling Cellular Actin Organization

Handb.Exp.Pharmacol., 235

DOI: 10.1007/164_2016_35 PubMed

Kage F., Steffen A., Ellinger A., Ranftler C., Gehre C., Brakebusch C., Pavelka M., ... , Stradal T., Rottner K. (2017)

FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42

Sci.Rep., 7 (1)

DOI: 10.1038/s41598-017-09952-1 HZI-Repositorium PubMed

Dimchev G., Steffen A., Kage F., Dimchev V., Pernier J., ... , Carlier M.F., Rottner K. (2017)

Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly

Mol.Biol.Cell, 28 (10)

DOI: 10.1091/mbc.E16-05-0334 HZI-Repositorium PubMed

Citalan-Madrid A.F., Vargas-Robles H., Garcia-Ponce A., Shibayama M., Betanzos A., Nava P., Salinas-Lara C., Rottner K., ... , Mennigen R., Schnoor M. (2017)

Cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe DSS-induced colitis

Mucosal.Immunol., 10 (5)

DOI: 10.1038/mi.2016.136 PubMed

Kage F., Winterhoff M., Dimchev V., Mueller J., Thalheim T., Freise A., Bruhmann S., Kollasser J., Block J., Dimchev G., Geyer M., Schnittler H.J., Brakebusch C., Stradal T.E., Carlier M.F., Sixt M., Kas J., ... , Faix J., Rottner K. (2017)

FMNL formins boost lamellipodial force generation

Nat.Commun., 8

DOI: 10.1038/ncomms14832 HZI-Repositorium PubMed

Leithner A., Eichner A., Muller J., Reversat A., Brown M., Schwarz J., Merrin J., de Gorter D.J., Schur F., Bayerl J., de Vries I, Wieser S., Hauschild R., Lai F.P., Moser M., Kerjaschki D., Rottner K., Small J.V., ... , Stradal T.E., Sixt M. (2016)

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes

Nat.Cell Biol., 18 (11)

DOI: 10.1038/ncb3426 HZI-Repositorium

Andritschke D., Dilling S., Emmenlauer M., Welz T., Schmich F., Misselwitz B., Ramo P., Rottner K., Kerkhoff E., Wada T., Penninger J.M., Beerenwinkel N., Horvath P., ... , Dehio C., Hardt W.D. (2016)

A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion

PLoS ONE, 11 (9)

DOI: 10.1371/journal.pone.0161965 HZI-Repositorium

Ponce A.G., Citalan Madrid A.F., Vargas Robles H., Chanez Paredes S., Nava P., Betanzos A., Zarbock A., Rottner K., ... , Vestweber D., Schnoor M. (2016)

Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility

Sci Rep., 6

DOI: 10.1038/srep29003 HZI-Repositorium PubMed

Rottner K. (2016)

CELL BIOLOGY. Formin' filaments at a faster CLIP

Science, 352 (6288)

DOI: 10.1126/science.aaf9624

Wollscheid H.P., Biancospino M., He F., Magistrati E., Molteni E., Lupia M., Soffientini P., Rottner K., Cavallaro U., Pozzoli U., Mapelli M., ... , Walters K.J., Polo S. (2016)

Diverse functions of myosin VI elucidated by an isoform-specific a[alpha]-helix domain

Nat.Struct.Mol.Biol., 23 (4)

DOI: 10.1038/nsmb.3187 HZI-Repositorium PubMed

Rottner K., Stradal T.E.B. (2016)

How distinct Arp2/3 complex variants regulate actin filament assembly

Nat.Cell Biol., 18 (1)

DOI: 10.1038/ncb3293 HZI-Repositorium PubMed

Kuhn S., Erdmann C., Kage F., Block J., Schwenkmezger L., Steffen A., ... , Rottner K., Geyer M. (2015)

The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation

Nat.Commun., 6

Chazeau A., Mehidi A., Nair D., Gautier J.J., Leduc C., Chamma I., Kage F., Kechkar A., Thoumine O., Rottner K., Choquet D., Gautreau A., ... , Sibarita J.B., Giannone G. (2014)

Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion

Embo Journal, 33

May M., Schelle I., Brakebusch C., Rottner K., Genth H. (2014)

Rac1-dependent recruitment of PAK2 to G phase centrosomes and their roles in the regulation of mitotic entry

Cell Cycle, 13 (14)

