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Editorial: Understanding mitochondrial dynamics and metabolic plasticity in cancer stem cells: Recent advances in cancer treatment and potential therapeutic approaches
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Front.Immunol.,
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Nat.Commun.,
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Shaikh H., Pezoldt J., Mokhtari Z., Gamboa Vargas J., Le D.D., Pena Mosca J., Arellano-Viera E., Kern M.A., Graf C., Beyersdorf N., Lutz M.B., Riedel A., Büttner-Herold M., Zernecke A., Einsele H., Saliba A.E., Ludewig B., ... , Hühn J., Beilhack A.
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Front.Immunol.,
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Clin.Exp.Allergy
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
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Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
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Fluvastatin mitigates SARS-CoV-2 infection in human lung cells
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Generation of Sequencing Libraries for Building Immune Cell Methylomes
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Matthias J., Heink S., Picard F.S., Zeiträg J., Kolz A., Chao Y.Y., Soll D., de Almeida G.P., Glasmacher E., Jacobsen I.D., Riedel T., Peters A., Floess S., Hühn J., Baumjohann D., Huber M., ... , Korn T., Zielinski C.E.
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Cossarizza A., Chang H.D., Radbruch A., Acs A., Adam D., dam-Klages S., Agace W.W., Aghaeepour N., Akdis M., Allez M., Almeida L.N., Alvisi G., Anderson G., Annunziato F., Anselmo A., Bacher P., Baldari C.T., Bari S., Barnaba V., Barros-Martins J., Battistini L., Bauer W., Baumgart S., Baumgarth N., Baumjohann D., Baying B., Bebawy M., Becher B., Beisker W., Benes V., Beyaert R., Blanco A., Boardman D.A., Bogdan C., Borger J.G., Borsellino G., Boulais P.E., Bradford J.A., Brenner D., Brinkman R.R., Brooks A.E.S., Busch D.H., Büscher M., Bushnell T.P., Calzetti F., Cameron G., Cammarata I., Cao X., Cardell S.L., Casola S., Cassatella M.A., Cavani A., Celada A., Chatenoud L., Chattopadhyay P.K., Chow S., Christakou E., Cicin-Sain L., Clerici M., Colombo F.S., Cook L., Cooke A., Cooper A.M., Corbett A.J., Cosma A., Cosmi L., Coulie P.G., Cumano A., Cvetkovic L., Dang V.D., ng-Heine C., Davey M.S., Davies D., De Biasi S., Del Zotto G., Dela Cruz G.V., Delacher M., Della Bella S., Dellabona P., Deniz G., Dessing M., Di Santo J.P., Diefenbach A., Dieli F., Dolf A., Dörner T., Dress R.J., Dudziak D., Dustin M., Dutertre C.A., Ebner F., Eckle S.B.G., Edinger M., Eede P., Ehrhardt G.R.A., Eich M., Engel P., Engelhardt B., Erdei A., Esser C., Everts B., Evrard M., Falk C.S., Fehniger T.A., Felipo-Benavent M., Ferry H., Feuerer M., Filby A., Filkor K., Fillatreau S., Follo M., Förster I., Foster J., Foulds G.A., Frehse B., Frenette P.S., Frischbutter S., Fritzsche W., Galbraith D.W., Gangaev A., Garbi N., Gaudilliere B., Gazzinelli R.T., Geginat J., Gerner W., Gherardin N.A., Ghoreschi K., Gibellini L., Ginhoux F., Goda K., Godfrey D.I., Goettlinger C., Goodyear C.S., Gori A., Grogan J.L., Grummitt D., Grützkau A., Haftmann C., Hahn J., Hammad H., Hämmerling G., Hansmann L., Hansson G., Harpur C.M., Hartmann S., Hauser A., Hauser A.E., Haviland D.L., Hedley D., Hernandez D.C., Herrera G., Herrmann M., Hess C., Höfer T., Hoffmann P., Hogquist K., Holland T., Höllt T., Holmdahl R., Hombrink P., Houston J.P., Hoyer B.F., Huang B., Huang F.P., Huber J.E., Hühn J., Hundemer M., Hunter C.A., Hwang W.Y.K., Iannone A., Ingelfinger F., Ivison S.M., Jäck H.M., Jani P.K., Jbvega B., Kaiser T., Kalina T., Kamradt T., Kaufmann S.H.E., Keller B., Ketelaars S.L.C., Khalilnezhad A., Khan S., Kisielow J., Klenerman P., Knopf J., Koay H.F., Kobow K., Kolls J.K., Kong W.T., Kopf M., Korn T., Kriegsmann K., Kristyanto H., Kroneis T., Krueger A., Kühne J., Kukat C., Kunkel D., Kunze-Schumacher H., Kurosaki T., Kurts C., Kvistborg P., Kwok I., Landry J., Lantz O., Lanuti P., LaRosa F., Lehuen A., LeibundGut-Landmann S., Leipold M.D., Leung L.Y.T., Levings M.K., Lino A.C., Liotta F., Litwin V., Liu Y., Ljunggren H.G., Lohoff M., Lombardi G., Lopez L., Lopez-Botet M., Lovett-Racke A.E., Lubberts E., Luche H., Ludewig B., Lugli E., Lunemann S., Maecker H.T., Maggi L., Maguire O., Mair F., Mair K.H., Mantovani A., Manz R.A., Marshall A.J., Martinez-Romero A., Martrus G., Marventano I., Maslinski W., Matarese G., Mattioli A.V., Maueröder C., Mazzoni A., McCluskey J., McGrath M., McGuire H.M., McInnes I.B., Mei H.E., ... , Melchers F., Melzer S.
