How Long COVID develops is still largely unknown. New molecular connections are revealed in a recent study led by the Centre for Individualised Infection Medicine (CiiM). Using their approach of examining different molecular levels within individual cells, the researchers identified a specific condition in immune cells that was directly associated with elevated inflammation markers, fatigue, and respiratory problems in patients with Long COVID. The study was published in the journal Nature Immunology. The CiiM is a joint institution of the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH).

The Helmholtz Association is kicking off 2026 with new research initiatives on strategic future topics to bring technological breakthroughs into practical application more quickly. The Helmholtz initiatives “Biomedical Engineering Initiative,” “Water Safety and Security Initiative,” and “Quantum Use Challenge” are generating innovative solutions – from needle-free blood glucose measurement via wearables to quantum sensors for more powerful batteries and innovative concepts for water management in large cities. The initiatives are being developed in close cooperation with partners from politics, business, and society and address key technologies and strategic research areas of the German government’s High-Tech Agenda. Four projects of the Helmholtz Centre for Infection Research (HZI) and its sites in Greifswald, Saarbrücken and Würzburg are part of the new research campaigns.

For decades, tuberculosis (TB) has been one of the deadliest infectious diseases worldwide. Resistant strains of Mycobacterium tuberculosis are particularly problematic, as many established drugs are becoming increasingly ineffective against them. However, a research team from the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and Saarland University has now discovered a new family of natural substances that exhibit excellent activity against the TB pathogen. They have also investigated these substances so comprehensively that targeted further development is possible for the first time. The researchers have now published their findings in the journal Angewandte Chemie International Edition.