Our service
Customized histo- pathology work for your research:
- Blinded and randomized histo-pathological evaluation (scores) specifically designed for your research question inclusive the interpretation and illustration of your data (approx. 50 projects per year)
- More than 100 antigen specific staining methods for bright field and fluorescence microscopy as single or double staining
- We establish staining methods upon your demand.
- Animal and human tissues as well as cytological samples and even cell cultures can be processed.
Overview of our technical services:
- Fixation using Formaldehyde, Ethanol-Carnoy, HOPE
- Tissue embedding and sectioning in Paraffin, cryo and plastic
- Automated hematoxylin-eosin (HE)- staining
- Histo-chemical staining (i.e. PAS, Masson-Trichrom, Ziehl-Neeslen, Gram staining, …)
- Immun-histo-chemical staining (i.e. CD4, FoxP3, CD11c, Influenza A, MCMV, …)
- Every antibody staining is possible in fluorescence as well
- Double staining (i.e. CD4/Caspase3, CD3/FoxP3), fluorescence and histo-chemical
Our service
Customized histo- pathology work for your research:
- Blinded and randomized histo-pathological evaluation (scores) specifically designed for your research question inclusive the interpretation and illustration of your data (approx. 50 projects per year)
- More than 100 antigen specific staining methods for bright field and fluorescence microscopy as single or double staining
- We establish staining methods upon your demand.
- Animal and human tissues as well as cytological samples and even cell cultures can be processed.
Overview of our technical services:
- Fixation using Formaldehyde, Ethanol-Carnoy, HOPE
- Tissue embedding and sectioning in Paraffin, cryo and plastic
- Automated hematoxylin-eosin (HE)- staining
- Histo-chemical staining (i.e. PAS, Masson-Trichrom, Ziehl-Neeslen, Gram staining, …)
- Immun-histo-chemical staining (i.e. CD4, FoxP3, CD11c, Influenza A, MCMV, …)
- Every antibody staining is possible in fluorescence as well
- Double staining (i.e. CD4/Caspase3, CD3/FoxP3), fluorescence and histo-chemical
Dr Marina Greweling-Pils
Mouse pathology can give us an overview – offer a first glimpse, if you will – of the relationship between the infection and the immune response.
Marina Greweling-Pils studied veterinary medicine at the Hanover Veterinary School and the École Nationale Veterinaire de Lyon (France). After her graduation in 2004, she came to the Helmholtz Centre for her PhD thesis. Her research at the HZI focused on colitis and infections. During her Postdoc at the Hanover Medical School, Dr Greweling-Pils worked on the induction of tolerance in organ transplantation. She returned to the HZI as deputy head of the animal facility in 2009 and since 2011, she is head of the mouse pathology platform.
Team
Selected Publications
Pezoldt, J., et al., Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection. J Infect Dis, 2017. 216(6): p. 752-760.
Plaza-Sirvent, C., et al., c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity. Cell Rep, 2017. 18(1): p. 12-22.
Perner, F., et al., Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function. Leukemia, 2016. 30(4): p. 991-5.
Blazejewski, A.J., et al., Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation. Cell Rep, 2017. 19(11): p. 2319-2330.
Schuster, M., et al., c-REL and IkappaBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors. J Immunol, 2017. 199(3): p. 920-930.
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