Prof. Dr. Mark Brönstrup

Weber B.S., Ritchie N.E., Hilker S., Chan D.C.K., Peukert C., Deisinger J.P., Ives R., Ardal C., Burrows L.L., Brönstrup M., Magolan J., ... , Raivio T.L., Brown E.D. (2024)

High-Throughput Discovery of Synthetic Siderophores for Trojan Horse Antibiotics

ACS Infect.Dis.

DOI: 10.1021/acsinfecdis.4c00359 PubMed

Kohnhäuser D., Seedorf T., Cirnski K., Heimann D., Coetzee J., Sordello S., Richter J., Stappert M., Sabuco J.F., Corbett D., Bacque E., Rox K., Herrmann J., Vassort A., Müller R., ... , Kirschning A., Brönstrup M. (2024)

Optimization of the Central a[alpha]-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861

J.Med.Chem.

DOI: 10.1021/acs.jmedchem.4c00927 HZI-Repositorium PubMed

Mahdavi S.M., Bockfeld D., Esarev I.V., Lippmann P., Frank R., Brönstrup M., ... , Ott I., Tamm M. (2024)

Gold(i) and gold(iii) carbene complexes from the marine betaine norzooanemonin: inhibition of thioredoxin reductase, antiproliferative and antimicrobial activity

RSC Medicinal Chemistry

DOI: 10.1039/d4md00358f HZI-Repositorium PubMed

Rox K., Kühne A., Herrmann J., Jansen R., Hüttel S., Bernecker S., Hagos Y., Brönstrup M., Stadler M., ... , Hesterkamp T., Müller R. (2024)

Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters

ACS Pharm.Transl.Sci.

DOI: 10.1021/acsptsci.4c00183 HZI-Repositorium

Büssing R., Bublitz A., Karge B., Brönstrup M., Strowig T., Ott I. (2024)

An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile

J.Biol.Inorg.Chem.

DOI: 10.1007/s00775-024-02064-y HZI-Repositorium PubMed

Esarev I.V., Karge B., Zeng H., Lippmann P., Jones P.G., Schrey H., ... , Brönstrup M., Ott I. (2024)

Silver Organometallics that are Highly Potent Thioredoxin and Glutathione Reductase Inhibitors: Exploring the Correlations of Solution Chemistry with the Strong Antibacterial Effects

ACS infectious diseases, 10 (5)

DOI: 10.1021/acsinfecdis.4c00104 HZI-Repositorium PubMed

Li Q., Jansen H., Hansen G., Nurjadi D., Herrmann J., Stadler M., Brönstrup M., Müller R., He C., Graspeuntner S., ... , Rupp J., Shima K. (2024)

Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis

Int.J.Antimicrob.Agents

DOI: 10.1016/j.ijantimicag.2024.107132 PubMed

Jerye K., Lüken H., Steffen A., Schlawis C., Jänsch L., ... , Schulz S., Brönstrup M. (2024)

Activity-Based Protein Profiling Identifies Protein Disulfide-Isomerases as Target Proteins of the Volatile Salinilactones

Adv.Sci.

DOI: 10.1002/advs.202309515 HZI-Repositorium PubMed

Zuffa S., Schmid R., Bauermeister A., Gomes P., Caraballo-Rodriguez A.M., El Abiead Y., Aron A.T., Gentry E.C., Zemlin J., Meehan M.J., Avalon N.E., Cichewicz R.H., Buzun E., Terrazas M.C., Hsu C.Y., Oles R., Ayala A.V., Zhao J., Chu H., Kuijpers M.C.M., Jackrel S.L., Tugizimana F., Nephali L.P., Dubery I.A., Madala N.E., Moreira E.A., Costa-Lotufo L.V., Lopes N.P., Rezende-Teixeira P., Jimenez P.C., Rimal B., Patterson A.D., Traxler M.F., Pessotti R.D.C., Alvarado-Villalobos D., Tamayo-Castillo G., Chaverri P., Escudero-Leyva E., Quiros-Guerrero L.M., Bory A.J., Joubert J., Rutz A., Wolfender J.L., Allard P.M., Sichert A., Pontrelli S., Pullman B.S., Bandeira N., Gerwick W.H., Gindro K., Massana-Codina J., Wagner B.C., Forchhammer K., Petras D., Aiosa N., Garg N., Liebeke M., Bourceau P., Kang K.B., Gadhavi H., Carvalho L.P.S., Silva dos Santos M., Perez-Lorente A.I., Molina-Santiago C., Romero D., Franke R., Brönstrup M., Vera-Ponce de Leon A., Pope P.B., La Rosa S.L., La Barbera G., Roager H.M., Laursen M.F., Hammerle F., Siewert B., Peintner U., Licona-Cassani C., Rodriguez-Orduna L., Rampler E., Hildebrand F., Koellensperger G., Schoeny H., Hohenwallner K., Panzenboeck L., Gregor R., O'Neill E.C., Roxborough E.T., Odoi J., Bale N.J., Ding S., Sinninghe Damste J.S., Guan X.L., Cui J.J., Ju K.S., Silva D.B., Silva F.M.R., da Silva G.F., Koolen H.H.F., Grundmann C., Clement J.A., Mohimani H., Broders K., McPhail K.L., Ober-Singleton S.E., Rath C.M., McDonald D., Knight R., ... , Wang M., Dorrestein P.C. (2024)

