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After an infection with the coronavirus SARS-CoV-2, patients have antibodies against the pathogen in their blood. These are retained over a long period of time and are an indication for a past infection. It is assumed that patients who have recovered from the Covid-19 disease cannot be re-infected with SARS-CoV-2. To date, no data are available on whether there is an unrecognized Covid-19 immunity in the population beyond the SARS-CoV-2 infections recorded. The Helmholtz Centre for Infection Research (HZI) in Braunschweig is now coordinating a study to investigate this question. Anonymous sera from more than 100,000 donors will be analyzed in the population study. The blood will be regularly tested for antibodies against the Covid-19 pathogen. The study will provide a more accurate picture of immunity and pandemic development.