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The European Research Council (ERC) grants are among the most prestigious awards in the scientific community. Prof Anna Hirsch from the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has now succeeded in acquiring a coveted ERC grant for the second time. Under the "Proof of Concept" funding program, she will receive €150,000 to bring her basic research findings closer to a potential application. Thematically, Hirsch's project focuses on medicinal chemistry approaches to develop novel antibiotics against resistant bacteria.

24.01.2023

HIPS

Pseudomoas aeruginosa and Quorum Sensing Inhibitors

News

The pathogen Pseudomonas aeruginosa is the cause of a large number of serious infections and places a particular burden on immunocompromised patients. The increasing spread of antimicrobial resistance makes it even more difficult to combat the dreaded hospital pathogen. A research team led by Dr Martin Empting of the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has now discovered a new class of active compounds that disrupt the bacterium's chemical communication pathways. This not only reduces the pathogen's disease-causing properties, but also simultaneously enhances the effectiveness of antibiotics. The researchers published their findings in the journal Advanced Science. HIPS is a site of the Helmholtz Centre for Infection Research (HZI) in collaboration with Saarland University.

23.01.2023

HZI Campus

HIPS

Host cells stained in blue with binding of LecA (green)

News

The hospital pathogen Pseudomonas aeruginosa requires the sugar-binding proteins LecA and LecB to form biofilms as well as to attach to and penetrate host cells. These so-called lectins are therefore suitable targets for active substances to combat Pseudomonas infections. Researchers from Saarbrücken and Freiburg have now produced potent inhibitors for LecA and LecB that are more stable and soluble than previous drug candidates. These optimized molecules have been tested in virulence assays and show promising properties for the development of new drugs.

16.01.2023

HIPS

Symbolic image: Illustration of human cells

News

Würzburg, January 10, 2023 — Do we simply ingest a diagnostic probiotic based on programmed ribonucleic acids to analyze the intestinal health from individual cells in the future? Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Julius-Maximilians-Universität (JMU) in Würzburg have developed a new technology they call TIGER. It allows complex processes in individual cells to be deciphered in vivo by recording past RNA transcripts. The findings were published in the journal Nature Biotechnology on 5 January 2023.

10.01.2023

HIRI

News

The 2022 Prize for Translational Infection Research of the German Center for Infection Research (DZIF), endowed with 5,000 euros, goes to the DZIF scientist and epidemiologist Gérard Krause, head of the department "Epidemiology" at the Helmholtz Centre for Infection Research (HZI) in Braunschweig. Prof Krause researches the spread and clinical consequences of infectious diseases in the population and develops methods for their prevention, diagnosis and epidemic control. He has now been honoured with the DZIF Prize for his outstanding contributions in the field of translational infection epidemiology and in particular for the development of the epidemic management system SORMAS.

09.01.2023

HZI Campus

Prof. Dr. Chase Beisel and Dr. Oleg Dmytrenko.

News

It is an unexpected discovery by scientists at the Helmholtz Institute Würzburg in cooperation with Benson Hill, Inc. (Missouri) and Utah State University in the U.S.: They have found a nuclease, which they dubbed Cas12a2, that represents an entirely new type of CRISPR immune defense. Unlike any other previously known nuclease of the CRISPR-Cas immune system, the source of "gene scissors", Cas12a2 destroys DNA to shut down an infected cell. The findings could lead to new CRISPR technologies for molecular biology diagnostics, among other applications, and were published today in the journal Nature.

04.01.2023

HIRI

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HZI in the media

... diesem Ergebnis kommt ein Forschungsteam des Helmholtz-Zentrums für Infektionsforschung (HZI) in Zusammenarbeit mit der ...

14.10.2025

Deutsches Ärzteblatt

Individualisierte Infektionsmedizin, einer gemeinsamen Einrichtung des Helmholtz-Zentrums für Infektionsforschung und der MHH. Bis zuletzt

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Springer

Ein Grippe-Test könnte in Zukunft womöglich sehr schnell gehen: einfach ein Kaugummi kauen. Ein deutsches ...

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Apotheken Umschau

... am 1. Oktober 2025. Das HIPS ist ein Standort des Helmholtz-Zentrums für Infektionsforschung (HZI) in ...

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juraforum.de

... „Epidemiologie und Ökologie antimikrobieller Resistenz“ am HZI-Standort Helmholtz-Institut für One Health (HIOH), am Projekt ...

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Bochumer-Zeitung

” says Mark Brönstrup, a professor at both the Helmholtz Center for Infection Research and Leibniz University Hannover, who wasn’t involved

04.10.2025

MIT CSAIL

... Hannover (MHH) und Klinischer Direktor des Helmholtz-Zentrums für Infektionsforschung (HZI). Auch an der Gründung des ...

03.10.2025

Deutsches Ärzteblatt

... des Sensormoleküls

Prof. Carlos A. Guzmán (Helmholtz-Zentrum für Infektionsforschung, Braunschweig) mit den Teams um Dr. ...

02.10.2025

Medizin Aspekte

... ” Seit Mai 2025 im Humanprogramm des Helmholtz-Zentrums für Infektionsforschung (HZI), Dr. Max Kellner-Leiter der jungen ...

25.09.2025

Die heutigen Nachrichten

” (Vico) within the Human program at the Helmholtz Centre for Infection Research (HZI).the‌ Vico group continues to investigate resilience

25.09.2025

World Today News

Forschende des Helmholtz-Instituts für RNA-basierte Infektionsforschung (HIRI), einem Standort des Braunschweiger Helmholtz-Zentrums für ...

19.09.2025

Verband Deutscher Biologen e.V.

purposes.

Researchers at the HIRI, a site of the Braunschweig Helmholtz Center for Infection Research (HZI), in cooperation with the Julius

19.09.2025

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