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Nature microbiology, 9 (2)

DOI: 10.1038/s41564-023-01575-9 HZI-Repositorium PubMed

Pfütze S., Charria-Giron E., Schulzke E., Toshe R., Khonsanit A., Franke R., Surup F., ... , Brönstrup M., Stadler M. (2024)

Depicting the Chemical Diversity of Bioactive Meroterpenoids Produced by the Largest Organism on Earth

Angew.Chem.Int.Ed Engl.

DOI: 10.1002/anie.202318505 HZI-Repositorium PubMed

Haid S., Matthaei A., Winkler M., Sake S.M., Gunesch A.P., Milke V., Köhler N.M., Rückert J., Vieyres G., Kühl D., Nguyen T.-T., Göhl M., Lasswitz L., Zapatero-Belinchon F.J., Brogden G., Gerold G., Wiegmann B., Bilitewski U., Brown R.J.P., Brönstrup M., ... , Schulz T.F., Pietschmann T. (2024)

Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets

Antimicrob.Agents Chemother.

DOI: 10.1128/aac.01210-23 HZI-Repositorium PubMed

Eggert A., Schuppe K.T., Fuchs H.L.S., Brönstrup M., Kalesse M. (2023)

Total Synthesis of Acanthodoral Using a Rearrangement Strategy

Organic Letters

DOI: 10.1021/acs.orglett.3c03717 HZI-Repositorium PubMed

Mahdavi S.M., Bockfeld D., Büssing R., Karge B., Bannenberg T., Frank R., Brönstrup M., ... , Ott I., Tamm M. (2024)

Synthesis of N-heterocyclic carbene gold(i) complexes from the marine betaine 1,3-dimethylimidazolium-4-carboxylate

Dalton Transactions

DOI: 10.1039/d3dt04135b HZI-Repositorium PubMed

Rox K., Jansen R., Lukezic T., Greweling-Pils M., Herrmann J., Miethke M., Hüttel S., Hennessen F., Abou Fayad A., Holzhausen C., Lundberg C.V., Teague J., Sudarman E., Bülter L., Hesterkamp T., Stadler M., ... , Brönstrup M., Müller R. (2024)

Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models

Microbiol.Spectr., 12 (1)

DOI: 10.1128/spectrum.01289-23 HZI-Repositorium PubMed

Charria-Giron E., Marin-Felix Y., Beutling U., Franke R., Brönstrup M., Vasco-Palacios A.M., ... , Caicedo N.H., Surup F. (2023)

Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes

Microbiol.Spectr.

DOI: 10.1128/spectrum.02743-23 HZI-Repositorium PubMed

Schwitalla J.W., Le N.T.H., Um S., Schalk F., Brönstrup M., ... , Baunach M., Beemelmanns C. (2023)

Heterologous expression of the cryptic mdk gene cluster and structural revision of maduralactomycin A

RSC Adv., 13 (48)

DOI: 10.1039/d3ra05931f HZI-Repositorium PubMed

Schneider I., Fetz V., Prochnow H.P., Brönstrup M. (2023)

Artificial Siderophores with a Trihydroxamate-DOTAM Scaffold Deliver Iron and Antibiotic Cargo into the Bacterial Pathogen Escherichia coli

Isr.J.Chem., 63 (7-8)

DOI: 10.1002/ijch.202300057 HZI-Repositorium

Jian L., Zscherp R., Beutling U., Shen X., Xu S., Zhang X., Brönstrup M., ... , Klahn P., Sun Q. (2023)

Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors

J.Med.Chem.

