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Cas12a-Nukleasen sind leistungsstarke Werkzeuge zur Genombearbeitung, erfordern jedoch ein PAM neben jeder ausgewählten Zielsequenz. Beisels Forschungsgruppe fand heraus, dass zwei sehr ähnliche Cas12a-Nukleasen unterschiedliche PAMs erkennen können.
News
CRISPR technologies are revolutionary genome-editing tools that rely on molecular scissors called Cas nucleases to cut DNA. While these scissors can be programmed to cut virtually any sequence, that target must be...
07.05.2020
Der Virologe Luka Cicin-Sain erforscht SARS-CoV-2-neutralisierende Antikörper, die von der Technischen Universität Braunschweig und YUMAB isoliert wurden.
News
Neutralizing antibodies are the interceptors of our immune system. They bind precisely to pathogens and prevent them from entering our cells. After an infection, the immune system needs about two weeks to produce mature...
07.05.2020
Katharina Rox in the lab
Story
The Pharmacokinetics/Pharmacodynamics unit (PK/PD unit) at the Helmholtz Centre for Infection Research (HZI) in Braunschweig investigates the potential of drug candidates against pathogens, using special testing...
06.05.2020
How susceptible are small children to the new coronavirus? Tests on 500 LöwenKIDS are underway.
News
Currently, little is known about children and their susceptibility to the new coronavirus. It has been observed that young children have rarely presented with COVID-19 up to now. No specific investigations have been...
28.04.2020
In der weltweit größten Substanz-Repurposing-Bank „ReFrame“ suchen Wissenschaftler nach Medikamenten gegen COVID-19.
News
Innovations based on proven active ingredients, new indications for established drugs – the principle of repurposing has often led to success in medicine. This is why it is also used against SARS-CoV-2: In order to...
24.04.2020
Flagella that protrude from bacterial cells
News
Several whip-like appendages, called the flagella, protrude from the body of bacteria such as Salmonella Typhimurium. It has long been understood that the flagella are responsible for bacterial motility, which enables...
24.04.2020
Der Leiter der Zentralen Einrichtung für Molekulare Diagnostik (ZEM) im Institut für Pathologie, Dr. Horst Hannig.
News
Außergewöhnliche Situationen bringen die Menschen näher zusammen. Das gilt aktuell in unserer Region. Während sich das Klinikum Braunschweig auf große Herausforderungen einstellt, ist die Hilfsbereitschaft von...
21.04.2020
Bakterien der Art Pseudomonas aeruginosa sind äußerst widerstandfähig und kommen fast überall vor.
News
Scientists at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) have developed a strategy to administer antibacterial agents in a way that makes them many times more effective. Their results give rise...
17.04.2020