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Displaying results 41 to 50 of 83.
Laboratory of Transmission Immunology
Transmission of viruses is only possible during a specific time frame after infection: we can call this the “window of transmission”. A major gap in mitigating (e.g., airborne) transmission and closing this window quickly is the lack of understanding of critical immune determinants of efficient transmission. To be able to close the window of transmission through the design of better mitigation strategies, we develop a mechanistic understanding of the spatial and longitudinal interplay between virus tropism, innate and adaptive immune responses, changes in host physiology, and exhalation or shedding of infectious virus in droplets or fluids.
Core Facility of Comparative Medicine
To be able to investigate diseases, understand the relationships between pathogens and their host and to develop novel strategies against pathogens, the scientists at the HZI depend on experiments that involve the use of laboratory animals. For this purpose, the HZI operates a central animal facility on campus. The primary task of this service unit is the breeding and keeping of laboratory mice as well as provision of services for the scientists of the HZI, centered around laboratory animal science.
Viral Immunology
“Back then, I wasn’t ill so often”: With advancing age not only the skin loses its elasticity – many organs lose their functions. So does the immune system: Defense cells do not react promptly anymore, and immunological memory is not established. As a result, we are poorly protected by vaccines and more susceptible to infections, but at the same time suffer from inflammatory disease. While the mechanisms of immune aging remain unknown, chronic viral infections are environmental factors that may accelerate the age-related changes of the immune system. Read more about how pathogens may have an impact on the real age of our immune system.
Drug Design and Optimization
In order to combat the increasing number of resistant pathogens, the development of new anti-infective drugs is an important goal for pharmaceutical research. Efficient medications with novel modes-of-action to fight infectious diseases are urgently needed. Below, you may read more about the design, identification and optimisation of new drug candidates. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) .
Drug Bioinformatics
Bioinformatics is instrumental in all areas of molecular biology, from analysis of genome sequences towards predicting three-dimensional structure of drug-target complexes. We apply cutting-edge bioinformatics and computer science techniques for discovery of novel resistance mechanisms and predicting mode-of-action of bioactive compounds. This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Central Facility for Microscopy
Light microscopy and electron microscopy are excellent high resolution tools to investigate the adhesion and invasion mechanisms of pathogenic bacteria. High resolution electron microscopy permits to examine and unravel pathogenicity mechanisms on a morphological basis. ZEIM offers equipment and highly sophisticated expertise for the preparation and observation of biological samples.
Postdoc with focus on translational activities: clinical development of a method to assess cancer risk and immune defects (m/w/d)
The PERI department, headed by Prof Dr Kathrin de la Rosa, is offering a postdoctoral position.
Postdoc that combines science and management: B cells and antibodies for novel solutions in infectious diseases (m/w/d)
The PERI department, headed by Prof Dr Kathrin de la Rosa, is offering a postdoctoral position.
Head (f/m/d) of the ‘Corporate Controlling’ team
The ‘Finance and Controlling’ department is looking for a manager for the ‘Corporate Controlling’ team
Employee / Research Officer - EU/national/international (f/m/d)
The department External Funding Acquisition is looking for a Research Officer to start as soon as possible.