Steffen A., Koestler S.A., Rottner K. (2014)

Requirements for and consequences of Rac-dependent protrusion

Europan Journal of Cell Biology, 93 (5-6)

Duplan M.B., Zalli D., Stephens S., Zenger S., Neff L., Oelkers J.M., Lai F.P.L.L., Horne W., ... , Rottner K., Baron R. (2014)

Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and src

Molecular and Cellular Biology, 34 (1)

Huelsenbeck S.C., Roggenkamp D., May M., Huelsenbeck J., Brakebusch C., Rottner K., Ladwein M., Just I., Fritz G., ... , Schmidt G., Genth H. (2013)

Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1

International Journal of Biochemistry and Cell Biology, 45 (8)

Dang I., Gorelik R., Sousa-Blin C., Derivery E., Guerin C., Linkner J., Nemethova M., Dumortier J.G., Giger F.A., Chipysheva T.A., Ermilova V.D., Vacher S., Campanacci V., Herrada I., Planson A.G., Fetics S., Henriot V., David V., Oguievetskaia K., Lakisic G., Pierre F., Steffen A., Boyreau A., Peyrieras N., Rottner K., Zinn-Justin S., Cherfils J., Bieche I., Alexandrova A.Y., David N.B., Small J.V., Faix J., ... , Blanchoin L., Gautreau A. (2013)

Inhibitory signalling to the Arp2/3 complex steers cell migration

Nature, 503 (7475)

Steffen A., Ladwein M., Dimchev G.A., Hein A., Schwenkmezger L., Arens S., Ladwein K.I., Holleboom J.M., Schur F., Small J.V., Schwarz J., Gerhard R., Faix J., Stradal Theresia E.B., ... , Brakebusch C., Rottner K. (2013)

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

Journal of Cell Science, 126 (20)

DOI: 10.1242/jcs.118232 HZI-Repositorium PubMed

Koestler S.A., Steffen A., Nemethova M., Winterhoff M., Luo N., Holleboom J.Margit, Krupp J., Jacob S., Vinzenz M., Schur F., Schluter K., Gunning P.W., Winkler C., Schmeiser C., Faix J., Stradal T.E., ... , Small J.V., Rottner K. (2013)

Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin1

Molecular Biology of the Cell, 24 (18)

DOI: 10.1091/mbc.E12-12-0857 HZI-Repositorium PubMed

Wolters M., Boyle E.C., Lardong K., Trulzsch K., Steffen A., Rottner K., ... , Ruckdeschel K., Aepfelbacher M. (2013)

Cytotoxic necrotizing factor-y boosts yersinia effector translocation by activating rac protein

Journal of Biological Chemistry, 288 (32)

DOI: 10.1074/jbc.M112.448662 HZI-Repositorium PubMed

Junemann A., Winterhoff M., Nordholz B., Rottner K., Eichinger L., ... , Graf R., Faix J. (2013)

ForC lacks canonical formin activity but bundles actin filaments and is required for multicellular development of Dictyostelium cells

European Journal of Cell Biology, 92 (6-7)

Thoss F., Dietrich F., Punkt K., Illenberger S., Rottner K., ... , Himmel M., Ziegler W.H. (2013)

Metavinculin: New insights into functional properties of a muscle adhesion protein

Biochemical and Biophysical Research Communications, 430 (1)

Block J., Breitsprecher D., Kuhn S., Winterhoff M., Kage F., Geffers R., Duwe P., Rohn J.L., Baum B., Brakebusch C., Geyer M., Stradal T.E., ... , Faix J., Rottner K. (2012)

FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42

Current biology, 22 (11)

DOI: 10.1016/j.cub.2012.03.064 HZI-Repositorium PubMed

Hanisch J., Stradal T.E., Rottner K. (2012)

A novel contractility pathway operating in Salmonella invasion

Virulence, 3 (1)

Breitsprecher D., Koestler S.A., Chizhov I., Nemethova M., Mueller J., Goode B.L., Small J.V., ... , Rottner K., Faix J. (2011)

Cofilin cooperates with fascin to disassemble filopodial actin filaments

Journal of Cell Science, 124 (Pt 19)

Rottner K., Stradal T.E. (2011)

Actin dynamics and turnover in cell motility

Current Opinion in Cell Biology, 23 (5)

