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Displaying results 611 to 620 of 673.
Helmholtz Data Science Career Day
At the Helmholtz Data Science Career Day on September 22, 2021, centers and partner institutions will now come together to present career opportunities from PhD to professorship in all research areas to international Data Science talents. The early afternoon conference…
Strengthening of Drug Bioinformatics at the Saarbrücken Site
With additional funding of €100,000, the Klaus Faber Foundation supports Kalinina's project "bioINFpro," which aims to expand drug research through AI-based methods and develop new antibiotics against antibiotic-resistant bacteria. In doing so, the foundation makes a…
Four new junior research groups at the Helmholtz Centre for Infection Research
The ability to react to changes, to survive in existing habitats and to colonize new ones is a prerequisite for prevailing in the course of evolution. These principles of resilience and adaptability, especially in microorganisms, are at the heart of the HZI project…
Jump start for young female scientists
What sparked your interest in pharmaceutical research and how did you come to HIPS in particular? I find pharmaceutical research so exciting because it is so interdisciplinary and translational. When I decided to study pharmacy, I deliberately didn't want to focus on…
On the effectiveness of non-pharmaceutical interventions to combat pathogens
The novel coronavirus known as SARS-CoV-2 first appeared in the Chinese city of Wuhan at the end of 2019 and spread rapidly around the world. The first case in Germany was confirmed in January 2020. In early 2020, SARS-CoV-2 was identified as the cause of the infectious…
Molecular Structural Biology
Combating infectious diseases depends critically on a deep understanding of the underlying molecular processes. Structural biology plays a crucial role in advancing biomedicine by providing valuable insights into the structure, function, and interactions of biological macromolecules at the atomic and molecular level. It combines state-of-the-art techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy and cryo-electron microscopy (cryo-EM) as well as advanced computer-based structure prediction methods to elucidate and analyze the three-dimensional structures of proteins, nucleic acids, and other biomolecules. Thus structural biology plays a critical role in infection research by providing a precise view on virulence factors, host-pathogen interactions, and the mechanisms of pathogenesis and host defense, paving the way towards the development of new anti-infectives and vaccines.
RNA Biology of bacterial infections
The Vogel lab strives to chart the diversity of noncoding RNA functions and RNA-binding proteins in major bacterial pathogens and in the hundreds of different bacteria that make up the human microbiome. We develop new RNA deep sequencing-based techniques to capture the RNA world of any microbe, ideally at the single cell level. We want to understand how and why bacteria use RNA as a regulator during infection and exploit this knowledge to target pathogens and edit the microbiota with precision. Projects focus on several bacteria from our major workhorse Salmonella Typhimurium to anaerobic microbes that are associated with colorectal cancer such as Fusobacterium nucleatum. This Department is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
Ecology and Emergence of Zoonoses
Zoonoses, diseases transmitted between animals and humans, substantially threaten human health, but also domestic animals and wildlife. Influenced by climate change, globalization, anthropogenic disturbance and habitat fragmentation, contacts at human-animal interfaces become more frequent, thus increasing the risk of zoonotic emergence and, ultimately, pandemics. Our research aims to understand emergence and ecology of such zoonoses, i.e., how pathogens are transmitted between populations, landscapes and ecosystems. By incorporating data on the biotic and abiotic context of these transmissions, we generate evidence that allows us to contribute to pandemic preparedness and prevention. This department is located at the Helmholtz Institute for One Health (HIOH) .
