Prof. Dr. Jochen Hühn

Prof. Dr. Jochen Hühn
Forschungsgruppenleiter

Jochen Hühn erkannte bereits früh seine Begeisterung für die Immunologie. Zunächst studierte er Biochemie und Molekularbiologie an der Universität Hamburg. Schon während seiner Diplomarbeit und dann auch in der anschließenden Promotion am Hamburger Bernhard-Nocht-Institut für Tropenmedizin forschte er an Signalwegen in T-Zellen, einem besonders wichtigen Immunzelltyp. Nach einem Jahr als wissenschaftlicher Mitarbeiter des Bernhard-Nocht-Instituts wechselte Jochen Hühn im Jahr 2000 in die Arbeitsgruppe "Experimentelle Rheumatologie" der Charité Universitätsmedizin Berlin.

Ab 2006 arbeitete er dort als Juniorprofessor für Immunregulation mit den Schwerpunkten Rheumatologie und Klinische Immunologie. Für seine erfolgreiche Forschung an regulatorischen T-Zellen wurde er während seiner Zeit an der Charité mit dem Avrion-Mitchison-Preis für Rheumaforschung (2002), dem Wolfgang-Schulze-Preis für Rheumaforschung (2007) und dem Langener Wissenschaftspreis (2007) ausgezeichnet.

Seit August 2008 arbeitet Jochen Hühn als Leiter der Abteilung „Experimentelle Immunologie“ am HZI in Braunschweig sowie als Professor an der Medizinischen Hochschule Hannover (MHH). Seine Forschung konzentriert sich auf regulatorische und Effektor-T-Zellen mit einem Fokus auf Epigenetik, mukosale Immunität, Mikrobiota und neonatale Infektionen.

Publikationen
Zhang B., Zhang Z., Koeken V.A.C.M., Kumar S., Aillaud M., Tsay H.C., Liu Z., Kraft A.R.M., Soon C.F., Odak I., Bosnjak B., Vlot A., Swertz M.A., Ohler U., Geffers R., Illig T., Hühn J., Saliba A.E., Sander L.E., Förster R., Xu C.J., Cornberg M., Schulte L.N., ... , Li Y., Deutsche C.O.V.I. (2023)
Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19
Cell Genom.

Braband K.L., Kaufmann T., Floess S., Zou M., Hühn J., Delacher M. (2022)
Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells
Front.Immunol., 13

Pezoldt J., Wiechers C., Zou M., Litovchenko M., Biocanin M., Beckstette M., Sitnik K., Palatella M., van Mierlo G., Chen W., Gardeux V., Floess S., Ebel M., Russeil J., Arampatzi P., Vafardanejad E., Saliba A.E., ... , Deplancke B., Hühn J. (2022)
Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets
Nat.Commun., 13 (1)

Shaikh H., Pezoldt J., Mokhtari Z., Gamboa Vargas J., Le D.D., Pena Mosca J., Arellano-Viera E., Kern M.A., Graf C., Beyersdorf N., Lutz M.B., Riedel A., Büttner-Herold M., Zernecke A., Einsele H., Saliba A.E., Ludewig B., ... , Hühn J., Beilhack A. (2022)
Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells
JCI.Insight.

Yang J., Zou M., Chu X., Floess S., Li Y., ... , Delacher M., Hühn J. (2022)
Inflammatory perturbations in early life long-lastingly shape the transcriptome and TCR repertoire of the first wave of regulatory T cells
Front.Immunol., 13

Beckstette M., Lu C.W., Herppich S., Diem E.C., Ntalli A., Ochel A., Kruse F., Pietzsch B., Neumann K., Hühn J., ... , Floess S., Lochner M. (2022)
Profiling of epigenetic marker regions in murine ILCs under homeostatic and inflammatory conditions
J Exp Med, 219 (10)

Ataide M.A., Knöpper K., Cruz de Casas P., Ugur M., Eickhoff S., Zou M., Shaikh H., Trivedi A., Grafen A., Yang T., Prinz I., Ohlsen K., Gomez de Agüero M., Beilhack A., Hühn J., Gaya M., Saliba A.E., ... , Gasteiger G., Kastenmüller W. (2022)
Lymphatic migration of unconventional Tcells promotes site-specific immunity in distinct lymph nodes
Immunity.

Palatella M., Guillaume S.M., Linterman M.A., Hühn J. (2022)
The dark side of Tregs during aging
Front Immunol., 13

Nair V.S., Heredia M., Samsom J., Hühn J. (2022)
Impact of gut microenvironment on epigenetic signatures of intestinal T helper cell subsets
Immunol.Lett., 246 (June 2022)

Laubert M., Bonifacius A., Dragon A.C., Mangare C., Blasczyk R., ... , Hühn J., Eiz-Vesper B. (2022)
Enhancement of Antiviral T-Cell Responses by Vitamin C Suggests New Strategies to Improve Manufacturing of Virus-Specific T Cells for Adoptive Immunotherapy
Biology, 11 (4)