Schnoor M., Lai F.P., Zarbock A., Klaver R., Polaschegg C., Schulte D., Weich H.A., Oelkers J.M., ... , Rottner K., Vestweber D. (2011)

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo

Journal of Experimental Medicine, 208 (8)

DOI: 10.1084/jem.20101920 HZI-Repositorium PubMed

Williams M.J., Rottner K. (2010)

Introduction to Small GTPases

Small Gtpases., 1 (1)

DOI: 10.4161/sgtp.1.1.12245 HZI-Repositorium PubMed

Oelkers J.M., Vinzenz M., Nemethova M., Jacob S., Lai F.P., Block J., Szczodrak M., Kerkhoff E., Backert S., Schluter K., Stradal T.E., Small J.V., ... , Koestler S.A., Rottner K. (2011)

Microtubules as platforms for assaying actin polymerization in vivo

PLoS ONE, 6 (5)

DOI: 10.1371/journal.pone.0019931 HZI-Repositorium PubMed

Dubielecka P.M., Ladwein K.I., Xiong X., Migeotte I., Chorzalska A., Anderson K.V., Sawicki J.A., Rottner K., ... , Stradal T.E., Kotula L. (2011)

Essential role for Abi1 in embryonic survival and WAVE2 complex integrity

Proceedings of the National Academy of Sciences USA, 108 (17)

DOI: 10.1073/pnas.1016811108 HZI-Repositorium PubMed

Hänisch J., Kolm R., Wozniczka M., Bumann D., Rottner K., Stradal T.E. (2011)

Activation of a RhoA/Myosin II-Dependent but Arp2/3 Complex-Independent Pathway Facilitates Salmonella Invasion

Cell Host and Microbe, 9 (4)

Jackson B., Peyrollier K., Pedersen E., Basse A., Karlsson R., Wang Z., Lefever T., Ochsenbein A.M., Schmidt G., Aktories K., Stanley A., Quondamatteo F., Ladwein M., Rottner K., ... , van Hengel J., Brakebusch C. (2011)

RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes

Molecular Biology of the Cell, 22 (5)

DOI: 10.1091/mbc.E09-10-0859 HZI-Repositorium PubMed

Rottner K., Hanisch J., Campellone K.G. (2010)

WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond

Trends in Cell Biology, 20 (11)

Marg S., Winkler U., Sestu M., Himmel M., Schonherr M., Bar J., Mann A., Moser M., Mierke C.T., Rottner K., Blessing M., ... , Hirrlinger J., Ziegler W.H. (2010)

The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin

PLoS ONE, 5 (7)

DOI: 10.1371/journal.pone.0011530 HZI-Repositorium PubMed

Hertzog M., Milanesi F., Hazelwood L., Disanza A., Liu H., Perlade E., Malabarba M.G., Pasqualato S., Maiolica A., Confalonieri S., Le Clainche C., Offenhauser N., Block J., Rottner K., Di Fiore P.P., Carlier M.F., Volkmann N., ... , Hanein D., Scita G. (2010)

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping

PLoS Biology, 8 (6)

DOI: 10.1371/journal.pbio.1000387 HZI-Repositorium PubMed

Klink B.U., Barden S., Heidler T.V., Borchers C., Ladwein M., Stradal T.B., ... , Rottner K., Heinz D.W. (2010)

Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry

Journal of Biological Chemistry, 285 (22)

DOI: 10.1074/jbc.M110.107953 HZI-Repositorium PubMed

Hänisch J., Ehinger J., Ladwein M., Rohde M., Derivery E., Bosse T., Steffen A., Bumann D., Misselwitz B., Hardt W.D., Gautreau A., ... , Stradal T.E., Rottner K. (2010)

Molecular dissection of Salmonella-induced membrane ruffling versus invasion

Cellular Microbiology, 12 (1)

DOI: 10.1111/j.1462-5822.2009.01380.x HZI-Repositorium PubMed

Rottner K., Stradal Theresia E.* (2009)

Poxviruses taking a ride on actin: new users of known hardware

Cell Host and Microbe, 6 (6)

Lai F.P., Szczodrak M., Oelkers J.M., Ladwein M., Acconcia F., Benesch S., Auinger S., Faix J., Small J.V., Polo S., ... , Stradal T.E., Rottner K. (2009)

Cortactin Promotes Migration and PDGF-induced Actin Reorganization by Signaling to Rho-GTPases