(2019)
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Eur.J.Immunol.,
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Author count: 5
Schuster M., Plaza-Sirvent C., Visekruna A., Hühn J., Schmitz I.
(2019)
Generation of Foxp3+CD25- regulatory T-cell precursors requires c-rel and IkBNS
Front.Immunol.,
10
(JULY)
Author count: 4
Pezoldt J., Yang J., Zou M., Hühn J.
(2018)
Microbiome and gut immunity: T cells
(9)
Author count: 6
Pandiyan P., Bhaskaran N., Zou M., Schneider E., Jayaraman S., Hühn J.
(2019)
Microbiome Dependent Regulation of T regs and Th17 Cells in Mucosa
Front Immunol,
10
Author count: 22
Lyszkiewicz M., Winter S.J., Witzlau K., Fohse L., Brownlie R., Puchalka J., Verheyden N.A., Kunze-Schumacher H., Imelmann E., Blume J., Raha S., Sekiya T., Yoshimura A., Frueh J.T., Ullrich E., Hühn J., Weiss S., Gutierrez M.G., Prinz I., Zamoyska R., ... , Zietara N., Krueger A.
(2019)
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity
PLoS.Biol.,
17
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Author count: 22
Garg G., Muschaweckh A., Moreno H., Vasanthakumar A., Floess S., Lepennetier G., Oellinger R., Zhan Y., Regen T., Hiltensperger M., Peter C., Aly L., Knier B., Palam L.R., Kapur R., Kaplan M.H., Waisman A., Rad R., Schotta G., Hühn J., ... , Kallies A., Korn T.
(2019)
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
Cell Rep.,
26
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Author count: 11
Elfiky A., Bonifacius A., Pezoldt J., Pasztoi M., Chaoprasid P., Sadana P., El-Sherbeeny N., Hagras M., Scrima A., ... , Dersch P., Hühn J.
(2018)
Yersinia Pseudotuberculosis Modulates Regulatory T Cell Stability via Injection of Yersinia Outer Proteins in a Type III Secretion System-Dependent Manner
Eur.J.Microbiol.Immunol.(Bp),
8
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Author count: 2
Ludwig R., Hühn J.
(2018)
Already ENLIGHT-TENed? Equipping young immunologists with a combination of research-related and transferrable competencies
Eur.J.Immunol.,
48
(12)
Author count: 5
Yang J., Zou M., Pezoldt J., Zhou X., Hühn J.
(2018)
Thymus-derived Foxp3(+) regulatory T cells upregulate RORg[gamma]t expression under inflammatory conditions
J.Mol.Med.(Berl),
96
(12)
Author count: 6
Prajeeth C.K., Dittrich-Breiholz O., Talbot S.R., Robert P.A., Hühn J., Stangel M.
(2018)
IFN-g[gamma] producing Th1 cells induce different transcriptional profiles in microglia and astrocytes
Front.Cell.Neurosci.,
12
Author count: 24
Pezoldt J., Pasztoi M., Zou M., Wiechers C., Beckstette M., Thierry G.R., Vafadarnejad E., Floess S., Arampatzi P., Buettner M., Schweer J., Fleissner D., Vital M., Pieper D.H., Basic M., Dersch P., Strowig T., Hornef M., Bleich A., Bode U., Pabst O., Bajenoff M., ... , Saliba A.E., Hühn J.
(2018)
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes
Nat.Commun.,
9
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Author count: 15
Kyburz A., Fallegger A., Zhang X., Altobelli A., Artola-Boran M., Borbet T., Urban S., Paul P., Münz C., Floess S., Hühn J., Cover T.L., Blaser M.J., ... , Taube C., Müller A.
(2018)
Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells
J.Allergy Clin.Immunol.,
143
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Author count: 4
Schmidl C., Delacher M., Hühn J., Feuerer M.