DOI: 10.1021/acs.jmedchem.3c00549 PubMed

Wu Y., Zoller B.G.E., Kamal M.A.M., Hotop S.K., Lehr C.M., Brönstrup M., ... , Dersch P., Empting M. (2023)

Establishment of an In Bacterio assay for the Assessment of Carbon Storage Regulator A (CsrA) inhibitors

Chembiochem.

DOI: 10.1002/cbic.202300369 HZI-Repositorium PubMed

Allartz P., Hotop S.K., Muntau B., Schlaphof A., Thome-Bolduan C., Gabriel M., Petersen N., Lintzel M., Behrens C., Eggert P., Pörtner K., Steiner J., ... , Brönstrup M., Tappe D. (2023)

Detection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study

Infection

DOI: 10.1007/s15010-023-02048-1 HZI-Repositorium PubMed

Friederich J., Xu C., Raunft P., Fuchs H.L.S., Brönstrup M. (2023)

Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin

Chem.Commun., 59 (48)

DOI: 10.1039/d3cc01334k PubMed

Peukert C., Vetter A.C., Fuchs H.L.S., Harmrolfs K., Karge B., ... , Stadler M., Brönstrup M. (2023)

Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant E. coli

Chem.Sci., 14

DOI: 10.1039/d2sc06850h HZI-Repositorium

Cedeno-Sanchez M., Charria-Giron E., Lambert C., Luangsa-ard J.J., Decock C., Franke R., ... , Brönstrup M., Stadler M. (2023)

Segregation of the genus Parahypoxylon (Hypoxylaceae, Xylariales) from Hypoxylon by a polyphasic taxonomic approach

MycoKeys, 95

DOI: 10.3897/MYCOKEYS.95.98125 HZI-Repositorium

Zapol'skii V.A., Kaul S., Karge B., Brönstrup M., Gjikaj M., Kaufmann D.E. (2023)

A New Way to 2,3,4-Trisubstituted Benzo[h]quinolines: Synthesis, Consecutive Reactions and Cellular Activities â

Molecules., 28 (6)

DOI: 10.3390/molecules28062479 HZI-Repositorium PubMed

Maingot M., Bourotte M., Vetter A.C., Schellhorn B., Antraygues K., Scherer H., Gitzinger M., Kemmer C., Dale G.E., Defert O., Lociuro S., Brönstrup M., ... , Willand N., Trebosc V. (2023)

Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against Acinetobacter baumannii

Eur.J.Med.Chem., 252

DOI: 10.1016/j.ejmech.2023.115257 PubMed

Lai Y.H., Franke R., Pinkert L., Overwin H., Brönstrup M. (2023)

Molecular Signatures of the Eagle Effect Induced by the Artificial Siderophore Conjugate LP-600 in E. coli

ACS Infect.Dis., 9 (3)

DOI: 10.1021/acsinfecdis.2c00567 HZI-Repositorium PubMed

Peukert C., Rox K., Karge B., Hotop S.K., Brönstrup M. (2023)

Synthesis and Characterization of DOTAM-Based Sideromycins for Bacterial Imaging and Antimicrobial Therapy

ACS Infect.Dis., 9 (2)

DOI: 10.1021/acsinfecdis.2c00523 HZI-Repositorium PubMed

Wimmer S., Hoff K., Martin B., Grewer M., Denni L., Lascorz Massanet R., Raimondi M.V., Bülbül E.F., Melesina J., Hotop S.K., Haupenthal J., Rohde H., Heisig P., Hirsch A.K.H., Brönstrup M., ... , Sippl W., Holl R. (2022)

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors

Bioorg.Chem., 131

DOI: 10.1016/j.bioorg.2022.106331 PubMed

Borgert S.R., Henke S., Witzgall F., Schmelz S., Zur Lage S., Hotop S.K., Stephen S., Lübken D., Krüger J., Gomez N.O., Van Ham M., Jänsch L., Kalesse M., Pich A., Brönstrup M., ... , Häußler S., Blankenfeldt W. (2022)

Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa

Nat.Commun., 13 (1)

