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How pollen increases susceptibility to virus infection
From March to May, birch pollen causes problems for many people. The leafy tree with the white bark is widespread in our part of Europe and triggers symptoms such as rhinitis and watery eyes in allergy sufferers. The health of non-allergy sufferers can also be affected…
Change with age: As bats mature their immune cells differ
Bat immunology remains mysterious. Many zoonoses originate from wildlife and several emerging, high-impact viruses are bat-borne. Despite harboring lethal viruses little is known about the bat immune system. The group of Anca Dorhoi together with colleagues at the…
HIPS and CISPA join forces to make future active ingredients safer
Researchers worldwide are driven by the search for new antibiotics or virostatics that keep multidrug-resistant pathogens at bay or fight new pathogens. If an active ingredient looks promising, it has to be put through its paces before it can be approved for use in…
When editing bacteria with CRISPR, less is more
The ability to genetically manipulate bacteria has been key to exploring the microbial world. Genome editing is crucial for the development of new antibiotics and harnessing bacteria as miniature factories for the sustainable production of chemicals, materials, and…
Bacterial weapons against viral diseases
The COVID-19 pandemic caused by SARS-CoV-2 has challenged healthcare systems around the world in an unprecedented way. The rapid global spread of this pathogen, combined with sometimes severe disease progression, shows how urgently effective drugs are needed to treat…
Novel candidate drug against persistent intestinal pathogen
“Infection with the bacterial pathogen Clostridioides difficile can lead to severe diarrhoeal diseases in humans and animals. Especially so, if the natural microbiome of the intestine is disturbed, for example by previous treatment with a broad-spectrum antibiotic,”…
New cell model for the human lung
Since the 1950s, the ability to grow individual human cells in the laboratory has enabled researchers to investigate new drug candidates in the laboratory without having to conduct tests on animals or even humans. In many cases, the cultured cells are cancer cells. This…
ERC Proof of Concept Grant for Anna Hirsch
The COVID-19 pandemic has highlighted the importance of effective drugs to combat infectious diseases and has led to numerous innovations and developments in antiviral agents. At the same time, however, it may also have provided a significant boost to the spread of…
Disarming pathogens: New drug candidates to combat chronic infections
Although bacteria are among the simplest life forms on our planet, in the course of evolution they have developed ways to communicate efficiently with each other. Unlike humans, their communication is not mediated with words but with chemical signals. This interaction…
Sugar-based inhibitors disarm the pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative bacterium that belongs to the group of highly antibiotic-resistant and clinically relevant ESKAPE pathogens. According to the World Health Organization (WHO), it is one of the critical priority pathogens because it is often…
