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The nuclease Cas13b associated with CRISPR defense systems—also known as genetic scissors—has the potential to be used in the future in hereditary diseases to silence adverse genes. In the fight against infections, it is also being researched as an antiviral agent, as Cas13b can target the genome of viruses and render them harmless. Despite these promising features, researchers are looking for nuclease inhibitors that can control or stop such activities. The aim is to increase the safety and efficacy of future therapies and to help prevent off-target effects. An international team led by the Helmholtz Institute in Würzburg in cooperation with the University of Freiburg has now applied deep learning for the first time to find natural nuclease inhibitors. The study, published today in the scientific journal "Molecular Cell", identified the first such inhibitor that blocks the activity of Cas13b.

31.05.2022

HIRI

Story

Since mid-May 2022, several countries where mpox/monkeypox is not endemic have reported an accumulation of infections with the monkeypox virus. Cases have also been diagnosed in Germany, as of May 2023 around 3700 infections were recorded. Researchers at the Helmholtz Centre for Infection Research (HZI) are contributing their expertise to assessing the current situation and informing the public.

24.05.2022

HZI Campus

HIOH

Elektronenmikroskopische Aufnahme von Staphylococcus aureus

News

The detection of bacterial pathogens in clinical samples is an important prerequisite for successful antimicrobial treatment. A team from the Helmholtz Centre for Infection Research (HZI) in Braunschweig, the German Center for Infection Research (DZIF) and Tel Aviv University, Israel, has now developed molecular probes that can detect different bacterial species with high sensitivity. Bacterial cells activate the probes and make them glow. This signal enables pathogen detection directly in clinical samples. The results were published in the journal Angewandte Chemie.

12.05.2022

HZI Campus

News

With numerous supporters and cooperation partners, the Helmholtz Institute for RNA-based Infection Research (HIRI) Würzburg celebrated its fifth anniversary today, May 10. The location of the Helmholtz Centre for Infection Research (HZI) in Braunschweig in cooperation with the Julius-Maximilians-Universität (JMU) Würzburg had invited about 200 guests from science, politics, ministries and authorities to the Würzburg Residence. Together, they celebrated achievements to date and looked ahead to the institute's upcoming projects. Among the guests congratulating the institute was Ilse Aigner, President of the Bavarian State Parliament.

10.05.2022

HIRI

Story

HZI researchers traveled to Yaoundé, Cameroon, for a workshop on the collection, culture and identification of fungal strains. A new research hub will strengthen natural product research in fungi in the country.

03.05.2022

HZI Campus

News

The Helmholtz Institute for One Health (HIOH) was ceremoniously founded on 26 April 2022 in Greifswald. The HIOH is a new institute of the Helmholtz Centre for Infection Research (HZI) in Braunschweig, which is being established together with the University of Greifswald, the Greifswald University Medicine and the Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health (FLI) as local founding partners. The founding director is the veterinarian and microbiologist Prof Fabian Leendertz. Research at the new institute will focus on the threats posed by the emergence of pathogens, as well as the epidemiology and ecology of antimicrobial resistance (AMR) to common medicines and vaccines.

26.04.2022

HIOH

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HZI in the media

before and we just didn’t notice?” asks Fabian Leendertz, director of the Helmholtz Institute for One Health. He points out that wildlife

25.06.2025

Resurgence

... Samonellen liegen unter Schwarzlicht im Labor des Helmholtz-Zentrums in Braunschweig. Foto: Peter Steffen/dpa ...

23.06.2025

Kurier

Slevogt from the MHH and the Helmholtz Centre for Infection Research (“Helmholtz-Zentrum für Infektionsforschung“; HZI). An application for

23.06.2025

Trading View

... der Universität des Saarlandes , des Helmholtz-Instituts für Pharmazeutische Forschung Saarland (HIPS) und internationalen Teams ...

19.06.2025

CHIP

Forschende am Helmholtz-Zentrum für Infektionsforschung in Braunschweig (Niedersachsen) arbeiten an einer neuer Impfstoff-Technologie, die

18.06.2025

17:30 SAT.1 REGIONAL

... machen

Die Studie der Wissenschaftler des Helmholtz-Zentrums für Infektionsforschung (HZI) in Braunschweig will daher vor ...

18.06.2025

Cityblick 24

including Dr. Max Kellner and Prof.‌ Josef Penninger of the⁢ Helmholtz Center for Infection Research (HZI), explored this ‌resilience.They

17.06.2025

Newsdirectory3

the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Chair of Microbiology of the Julius-Maximilians-Universität Würzburg

17.06.2025

Phys.org

Instituts für RNA-basierte Infektionsforschung (HIRI), einem Standort des Braunschweiger Helmholtz-Zentrums für Infektionsforschung (HZI) ...

17.06.2025

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