Cossarizza A., Chang H.D., Radbruch A., Abrignani S., Addo R., Akdis M., Andrä I., Andreata F., Annunziato F., Arranz E., Bacher P., Bari S., Barnaba V., Barros-Martins J., Baumjohann D., Beccaria C.G., Bernardo D., Boardman D.A., Borger J., Böttcher C., Brockmann L., Burns M., Busch D.H., Cameron G., Cammarata I., Cassotta A., Chang Y., Chirdo F.G., Christakou E., Cicin-Sain L., Cook L., Corbett A.J., Cornelis R., Cosmi L., Davey M.S., De Biasi S., De Simone G., Del Zotto G., Delacher M., Di Rosa F., Santo J.D., Diefenbach A., Dong J., Dörner T., Dress R.J., Dutertre C.A., Eckle S.B.G., Eede P., Evrard M., Falk C.S., Feuerer M., Fillatreau S., Fiz-Lopez A., Follo M., Foulds G.A., Fröbel J., Gagliani N., Galletti G., Gangaev A., Garbi N., Garrote J.A., Geginat J., Gherardin N.A., Gibellini L., Ginhoux F., Godfrey D.I., Gruarin P., Haftmann C., Hansmann L., Harpur C.M., Hayday A.C., Heine G., Hernandez D.C., Herrmann M., Hoelsken O., Huang Q., Huber S., Huber J.E., Hühn J., Hundemer M., Hwang W.Y.K., Iannacone M., Ivison S.M., Jäck H.M., Jani P.K., Keller B., Kessler N., Ketelaars S., Knop L., Knopf J., Koay H.F., Kobow K., Kriegsmann K., Kristyanto H., Krueger A., Kuehne J.F., Kunze-Schumacher H., Kvistborg P., Kwok I., Latorre D., Lenz D., Levings M.K., Lino A.C., Liotta F., Long H.M., Lugli E., MacDonald K.N., Maggi L., Maini M.K., Mair F., Manta C., Manz R.A., Mashreghi M.F., Mazzoni A., McCluskey J., Mei H.E., Melchers F., Melzer S., Mielenz D., Monin L., Moretta L., Multhoff G., Munoz L.E., Munoz-Ruiz M., Muscate F., Natalini A., Neumann K., Ng L.G., Niedobitek A., Niemz J., Almeida L.N., Notarbartolo S., Ostendorf L., Pallett L.J., Patel A.A., Percin G.I., Peruzzi G., Pinti M., Pockley A.G., Pracht K., Prinz I., Pujol-Autonell I., Pulvirenti N., Quatrini L., Quinn K.M., Radbruch H., Rhys H., Rodrigo M.B., Romagnani C., Saggau C., Sakaguchi S., Sallusto F., Sanderink L., Sandrock I., Schauer C., Scheffold A., Scherer H.U., Schiemann M., Schildberg F.A., Schober K., Schoen J., Schuh W., ler T., Schulz A.R., Schulz S., Schulze J., Simonetti S., Singh J., Sitnik K.M., Stark R., Starossom S., Stehle C., Szelinski F., Tan L., Tarnok A., Tornack J., Tree T.I.M., van Beek J.J.P., van de Veen W., van Gisbergen K., Vasco C., Verheyden N.A., von Borstel A., Ward-Hartstonge K.A., Warnatz K., Waskow C., Wiedemann A., Wilharm A., Wing J., Wirz O., Wittner J., ... , Yang J.H.M., Yang J. (2021)
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Eur.J.Immunol., 51 (12)

Haftmann C., Zwicky P., Ingelfinger F., Mair F., Floess S., Riedel R., Durek P., Spalinger M.R., Friebel E., Leung B.P., Lutz M., Puertas N., Amorim A., Schürli S., Becher B., Kisielow J., Waisman A., Mashreghi M.F., ... , Hühn J., Becher B. (2021)
Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development
Sci.Immunol., 6 (65)

Pezoldt J., Wiechers C., Erhard F., Rand U., Bulat T., Beckstette M., Brendolan A., Hühn J., Kalinke U., Mueller M., Strobl B., Deplancke B., ... , Cicin-Sain L., Sitnik K.M. (2021)
Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
Commun.Biolog., 4 (1)

Formaglio P., Alabdullah M., Siokis A., Handschuh J., Sauerland I., Fu Y., Krone A., Gintschel P., Stettin J., Heyde S., Mohr J., Philipsen L., Schröder A., Robert P.A., Zhao G., Khailaie S., Dudeck A., Bertrand J., Späth G.F., Kahlfuß S., Bousso P., Schraven B., Hühn J., Binder S., ... , Meyer-Hermann M., Müller A.J. (2021)
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells
Immunity

Ruck T., Bock S., Pfeuffer S., Schroeter C.B., Cengiz D., Marciniak P., Lindner M., Herrmann A., Liebmann M., Kovac S., Gola L., Rolfes L., Pawlitzki M., Opel N., Hahn T., Dannlowski U., Pap T., Luessi F., Schreiber J.A., Wünsch B., Kuhlmann T., Seebohm G., Tackenberg B., Seja P., Döring F., Wischmeyer E., Chasan A.I., Roth J., Klotz L., Meyer Zu Hörste G., Wiendl H., Marschall T., Floess S., Hühn J., Budde T., Bopp T., ... , Bittner S., Meuth S.G. (2021)
K2P18.1 translates T cell receptor signals into thymic regulatory T cell development
Cell Research

