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Displaying results 71 to 80 of 83.
Postdoc with focus on translational activities: clinical development of a method to assess cancer risk and immune defects (m/w/d)
The PERI department, headed by Prof Dr Kathrin de la Rosa, is offering a postdoctoral position.
Postdoc that combines science and management: B cells and antibodies for novel solutions in infectious diseases (m/w/d)
The PERI department, headed by Prof Dr Kathrin de la Rosa, is offering a postdoctoral position.
Head (f/m/d) of the ‘Corporate Controlling’ team
The ‘Finance and Controlling’ department is looking for a manager for the ‘Corporate Controlling’ team
Employee / Research Officer - EU/national/international (f/m/d)
The department External Funding Acquisition is looking for a Research Officer to start as soon as possible.
Masterstudent (m/f/d)
The Helmholtz Centre for Infection Research (HZI), Department of Respiratory Infection Dynamics (DINF), led by Prof. Dr. med. Hortense Slevogt, is seeking a master's student to join the team at the earliest opportunity.
Technical Assistance (f/m/d)
The junior research group CPIC, headed by Dr Milan Gerovac, is looking for a technical assistant.
Genome Architecture and Evolution of RNA Viruses
RNA viruses are a major threat to human health and responsible for millions of deaths each year. Their replication is orchestrated by the RNA genome, which encodes for viral proteins needed to hijack the host cell. Traditionally, infectious disease research has focused on blocking viral replication by inhibiting these proteins. However, we now appreciate that the genomes of RNA viruses are not just passive carriers of protein coding information, but active participants in the viral infection process through the action of non-coding RNA. We study the structure and function of viral non-coding RNA, with the goal of harnessing the resulting knowledge in the design of next generation RNA-based therapies. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI) .
Single-cell Analysis
Pathogenic bacteria can reside in a mammalian host for a life-long period and chronic carriers form a reservoir leading to recurrent infections. Despite the importance of chronic infections for public health, how a subset of pathogens escape the host’s immune surveillance and how the host contains the spread of bacteria are still poorly understood. Scientists within the Single-Cell Analysis group develop and use single-cell transcriptomics and computational approaches to decipher the microenvironments of individual pathogens and ultimately their functional consequences on infection outcome. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
Virology and Innate Immunity
Pathogens (germs) infiltrate our bodies daily but do not remain undetected. They encounter the strong defenses of our immune system, which recognizes invaders and promptly takes appropriate measures. However, many pathogens can produce life-long infections even with an intact immune system. The herpesvirus family is one such group of pathogens. Upon infection, herpesviruses establish a chronic infection and become lifelong companions.
Immune Regulation
Due to their physiological functions our mucosal surfaces are in direct contact to the environment and thus represent the major port of entry for pathogens. To protect the body from severe infections an effective mucosal immune system is indispensable. We are studying respiratory tract infections with the focus on influenza and pneumococci, which represent the most frequent viral and bacterial infectious agents for pneumonia in humans. A major focus of our research is to study molecular and cellular processes during coinfection with influenza and pneumococci and here in particular the immunological functions of the alveolar epithelium in host defense.
