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Displaying results 121 to 130 of 231.
Single-cell Analysis
Pathogenic bacteria can reside in a mammalian host for a life-long period and chronic carriers form a reservoir leading to recurrent infections. Despite the importance of chronic infections for public health, how a subset of pathogens escape the host’s immune surveillance and how the host contains the spread of bacteria are still poorly understood. Scientists within the Single-Cell Analysis group develop and use single-cell transcriptomics and computational approaches to decipher the microenvironments of individual pathogens and ultimately their functional consequences on infection outcome. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
Chemical Biology
In their ongoing quest for new therapies against pathogens, scientists are focusing primarily on chemical agents. Discovering new bioactive compounds, characterising their functionality and optimising their properties are the three main goals of the Department of Chemical Biology (CBIO) at the HZI.
Biological Barriers and Drug Delivery
While considering the confusing flood of drugs in the pharmacies it is hard to believe in a lack of medication. But there are still many infectious diseases and also cancer that cannot be treated sufficiently. During a medical treatment it is essential that the drug arrives at the envisaged body region. Read more about the research of the department “Biological Barriers and Drug Delivery” on techniques for the correct distribution of novel drugs. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Anti-infectives from Microbiota
The department of Prof Christine Beemelmanns focuses on the identification and functional analysis of novel anti-infective natural products from microbial communities. Co-cultivation studies as well as cell-based assays in combination with chemical-analytical and molecular-biological methods are used to evaluate and prioritize novel natural product producers. The department uses established and innovative metabolomic-, activity and genome-based methods to identify and determine the structure of the secreted natural products. Based on the isolated novel natural substances, the functional analysis and evaluation of their range of effects is carried out. This department is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Transfer of Knowledge
Transfer of Knowledge The HZI's research program places particular emphasis on the effective transfer of research results into clinical and industrial applications . In addition, the transfer of knowledge to society also plays a major role for us. The…
Biological Barriers
Biological Barriers © HZI/Manfred Rohde Electron micrograph of macrophages. Why is it that you can't just take insulin as a tablet? The answer: Biological barriers. Millions of diabetics have to administer this pancreatic hormone by daily injections.…
Natural Substances
Nature - our medicine cabinet © HZI Promising agar plates: Discovering new drugs in bacterial cultures. The meaning of the term, "natural product", varies depending on perspective: While laymen understand the term to simply mean substances originating from…
System Biology
System biology - it's all about the big picture © HZI/Frank Bierstedt A pipetting robot in the HZI laboratory. The aim of system biologists is to describe the dynamic processes of life and biological systems using mathematical models. Genomics, proteomics,…
Nano-particles
Nano-particles - small, but powerful © HZI/HIPS Electromicroscopic image of nanoparticles. Change the world with tiny particles? Thanks to nanotechnology, it’s not that unrealistic. Nano-particles are so small that they cannot be seen even with a light…