Herppich S., Beckstette M., Hühn J. (2021)
The thymic microenvironment gradually modulates the phenotype of thymus-homing peripheral conventional dendritic cells
Immunity, Inflammation and Disease

Elfaki Y., Yang J., Boehme J., Schultz K., Bruder D., Falk C.S., ... , Hühn J., Floess S. (2021)
Tbx21 and foxp3 are epigenetically stabilized in t-bet+ tregs that transiently accumulate in influenza a virus-infected lungs
Int.J.Mol.Sci., 22 (14)

Shaikh H., Vargas J.G., Mokhtari Z., Jarick K.J., Ulbrich M., Mosca J.P., Viera E.A., Graf C., Le D.D., Heinze K.G., Büttner-Herold M., Rosenwald A., Pezoldt J., ... , Hühn J., Beilhack A. (2021)
Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract
Front.Immunol., 12

Ciurkiewicz M., Floess S., Beckstette M., Kummerfeld M., Baumgärtner W., ... , Hühn J., Beineke A. (2021)
Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination
Brain Pathology

Floess S., Hühn J. (2021)
Generation of Sequencing Libraries for Building Immune Cell Methylomes
Methods Mol.Biol., 2285 (21)

Delacher M., Simon M., Sanderink L., Hotz-Wagenblatt A., Wuttke M., Schambeck K., Schmidleithner L., Bittner S., Pant A., Ritter U., Hehlgans T., Riegel D., Schneider V., Groeber-Becker F.K., Eigenberger A., Gebhard C., Strieder N., Fischer A., Rehli M., Hoffmann P., Edinger M., Strowig T., Hühn J., Schmidl C., Werner J.M., Prantl L., Brors B., ... , Imbusch C.D., Feuerer M. (2021)
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
Immunity, 54 (4)

Zou M., Wiechers C., Hühn J. (2021)
Lymph node stromal cell subsets-Emerging specialists for tailored tissue-specific immune responses
Int.J.Med.Microbiol., 311 (3)

Elfaki Y., Robert P.A., Binz C., Falk C.S., Bruder D., Prinz I., Floess S., ... , Meyer-Hermann M., Hühn J. (2021)
Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice
Eur.J.Immunol.

Permanyer M., Bosnjak B., Glage S., Friedrichsen M., Floess S., Hühn J., Patzer G.E., Odak I., Eckert N., Zargari R., Ospina-Quintero L., ... , Georgiev H., Förster R. (2021)
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool
Cell Mol.Immunol, 18 (2)

Bonifacius A., Goldmann O., Floess S., Holtfreter S., Robert P.A., Nordengrün M., Kruse F., Lochner M., Falk C.S., Schmitz I., Bröker B.M., ... , Medina E., Hühn J. (2020)
Staphylococcus aureus Alpha-Toxin Limits Type 1 While Fostering Type 3 Immune Responses
Front Immunol., 11

Zou M., Yang J., Wiechers C., Hühn J. (2020)
Acute neonatal Listeria monocytogenes infection causes long-term, organ-specific changes in immune cell subset composition
Eur.J.Microbiol.Immunol.(Bp)

Matthias J., Heink S., Picard F.S., Zeiträg J., Kolz A., Chao Y.Y., Soll D., de Almeida G.P., Glasmacher E., Jacobsen I.D., Riedel T., Peters A., Floess S., Hühn J., Baumjohann D., Huber M., ... , Korn T., Zielinski C.E. (2020)
Salt generates anti-inflammatory Th17 cells but amplifies their pathogenicity in pro-inflammatory cytokine microenvironments
J.Clin.Invest, 130 (9)

Kouakanou L., Peters C., Sun Q., Floess S., Bhat J., ... , Hühn J., Kabelitz D. (2020)
Vitamin C supports conversion of human g[gamma]d[delta] T cells into FOXP3-expressing regulatory cells by epigenetic regulation
Sci.Rep., 10 (1)

Nikolouli E., Elfaki Y., Herppich S., Schelmbauer C., Delacher M., Falk C., Mufazalov I.A., Waisman A., ... , Feuerer M., Hühn J. (2021)
Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions
Cell.Mol.Immunol, 18 (1)

Maluski M., Ghosh A., Herbst J., Scholl V., Baumann R., Hühn J., Geffers R., Meyer J., Maul H., Eiz-Vesper B., Krueger A., Schambach A., ... , van den Brink M.R.M., Sauer M.G. (2019)
Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development
J.Clin.Invest., 129 (12)

Andersen L., Gülich A.F., Alteneder M., Preglej T., Orola M.J., Dhele N., Stolz V., Schebesta A., Hamminger P., Hladik A., Floess S., Krausgruber T., Faux T., Andrabi S.B.A., Hühn J., Knapp S., Sparwasser T., Bock C., Laiho A., Elo L.L., Rasool O., Lahesmaa R., ... , Sakaguchi S., Ellmeier W. (2019)
The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells
Cell Rep., 29 (13)

