Prof Dr Thekla Cordes

Prof Dr Thekla Cordes
Head of Research Group
+49 531 3915-5202

With a diverse background in metabolism, mass spectrometry, metabolic flux analysis strategies, and bioprocess engineering, Prof Thekla Cordes brings an interdisciplinary and international perspective to her research. Her research focuses on investigating the role of mitochondrial dysfunction in mammalian metabolism by employing stable isotope tracer-assisted metabolic flux analysis to enhance our understanding of metabolism in health and disease.

Cordes began her academic journey by receiving a diploma in biotechnology from the Technische Universität Braunschweig (Germany) before joining Novartis Biologics in Basel (Switzerland) to conduct research in bioprocess engineering. Cordes received her Ph.D. at the Luxembourg Centre for Systems Biomedicine (Luxembourg). She was a DFG (German Research Foundation) Fellow and a Research Scientist at the University of California, San Diego (UCSD) and SALK Institute for Biological Studies in La Jolla (USA). Cordes is currently a professor of Cellular Metabolism at the Institute for Biochemistry, Biotechnology, and Bioinformatics at the TU Braunschweig (Germany) and head of the group Cellular Metabolism in Infection (CMII) at Helmholtz Centre for Infection Research (HZI). The Cordes laboratory is located at the Braunschweig Integrative Centre of Systems Biology (BRICS).

Publications

Parker S., Cordes T. (2024)
Editorial overview: Tumor-stroma crosstalk: Shaping and characterizing the metabolic microenvironment of tumors
Curr.Opin.Biotechnol., 87
DOI: 10.1016/j.copbio.2024.103095 PubMed
Kuhlmann-Hogan A., Cordes T., Xu Z., Kuna R.S., Traina K.A., Robles-Oteiza C., Ayeni D., Kwong E.M., Levy S., Globig A.M., Nobari M.M., Cheng G.Z., Leibel S.L., Homer R.J., Shaw R.J., Metallo C.M., ... , Politi K., Kaech S.M. (2024)
EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth
Cancer Discov.
DOI: 10.1158/2159-8290.CD-23-0434 PubMed
Chen F., Dowerg B., Cordes T. (2023)
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr.Opin.Biotechnol., 84 (Dec 2023)
DOI: 10.1016/j.copbio.2023.102996 PubMed
Nikolka F., Karagöz M.S., Nassef M.Z., Hiller K., Steinert M., Cordes T. (2023)
The Virulence Factor Macrophage Infectivity Potentiator (Mip) Influences Branched-Chain Amino Acid Metabolism and Pathogenicity of Legionella pneumophila
Metabolites, 13 (7)
DOI: 10.3390/metabo13070834 HZI-Repositorium PubMed
Turner R., Cordes T., Wallace M. (2023)
Itaconate trims the fat
Nature Meta., 5 (6)
DOI: 10.1038/s42255-023-00819-6 PubMed
Chen F., Willenbockel H.F., Cordes T. (2023)
Mapping the Metabolic Niche of Citrate Metabolism and SLC13A5
Metabolites., 13 (3)
DOI: 10.3390/metabo13030331 HZI-Repositorium PubMed
He W., Henne A., Lauterbach M., Geißmar E., Nikolka F., Kho C., Heinz A., Dostert C., Grusdat M., Cordes T., Härm J., Goldmann O., Ewen A., Verschueren C., Blay-Cadanet J., Geffers R., Garritsen H., Kneiling M., Holm C.K., Metallo C.M., Medina E., Abdullah Z., Latz E., ... , Brenner D., Hiller K. (2022)
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages
Nat.Metab, 4 (5)
DOI: 10.1038/s42255-022-00565-1 HZI-Repositorium PubMed
Michelucci A., Cordes T., Ghelfi J., Pailot A., Reiling N., Goldmann O., Binz T., Wegner A., Tallam A., Rausell A., Buttini M., Linster C.L., Medina Eva, ... , Balling R., Hiller K. (2013)
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
Proceedings of the National Academy of Sciences USA, 110 (19)
DOI: 10.1073/pnas.1218599110 HZI-Repositorium PubMed

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