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Researchers at the Helmholtz Centre for Infection Research (HZI) have contributed to a study by the Medical Center Hamburg-Eppendorf (UKE) that has uncovered a new mechanism of neuron damage in the autoimmune disease multiple sclerosis (MS). Until now, it was unclear how inflammation in MS reduces protein degradation and leads to their harmful accumulation in neurons. A combination of new molecular biological, biochemical, and genetic methods enabled the international research team to identify a previously unknown mechanism of impaired protein degradation in inflamed neurons and its key regulator, the immunoproteasome.

18.06.2025

HZI Campus

Electron microscope image of Bacteroides thetaiotaomicron, illustrating the differences in the size of the bacterial cells.

News

Despite being genetically identical, bacteria can vary considerably in shape and size. Whether these variations affect bacterial function has remained an open question. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Chair of Microbiology of the Julius-Maximilians-Universität Würzburg (JMU) have now characterized the functional differences between various forms of the gut bacterium Bacteroides thetaiotaomicron. They demonstrated a link between cell type and metabolic function. These findings offer deeper insights into microbial gut diversity and pave the way for new possibilities in microbiome-based therapies. The study was recently published in the journal Cell Reports.

17.06.2025

HZI Campus

HIRI

Students and lecturers of the NOZGEKA Master program in Malawi

News

An efficient global pandemic preparedness and response requires experts who are trained to perform epidemiological studies and infectious disease modelling. The Helmholtz Centre for Infection Research (HZI) leads the consortium NOZGEKA with the aim of establishing a Master of Science in Public Health with a focus on infectious disease epidemiology in Malawi. The University of Münster and Medical Center - University of Freiburg, and University of Livingstonia (UNILIA) and Mzuzu University (MZUNI) in Malawi are collaborators in the consortium.

17.06.2025

HZI Campus

News

Every year, the Controlled Release Society (CRS) honors outstanding individuals who have significantly advanced the field of drug delivery. This year, Prof. Claus-Michael Lehr has been awarded the CRS Distinguished Service Award for his long-standing commitment to the society and his influential contributions to pharmaceutical science.

12.06.2025

HIPS

Three intestinal organoids (gray) with spreading Shigella infection (green)

News

Thanks to lab-grown miniature intestines, researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg in collaboration with Uppsala University in Sweden have successfully mapped how aggressive Shigella bacteria infect the human gut. The study, published today in the journal Nature Genetics, opens the door to using cultured human mini-organs to investigate a wide range of other serious infections.

12.06.2025

HIRI

News

New, resistance-breaking drugs are urgently needed to effectively treat infections with antibiotic-resistant germs in the future. Researchers from Saarbrücken and Vienna have now found a possible starting point for the development of such drugs in the natural product Saarvienin A. This novel molecule is capable of killing bacteria even if they are already resistant to clinically used antibiotics. The researchers published their findings in the journal Angewandte Chemie International Edition.

28.05.2025

HIPS

HZI in the media

... Brinkmann (Archivbild): Die Virologin forscht am Helmholtz-Zentrum für Infektionsforschung in Braunschweig. (Quelle: teutopress/ ...

11.07.2025

t-online.de

... des HZI, der Technischen Universität Braunschweig und des Fördervereins des HZI.

Promotionspreise des HZI

Der ...

11.07.2025

Regional Heute

... lassen. Ein weiterer Partner ist das Helmholtz-Zentrum für Infektionsforschung (HZI) in Braunschweig. Finanziert wird das ...

07.07.2025

MDR

... Pneumologie an der UMMD sowie dem Helmholtz-Zentrum für Infektionsforschung (HZI) in Braunschweig. Gefährliche Folgeinfektion mit ...

06.07.2025

Magdeburger News

... von der Abteilung Mikrobielle Immunregulation am Helmholtz-Zentrum für Infektionsforschung (HZI) in einer Pressemitteilung des ...

04.07.2025

Pharmazeutische Zeitung

In a groundbreaking new study, researchers from the Helmholtz Center for Infection Research (HZI) and Hannover Medical School (MHH) have

04.07.2025

Maldankon

removed from the gut?

Researchers from the Helmholtz Center for Infection Research (HZI), in collaboration with researchers from Hannover

03.07.2025

Phys.org

Würzburg – Eine Arbeitsgruppe des Würzburger Helmholtz-Instituts für RNA-basierte Infektionsforschung (HIRI) sowie aus Schweden und ...

03.07.2025

Deutsches Ärzteblatt

An international research team led by the Helmholtz Center for Infection Research (HZI) has discovered a new strategy used by the human

02.07.2025

MSN.com

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