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The Federal Ministry of Health (BMG) has appointed new members to the Standing Committee on Vaccination (STIKO). Among the 19 experts is Dr Berit Lange, acting head of the department “Epidemiology” at the Helmholtz Centre for Infection Research (HZI) in Braunschweig. The STIKO is an independent, voluntary committee of experts with the aim of developing vaccination recommendations for the population in Germany. The newly appointed STIKO will hold its inaugural meeting on March 12 and 13, 2024.

The respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, particularly in young children. To date, there is neither an antiviral therapy against the virus nor a vaccination for children. This is why researchers led by Thomas Pietschmann at TWINCORE, a joint institution of Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI) in Braunschweig, are looking for new active substances against RSV. In a large-scale study, they have now identified lonafarnib as a promising candidate. They have published their results in the journal Nature Communications.

Researchers from the Würzburg Helmholtz Institute for RNA-based Infection Research (HIRI) deployed CRISPR interference for the first time for the functional characterization of the gut mutualist Bacteroides thetaiotaomicron. They identified a small ribonucleic acid (sRNA) that modulates the microorganisms' growth in the presence of bile. The findings should contribute to a better understanding of the bacterium’s lifestyle in its native environment, the human intestine, and to the development of clinical applications. The study was published in the journal PNAS.

As Alliance of Science Organisations in Germany, we emphatically condemn all and any anti-democratic and inhumane endeavours. We vehemently reject the racist statements that have circulated in recent weeks. They are in no way compatible with the values of our organisations. United, we oppose them in the clearest possible terms.

On Friday, February 2, 2024, the German Research Foundation (DFG) and the German Council of Science and Humanities (WR) announced which proposals for new Clusters of Excellence will be invited to submit full proposals. Saarland University (UdS) has successfully cleared this first hurdle with its proposal "nextAID³ - Next Generation of Al-driven Drug Discovery and Development".

The interplay between ribonucleic acid (RNA) and proteins is not only important for maintaining cellular homeostasis but is also at the center of the tug-of-war between virus and host. Until now, there has been no method to globally map direct interactions of individual RNA regions in an unbiased fashion without the need for genetic modification of the target RNA or cell. Researchers from the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg and the Broad Institute of MIT and Harvard in the US have now developed a breakthrough tool that overcomes this limitation. Their findings were recently published in the journal Nucleic Acids Research.