(2018)
Epigenetic mechanisms regulating T-cell responses
J.Allergy Clin.Immunol.,
142
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Author count: 3
Prajeeth C.K., Hühn J., Stangel M.
(2018)
Regulation of neuroinflammatory properties of glial cells by T cell effector molecules
Neural Regen.Res.,
13
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Author count: 13
Uhde A.K., Ciurkiewicz M., Herder V., Khan M.A., Hensel N., Claus P., Beckstette M., Teich R., Floess S., Baumgartner W., Jung K., ... , Hühn J., Beineke A.
(2018)
Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice
Sci.Rep.,
8
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Author count: 32
Lipps C., Klein F., Wahlicht T., Seiffert V., Butueva M., Zauers J., Truschel T., Luckner M., Köster M., MacLeod R., Pezoldt J., Hühn J., Yuan Q., Muller P.P., Kempf H., Zweigerdt R., Dittrich-Breiholz O., Pufe T., Beckmann R., Drescher W., Riancho J., Sanudo C., Korff T., Opalka B., Rebmann V., Gothert J.R., Alves P.M., Ott M., Schucht R., Hauser H., ... , Wirth D., May T.
(2018)
Expansion of functional personalized cells with specific transgene combinations
Nat.Commun.,
9
(1)
Author count: 5
Schmoeckel K., Mrochen D.M., Hühn J., Pötschke C., Bröker B.M.
(2018)
Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree
PLoS ONE,
13
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Author count: 23
Essig K., Hu D., Guimaraes J.C., Alterauge D., Edelmann S., Raj T., Kranich J., Behrens G., Heiseke A., Floess S., Klein J., Maiser A., Marschall S., Hrabe de Angelis M., Leonhardt H., Calkhoven C.F., Noessner E., Brocker T., Hühn J., Krug A.B., Zavolan M., ... , Baumjohann D., Heissmeyer V.
(2017)
Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
Immunity,
47
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Author count: 11
Prajeeth C.K., Kronisch J., Khorooshi R., Knier B., Toft-Hansen H., Gudi V., Floess S., Hühn J., Owens T., ... , Korn T., Stangel M.
(2017)
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties
J.Neuroinflammation.,
14
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Author count: 25
Ranjan S., Goihl A., Kohli S., Gadi I., Pierau M., Shahzad K., Gupta D., Bock F., Wang H., Shaikh H., Kahne T., Reinhold D., Bank U., Zenclussen A.C., Niemz J., Schnoder T.M., Brunner-Weinzierl M., Fischer T., Kalinski T., Schraven B., Luft T., Hühn J., Naumann M., ... , Heidel F.H., Isermann B.
(2017)
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Nat.Commun.,
8
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Author count: 17
Van Ham M., Teich R., Philipsen L., Niemz J., Amsberg N., Wissing J., Nimtz M., Grobe L., Kliche S., Thiel N., Klawonn F., Hubo M., Jonuleit H., Reichardt P., Muller A.J., ... , Hühn J., Jänsch L.
(2017)
TCR signalling network organization at the immunological synapses of murine regulatory T cells
Eur.J.Immunol.,
47
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Author count: 9
Pasztoi M., Pezoldt J., Beckstette M., Lipps C., Wirth D., Rohde M., Paloczi K., ... , Buzas E.I., Hühn J.
(2017)
Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells
Eur.J.Immunol.,
47
(12)
Author count: 7
Kyburz A., Urban S., Altobelli A., Floess S., Hühn J., ... , Cover T.L., Muller A.
(2017)
Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy
Clin.Exp.Allergy
Author count: 14
Szilagyi B.A., Triebus J., Kressler C., de Almeida M., Tierling S., Durek P., Mardahl M., Szilagyi A., Floess S., Hühn J., Syrbe U., Walter J., ... , Polansky J.K., Hamann A.
(2017)
Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells
Mucosal.Immunol.,
10
(6)
Author count: 8
Nikolouli E., Hardtke-Wolenski M., Hapke M., Beckstette M., Geffers R., Floess S., ... , Jaeckel E., Hühn J.
(2017)
Alloantigen-induced regulatory t cells generated in presence of vitamin c display enhanced stability of foxp3 expression and promote skin allograft acceptance
Front.Immunol.,
8
(748)
Author count: 9
Schuster M., Plaza-Sirvent C., Matthies A.M., Heise U., Jeron A., Bruder D., Visekruna A., ... , Hühn J., Schmitz I.
(2017)
c-REL and IkappaBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors
J.Immunol.,
199
(3)
Author count: 11
Niemz J., Kliche S., Pils M.C., Morrison E., Manns A., Freund C., Crittenden J.R., Graybiel A.M., Galla M., ... , Jänsch L., Hühn J.
