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SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One of the most urgent tasks is to gain a detailed understanding of the molecular interactions between the virus and the cells it infects. It must also be clarified, whether these interactions favour the multiplication of the virus or - on the contrary - activate defence mechanisms. In order to multiply, SARS-CoV-2 uses proteins of the host cell. However, thus far no detailed information on the part of the human proteome - i.e. the total of all proteins occurring in human cells – that is in direct contact with the viral RNA existed. This void has now been filled. Scientists from the Helmholtz Institute for RNA-based Infection Research (HIRI) Würzburg, the Julius-Maximilians-Universität Würzburg (JMU) and the Broad Institute (Cambridge, USA) have succeeded in creating the first global atlas of direct interactions between the SARS-CoV-2 RNA and the proteome of the human host. The HIRI is a site of the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany, in collaboration with JMU. In addition, the authors identified important regulators of viral replication. Dr Mathias Munschauer from HIRI and Professor Jochen Bodem from the Institute of Virology and Immunobiology at JMU were responsible for the study. They present the results of their work in the latest issue of the journal Nature Microbiology.

21.12.2020

HIRI

News

Prof Rolf Müller, Managing Director of the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), has been awarded the Gottfried Wilhelm Leibniz Prize 2021 by the German Research Foundation (DFG) for his outstanding research achievements. The Leibniz Prize is the most highly endowed award regularly presented to scientists in Germany. The HIPS is a site of the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany, in collaboration with Saarland University.

10.12.2020

HIPS

Arme und Hände die auf einer Tastatur liegen

News

Der Haushaltsausschuss des Bundes hat dem Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS) Förderung in Höhe von 47 Millionen Euro für den weiteren Ausbau des Instituts zugesichert. Zusammen mit Mitteln aus dem Landeshaushalt des Saarlandes erhält das HIPS bis 2025 somit eine Gesamtsumme von 70 Millionen Euro. Geplant sind ein Erweiterungsbau und weitere Forschungsgruppen mit Fokus auf antibakteriellen und antiviralen Wirkstoffen.

01.12.2020

HIPS

Elektronenmikroskopische Aufnahme von Staphylokokken auf HeLa-Zellen.

News

Hospital-acquired bacterial pneumonia is the most frequent nosocomial infection. It is mostly caused by the bacterium Staphylococcus aureus, which in many cases is already resistant to commonly used antibiotics and is therefore difficult to treat. A team from the Helmholtz Centre for Infection Research (HZI) in cooperation with the Lead Discovery Center GmbH (LDC), a spin-off of Max Planck Innovation and the Max Planck Society e.V., aims to further develop a drug that prevents staphylococci from colonizing the lungs. The research team will now receive milestone-dependent funding of initially 1.33 million US dollars from the non-profit organization CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator), with CARB-X anticipating a further 7.44 million US dollars depending on the progress of the project.

01.12.2020

HZI Campus

Die entwickelten Pathoblocker inaktivieren das Enzym LasB und entwaffnen somit den Krankheitserreger Pseudomonas aeruginosa.

News

01.12.2020

HZI Campus

HIPS

Prof. Alice McHardy und Prof. Jörg Vogel

News

The annual list of “Highly-cited researchers” identifies scientists who have demonstrated a significant impact in their chosen field over the last ten years through the publication of several highly-cited papers. This year, the Braunschweig Helmholtz Centre for Infection Research (HZI) has two researchers on the list: bioinformatician Prof Alice McHardy and biochemist Prof Jörg Vogel. The ranking by Clarivate Analytics, a company specialising in bibliometric data, includes more than 6,100 researchers.

30.11.2020

HZI Campus

HIRI

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HZI in the media

... späten 1990ern hob sie der am Saarbrücker Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS) tätige ...

08.03.2026

Saarbrücker Zeitung

European institutions, including Germany’s Helmholtz Institute for RNA-based Infection Research, Helmholtz Center for Infection Research,

06.03.2026

Clinical Lab Products

Die Zellen kontrollieren die Reaktion des Immunsystems und verhindern Schäden durch Selbstangriffe. Forschende arbeiten daran, sie zur Therapie einzusetzen.

05.03.2026

NDR Norddeutscher Rundfunk

Nachwuchsgruppe „Nanoinfektionsbiologie“ am HZI. Diese Lücke soll das Projekt ONEMUC (Respiratorischer Mukus als One Health-Schnittstelle) ...

03.03.2026

DeutschesGesundheitsPortal

Hochschule Hannover (MHH) und des Helmholz-Zentrums für Infektionsforschung (HZI) erforschen im Rahmen des Projektes StopPSC ( ...

03.03.2026

Biermann Medizin

Mdisk, stock.adobe.com

Braunschweig – Das Helmholtz-Zentrum für Infektionsforschung ( HZI ) in Braunschweig erhält für sein ...

03.03.2026

Deutsches Ärzteblatt

Josef Penninger, wissenschaftlicher Geschäftsführer des Helmholtz Zentrums für Infektionsforschung in Braunschweig und Professor für

01.03.2026

EUROPE SAYS

... Körperzellen. Damit tragen wir, wie das Helmholtz-Zentrum für Infektionsforschung (HZI) es treffend beschreibt, unseren „ganz ...

27.02.2026

MSN Deutschland

Eine Impfung bringt das Immunsystem in Stellung, bevor der echte Erreger kommt. Erfahren Sie, wie ...

26.02.2026

Apotheken Umschau

Livia V. Patrono, one of the senior authors at the Helmholtz Institute for One Health (HIOH) in Germany, said in a statement .

The research

25.02.2026

IFL Science

says Livia Patrono, a veterinarian and disease ecologist at Helmholtz Institute for One Health in Greifswald, Germany. In 2012, an infected

24.02.2026

Science News

... Dr. rer. nat. Jakob Wirbel vom Helmholtz-Zentrum für Infektionsforschung (Braunschweig). Das Experiment aus Stanford sei ...

20.02.2026

Deutsches Ärzteblatt

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