Herppich S., Toker A., Pietzsch B., Kitagawa Y., Ohkura N., Miyao T., Floess S., Hori S., ... , Sakaguchi S., Hühn J. (2019)
Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells
Front.Immunol., 10

Cossarizza A., Chang H.D., Radbruch A., Acs A., Adam D., dam-Klages S., Agace W.W., Aghaeepour N., Akdis M., Allez M., Almeida L.N., Alvisi G., Anderson G., Annunziato F., Anselmo A., Bacher P., Baldari C.T., Bari S., Barnaba V., Barros-Martins J., Battistini L., Bauer W., Baumgart S., Baumgarth N., Baumjohann D., Baying B., Bebawy M., Becher B., Beisker W., Benes V., Beyaert R., Blanco A., Boardman D.A., Bogdan C., Borger J.G., Borsellino G., Boulais P.E., Bradford J.A., Brenner D., Brinkman R.R., Brooks A.E.S., Busch D.H., Büscher M., Bushnell T.P., Calzetti F., Cameron G., Cammarata I., Cao X., Cardell S.L., Casola S., Cassatella M.A., Cavani A., Celada A., Chatenoud L., Chattopadhyay P.K., Chow S., Christakou E., Cicin-Sain L., Clerici M., Colombo F.S., Cook L., Cooke A., Cooper A.M., Corbett A.J., Cosma A., Cosmi L., Coulie P.G., Cumano A., Cvetkovic L., Dang V.D., ng-Heine C., Davey M.S., Davies D., De Biasi S., Del Zotto G., Dela Cruz G.V., Delacher M., Della Bella S., Dellabona P., Deniz G., Dessing M., Di Santo J.P., Diefenbach A., Dieli F., Dolf A., Dörner T., Dress R.J., Dudziak D., Dustin M., Dutertre C.A., Ebner F., Eckle S.B.G., Edinger M., Eede P., Ehrhardt G.R.A., Eich M., Engel P., Engelhardt B., Erdei A., Esser C., Everts B., Evrard M., Falk C.S., Fehniger T.A., Felipo-Benavent M., Ferry H., Feuerer M., Filby A., Filkor K., Fillatreau S., Follo M., Förster I., Foster J., Foulds G.A., Frehse B., Frenette P.S., Frischbutter S., Fritzsche W., Galbraith D.W., Gangaev A., Garbi N., Gaudilliere B., Gazzinelli R.T., Geginat J., Gerner W., Gherardin N.A., Ghoreschi K., Gibellini L., Ginhoux F., Goda K., Godfrey D.I., Goettlinger C., Goodyear C.S., Gori A., Grogan J.L., Grummitt D., Grützkau A., Haftmann C., Hahn J., Hammad H., Hämmerling G., Hansmann L., Hansson G., Harpur C.M., Hartmann S., Hauser A., Hauser A.E., Haviland D.L., Hedley D., Hernandez D.C., Herrera G., Herrmann M., Hess C., Höfer T., Hoffmann P., Hogquist K., Holland T., Höllt T., Holmdahl R., Hombrink P., Houston J.P., Hoyer B.F., Huang B., Huang F.P., Huber J.E., Hühn J., Hundemer M., Hunter C.A., Hwang W.Y.K., Iannone A., Ingelfinger F., Ivison S.M., Jäck H.M., Jani P.K., Jbvega B., Kaiser T., Kalina T., Kamradt T., Kaufmann S.H.E., Keller B., Ketelaars S.L.C., Khalilnezhad A., Khan S., Kisielow J., Klenerman P., Knopf J., Koay H.F., Kobow K., Kolls J.K., Kong W.T., Kopf M., Korn T., Kriegsmann K., Kristyanto H., Kroneis T., Krueger A., Kühne J., Kukat C., Kunkel D., Kunze-Schumacher H., Kurosaki T., Kurts C., Kvistborg P., Kwok I., Landry J., Lantz O., Lanuti P., LaRosa F., Lehuen A., LeibundGut-Landmann S., Leipold M.D., Leung L.Y.T., Levings M.K., Lino A.C., Liotta F., Litwin V., Liu Y., Ljunggren H.G., Lohoff M., Lombardi G., Lopez L., Lopez-Botet M., Lovett-Racke A.E., Lubberts E., Luche H., Ludewig B., Lugli E., Lunemann S., Maecker H.T., Maggi L., Maguire O., Mair F., Mair K.H., Mantovani A., Manz R.A., Marshall A.J., Martinez-Romero A., Martrus G., Marventano I., Maslinski W., Matarese G., Mattioli A.V., Maueröder C., Mazzoni A., McCluskey J., McGrath M., McGuire H.M., McInnes I.B., Mei H.E., ... , Melchers F., Melzer S. (2019)
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Eur.J.Immunol., 49 (10)