(2017)
The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells
Eur.J.Microbiol.Immunol.(Bp),
7
(2)
Author count: 9
Ciurkiewicz M., Herder V., Khan M.A., Uhde A.K., Teich R., Floess S., Baumgartner W., ... , Hühn J., Beineke A.
(2017)
Cytotoxic CD8+ T cells ablation enhances the capacity of regulatory T cells to delay viral elimination in Theiler's murine encephalomyelitis
Brain Pathol.,
28
(3)
Author count: 12
Pasztoi M., Bonifacius A., Pezoldt J., Kulkarni D., Niemz J., Yang J., Teich R., Hajek J., Pisano F., Rohde M., ... , Dersch P., Hühn J.
(2017)
Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling
Cell Mol.Life Sci.,
74
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Author count: 16
Garg G., Nikolouli E., Hardtke-Wolenski M., Toker A., Ohkura N., Beckstette M., Miyao T., Geffers R., Floess S., Gerdes N., Lutgens E., Osterloh A., Hori S., Sakaguchi S., ... , Jaeckel E., Hühn J.
(2017)
Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells
Oncotarget.,
8
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Author count: 11
Pezoldt J., Pisano F., Heine W., Pasztoi M., Rosenheinrich M., Nuss A.M., Pils M.C., Prinz I., Forster R., ... , Hühn J., Dersch P.
(2017)
Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection
J Infect.Dis.,
216
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Author count: 2
Beyer M., Hühn J.
(2017)
Epigenetic orchestration of thymic T reg cell development
Nat.Immunol.,
18
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Author count: 13
Noyan F., Zimmermann K., Hardtke-Wolenski M., Knoefel A., Schulde E., Geffers R., Hust M., Hühn J., Galla M., Morgan M., Jokuszies A., ... , Manns M.P., Jaeckel E.
(2016)
Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor
Am J Transplant.,
17
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Author count: 2
Pezoldt J., Hühn J.
(2016)
Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4+ T Cell Differentiation
Eur.J Microbiol.Immunol.(Bp),
6
(3)
Author count: 18
Pink M., Ratsch B.A., Mardahl M., Durek P., Polansky J.K., Karl M., Baumgrass R., Wallner S., Cadenas C., Gianmoena K., Floess S., Chen W., Nordstroem K., Tierling S., Olek S., Walter J., ... , Hamann A., Syrbe U.
(2016)
Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene
J Immunol.,
197
Author count: 10
Uhde A.K., Herder V., Akram Khan M., Ciurkiewicz M., Schaudien D., Teich R., Floess S., Baumgartner W., ... , Hühn J., Beineke A.
(2016)
Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice
PLoS ONE,
11
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Author count: 9
Goldstein J.D., Burlion A., Zaragoza B., Sendeyo K., Polansky J.K., Hühn J., Piaggio E., ... , Salomon B.L., Marodon G.
(2016)
Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression
PLoS ONE,
11
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Author count: 10
Brand S., Kesper D.A., Teich R., Kilic-Niebergall E., Pinkenburg O., Bothur E., Lohoff M., Garn H., ... , Pfefferle P.I., Renz H.
(2012)
DNA methylation of T H1/T H2 cytokine genes affects sensitization and progress of experimental asthma
Journal of Allergy and Clinical Immunology,
129
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Author count: 5
Polansky J.K., Floess S., Freyer J., Hamann A., Hühn J.
(2009)
Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells
(2)
Author count: 8
Milanez-Almeida P., Ulas T., Pasztoi M., Glage S., Schughart K., Lutz M.B., ... , Schultze J.L., Hühn J.
(2015)
CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice
Eur.J Microbiol.Immunol.(Bp),
5
(4)
Author count: 3
Pasztoi M., Pezoldt J., Hühn J.
(2015)
Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells
Prog.Mol.Biol.Transl.Sci,
136
Author count: 18
Klysz D., Tai X., Robert P.A., Craveiro M., Cretenet G., Oburoglu L., Mongellaz C., Flöß S., Fritz V., Matias M.I., Yong C., Surh N., Marie J.C., Hühn J., Zimmermann V., Kinet S., ... , Dardalhon V., Taylor N.
(2015)
Glutamine-dependent a[alpha]-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Sci Signal,
8
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Author count: 15
Yang B.H., Hagemann S., Mamareli P., Lauer U., Hoffmann U., Beckstette M., Fohse L., Prinz I., Pezoldt J., Suerbaum S., Sparwasser T., Hamann A., Floess S., ... , Hühn J., Lochner M.
(2016)
Foxp3+ T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation
Mucosal.Immunol.,
9
Author count: 13
Braun A., Dewert N., Brunnert F., Schnabel V., Hardenberg J.H., Richter B., Zachmann K., Cording S., Classen A., Brans R., Hamann A., ... , Hühn J., Schon M.P.