Molecular Biology of the Cell, 20 (14)

Himmel M., Ritter A., Rothemund S., Pauling B.V., Rottner K., ... , Gingras A.R., Ziegler W.H. (2009)

Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions

Journal of Biolical Chemistry, 284 (20)

DOI: 10.1074/jbc.M900266200 HZI-Repositorium PubMed

Faix J., Breitsprecher D., Stradal T.E.B., Rottner K. (2009)

Filopodia: Complex models for simple rods

The International Journal of Biochemistry and Cell Biology, 41 (8-9)

DOI: 10.1016/j.biocel.2009.02.012 HZI-Repositorium PubMed

Koestler S.A., Rottner K., Lai F., Block J., Vinzenz M., Small J.V. (2009)

F- and G-actin concentrations in lamellipodia of moving cells

PLoS ONE, 4 (3)

DOI: 10.1371/journal.pone.0004810 HZI-Repositorium PubMed

Weiss S.M., Ladwein M., Schmidt D., Ehinger J., Lommel S., Städing K., Beutling U., Disanza A., Frank R., Jänsch L., Scita G., Gunzer F., ... , Rottner K., Stradal T.E. (2009)

IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation

Cell Host and Microbe, 5 (3)

Halabi-Cabezon I., Huelsenbeck J., May M., Ladwein M., Rottner K., ... , Just I., Genth H. (2008)

Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1

Febs Letters, 582 (27)

Block J., Stradal T.E.B., Hanisch J., Geffers R., Kostler S.A., Urban E., Small J.V., ... , Rottner K., Faix J. (2008)

Filopodia formation induced by active mDia2/Drf3

Journal of Microscopy, 231 (3)

DOI: 10.1111/j.1365-2818.2008.02063.x HZI-Repositorium PubMed

Ladwein M., Rottner K. (2008)

On the Rho'd: The regulation of membrane protrusions by Rho-GTPases

Febs Letters, 582 (14)

DOI: 10.1016/j.febslet.2008.04.033 HZI-Repositorium PubMed

Steffen A., Le Dez G., Poincloux R., Recchi C., Nassoy P., Rottner K., ... , Galli T., Chavrier P. (2008)

MT1-MMP-Dependent Invasion Is Regulated by TI-VAMP/VAMP7

Current biology, 18 (12)

Koestler S.A., Auinger S., Vinzenz M., Rottner K., Small J.V. (2008)

Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front

Nature Cell Biology, 10 (3)

DOI: 10.1038/ncb1692 HZI-Repositorium PubMed

Bosse T., Ehinger J., Czuchra A., Benesch S., Steffen A., Wu X., Schloen K., Niemann H.H., Scita G., Stradal T.E.B., ... , Brakebusch C., Rottner K. (2007)

Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways

Molecular and Cellular Biology, 27 (19)

DOI: 10.1128/MCB.00367-07 HZI-Repositorium PubMed

Müller-Taubenberger A., Vos M.J., Böttger A., Lasi M., Lai F.P.L., ... , Fischer M., Rottner K. (2006)

Monomeric red fluorescent protein variants used for imaging studies in different species

European Journal of Cell Biology, 85 (9-10)

Caspani E.M., Echevarria D., Rottner K., Small J.V. (2006)

Live imaging of glioblastoma cells in brain tissue shows requirement of actin bundles for migration

Neuron Glia Biology, 2 (2)

DOI: 10.1017/S1740925X06000111 HZI-Repositorium

Faix J., Rottner K. (2006)

The making of filopodia

Current Opinion in Cell Biology, 18 (1)

DOI: 10.1016/j.ceb.2005.11.002 HZI-Repositorium PubMed

Rottner K., Kaverina I.N., Stradal Theresia E.B.* (2006)

Cytoskeleton proteins

, 3rd

Steffen A., Faix J., Resch G.P., Linkner J., Wehland J., Small J.V., ... , Rottner K., Stradal T.E.B. (2006)

Filopodia formation in the absence of functional WAVE- and Arp2/3-complex

Molecular Biology of the Cell, 17

DOI: 10.1091/mbc.E05-11-1088 HZI-Repositorium PubMed

Stamm L., Pak M.A., Morisaki J.H., Snapper S.B., Rottner K., ... , Lommel S., Brown E.J. (2005)

Role of the WASP family proteins for Mycobacterium marinum actin tail formation

Proceedings of the National Academy of Sciences of the United States of America, 102 (41)

