Core Facility for Translational Proteomics

Technology Platforms

HZI Campus

Proteins are essential components of all living organisms and the prime drug targets, driving critical processes in health, disease and therapy. Pathogens such as bacteria and viruses exploit host proteins to manipulate immune responses, shaping the course of infections. Understanding these molecular interactions is crucial for combating infectious diseases in humans as well as in animals, aligning with the One Health approach.

At the Helmholtz Centre for Infection Research (HZI), the Core Facility for Translational Proteomics (CFTP) supports scientists in uncovering protein-driven mechanisms of infection and immunity. We provide cutting-edge expertise, technology, and analytical tools (i) to identify proteins involved in host-pathogen interactions, (ii) to discover biomarkers in infections and immune responses and (iii) to characterize drug targets for therapeutic development.

Head

Prof Dr Lothar Jänsch

Head of Research Group

+49 531 6181-3030 E-Mail

Our Expertise

The Core Facility for Translational Proteomics (CFTP) provides proteome-scaled analyses as full service as well as in collaborative projects. We combine expertise in protein biochemistry, mass spectrometry (MS) and biostatistics matching the demands in academical and translational research.

The Core Facility is equipped with modern mass spectrometry with ion mobility for untargeted and targeted proteome studies (DDA, DIA, PRM). Data analysis is conducted using a combination of commercial, academic, and in-house software solutions and databases, ensuring project-specific data mining and management. The established workflows allow the identification of proteins and post-translational mechanisms that are key regulators in infections. By this, CFTP contributes to the discovery of novel drug targets in host-pathogen interaction networks that coordinate the course of infections.