(2015)
Integrin a[alpha]E(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity
J Invest Dermatol.
Author count: 6
Roesner L.M., Flöß S., Witte T., Olek S., Hühn J., Werfel T.
(2015)
Foxp3 regulatory T cells are expanded in severe atopic dermatitis patients
Allergy: European Journal of Allergy and Clinical Immunology,
70
(12)
Author count: 9
Walter F.R., Veszelka S., Pasztoi M., Peterfi Z.A., Toth A., Rakhely G., Cervenak L., ... , Abraham C.S., Deli M.A.
(2015)
Tesmilifene modifies brain endothelial functions and opens the blood-brain/blood-glioma barrier
J Neurochem.,
134
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Author count: 2
Hühn J., Beyer M.
(2015)
Epigenetic and transcriptional control of Foxp3 regulatory T cells
Semin.Immunol.,
27
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Author count: 4
Hühn J., Floess S., Ohkura N., Sakaguchi S.
(2015)
Comment on "cutting edge: Epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory t cells in tumors from mice and humans"
J.Immunol.,
194
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Author count: 11
Prajeeth C.K., Beineke A., Iskandar C., Gudi V., Herder V., Gerhauser I., Haist V., Teich R., Hühn J., ... , Baumgartner W., Stangel M.
(2014)
Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice
J Neuroinflammation.,
11
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Author count: 4
Milanez-Almeida P., Klawonn F., Meyer-Hermann M., Hühn J.
(2014)
Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen
Eur.J Microbiol.Immunol.(Bp),
4
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Author count: 6
Delacher M., Schreiber L., Richards D.M., Farah C., Feuerer M., Hühn J.
(2014)
Transcriptional control of regulatory T cells
Curr Top.Microbiol.Immunol.,
381
Author count: 9
Yang B.H., Flöß S., Hagemann S., Deyneko I.V., Gröbe L., Pezoldt J., Sparwasser T., ... , Lochner M., Hühn J.
(2015)
Development of a unique epigenetic signature during in vivo Th17 differentiation
Nucleic Acids Res,
43
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Author count: 11
Mayer Christian T., Lahl K., Milanez-Almeida P., Watts D., Dittmer U., Fyhrquist N., Hühn Jochen, Kopf M., Kretschmer K., ... , Rouse B., Sparwasser Tim
(2014)
Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice
Immunity, Inflammation and Disease,
2
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Author count: 10
Franckaert D., Dooley J., Roos E., Flöß S., Hühn J., Luche H., Fehling H.J., Liston A., ... , Linterman M.A., Schlenner S.M.
(2014)
Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3 and Foxp3 T cells
Immunology and Cell Biology,
93
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Author count: 7
Tebartz C., Horst Sarah A., Sparwasser Tim, Hühn Jochen, Beineke A., ... , Peters G., Medina Eva
(2014)
A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection
Journal of Immunology,
194
(3)
Author count: 5
Khailaie S., Robert P.A., Toker A., Hühn J., Meyer-Hermann M.
(2014)
A signal integration model of thymic selection and natural regulatory T cell commitment
Journal of Immunology,
193
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Author count: 5
Milanez-Almeida P., Meyer-Hermann M., Toker A., Khailaie S., Hühn J.
(2014)
Foxp3 regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen
European Journal of Immunology,
45
Author count: 20
Berod L., Friedrich C., Nandan A., Freitag J., Hagemann S., Harmrolfs K., Sandouk A., Hesse C., Castro C.N., Bahre H., Tschirner S.K., Gorinski N., Gohmert M., Mayer C.T., Hühn Jochen, Ponimaskin E., Abraham Wolf-Rainer, Müller Rolf, ... , Lochner M., Sparwasser Tim
(2014)
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
Nature medicine,
20
Author count: 12
Blankenhaus B., Reitz M., Brenz Y., Eschbach M.L., Hartmann W., Haben I., Sparwasser Tim, Hühn J., Kühl A., Feyerabend T.B., ... , Rodewald H.R., Breloer M.
(2014)
Foxp3+ Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice
PLoS Pathogens,
10
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Author count: 7
Schreiber L., Pietzsch B., Flöß S., Farah C., Jänsch L., ... , Schmitz I., Hühn J.
(2014)
The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-?B signaling
PLoS ONE,
9
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Author count: 6
Khailaie Sahamoddin, Bahrami F., Janahmadi M., Milanez-Almeida P., Hühn J., Meyer-Hermann M.
(2013)
A mathematical model of immune activation with a unified self-nonself concept
Frontiers in Immunology,
4
Author count: 11
Prajeeth C.K., Lohr K., Flöß S., Zimmermann J., Ulrich R., Gudi V., Beineke A., Baumgartner W., Muller M., ... , Hühn J., Stangel M.