Czuchra A., Wu X., Meyer H., Van Hengel J., Schroeder T., Geffers R., ... , Rottner K., Brakebusch C. (2005)

Cdc42 is not essential for filopodium formation, directed migration, cell polarization and mitosis in fibroblastoid cells

Molecular Biology of the Cell, 16 (10)

DOI: 10.1091/mbc.E05-01-0061. HZI-Repositorium

Disanza A., Steffen A., Hertzog M., Frittoli E., Rottner K., Scita G. (2005)

Actin polymerization machinery: the finish line of signalling networks, the starting point of cellular movement

Cellular and Molecular Life Sciences, 62

Innocenti M., Gerboth S., Rottner K., Lai Frank P.L., Hertzog M., Stradal T.E.B., Frittoli E., Didry D., Polo S., Disanza A., Benesch S., Di Fiore P.P., ... , Carlier M.-F., Scita G. (2005)

Abi1regulates the activity of N-WASP and WAVE in distinct actin-based processes

Nature Cell Biology, 7 (10)

Benesch S., Polo S., Lai F.P.L., Anderson K.I., Stradal T.E.B., ... , Wehland J., Rottner K. (2005)

N-WASP deficiency impairs EGF internalization and actin assembly at clathrin coated pits

Journal of Cell Science, 118

DOI: 10.1242/jcs.02444 PubMed

Rottner K., Stradal T.E.B., Wehland J. (2005)

Bacteria - host cell interactions at the plasma membrane: stories on actin cytoskeleton subversion

Developmental Cell, 9

Stradal T.E.B., Lommel S., Wehland J., Rottner K. (2005)

Host-pathogen interactions and cell motility: learning from bacteria

(12)

Wang Y.L., Burridge K., Dembo M., Gabbiani G., Hanks S.K., Hosoya H., Janmey P., Karlsson R., Lindberg U., Mabuchi I., Otey C., Rottner K., Small J.V., ... , Wang C.L., Zigmond S. (2004)

Biomedical research publication system

Science, 303

Rottner K., Lommel S., Wehland J., Stradal T.E.B. (2004)

Pathogen-induced actin filament rearrangement in infectious diseases

Journal of Pathology, 204

Pacholsky D., Himmel M., Löw T., Stradal T.E.B., Rottner K., ... , Fürst D.O., Van der Ven P.F. (2004)

Xin repeats define a novel actin binding motif

Journal of Cell Science, 117

Stradal T.E.B., Rottner K., Disanza A., Confalonieri S., Innocenti M., Scita G. (2004)

Regulation of actin dynamics by WASF and WAVE family proteins

Trends in Cell Biology, 14

Steffen A., Rottner K., Ehinger J., Innocenti M., Scita G., ... , Wehland J., Stradal T.E.B. (2004)

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation

Embo Journal, 23 (4)

Stradal T.B., Sechi A.S., Wehland J., Rottner K. (2003)

The cytoskeleton

Breitbach K., Rottner K., Klocke S., Rohde M., Jenzora A., ... , Wehland J., Steinmetz I. (2003)

Actin-based motility of Burkholderia pseudomallei

Cellular Microbiology, 5 (6)

Small J.V., Stradal T., Vignal E., Rottner K. (2002)

The lamellipodium: Where motility begins.

Trends in Cell Biology, 12

Benesch S., Lommel S., Steffen A., Stradal T.E., Scaplehorn N., Way M., ... , Wehland J., Rottner K. (2002)

Phosphatidylinositol 4,5-Biphosphate (PIP2)-induced Vesicle Movement Depends on N-WASP and Involves Nck, WIP, and Grb2*210

Journal of Biological Chemistry, 277 (40)

DOI: 10.1074/jbc.M204145200 PubMed

Stradal T.B., Courtney K., Rottner K., Hahne P., Small J.V., Pendergast A.M. (2001)

The Abl-interactor (Abi) proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.

Current biology, 11

Rottner K., Krause M., Gimona M., Small J.V., Wehland J. (2001)

Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions

Molecular Biology of the Cell, 12 (10)

HZI-Repositorium PubMed

Lommel S., Benesch S., Rottner K., Franz T., Wehland J., Kühn R. (2001)

Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP- defective cells

EMBO Reports, 2 (9)

Prof Dr Klemens Rottner

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