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Integrative Informatics for Infection Biology
Recent years have seen accelerating development of high-throughput technologies in infection biology. Now, thousands of genetic loci can be simultaneously interrogated in a single experiment, providing an array of measurements of transcription, translation, regulatory interactions, and fitness effects. The bottleneck in advancing our understanding of pathogens now lies in moving from hypothesis-free screening through data integration to hypothesis generation. We develop new statistical, computational, and visualization approaches to overcome this bottleneck in the interpretation of complex post-genomic data. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI).
Genome Architecture and Evolution of RNA Viruses
RNA viruses are a major threat to human health and responsible for millions of deaths each year. Their replication is orchestrated by the RNA genome, which encodes for viral proteins needed to hijack the host cell. Traditionally, infectious disease research has focused on blocking viral replication by inhibiting these proteins. However, we now appreciate that the genomes of RNA viruses are not just passive carriers of protein coding information, but active participants in the viral infection process through the action of non-coding RNA. We study the structure and function of viral non-coding RNA, with the goal of harnessing the resulting knowledge in the design of next generation RNA-based therapies. This group is located at the Helmholtz Institute for RNA-based Infection Research (HIRI) .
Microbial Proteomics
A genome contains all the information that is needed to build an organism like, for instance, a bacterium. One of functional genomics’ central questions is: How are these blueprints implemented so that relatively simple molecular codes ultimately give rise to a microorganism with the potential of getting us sick? What are some of the underlying mechanisms and under what conditions do they become activated?
Microbial Interactions and Processes
Microorganisms in the environment are living in complex and interacting communities. Also the surfaces of the human body are inhabited by microorganisms, where the bacterial cell number significantly exceeds that of the human cells. These communities have co-evolved with the human host and are important for human health. They can, however, also be a reservoir for pathogenic microorganisms.
Dr Lothar Gröbe
Dr Lothar Gröbe Head of Research Group +49 531 6181-3073 E-Mail Dr Lothar Gröbe Lothar Gröbe studied biology at the University of Braunschweig. He worked as PhD student at the GBF, the ancestor of the HZI, and received his PhD about the „Interaction of the…
Purchasing
Purchasing All orders and procurements at the Helmholtz Centre for Infection Research are handled centrally by the Purchasing & Materials Management department. As a service provider for science, our aim is to realise both economical and optimal solutions…
Dr Marina Greweling-Pils
Dr Marina Greweling-Pils Head of Research Group +49 531 6181-3800 E-Mail Dr Marina Greweling-Pils Marina Greweling-Pils studied veterinary medicine at the Hanover Veterinary School and the École Nationale Veterinaire de Lyon (France). After her graduation…
Hair follicle models from the 3D printer
Hair follicles are complex structures that surround the hair root, anchoring it to the skin and giving the hair its hold. At the same time, the area between the skin and the follicle provides optimal conditions for microorganisms to multiply unhindered. This often leads…