(2014)
Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia
Brain, Behavior, and Immunity,
37
Author count: 9
Cording S., Fleißner Diana, Heimesaat M.M., Bereswill S., Loddenkemper C., Uematsu S., Akira S., ... , Hamann A., Hühn Jochen
(2013)
Commensal microbiota drive proliferation of conventional and Foxp3 regulatory CD4 T cells in mesenteric lymph nodes and Peyer's patches
European Journal of Microbiology and Immunology,
3
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Author count: 16
Cording S., Wahl B., Kulkarni D., Chopra H., Pezoldt Jörn, Buettner M., Dummer A., Hadis U., Heimesaat M., Bereswill S., Falk C., Bode U., Hamann A., Fleissner D., ... , Hühn Jochen, Pabst O.
(2014)
The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes
Mucosal Immunology,
7
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Author count: 9
Schweer J., Kulkarni D., Kochut A., Pezoldt J., Pisano F., Pils M.C., Genth H., ... , Hühn J., Dersch P.
(2013)
The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases
PLoS Pathogens,
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Author count: 8
Huang Yi-Ju, Haist V., Baumgartner W., Fohse L., Prinz I., Suerbaum S., ... , Flöß S., Hühn J.
(2013)
Induced and thymus-derived Foxp3 regulatory T cells share a common niche
European Journal of Immunology,
44
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Author count: 11
Sledzinska A., Hemmers S., Mair F., Gorka O., Ruland J., Fairbairn L., Nissler A., Müller W., Waisman A., ... , Becher B., Buch T.
(2013)
TGF-b[beta] Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function
PLoS Biology,
11
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Author count: 17
Kreutzfeldt M., Bergthaler A., Fernandez M., Brück W., Steinbach K., Vorm M., Coras R., Blümcke I., Bonilla W.V., Fleige A., Forman R., Müller W., Becher B., Misgeld T., Kerschensteiner M., ... , Pinschewer D.D., Merkler D.
(2013)
Neuroprotective intervention by interferon-? blockade prevents CD8+ T cell-mediated dendrite and synapse loss
Journal of Experimental Medicine,
210
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Author count: 14
Patzelt D., Wang H., Buchholz I., Rohde M., Gröbe L., Pradella S., Neumann A., Schulz S., Heyber S., Munch K., Munch R., Jahn D., ... , Wagner-Döbler I., Tomasch J.
(2013)
You are what you talk: quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae
ISME Journal,
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Author count: 11
Kühlhorn F., Rath M., Schmoeckel K., Cziupka K., Nguyen H.H., Hildebrandt P., Hünig T., Sparwasser Tim, Hühn Jochen, ... , Pötschke C., Bröker B.M.
(2013)
Foxp3+ Regulatory T Cells Are Required for Recovery from Severe Sepsis
PLoS ONE,
8
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Author count: 18
Toker A., Engelbert D., Garg G., Polansky J.K., Floess S., Miyao T., Baron U., Düber S., Geffers R., Giehr P., Schallenberg S., Kretschmer K., Olek S., Walter J., Weiss S., Hori S., ... , Hamann A., Hühn J.
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Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
Journal of Immunology,
190
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Author count: 20
Weiss J.M., Bilate A.M., Gobert M., Ding Y., de Lafaille M.A.C., Parkhurst C.N., Xiong H., Dolpady J., Frey A.B., Ruocco M.G., Yang Y., Flöß S., Hühn J., Oh S., Li M.O., Niec R.E., Rudensky A.Y., Dustin M.L., ... , Littman D.R., Lafaille J.J.
(2012)
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosagenerated induced Foxp3+ T reg cells
Journal of Experimental Medicine,
209
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Author count: 6
Gereke Marcus, Autengruber A., Gröe Lothar, Jeron A., Bruder Dunja, Stegemann-Koniszewski S.
(2012)
Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies
Journal of Visualized Experiments: JoVE
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Author count: 14
Schuster M., Glauben R., Plaza-Sirvent C., Schreiber L., Annemann M., Floess S., Kuhl A.A., Clayton L.K., Sparwasser T., Schulze-Osthoff K., Pfeffer K., Hühn J., ... , Siegmund B., Schmitz I.
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IkappaB(NS) Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor
Immunity,
37
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Author count: 15
Ohkura N., Hamaguchi M., Morikawa H., Sugimura K., Tanaka A., Ito Y., Osaki M., Tanaka Y., Yamashita R., Nakano N., Hühn Jochen, Fehling H.J., Sparwasser Tim*, ... , Nakai K., Sakaguchi S.
(2012)
T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for treg cell development
Immunity,
37
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Author count: 11
Koenecke C., Lee C.W., Thamm K., Fohse L., Schafferus M., Mittrucker H.W., Floess S., Hühn J., Ganser A., ... , Forster R., Prinz I.
