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Anti-infectives from Microbiota
The department of Prof Christine Beemelmanns focuses on the identification and functional analysis of novel anti-infective natural products from microbial communities. Co-cultivation studies as well as cell-based assays in combination with chemical-analytical and molecular-biological methods are used to evaluate and prioritize novel natural product producers. The department uses established and innovative metabolomic-, activity and genome-based methods to identify and determine the structure of the secreted natural products. Based on the isolated novel natural substances, the functional analysis and evaluation of their range of effects is carried out. This department is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Dr Youssef el Mouali Benomar
Pavaret Sivapornnukul
Microbiome research: Small RNA plays a crucial role in colonization
The intestinal microbiome is a highly complex ecosystem with thousands of different types of bacteria. Live and let live, that is the motto. Harmonious coexistence is based on the fact that intestinal bacteria occupy different niches and communicate with each other.…
Bacterial Infection Ecology
Microbial communities colonise many parts of our bodies, critically impacting our health such as by protecting against pathogens. But how the diverse microbes arrange and organise themselves to generate health effects is largely unknown. To tackle this challenge, we are developing methods to map the structure of the microbiome and resolve how this structure affects health benefits. In addition, we study how microbiota influence and manipulate us, aiming for real translational and clinical potential including the development of probiotic anti-infectives and microbiota-inspired immunotherapeutics.
Perspectives for the Medicine of the Future
What are the molecular causes of diseases? How can AI and data science help us understand them at the cellular level? And how can future pandemics be prevented or mitigated? These are the questions scientists in the Helmholtz Health research field are tackling. At the…
