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Mpox/Monkeypox - What the HZI experts say
Monkeypox virus (MPXV) is related to the eradicated smallpox virus. Despite the name, monkeys are not the natural reservoir of the virus. Instead, rodents are probably the reservoir from which monkeys can also contract the virus. It is currently unknown via which…
Paths into the unknown
EM started in 1982 at the former Gesellschaft für Biotechnologische Forschung (GBF) and in 1989 moved into a new building, which presented a major challenge in itself: The floors of the new building were covered with vibrating screed, which is not suitable for…
Integrative Informatics for Infection Biology
Recent years have seen accelerating development of high-throughput technologies in infection biology. Now, thousands of genetic loci can be simultaneously interrogated in a single experiment, providing an array of measurements of transcription, translation, regulatory interactions, and fitness effects. The bottleneck in advancing our understanding of pathogens now lies in moving from hypothesis-free screening through data integration to hypothesis generation. We develop new statistical, computational, and visualization approaches to overcome this bottleneck in the interpretation of complex post-genomic data. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
Microbial Proteomics
A genome contains all the information that is needed to build an organism like, for instance, a bacterium. One of functional genomics’ central questions is: How are these blueprints implemented so that relatively simple molecular codes ultimately give rise to a microorganism with the potential of getting us sick? What are some of the underlying mechanisms and under what conditions do they become activated?
Microbial Interactions and Processes
Microorganisms in the environment are living in complex and interacting communities. Also the surfaces of the human body are inhabited by microorganisms, where the bacterial cell number significantly exceeds that of the human cells. These communities have co-evolved with the human host and are important for human health. They can, however, also be a reservoir for pathogenic microorganisms.
Hair follicle models from the 3D printer
Hair follicles are complex structures that surround the hair root, anchoring it to the skin and giving the hair its hold. At the same time, the area between the skin and the follicle provides optimal conditions for microorganisms to multiply unhindered. This often leads…
Making sense of the data jungle
Antibiotic resistance is rising worldwide and poses a major challenge to healthcare systems. Understanding the underlying processes of how and why some bacteria develop such defenses is critical. Differences in bacterial gene expression—in which the information in a…
Chemical Biology
In their ongoing quest for new therapies against pathogens, scientists are focusing primarily on chemical agents. Discovering new bioactive compounds, characterising their functionality and optimising their properties are the three main goals of the Department of Chemical Biology (CBIO) at the HZI.
Biological Barriers and Drug Delivery
While considering the confusing flood of drugs in the pharmacies it is hard to believe in a lack of medication. But there are still many infectious diseases and also cancer that cannot be treated sufficiently. During a medical treatment it is essential that the drug arrives at the envisaged body region. Read more about the research of the department “Biological Barriers and Drug Delivery” on techniques for the correct distribution of novel drugs. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
