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How bacteria imprint the intestinal immune system in newborns
The regulatory T cells (or "Tregs" for short) play a very important role in our immune system: They teach other immune cells which dangerous invaders to attack and which harmless to ignore. In doing so, the Tregs enable the immune cells to be tolerant to foreign…
Joining forces for immune research
“What we have learned about the immune system and its role in many widespread diseases over the last ten years opens up countless perspectives for research," says Prof Martin Lohse, Scientific Director of the Max Delbrück Center for Molecular Medicine (MDC), the centre…
How the body produces an endogenous antibiotic with anti-inflammatory effects
For a long time, itaconic acid was only known as a metabolic product of fungi. Its function was unknown, but for decades it has been used industrially for polymer production. In 2013, it was surprisingly discovered as an important metabolic product in the immune system.…
Ascenion's Portfolio Company WBC Acquired by Klaria
Ascenion’s team has closely worked with the inventors to secure patent protection as a basis for future commercialisation and helped negotiate an exclusive licence between the institutes and WBC. "The take-over by Klaria paves the way for translating the invention into…
Flu vaccination 2.0: Bill and Melinda Gates Foundation supports HZI vaccine research
The Bill & Melinda Gates Foundation is now funding an HZI research project in which neuraminidase is modified to improve stability and promote longer lasting immunity against multiple kinds of influenza viruses. The vision behind this is to develop a universal influenza…
How bacteria produce antibiotics
”To develop bottromycins further, the producing bacteria need to be persuaded to make new versions of bottromycin that have improved properties,“ says Jun.-Prof. Jesko Köhnke, who heads the junior research group ”Structural Biology of Biosynthetic Enzymes“ at HIPS. For…
Big Data: Funding for innovative projects in infection medicine
“Life science research is of paramount importance in Lower Saxony. The continued development of computer technologies and the use of large amounts of data offer enormous potential that can make a decisive impact on people's lives and health, not only in research but…
Humboldt Fellow Peter Fineran visits HIRI
Bacteriophages are viruses that infect bacteria by injecting their genetic material into host cells. This DNA is transcribed and translated into proteins that make up new viral particles. Eventually, the bacterial host cell bursts open and releases new bacteriophages.…
Producing pharmaceutical ingredients from wood
Lignin is a component of wood and endows it with its flexibility. For the production of paper, it needs to be removed in order to prevent yellowing and increase the strength of the paper. That leads to large amounts of unwanted lignin, which has been awaiting…
Helmholtz Young Investigator Group for Mathias Munschauer at HIRI
The human genome contains the information for thousands of lncRNAs. Modern sequencing technologies have shown that a large number of these lncRNAs are activated during infections. “LncRNAs are important regulators of the host response to a pathogen. But how lncRNAs…