Schuster M., Plaza-Sirvent C., Visekruna A., Hühn J., Schmitz I. (2019)
Generation of Foxp3+CD25- regulatory T-cell precursors requires c-rel and IkBNS
Front.Immunol., 10 (JULY)

Pezoldt J., Yang J., Zou M., Hühn J. (2018)
Microbiome and gut immunity: T cells
(9)

Pandiyan P., Bhaskaran N., Zou M., Schneider E., Jayaraman S., Hühn J. (2019)
Microbiome Dependent Regulation of T regs and Th17 Cells in Mucosa
Front Immunol, 10

Lyszkiewicz M., Winter S.J., Witzlau K., Fohse L., Brownlie R., Puchalka J., Verheyden N.A., Kunze-Schumacher H., Imelmann E., Blume J., Raha S., Sekiya T., Yoshimura A., Frueh J.T., Ullrich E., Hühn J., Weiss S., Gutierrez M.G., Prinz I., Zamoyska R., ... , Zietara N., Krueger A. (2019)
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity
PLoS.Biol., 17 (3)

Garg G., Muschaweckh A., Moreno H., Vasanthakumar A., Floess S., Lepennetier G., Oellinger R., Zhan Y., Regen T., Hiltensperger M., Peter C., Aly L., Knier B., Palam L.R., Kapur R., Kaplan M.H., Waisman A., Rad R., Schotta G., Hühn J., ... , Kallies A., Korn T. (2019)
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
Cell Rep., 26 (7)

Elfiky A., Bonifacius A., Pezoldt J., Pasztoi M., Chaoprasid P., Sadana P., El-Sherbeeny N., Hagras M., Scrima A., ... , Dersch P., Hühn J. (2018)
Yersinia Pseudotuberculosis Modulates Regulatory T Cell Stability via Injection of Yersinia Outer Proteins in a Type III Secretion System-Dependent Manner
Eur.J.Microbiol.Immunol.(Bp), 8 (4)

Ludwig R., Hühn J. (2018)
Already ENLIGHT-TENed? Equipping young immunologists with a combination of research-related and transferrable competencies
Eur.J.Immunol., 48 (12)

Yang J., Zou M., Pezoldt J., Zhou X., Hühn J. (2018)
Thymus-derived Foxp3(+) regulatory T cells upregulate RORg[gamma]t expression under inflammatory conditions
J.Mol.Med.(Berl), 96 (12)

Prajeeth C.K., Dittrich-Breiholz O., Talbot S.R., Robert P.A., Hühn J., Stangel M. (2018)
IFN-g[gamma] producing Th1 cells induce different transcriptional profiles in microglia and astrocytes
Front.Cell.Neurosci., 12

Pezoldt J., Pasztoi M., Zou M., Wiechers C., Beckstette M., Thierry G.R., Vafadarnejad E., Floess S., Arampatzi P., Buettner M., Schweer J., Fleissner D., Vital M., Pieper D.H., Basic M., Dersch P., Strowig T., Hornef M., Bleich A., Bode U., Pabst O., Bajenoff M., ... , Saliba A.E., Hühn J. (2018)
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes
Nat.Commun., 9 (1)

Kyburz A., Fallegger A., Zhang X., Altobelli A., Artola-Boran M., Borbet T., Urban S., Paul P., Münz C., Floess S., Hühn J., Cover T.L., Blaser M.J., ... , Taube C., Müller A. (2018)
Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells
J.Allergy Clin.Immunol., 143 (4)

Schmidl C., Delacher M., Hühn J., Feuerer M. (2018)
Epigenetic mechanisms regulating T-cell responses
J.Allergy Clin.Immunol., 142 (3)

Prajeeth C.K., Hühn J., Stangel M. (2018)
Regulation of neuroinflammatory properties of glial cells by T cell effector molecules
Neural Regen.Res., 13 (2)

Uhde A.K., Ciurkiewicz M., Herder V., Khan M.A., Hensel N., Claus P., Beckstette M., Teich R., Floess S., Baumgartner W., Jung K., ... , Hühn J., Beineke A. (2018)
Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice
Sci.Rep., 8 (1)

Sadana P., Geyer R., Pezoldt J., Helmsing S., Hühn J., Hust M., ... , Dersch P., Scrima A. (2018)
The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine
J.Biol.Chem., 293 (22)

Lipps C., Klein F., Wahlicht T., Seiffert V., Butueva M., Zauers J., Truschel T., Luckner M., Köster M., MacLeod R., Pezoldt J., Hühn J., Yuan Q., Muller P.P., Kempf H., Zweigerdt R., Dittrich-Breiholz O., Pufe T., Beckmann R., Drescher W., Riancho J., Sanudo C., Korff T., Opalka B., Rebmann V., Gothert J.R., Alves P.M., Ott M., Schucht R., Hauser H., ... , Wirth D., May T. (2018)
Expansion of functional personalized cells with specific transgene combinations
Nat.Commun., 9 (1)

Schmoeckel K., Mrochen D.M., Hühn J., Pötschke C., Bröker B.M. (2018)
Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree
PLoS ONE, 13 (2)

