Prof Dr Thekla Cordes

Prof Dr Thekla Cordes
Head of Research Group

With a diverse background in metabolism, mass spectrometry, metabolic flux analysis strategies, and bioprocess engineering, Prof Thekla Cordes brings an interdisciplinary and international perspective to her research. Her research focuses on investigating the role of mitochondrial dysfunction in mammalian metabolism by employing stable isotope tracer-assisted metabolic flux analysis to enhance our understanding of metabolism in health and disease.

Cordes began her academic journey by receiving a diploma in biotechnology from the Technische Universität Braunschweig (Germany) before joining Novartis Biologics in Basel (Switzerland) to conduct research in bioprocess engineering. Cordes received her Ph.D. at the Luxembourg Centre for Systems Biomedicine (Luxembourg). She was a DFG (German Research Foundation) Fellow and a Research Scientist at the University of California, San Diego (UCSD) and SALK Institute for Biological Studies in La Jolla (USA). Cordes is currently a professor of Cellular Metabolism at the Institute for Biochemistry, Biotechnology, and Bioinformatics at the TU Braunschweig (Germany) and head of the group Cellular Metabolism in Infection (CMII) at Helmholtz Centre for Infection Research (HZI). The Cordes laboratory is located at the Braunschweig Integrative Centre of Systems Biology (BRICS).

Publications
Cordes T., Hiller K. (2024)
Itaconate modulates mitochondria for antiviral IFN-b[beta]
Nature Metabolism

Willenbockel H.F., Dowerg B., Cordes T. (2024)
Multifaceted metabolic role of infections in the tumor microenvironment
Current Opinion in Biotechnology, 89 (October 2024)

Ketelhuth D.F.J., Desler C., Cordes T., Corrrado M., Arguello R.J., ... , Everts B., Van den Bossche L. (2024)
Proceedings of EIMN's 1st European Immunometabolism Conference
Immunometabolism, 6 (3)

Parker S., Cordes T. (2024)
Editorial overview: Tumor-stroma crosstalk: Shaping and characterizing the metabolic microenvironment of tumors
Curr.Opin.Biotechnol., 87

Kuhlmann-Hogan A., Cordes T., Xu Z., Kuna R.S., Traina K.A., Robles-Oteiza C., Ayeni D., Kwong E.M., Levy S., Globig A.M., Nobari M.M., Cheng G.Z., Leibel S.L., Homer R.J., Shaw R.J., Metallo C.M., ... , Politi K., Kaech S.M. (2024)
EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth
Cancer Discov.

Chen F., Dowerg B., Cordes T. (2023)
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr.Opin.Biotechnol., 84 (Dec 2023)

Nikolka F., Karagöz M.S., Nassef M.Z., Hiller K., Steinert M., Cordes T. (2023)
The Virulence Factor Macrophage Infectivity Potentiator (Mip) Influences Branched-Chain Amino Acid Metabolism and Pathogenicity of Legionella pneumophila
Metabolites, 13 (7)

Turner R., Cordes T., Wallace M. (2023)
Itaconate trims the fat
Nature Meta., 5 (6)

Chen F., Willenbockel H.F., Cordes T. (2023)
Mapping the Metabolic Niche of Citrate Metabolism and SLC13A5
Metabolites., 13 (3)

He W., Henne A., Lauterbach M., Geißmar E., Nikolka F., Kho C., Heinz A., Dostert C., Grusdat M., Cordes T., Härm J., Goldmann O., Ewen A., Verschueren C., Blay-Cadanet J., Geffers R., Garritsen H., Kneiling M., Holm C.K., Metallo C.M., Medina E., Abdullah Z., Latz E., ... , Brenner D., Hiller K. (2022)
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages
Nat.Metab, 4 (5)

Michelucci A., Cordes T., Ghelfi J., Pailot A., Reiling N., Goldmann O., Binz T., Wegner A., Tallam A., Rausell A., Buttini M., Linster C.L., Medina Eva, ... , Balling R., Hiller K. (2013)
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
Proceedings of the National Academy of Sciences USA, 110 (19)