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Microorganisms produce a wide variety of natural products that can be used as active ingredients to treat diseases such as infections or cancer. The blueprints for these molecules can be found in the microbes' genes, but often remain inactive under laboratory conditions. A team of researchers at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has now developed a groundbreaking genetic method that leverages a natural bacterial mechanism for the transfer of genetic material and uses it for the production of new active ingredients. The team published its results in the journal Science.

In April 2024, the Helmholtz Centre for Infection Research (HZI) completely revamped its website together with the digital agency +Pluswerk. The aim of this relaunch was to present the HZI and its scientific work to the public in an appealing, contemporary design. The new HZI website has now won the TYPO3 Award in the “Health” category. The award was presented at the TYPO3 Conference 2024 in Düsseldorf.

When women are pregnant and nurse their babies, their bodies change and various organs, such as the breasts or the immune system, are adapted to ensure the health of both mother and child. This happens throughout evolution in all mammals. An international research team led by Josef Penninger, Scientific Director of the Helmholtz Centre for Infection Research (HZI), and Masahiro Onji from the Medical University of Vienna now reports the surprising finding that the intestine also changes completely in pregnant and nursing females, resulting in a doubling of the intestinal surface area and a striking structural reorganisation. The researchers also provide the first genetic and mechanistic evidence of how this intestinal epithelial expansion occurs in mothers, with direct implications for the transgenerational health of the babies. The study has now been published in the journal Nature.

On 29 November 2024, a matchmaking workshop between scientists of the Helmholtz Centre for Infection Research (HZI) and the Centre for Structural Systems Biology (CSSB) in Hamburg was held at the HZI campus in Braunschweig, bringing together about 50 researchers from Braunschweig, Hannover, Würzburg and Hamburg. CSSB was established in Hamburg as a joint initiative of ten northern German research partners, including the HZI, and is an interdisciplinary center where biologists, chemists, physicians, physicists and engineers explore the interaction of pathogens with their hosts. The event featured flash talks by early-career researchers and PIs, as well as poster pitches and in-depth presentations of the core facilities at HZI in Braunschweig and CSSB in Hamburg.

A conversation with Prof. Andreas Keller from the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and Prof. Yang Li from the Centre for Individualised Infection Medicine (CiiM) about artificial intelligence (AI) in individualized infection medicine.

Veterinarian Dr. Fee Zimmermann collects long-term data on human, animal and environmental health in the African tropics and on her doorstep - in Mecklenburg-Western Pomerania. She heads a research group at the Helmholtz Institute for One Health (HIOH) in Greifswald. In this interview, she talks about the importance of the tropics for future disease outbreaks and about animal helpers in data collection.