DOI: 10.1038/s41467-022-35030-w HZI-Repositorium PubMed

Peukert C., Gasser V., Orth T., Fritsch S., Normant V., Cunrath O., ... , Schalk I.J., Brönstrup M. (2022)

Trojan Horse Siderophore Conjugates Induce Pseudomonas aeruginosa Suicide and Qualify the TonB Protein as a Novel Antibiotic Target

J.Med.Chem., 66 (1)

DOI: 10.1021/acs.jmedchem.2c01489 HZI-Repositorium PubMed

Kruck D., Bode H., Krusche J., Beck C., Ohlsen K., Sander J., Römling U., Burrichter A., Varo J.G., ... , Charoenpattarapreeda J., Brönstrup M. (2022)

Journal Club : [u.a.] Gesteuerter Abbau von Proteinen in Bakterien durch BacPROTAC-Wirkstoffe [etc.]

Biospektrum, 28 (7)

DOI: 10.1007/s12268-022-1853-z

Fiorini F., Bajerski F., Jeske O., Lepleux C., Overmann J., Brönstrup M. (2022)

A Metabolomics-Based Toolbox to Assess and Compare the Metabolic Potential of Unexplored, Difficult-to-Grow Bacteria

Mar Drugs, 20 (11)

DOI: 10.3390/md20110713 HZI-Repositorium PubMed

Cooper M.S., Zhang L., Ibrahim M., Zhang K., Sun X., Röske J., Göhl M., Brönstrup M., Cowell J.K., Sauerhering L., Becker S., Vangeel L., Jochmans D., Neyts J., Rox K., Marsh G.P., ... , Maple H.J., Hilgenfeld R. (2022)

Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease

J.Med.Chem., 65 (19)

DOI: 10.1021/acs.jmedchem.2c01131 HZI-Repositorium PubMed

Suo H., Hochnadel I., Petriv N., Franke R., Schmidt J., Limanska N., Tugai A., Jedicke N., Brönstrup M., ... , Manns M.P., Yevsa T. (2022)

Elucidating the mechanism behind and investigating the efficacy of Traditional Chinese Medicine and Traditional Tibetan Medicine in combination with standard therapeutics in hepatocellular carcinoma and cholangiocarcinoma in vitro

Front Pharmacol., 13

DOI: 10.3389/fphar.2022.906468 HZI-Repositorium PubMed

Testolin G., Richter J., Ritter A., Prochnow H., Köhnke J., Brönstrup M. (2022)

Optical Modulation of Antibiotic Resistance by Photoswitchable Cystobactamids

Chem.Eur.J.

DOI: 10.1002/chem.202201297 HZI-Repositorium PubMed

Göhl M., Zhang L., El Kilani H., Sun X., Zhang K., ... , Brönstrup M., Hilgenfeld R. (2022)

From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease G

Molecules, 27 (13)

DOI: 10.3390/molecules27134292 HZI-Repositorium PubMed

Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C. (2022)

Correction for Suerbaum et al., "Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model"

MBio.

DOI: 10.1128/mbio.02301-22 HZI-Repositorium PubMed

Arshad H., Siokis A., Franke R., Habib A., Alfonso J.C.L., Poliakova Y., Lücke E., Michaelis K., Brönstrup M., Meyer-Hermann M., Bilitewski U., Vila J., Abel L., Illig T., ... , Schreiber J., Pessler F. (2022)

Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease

Cells, 11 (15)

DOI: 10.3390/cells11152283 HZI-Repositorium PubMed

Brauer M., Hotop S.K., Wurster M., Herrmann J., Miethke M., Schlüter R., Dittmann S., Zühlke D., Brönstrup M., Lalk M., Müller R., Sievers S., ... , Bernhardt J., Riedel K. (2022)

Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress

mSphere

DOI: 10.1128/msphere.00302-22 HZI-Repositorium PubMed

Ballmann R., Hotop S.K., Bertoglio F., Steinke S., Heine P.A., Chaudhry M.Z., Jahn D., Pucker B., Baldanti F., Piralla A., Schubert M., Cícín-Saín L., Brönstrup M., ... , Hust M., Dübel S. (2022)

ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein

Viruses., 14 (6)

DOI: 10.3390/v14061326 HZI-Repositorium PubMed

Fritsch S., Gasser V., Peukert C., Pinkert L., Kuhn L., Perraud Q., Normant V., ... , Brönstrup M., Schalk I.J. (2022)