Essig K., Hu D., Guimaraes J.C., Alterauge D., Edelmann S., Raj T., Kranich J., Behrens G., Heiseke A., Floess S., Klein J., Maiser A., Marschall S., Hrabe de Angelis M., Leonhardt H., Calkhoven C.F., Noessner E., Brocker T., Hühn J., Krug A.B., Zavolan M., ... , Baumjohann D., Heissmeyer V. (2017)
Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
Immunity, 47 (6)

Prajeeth C.K., Kronisch J., Khorooshi R., Knier B., Toft-Hansen H., Gudi V., Floess S., Hühn J., Owens T., ... , Korn T., Stangel M. (2017)
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties
J.Neuroinflammation., 14 (1)

Ranjan S., Goihl A., Kohli S., Gadi I., Pierau M., Shahzad K., Gupta D., Bock F., Wang H., Shaikh H., Kahne T., Reinhold D., Bank U., Zenclussen A.C., Niemz J., Schnoder T.M., Brunner-Weinzierl M., Fischer T., Kalinski T., Schraven B., Luft T., Hühn J., Naumann M., ... , Heidel F.H., Isermann B. (2017)
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Nat.Commun., 8 (1)

Van Ham M., Teich R., Philipsen L., Niemz J., Amsberg N., Wissing J., Nimtz M., Grobe L., Kliche S., Thiel N., Klawonn F., Hubo M., Jonuleit H., Reichardt P., Muller A.J., ... , Hühn J., Jänsch L. (2017)
TCR signalling network organization at the immunological synapses of murine regulatory T cells
Eur.J.Immunol., 47 (12)

Pasztoi M., Pezoldt J., Beckstette M., Lipps C., Wirth D., Rohde M., Paloczi K., ... , Buzas E.I., Hühn J. (2017)
Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells
Eur.J.Immunol., 47 (12)

Kyburz A., Urban S., Altobelli A., Floess S., Hühn J., ... , Cover T.L., Muller A. (2017)
Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy
Clin.Exp.Allergy

Szilagyi B.A., Triebus J., Kressler C., de Almeida M., Tierling S., Durek P., Mardahl M., Szilagyi A., Floess S., Hühn J., Syrbe U., Walter J., ... , Polansky J.K., Hamann A. (2017)
Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells
Mucosal.Immunol., 10 (6)

Nikolouli E., Hardtke-Wolenski M., Hapke M., Beckstette M., Geffers R., Floess S., ... , Jaeckel E., Hühn J. (2017)
Alloantigen-induced regulatory t cells generated in presence of vitamin c display enhanced stability of foxp3 expression and promote skin allograft acceptance
Front.Immunol., 8 (748)

Schuster M., Plaza-Sirvent C., Matthies A.M., Heise U., Jeron A., Bruder D., Visekruna A., ... , Hühn J., Schmitz I. (2017)
c-REL and IkappaBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors
J.Immunol., 199 (3)

Niemz J., Kliche S., Pils M.C., Morrison E., Manns A., Freund C., Crittenden J.R., Graybiel A.M., Galla M., ... , Jänsch L., Hühn J. (2017)
The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells
Eur.J.Microbiol.Immunol.(Bp), 7 (2)

Ciurkiewicz M., Herder V., Khan M.A., Uhde A.K., Teich R., Floess S., Baumgartner W., ... , Hühn J., Beineke A. (2017)
Cytotoxic CD8+ T cells ablation enhances the capacity of regulatory T cells to delay viral elimination in Theiler's murine encephalomyelitis
Brain Pathol., 28 (3)

Pasztoi M., Bonifacius A., Pezoldt J., Kulkarni D., Niemz J., Yang J., Teich R., Hajek J., Pisano F., Rohde M., ... , Dersch P., Hühn J. (2017)
Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling
Cell Mol.Life Sci., 74 (15)

Garg G., Nikolouli E., Hardtke-Wolenski M., Toker A., Ohkura N., Beckstette M., Miyao T., Geffers R., Floess S., Gerdes N., Lutgens E., Osterloh A., Hori S., Sakaguchi S., ... , Jaeckel E., Hühn J. (2017)
Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells
Oncotarget., 8 (22)

Pezoldt J., Pisano F., Heine W., Pasztoi M., Rosenheinrich M., Nuss A.M., Pils M.C., Prinz I., Forster R., ... , Hühn J., Dersch P. (2017)
Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection
J Infect.Dis., 216 (6)

Beyer M., Hühn J. (2017)
Epigenetic orchestration of thymic T reg cell development
Nat.Immunol., 18 (2)

Noyan F., Zimmermann K., Hardtke-Wolenski M., Knoefel A., Schulde E., Geffers R., Hust M., Hühn J., Galla M., Morgan M., Jokuszies A., ... , Manns M.P., Jaeckel E. (2016)
Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor
Am J Transplant., 17 (4)

Pezoldt J., Hühn J. (2016)
Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4+ T Cell Differentiation
Eur.J Microbiol.Immunol.(Bp), 6 (3)

Uhde A.K., Herder V., Akram Khan M., Ciurkiewicz M., Schaudien D., Teich R., Floess S., Baumgartner W., ... , Hühn J., Beineke A. (2016)
Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice
PLoS ONE, 11 (9)

