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Displaying results 771 to 780 of 1491.
Genome Mining for Secondary Metabolites
The misuse of antibiotics on a global scale has led to an ever-growing antibiotic resistance crisis. Novel antimicrobial compounds are urgently needed. Microorganisms are considered to be one of the most prolific sources for natural product drugs including antibiotics. Developing novel genome mining approaches to harness the potential of the underexplored biosynthetic gene pathways and discover novel microbial natural products, is a potential antibiotic resistance crisis mitigation path. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Experimental Infection Research
If we are attacked by a virus, the immune system reacts within a matter of hours. Highly specialized immune cells recognise the pathogen and release highly efficient messengers, which activate the immune system. These messengers include the interferons, which ensure that individual host cells are mildly infected . At the same time, interferons can also influence the course of the immune response and the memory of the immune system. Without these messengers virus infections - which we normally overcome almost unnoticeably - become fatal within just a few days. The group Experimental Infection Research is based at the TWINCORE in Hannover.
Human-Microbe Systems Bioinformatics
The human body encompasses fewer human cells than microbes. They constantly interact with each other and the host and greatly affect an individual's health and well-being. In our group, we develop and apply state-of-the-art bioinformatics software to study the human-microbe systems and aim to discover natural products involved in communication between the two realms. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Genome Analytics
The Genome Analytics (GMAK) facility provides next-generation sequencing (NGS) technology to the HZI. External users may also have access to the technology, e.g. upon collaborative arrangements. In addition to sample DNA/RNA quality check, library preparation and sequencing, the facility provides primary data processing, data quality check and analysis. A number of pipelines for secondary data processing are established.
Laboratory of Transmission Immunology
Transmission of viruses is only possible during a specific time frame after infection: we can call this the “window of transmission”. A major gap in mitigating (e.g., airborne) transmission and closing this window quickly is the lack of understanding of critical immune determinants of efficient transmission. To be able to close the window of transmission through the design of better mitigation strategies, we develop a mechanistic understanding of the spatial and longitudinal interplay between virus tropism, innate and adaptive immune responses, changes in host physiology, and exhalation or shedding of infectious virus in droplets or fluids.
More than the sum of the parts
Mutations in the genome of viruses or bacteria occur every time the genetic material is replicated and rarely have a positive effect. If they do, they give the pathogen new characteristics. One example of these are the so-called “escape mutations”, which enable a virus…
IBT Lower Saxony: Incubator for Biomedical Innovation awards 1.6 million euros
New startup ideas receive 1.6 million euros boost Three projects each from the Hannover Medical School (MHH), the University Medical Center Göttingen (UMG) and the Helmholtz Center for Infection Research (HZI) in Braunschweig presented their promising ideas with…
MyxoTech takes off
What is the concept of MyxoTech? Nature has historically been a valuable source of small molecule therapeutics. HIPS and HZI have a long tradition of using such molecules as basis for the development of innovative anti-infectives. However, our efforts have generated…