Uptake Mechanisms and Regulatory Resfponses to MECAM- and DOTAM-Based Artificial Siderophores and Their Antibiotic Conjugates in Pseudomonas aeruginosa

ACS Infect.Dis., 8 (6)

DOI: 10.1021/acsinfecdis.2c00049 HZI-Repositorium PubMed

Peukert C., Popat Gholap S., Green O., Pinkert L., van den Heuvel J., Van Ham M., ... , Shabat D., Brönstrup M. (2022)

Enzyme-Activated, Chemiluminescent Siderophore-Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens

Angew.Chem.Int.Ed Engl.

DOI: 10.1002/anie.202201423 HZI-Repositorium PubMed

Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C. (2022)

Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model

MBio., 13 (2)

DOI: 10.1128/mbio.03755-21 HZI-Repositorium PubMed

Hotop S.K., Reimering S., Shekhar A., Asgari E., Beutling U., Dahlke C., Fathi A., Khan F., Lütgehetmann M., Ballmann R., Gerstner A., Tegge W., Cicin-Sain L., Bilitewski U., ... , McHardy A.C., Brönstrup M. (2022)

Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2

Emerg.Microbes Infect, 11 (1)

DOI: 10.1080/22221751.2022.2057874 HZI-Repositorium PubMed

Arisetti N., Fuchs H.L.S., Coetzer J., Orozco M., Ruppelt D., Bauer A., Heimann D., Kuhnert E., Bhamidimarri S.P., Bafna J.A., Hinkelmann B., Eckel K., Sieber S.A., Müller P.P., Herrmann J., Müller R., Winterhalter M., ... , Steinem C., Brönstrup M. (2021)

Total synthesis and mechanism of action of the antibiotic armeniaspirol A

Chem.Sci., 12 (48)

DOI: 10.1039/d1sc04290d HZI-Repositorium PubMed

Ahsendorf H.P., Diesterbeck U.S., Hotop S.K., Winkler M., Brönstrup M., Czerny C.P. (2022)

Characterisation of an Anti-Vaccinia Virus F13 Single Chain Fragment Variable from a Human Anti-Vaccinia Virus-Specific Recombinant Immunoglobulin Library

Viruses, 14 (2)

DOI: 10.3390/v14020197 HZI-Repositorium PubMed

Hotop S.K., Abd El Wahed A., Beutling U., Czerny F., Sievers C., Diederichsen U., Frank R., Stahl-Hennig C., ... , Brönstrup M., Fritz H.J. (2019)

Serological Analysis of Herpes B Virus at Individual Epitope Resolution: From Two-Dimensional Peptide Arrays to Multiplex Bead Flow Assays

Anal.Chem., 91 (17)

DOI: 10.1021/acs.analchem.9b01291 PubMed

Roche B., Garcia-Rivera M.A., Normant V., Kuhn L., Hammann P., Brönstrup M., ... , Mislin G.L.A., Schalk I.J. (2021)

A role for PchHI as the ABC transporter in iron acquisition by the siderophore pyochelin in Pseudomonas aeruginosa

Environmental Microbiology

DOI: 10.1111/1462-2920.15811 HZI-Repositorium PubMed

Jimidar C.C., Grunenberg J., Karge B., Fuchs H.L.S., Brönstrup M., Klahn P. (2021)

Masked Amino Trimethyl Lock (H2N-TML) Systems: New Molecular Entities for the Development of Turn-On Fluorophores and Their Application in Hydrogen Sulfide (H2S) Imaging in Human Cells

Chemistry - A European Journal

DOI: 10.1002/chem.202103525 HZI-Repositorium PubMed

Becker K., Cao S., Nilsson A., Erlandsson M., Hotop S.K., Kuka J., Hansen J., Haldimann K., Grinberga S., Berruga-Fernández T., Huseby D.L., Shariatgorji R., Lindmark E., Platzack B., Böttger E.C., Crich D., Friberg L.E., Vingsbo Lundberg C., Hughes D., Brönstrup M., Andrén P.E., ... , Liepinsh E., Hobbie S.N. (2021)

Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

EBioMedicine, 73 (November 2021)

DOI: 10.1016/j.ebiom.2021.103652 HZI-Repositorium PubMed

Pinkert L., Lai Y.H., Peukert C., Hotop S.K., Karge B., Schulze L.M., ... , Grunenberg J., Brönstrup M. (2021)

Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

J.Med.Chem.