(2012)
IFN-gamma Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease
Journal of Immunology,
189
(6)
Author count: 7
König S., Probst-Kepper M., Reinl T., Jeron A., Hühn Jochen, ... , Schraven B., Jänsch Lothar
(2012)
First insight into the kinome of human regulatory T cells
PLoS ONE,
7
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Author count: 12
Herder V., Gerhauser I., Klein S.K., Almeida P., Kummerfeld M., Ulrich R., Seehusen F., Rohn K., Schaudien D., Baumgartner W., ... , Hühn Jochen, Beineke A.
(2012)
Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis
Journal of Neuroimmunology,
249
(1-2)
Author count: 11
Bettini M.L., Pan F., Bettini M., Finkelstein D., Rehg J.E., Floess S., Bell B.D., Ziegler S.F., Hühn J., ... , Pardoll D.M., Vignali D.A.
(2012)
Loss of epigenetic modification driven by the foxp3 transcription factor leads to regulatory T cell insufficiency
Immunity,
36
(5)
Author count: 5
O'Connor R.A., Floess S., Hühn J., Jones S.A., Anderton S.M.
(2012)
Foxp3(+) Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production
European Journal of Immunology,
42
(5)
Author count: 4
Berod L., Puttur F., Hühn Jochen, Sparwasser Tim*
(2012)
Tregs in infection and vaccinology: heroes or traitors?
Microbial Biotechnology,
5
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Author count: 10
Hinz D., Bauer M., Roder S., Olek S., Hühn Jochen, Sack U., Borte M., Simon J.C., ... , Lehmann I., Herberth G.
(2012)
Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year
Allerg: European Journal of Allergy and Clinical Immunology,
67
(3)
Author count: 8
Miyao T., Floess S., Setoguchi R., Luche H., Fehling H.J., Waldmann H., ... , Hühn J., Hori S.
(2012)
Plasticity of foxp3(+) T cells reflects promiscuous foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
Immunity,
36
(2)
Author count: 5
Kahlisch L., Henne K., Gröbe Lothar*, Brettar I., Höfle Manfred G.*
(2011)
Assessing the Viability of Bacterial Species in Drinking Water by Combined Cellular and Molecular Analyses3526
Microbial Ecology,
63
(2)
Author count: 13
Brand S., Teich René*, Dicke T., Harb H., Yildirim A.O., Tost J., Schneider-Stock R., Waterland R.A., Bauer U.M., von Mutius E., Garn H., ... , Pfefferle P.I., Renz H.
(2011)
Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes
Journal of Allergy and Clinical Immunology,
128
(3)
Author count: 9
Blankenhaus B., Klemm U., Eschbach M.L., Sparwasser T., Hühn Jochen*, Kuhl A.A., Loddenkemper C., ... , Jacobs T., Breloer M.
(2011)
Strongyloides ratti infection induces expansion of Foxp3(+) regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice
Journal of Immunology,
186
(7)
Author count: 12
Steinfelder S., Floess S., Engelbert D., Haeringer B., Baron U., Rivino L., Steckel B., Gruetzkau A., Olek S., Geginat J., ... , Hühn J., Hamann A.
(2011)
Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells
Blood,
117
(10)
Author count: 2
Toker A., Hühn Jochen*
(2011)
To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
Science Signaling,
4
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Author count: 6
Mayer C.T., Floess S., Baru A.M., Lahl K., Hühn J., Sparwasser T.
(2011)
CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity
European Journal of Immunology,
41
(3)
Author count: 10
Hubert S., Rissiek B., Klages K., Hühn Jochen*, Sparwasser T., Haag F., Koch-Nolte F., Boyer O., ... , Seman M., Adriouch S.
(2010)
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway
Journal of Experimental Medicine,
207
(12)
Author count: 10
Polansky J.K., Schreiber L., Thelemann C., Ludwig L., Kruger M., Baumgrass R., Cording S., Floess S., ... , Hamann A., Hühn J.
(2010)
Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
Journal of Molecular Medicine,
88
(10)
Author count: 10
Klages K., Mayer C.T., Lahl K., Loddenkemper C., Teng M.W., Ngiow S.F., Smyth M.J., Hamann A., ... , Hühn Jochen*, Sparwasser T.
(2010)
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
Cancer Research,
70
(20)
Author count: 8
Menning A., Loddenkemper C., Westendorf A.M., Szilagyi B., Buer J., Siewert C., ... , Hamann A., Hühn Jochen*
(2010)
Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation
European Journal of Immunology,
40
(9)
Author count: 12
Lahl K., Mayer C.T., Bopp T., Hühn Jochen*, Loddenkemper C., Eberl G., Wirnsberger G., Dornmair K., Geffers Robert*, Schmitt E., ... , Buer J., Sparwasser T.
