Search
Displaying results 31 to 40 of 88.
Student Assistant (m/f/d)
The Purchasing and Materials Management department is looking for a Student Assistant (f/m/d) for up to 50 hours per month.
Doctoral Coordination (m/f/d)
The HZI, Department People and Culture, Team Young Scientists Support, is looking for a PhD Coordinator to start as soon as possible.
Secretary (m/f/d)
The HZI, Department of Structural Systems and Infection Biology is looking for a secretary.
IT System Administrator (m/f/d)
The HZI, TWINCORE site, is looking for an IT system administrator to start as soon as possible.
Doctoral Researcher (f/m/d) – "Deciphering host-pathogen interactions in the context of immune signaling"
The Department of Cellular Immune Signalling is looking for a PhD student.
Postdoc (f/m/d)
The Department of Immune Signalling (IMSI) at the HZI offers the position of a Postdoc (f/m/d).
Molecular Structural Biology
Combating infectious diseases depends critically on a deep understanding of the underlying molecular processes. Structural biology plays a crucial role in advancing biomedicine by providing valuable insights into the structure, function, and interactions of biological macromolecules at the atomic and molecular level. It combines state-of-the-art techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy and cryo-electron microscopy (cryo-EM) as well as advanced computer-based structure prediction methods to elucidate and analyze the three-dimensional structures of proteins, nucleic acids, and other biomolecules. Thus structural biology plays a critical role in infection research by providing a precise view on virulence factors, host-pathogen interactions, and the mechanisms of pathogenesis and host defense, paving the way towards the development of new anti-infectives and vaccines.
RNA Biology of bacterial infections
The Vogel lab strives to chart the diversity of noncoding RNA functions and RNA-binding proteins in major bacterial pathogens and in the hundreds of different bacteria that make up the human microbiome. We develop new RNA deep sequencing-based techniques to capture the RNA world of any microbe, ideally at the single cell level. We want to understand how and why bacteria use RNA as a regulator during infection and exploit this knowledge to target pathogens and edit the microbiota with precision. Projects focus on several bacteria from our major workhorse Salmonella Typhimurium to anaerobic microbes that are associated with colorectal cancer such as Fusobacterium nucleatum. This Department is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
Ecology and Emergence of Zoonoses
Zoonoses, diseases transmitted between animals and humans, substantially threaten human health, but also domestic animals and wildlife. Influenced by climate change, globalization, anthropogenic disturbance and habitat fragmentation, contacts at human-animal interfaces become more frequent, thus increasing the risk of zoonotic emergence and, ultimately, pandemics. Our research aims to understand emergence and ecology of such zoonoses, i.e., how pathogens are transmitted between populations, landscapes and ecosystems. By incorporating data on the biotic and abiotic context of these transmissions, we generate evidence that allows us to contribute to pandemic preparedness and prevention. This department is located at the Helmholtz Institute for One Health (HIOH) .
Nano Infection Biology
Viruses are nanoscale entities. Despite their size and low complexity, they efficiently enter host cells leading to infection and reprogramming of cellular functions. The critical processes involve only a handful of viral and cellular proteins. Yet this contact is critical for the outcome of infection and the cellular immune response. We look at these processes to understand which cellular processes are stimulated by viruses and how the host cell interprets an infecting virus at the molecular level. At the scale of single viruses, these processes, their dynamics and structural conditions remain mostly unclear. We thus use advanced microscopy techniques, which allow us to visualize viral and cellular nanostructures during the infection process.