DOI: 10.1021/acs.jmedchem.1c01482 PubMed

Rox K., Heyner M., Krull J., Harmrolfs K., Rinne V., Hokkanen J., Perez Vilaro G., Díez J., Müller R., Kröger A., ... , Sugiyama Y., Brönstrup M. (2021)

Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A

ACS Pharm.Transl.Sci., 4 (5)

DOI: 10.1021/acsptsci.1c00078 HZI-Repositorium PubMed

Rath S., Rox K., Kleine Bardenhorst S., Schminke U., Dörr M., Mayerle J., Frost F., Lerch M.M., Karch A., Brönstrup M., ... , Pieper D.H., Vital M. (2021)

Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria

mSystems.

DOI: 10.1128/mSystems.00945-21 HZI-Repositorium PubMed

Miethke M., Pieroni M., Weber T., Brönstrup M., Hammann P., Halby L., Arimondo P.B., Glaser P., Aigle B., Bode H.B., Moreira R., Li Y., Luzhetskyy A., Medema M.H., Pernodet J.L., Stadler M., Tormo J.R., Genilloud O., Truman A.W., Weissman K.J., Takano E., Sabatini S., Stegmann E., Brötz-Oesterhelt H., Wohlleben W., Seemann M., Empting M., Hirsch A.K.H., Loretz B., Lehr C.M., Titz A., Herrmann J., Jaeger T., Alt S., Hesterkamp T., Winterhalter M., Schiefer A., Pfarr K., Hoerauf A., Graz H., Graz M., Lindvall M., Ramurthy S., Karlen A., van Dongen M., Petkovic H., Keller A., Peyrane F., Donadio S., Fraisse L., Piddock L.J.V., Gilbert I.H., ... , Moser H.E., Müller R. (2021)

Towards the sustainable discovery and development of new antibiotics

Nat.Rev.Chem.

DOI: 10.1038/s41570-021-00313-1 HZI-Repositorium PubMed

Peukert C., Langer L.N.B., Wegener S.M., Tutov A., Bankstahl J.P., Karge B., Bengel F.M., ... , Ross T.L., Brönstrup M. (2021)

Optimization of Artificial Siderophores as (68)Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections

J.Med.Chem., 64 (16)

DOI: 10.1021/acs.jmedchem.1c01054 HZI-Repositorium PubMed

Büssing R., Karge B., Lippmann P., Jones P.G., Brönstrup M., Ott Ingo (2021)

Gold(I) and Gold(III) N-Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase

ChemMedChem.

DOI: 10.1002/cmdc.202100381 HZI-Repositorium PubMed

Rox K., Rath S., Pieper D.H., Vital M., Brönstrup M. (2021)

A simplified LC-MS/MS method for the quantification of the cardiovascular disease biomarker trimethylamine-N-oxide and its precursors

J.Pharmaceut.Analy.

DOI: 10.1016/j.jpha.2021.03.007 HZI-Repositorium

Franke R., Overwin H., Häussler S., Brönstrup M. (2021)

Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa

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Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)

Sci Rep., 6

DOI: 10.1038/srep32958 HZI-Repositorium PubMed

Bertrand R., Hamp I., Brönstrup M., Weck R., Lukacevic M., Polyak A., Ross T.L., Gotthardt M., ... , Plettenburg O., Derdau V. (2016)

Synthesis of GPR40 targeting H- and F-probes towards selective beta cell imaging

J Labelled Comp Radiopharm., 59 (14)

DOI: 10.1002/jlcr.3412 PubMed

Nicolaou K.C., Pulukuri K.K., Rigol S., Heretsch P., Yu R., Grove C.I., Hale C.R., ElMarrouni A., Fetz V., Brönstrup M., Aujay M., ... , Sandoval J., Gavrilyuk J. (2016)

Synthesis and Biological Investigation of Delta-Prostaglandin J (Delta-PGJ) Analogues and Related Compounds

J Am Chem.Soc., 138 (20)

DOI: 10.1021/jacs.6b02075

Bertrand R., Wolf A., Ivashchenko Y., Lohn M., Schafer M., Brönstrup M., Gotthardt M., ... , Derdau V., Plettenburg O. (2016)

