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Study authors Maureen Obara and Dr Matthias Bruhn

News

Monoclonal antibodies against SARS-CoV-2 were considered a promising approach for the prevention and therapy of corona virus infections. However, the ongoing evolution of the virus regularly produces new variants that are no longer neutralized by the antibodies. Researchers from TWINCORE, together with partners from Hanover and Bern, have now been able to clarify the underlying mechanism in more detail. The TWINCORE is a joint institution of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and Hannover Medical School (MHH). Instead of using a single antibody, they propose the combination of several antibodies for treatment. They have published their findings in the scientific journal eBioMedicine.

26.05.2025

TWINCORE

News

Decisions have been made on future Clusters of Excellence in the second round of competition under the Excellence Strategy – the joint initiative of the federal and state governments to further strengthen top-level research at universities in Germany. The Helmholtz Centre for Infection Research (HZI) is part of two of the funded Clusters of Excellence together with university partners: RESIST and NUCLEATE. RESIST at Hannover Medical School (MHH) will receive funding for another seven years. In this cluster, scientists are investigating how people who are susceptible to infection can be better protected. In the newly approved NUCLEATE cluster at the Julius-Maximilians-Universität Würzburg (JMU) with the Technical University of Munich and the Ludwig-Maximilians-Universität München, group leaders from the Helmholtz Institute for RNA-based Infection Research (HIRI), a site of the HZI in cooperation with the JMU, are conducting research into nucleic acid-based therapies. A total of 70 Clusters of Excellence were selected for funding.

26.05.2025

HZI Campus

TWINCORE

CiiM

HIRI

News

Bats are known as natural hosts for highly pathogenic viruses such as MERS- and SARS-related coronaviruses, as well as the Marburg and Nipah viruses. In contrast to the severe and often fatal disease outcomes these viruses cause in humans, bats generally do not show obvious signs of viral illness following infection. An international research team led by Dr. Max Kellner and Prof. Josef Penninger, Scientific Director of the Helmholtz Centre for Infection Research (HZI), has developed an innovative organoid research platform that allowed them to closely investigate the cellular antiviral defense mechanisms of mucosal epithelial tissues of bats. The results have now been published in Nature Immunology and could pave the way for the development of new therapies against viral diseases.

21.05.2025

HZI Campus

News

Yesterday, the biomedical project forge of the state of Lower Saxony reviewed the most promising ideas from across the region and selected the winners: At the fourth portfolio conference of the Institute for Biomedical Translation (IBT) Lower Saxony, a high-caliber jury selected projects from the Helmholtz Centre for Infection Research (HZI) in Braunschweig, the University Medical Center Göttingen (UMG) and TWINCORE - Centre for Experimental and Clinical Infection Research, which will receive funding of almost 3 million euros. TWINCORE is a joint institution of the HZI and Hannover Medical School (MHH). A total of 25 million euros will be available to the IBT Lower Saxony until 2028 to accelerate the transfer of cutting-edge research in the life sciences in Lower Saxony and bring it to the world in the form of start-ups and entrepreneurial ideas.

14.05.2025

HZI Campus

TWINCORE

CiiM

Analysis of natural products using liquid chromatography.

News

Natural products are among the most promising candidates for the development of new drugs. However, due to their structural complexity, they are often difficult to access. A team headed by Tobias Gulder from the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has now developed new synthetic strategies for the class of polycyclic tetramate macrolactams (PoTeMs), a group of natural products with a broad spectrum of biological activities. In addition to chemical synthesis, enzymatic catalysis and genetic engineering approaches were used. The strategies established in this way not only allow PoTeMs to be produced in large quantities, but also to modify their carbon structure and thus their pharmaceutical properties. The researchers published their results in the journal Angewandte Chemie International Edition, among others.

12.05.2025

HIPS

News

Influenza viruses are among the most likely triggers of future pandemics. A research team from the Helmholtz Centre for Infection Research (HZI) and the Medical Center - University of Freiburg has developed a method that can be used to study the interaction of viruses with host cells in unprecedented detail. With the help of their new development, they have also analyzed how novel influenza viruses use alternative receptors to enter target cells. The results were recently published in two papers in the journal Nature Communications.

07.05.2025

HZI Campus

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HZI in the media

Medicine (CiiM), which is a joint institution of the Helmholtz Center for Infection Research (HZI) and Hannover Medical School (MHH). Using

29.01.2026

Medical Xpress

... stumpfen ab“, erklärt Marc Brönstrup vom Helmholtz-Zentrum für Infektionsforschung in Braunschweig. Neue Antibiotika sind dringend ...

27.01.2026

Tvinfo.de

entered an exclusive research partnership with the Helmholtz Centre for Infection Research’s HIPS institute to investigate how the skin

22.01.2026

Simply Wall St News

... der MHH, des TWINCORE Hannover und des Helmholtz-Instituts für Infektionsforschung (HZI). Ihre wissenschaftliche Expertise ...

21.01.2026

hannover.de

... auch Teil des Ecoversity-Programms der Technischen Universität Braunschweig.

GN De hlth| Source | domain www.helmholtz-hzi.

20.01.2026

Die heutigen Nachrichten

... validierte Daten der MHH und des Helmholtz-Zentrum für Infektionsforschung (HZI), die zeitnah in Fachjournalen veröffentlichet ...

19.01.2026

wallstreet:online

institutions, including Hannover Medical School and the Helmholtz Centre for Infection Research in Germany, the University of Duisburg Essen

18.01.2026

Thailandmedical

Lange , Kommissarische Leiterin der Abteilung Epidemiologie am Helmholtz-Zentrum für Infektionsforschung (HZI), Braunschweig, gegenüber dem

16.01.2026

Medscape

... maßgeblich vorantreiben. In Zusammenarbeit mit dem Braunschweiger Helmholtz-Zentrum für Infektionsforschung (HZI) und der Utah State ...

16.01.2026

IT Boltwise

... Deutschen Zentrum für Neurodegenerative Erkrankungen, am Helmholtz-Zentrum für Infektionsforschung und am Max-Delbrück-Centrum für ...

16.01.2026

Handelsblatt

Das interdisziplinäre Team aus TWINCORE , Helmholtz Zentrum für Infektionsforschung (HZI) und der Medizinischen Hochschule Hannover ( ...

15.01.2026

Arzt & Wirtschaft

Manche fordern Placebo-kontrollierte Vergleiche von Geimpften und Ungeimpften, um die Sicherheit der Masern-Impfung zu testen. ...

15.01.2026

BR Bayerischer Rundfunk

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