Goldstein J.D., Burlion A., Zaragoza B., Sendeyo K., Polansky J.K., Hühn J., Piaggio E., ... , Salomon B.L., Marodon G. (2016)
Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression
PLoS ONE, 11 (4)

Polansky J.K., Floess S., Freyer J., Hamann A., Hühn J. (2009)
Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells
(2)

Milanez-Almeida P., Ulas T., Pasztoi M., Glage S., Schughart K., Lutz M.B., ... , Schultze J.L., Hühn J. (2015)
CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice
Eur.J Microbiol.Immunol.(Bp), 5 (4)

Pasztoi M., Pezoldt J., Hühn J. (2015)
Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells
Prog.Mol.Biol.Transl.Sci, 136

Klysz D., Tai X., Robert P.A., Craveiro M., Cretenet G., Oburoglu L., Mongellaz C., Flöß S., Fritz V., Matias M.I., Yong C., Surh N., Marie J.C., Hühn J., Zimmermann V., Kinet S., ... , Dardalhon V., Taylor N. (2015)
Glutamine-dependent a[alpha]-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Sci Signal, 8 (396)

Yang B.H., Hagemann S., Mamareli P., Lauer U., Hoffmann U., Beckstette M., Fohse L., Prinz I., Pezoldt J., Suerbaum S., Sparwasser T., Hamann A., Floess S., ... , Hühn J., Lochner M. (2016)
Foxp3+ T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation
Mucosal.Immunol., 9

Braun A., Dewert N., Brunnert F., Schnabel V., Hardenberg J.H., Richter B., Zachmann K., Cording S., Classen A., Brans R., Hamann A., ... , Hühn J., Schon M.P. (2015)
Integrin a[alpha]E(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity
J Invest Dermatol.

Roesner L.M., Flöß S., Witte T., Olek S., Hühn J., Werfel T. (2015)
Foxp3 regulatory T cells are expanded in severe atopic dermatitis patients
Allergy: European Journal of Allergy and Clinical Immunology, 70 (12)

Hühn J., Beyer M. (2015)
Epigenetic and transcriptional control of Foxp3 regulatory T cells
Semin.Immunol., 27 (1)

Hühn J., Floess S., Ohkura N., Sakaguchi S. (2015)
Comment on "cutting edge: Epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory t cells in tumors from mice and humans"
J.Immunol., 194 (8)

Prajeeth C.K., Beineke A., Iskandar C., Gudi V., Herder V., Gerhauser I., Haist V., Teich R., Hühn J., ... , Baumgartner W., Stangel M. (2014)
Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice
J Neuroinflammation., 11 (1)

Milanez-Almeida P., Klawonn F., Meyer-Hermann M., Hühn J. (2014)
Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen
Eur.J Microbiol.Immunol.(Bp), 4 (3)

Delacher M., Schreiber L., Richards D.M., Farah C., Feuerer M., Hühn J. (2014)
Transcriptional control of regulatory T cells
Curr Top.Microbiol.Immunol., 381

Yang B.H., Flöß S., Hagemann S., Deyneko I.V., Gröbe L., Pezoldt J., Sparwasser T., ... , Lochner M., Hühn J. (2015)
Development of a unique epigenetic signature during in vivo Th17 differentiation
Nucleic Acids Res, 43 (3)

Mayer Christian T., Lahl K., Milanez-Almeida P., Watts D., Dittmer U., Fyhrquist N., Hühn Jochen, Kopf M., Kretschmer K., ... , Rouse B., Sparwasser Tim (2014)
Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice
Immunity, Inflammation and Disease, 2 (3)

Franckaert D., Dooley J., Roos E., Flöß S., Hühn J., Luche H., Fehling H.J., Liston A., ... , Linterman M.A., Schlenner S.M. (2014)
Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3 and Foxp3 T cells
Immunology and Cell Biology, 93 (4)

Tebartz C., Horst Sarah A., Sparwasser Tim, Hühn Jochen, Beineke A., ... , Peters G., Medina Eva (2014)
A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection
Journal of Immunology, 194 (3)

Khailaie S., Robert P.A., Toker A., Hühn J., Meyer-Hermann M. (2014)
A signal integration model of thymic selection and natural regulatory T cell commitment
Journal of Immunology, 193 (12)

Milanez-Almeida P., Meyer-Hermann M., Toker A., Khailaie S., Hühn J. (2014)
Foxp3 regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen
European Journal of Immunology, 45

Berod L., Friedrich C., Nandan A., Freitag J., Hagemann S., Harmrolfs K., Sandouk A., Hesse C., Castro C.N., Bahre H., Tschirner S.K., Gorinski N., Gohmert M., Mayer C.T., Hühn Jochen, Ponimaskin E., Abraham Wolf-Rainer, Müller Rolf, ... , Lochner M., Sparwasser Tim (2014)
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
Nature medicine, 20