Synthesis and Characterization of a Promising Novel FFAR1/GPR40 Targeting Fluorescent Probe for b[beta]-Cell Imaging

ACS Chem.Biol., 11 (6)

DOI: 10.1021/acschembio.5b00791 PubMed

Bauer A., Brönstrup M. (2014)

Industrial natural product chemistry for drug discovery and development

Nat.Prod.Rep., 31 (1)

DOI: 10.1039/c3np70058e

Fetz V., Prochnow H., Bronstrup M., Sasse F. (2016)

Target identification by image analysis

Nat.Prod.Rep., 33 (5)

DOI: 10.1039/c5np00113g HZI-Repositorium PubMed

Wenzel S.C., Hoffmann H., Zhang J., Debussche L., Haag-Richter S., Kurz M., Nardi F., Lukat P., Kochems I., Tietgen H., Schummer D., Nicolas J.P., Calvet L., Czepczor V., Vrignaud P., Muhlenweg A., Pelzer S., ... , Müller R., Brönstrup M. (2015)

Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure-Activity Relationships

Angew.Chem Int.Ed Engl., 54

DOI: 10.1002/anie.201508277 HZI-Repositorium PubMed

Fu C., Keller L., Bauer A., Brönstrup M., Froidbise A., Hammann P., Herrmann J., Mondesert G., Kurz M., Schiell M., Schummer D., Toti L., ... , Wink J., Müller R. (2015)

Biosynthetic Studies of Telomycin Reveal New Lipopeptides with Enhanced Activity

J.Am.Chem.Soc., 137 (24)

DOI: 10.1021/jacs.5b01794 PubMed

Koutsoudakis G., Romero-Brey I., Berger C., Perez-Vilaro G., Perin P.M., Vondran F.W., Kalesse M., Harmrolfs K., Müller R., Martinez J.P., Pietschmann T., Bartenschlager R., Bronstrup M., ... , Meyerhans A., Diez J. (2015)

Soraphen A: a broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity

J Hepatol., 63 (4)

DOI: 10.1016/j.jhep.2015.06.002 HZI-Repositorium PubMed

Halland N., Brönstrup M., Czech J., Czechtizky W., Evers A., Follmann M., Kohlmann M., Schiell M., Kurz M., ... , Schreuder H.A., Kallus C. (2015)

Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin

J.Med.Chem., 58 (11)

Hoffmann H., Kogler H., Heyse W., Matter H., Caspers M., Schummer D., Klemke-Jahn C., Bauer A., Penarier G., ... , Debussche L., Brönstrup M. (2015)

Discovery, Structure Elucidation, and Biological Characterization of Nannocystin A, a Macrocyclic Myxobacterial Metabolite with Potent Antiproliferative Properties

Angew.Chem.Int.Ed Engl., 54

DOI: 10.1002/anie.201411377 PubMed

Kling A., Lukat P., Almeida D.V., Bauer A., Fontaine E., Sordello S., Zaburannyi N., Herrmann J., Wenzel S.C., Konig C., Ammerman N.C., Barrio M.B., Borchers K., Bordon-Pallier F., Brönstrup M., Courtemanche G., Gerlitz M., Geslin M., Hammann P., Heinz D.W., Hoffmann H., Klieber S., Kohlmann M., Kurz M., Lair C., Matter H., Nuermberger E., Tyagi S., Fraisse L., Grosset J.H., ... , Lagrange S., Müller R. (2015)

Targeting DnaN for tuberculosis therapy using novel griselimycins

Science, 348 (6239)

DOI: 10.1126/science.aaa4690 PubMed

Martinez J.P., Sasse Florenz, Brönstrup M., Diez J., Meyerhans A. (2014)

Antiviral drug discovery: broad-spectrum drugs from nature

Natural Product Reports, 32 (1)

DOI: 10.1039/c4np00085d HZI-Repositorium PubMed

Kopf T., Schaefer H.L., Troetzmueller M., Koefeler H., Brönstrup Marc, ... , Konovalova T., Schmitz G. (2014)

Influence of fenofibrate treatment on triacylglycerides, diacylglycerides and fatty acids in fructose fed rats

PLoS ONE, 9 (9)

DOI: 10.1371/journal.pone.0106849 HZI-Repositorium PubMed

Prof Dr Mark Brönstrup

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