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Displaying results 161 to 170 of 234.
Antiviral and Antivirulence Drugs
Work in the Empting lab focuses on tackling innovative and difficult-to-address anti-infective targets such as bacterial virulence regulatory systems as well as un(der)explored anti-herpesviral persitance mediators. By this, we aspire to circumvent common resistance mechanisms and to refill the dried out development pipeline. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Antiviral Antibody-Omics
Antibodies are key components of the adaptive immune system and are critical for defending against infectious diseases. In our research group, we strive to gain a better understanding of the mechanisms of antibody-mediated protection, with the ultimate objective of creating novel and more effective vaccine and treatment strategies for infectious diseases. The junior research group is based at TWINCORE in Hannover.
Anti-infectives from Microbiota
The department of Prof Christine Beemelmanns focuses on the identification and functional analysis of novel anti-infective natural products from microbial communities. Co-cultivation studies as well as cell-based assays in combination with chemical-analytical and molecular-biological methods are used to evaluate and prioritize novel natural product producers. The department uses established and innovative metabolomic-, activity and genome-based methods to identify and determine the structure of the secreted natural products. Based on the isolated novel natural substances, the functional analysis and evaluation of their range of effects is carried out. This department is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Innate Immunity and Infection
The moment a pathogen, which has successfully entered the body, is recognized, the body quickly mobilizes its defenses. Interferons are molecules that are counted among the body’s first line of defense. They prevent proliferation and the spread of viruses in the body and serve to alert the immune system. Read here about the different ways we use to try and decode this system, all in an effort to find new approaches to infectious disease prevention and therapy.
Transfer of Knowledge
Transfer of Knowledge The HZI's research program places particular emphasis on the effective transfer of research results into clinical and industrial applications . In addition, the transfer of knowledge to society also plays a major role for us. The…
Biological Barriers
Biological Barriers © HZI/Manfred Rohde Electron micrograph of macrophages. Why is it that you can't just take insulin as a tablet? The answer: Biological barriers. Millions of diabetics have to administer this pancreatic hormone by daily injections.…
Natural Substances
Nature - our medicine cabinet © HZI Promising agar plates: Discovering new drugs in bacterial cultures. The meaning of the term, "natural product", varies depending on perspective: While laymen understand the term to simply mean substances originating from…
System Biology
System biology - it's all about the big picture © HZI/Frank Bierstedt A pipetting robot in the HZI laboratory. The aim of system biologists is to describe the dynamic processes of life and biological systems using mathematical models. Genomics, proteomics,…
Nano-particles
Nano-particles - small, but powerful © HZI/HIPS Electromicroscopic image of nanoparticles. Change the world with tiny particles? Thanks to nanotechnology, it’s not that unrealistic. Nano-particles are so small that they cannot be seen even with a light…
One Health
One Health © AdobeStock/Abdul Momin Livestock market in Bangladesh The Triad of Environmental, Animal and Human Health Infectious diseases have always posed a threat to human health. But perhaps never more than today? “That is a difficult question to…