(2009)
Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice
Journal of Immunology,
183
(9)
Author count: 15
Humrich J.Y., Morbach H., Undeutsch R., Enghard P., Rosenberger S., Weigert O., Kloke L., Heimann J., Gaber T., Brandenburg S., Scheffold A., Hühn Jochen*, Radbruch A., ... , Burmester G.R., Riemekasten G.
(2010)
Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus
Proceedings of the National Academy of Sciences of the United States of America,
107
(1)
Author count: 9
Rausch S., Hühn Jochen*, Loddenkemper C., Hepworth M.R., Klotz C., Sparwasser T., Hamann A., ... , Lucius R., Hartmann S.
(2009)
Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) cells
Europen Journal of Immunology,
39
(11)
Author count: 10
Koenecke C., Czeloth N., Bubke A., Schmitz S., Kissenpfennig A., Malissen B., Hühn Jochen*, Ganser A., ... , Forster R., Prinz I.
(2009)
Alloantigen-specific de novo-induced Foxp3(+) Treg revert in vivo and do not protect from experimental GVHD
European Journal of Immunology,
39
(11)
Author count: 10
Marson A., Kretschmer Karsten*, Frampton G.M., Jacobsen E.S., Polansky J.K., MacIsaac K.D., Levine S.S., Fraenkel E., ... , von Boehmer H., Young R.A.
(2007)
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Nature,
445
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Author count: 10
Lahl K., Loddenkemper C., Drouin C., Freyer J., Arnason J., Eberl G., Hamann A., Wagner H., ... , Hühn Jochen*, Sparwasser T.
(2007)
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
Journal of Experimental Medicine,
204
(1)
Author count: 7
Kroger A., Stirnweiss A., Pulverer J.E., Klages K., Grashoff M., ... , Reimann J., Hauser Hansjörg*
(2007)
Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1
Cancer Research,
67
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Author count: 9
Siewert C., Menning A., Dudda J., Siegmund K., Lauer U., Floess S., Campbell D.J., ... , Hamann A., Hühn J.
(2007)
Induction of organ-selective CD4+ regulatory T cell homing
European Journal of Immunology,
37
(4)
Author count: 6
Menning A., Hopken U.E., Siegmund K., Lipp M., Hamann A., Hühn Jochen*
(2007)
Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets
European Journal of Immunology,
37
(6)
Author count: 14
Baron U., Floess S., Wieczorek G., Baumann K., Grutzkau A., Dong J., Thiel A., Boeld T.J., Hoffmann P., Edinger M., Turbachova I., Hamann A., ... , Olek S., Hühn J.
(2007)
DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
European Journal of Immunology,
37
(9)
Author count: 2
Polansky J.K., Hühn Jochen*
(2007)
[To be or not to be a Treg: epigenetic regulation of Foxp3 expression in regulatory T cells]
Zeitschrift für Rheumatologie,
66
(5)
Author count: 8
Doebis C., Siegmund K., Loddenkemper C., Lowe J.B., Issekutz A.C., Hamann A., ... , Hühn Jochen*, Syrbe U.
(2008)
Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction
American Journal of Pathology,
173
(4)
Author count: 6
Apostolou I., Verginis P., Kretschmer K., Polansky J., Hühn Jochen*, von Boehmer H.
(2008)
Peripherally induced Treg: mode, stability, and role in specific tolerance
Journal of Clinical Immunology,
28
(6)
Author count: 10
Hoffmann P., Boeld T.J., Eder R., Hühn J., Floess S., Wieczorek G., Olek S., Dietmaier W., ... , Andreesen R., Edinger M.
(2009)
Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation
European Journal of Immunology,
39
(4)
Author count: 12
Loddenkemper C., Hoffmann C., Stanke J., Nagorsen D., Baron U., Olek S., Hühn Jochen*, Ritz J.P., Stein H., Kaufmann A.M., ... , Schneider A., Cichon G.
(2009)
Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer
Cancer Science,
100
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Author count: 9
Schaub B., Liu J., Hoppler S., Schleich I., Hühn Jochen*, Olek S., Wieczorek G., ... , Illi S., von Mutius E.
(2009)
Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
Journal of Allergy and Clinical Immunology,
123
(4)
Author count: 20
Wieczorek G., Asemissen A., Model F., Turbachova I., Floess S., Liebenberg V., Baron U., Stauch D., Kotsch K., Pratschke J., Hamann A., Loddenkemper C., Stein H., Volk H.D., Hoffmuller U., Grutzkau A., Mustea A., Hühn J., ... , Scheibenbogen C., Olek S.
(2009)
Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue
Cancer Research,
69
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Author count: 3
Hühn Jochen*, Polansky J.K., Hamann A.
(2009)
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
Nature Reviews Immunology,
9
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