Blankenhaus B., Reitz M., Brenz Y., Eschbach M.L., Hartmann W., Haben I., Sparwasser Tim, Hühn J., Kühl A., Feyerabend T.B., ... , Rodewald H.R., Breloer M. (2014)
Foxp3+ Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice
PLoS Pathogens, 10 (2)

Schreiber L., Pietzsch B., Flöß S., Farah C., Jänsch L., ... , Schmitz I., Hühn J. (2014)
The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-?B signaling
PLoS ONE, 9 (2)

Khailaie Sahamoddin, Bahrami F., Janahmadi M., Milanez-Almeida P., Hühn J., Meyer-Hermann M. (2013)
A mathematical model of immune activation with a unified self-nonself concept
Frontiers in Immunology, 4

Prajeeth C.K., Lohr K., Flöß S., Zimmermann J., Ulrich R., Gudi V., Beineke A., Baumgartner W., Muller M., ... , Hühn J., Stangel M. (2014)
Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia
Brain, Behavior, and Immunity, 37

Cording S., Fleißner Diana, Heimesaat M.M., Bereswill S., Loddenkemper C., Uematsu S., Akira S., ... , Hamann A., Hühn Jochen (2013)
Commensal microbiota drive proliferation of conventional and Foxp3 regulatory CD4 T cells in mesenteric lymph nodes and Peyer's patches
European Journal of Microbiology and Immunology, 3 (1)

Cording S., Wahl B., Kulkarni D., Chopra H., Pezoldt Jörn, Buettner M., Dummer A., Hadis U., Heimesaat M., Bereswill S., Falk C., Bode U., Hamann A., Fleissner D., ... , Hühn Jochen, Pabst O. (2014)
The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes
Mucosal Immunology, 7 (2)

Schweer J., Kulkarni D., Kochut A., Pezoldt J., Pisano F., Pils M.C., Genth H., ... , Hühn J., Dersch P. (2013)
The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases
PLoS Pathogens, 9 (11)

Huang Yi-Ju, Haist V., Baumgartner W., Fohse L., Prinz I., Suerbaum S., ... , Flöß S., Hühn J. (2013)
Induced and thymus-derived Foxp3 regulatory T cells share a common niche
European Journal of Immunology, 44 (2)

Kühlhorn F., Rath M., Schmoeckel K., Cziupka K., Nguyen H.H., Hildebrandt P., Hünig T., Sparwasser Tim, Hühn Jochen, ... , Pötschke C., Bröker B.M. (2013)
Foxp3+ Regulatory T Cells Are Required for Recovery from Severe Sepsis
PLoS ONE, 8 (5)

Toker A., Engelbert D., Garg G., Polansky J.K., Floess S., Miyao T., Baron U., Düber S., Geffers R., Giehr P., Schallenberg S., Kretschmer K., Olek S., Walter J., Weiss S., Hori S., ... , Hamann A., Hühn J. (2013)
Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
Journal of Immunology, 190 (7)

Weiss J.M., Bilate A.M., Gobert M., Ding Y., de Lafaille M.A.C., Parkhurst C.N., Xiong H., Dolpady J., Frey A.B., Ruocco M.G., Yang Y., Flöß S., Hühn J., Oh S., Li M.O., Niec R.E., Rudensky A.Y., Dustin M.L., ... , Littman D.R., Lafaille J.J. (2012)
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosagenerated induced Foxp3+ T reg cells
Journal of Experimental Medicine, 209 (10)

Schuster M., Glauben R., Plaza-Sirvent C., Schreiber L., Annemann M., Floess S., Kuhl A.A., Clayton L.K., Sparwasser T., Schulze-Osthoff K., Pfeffer K., Hühn J., ... , Siegmund B., Schmitz I. (2012)
IkappaB(NS) Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor
Immunity, 37 (6)

Ohkura N., Hamaguchi M., Morikawa H., Sugimura K., Tanaka A., Ito Y., Osaki M., Tanaka Y., Yamashita R., Nakano N., Hühn Jochen, Fehling H.J., Sparwasser Tim*, ... , Nakai K., Sakaguchi S. (2012)
T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for treg cell development
Immunity, 37 (5)

Koenecke C., Lee C.W., Thamm K., Fohse L., Schafferus M., Mittrucker H.W., Floess S., Hühn J., Ganser A., ... , Forster R., Prinz I. (2012)
IFN-gamma Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease
Journal of Immunology, 189 (6)

König S., Probst-Kepper M., Reinl T., Jeron A., Hühn Jochen, ... , Schraven B., Jänsch Lothar (2012)
First insight into the kinome of human regulatory T cells
PLoS ONE, 7 (7)

Herder V., Gerhauser I., Klein S.K., Almeida P., Kummerfeld M., Ulrich R., Seehusen F., Rohn K., Schaudien D., Baumgartner W., ... , Hühn Jochen, Beineke A. (2012)
Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis
Journal of Neuroimmunology, 249 (1-2)

Bettini M.L., Pan F., Bettini M., Finkelstein D., Rehg J.E., Floess S., Bell B.D., Ziegler S.F., Hühn J., ... , Pardoll D.M., Vignali D.A. (2012)
Loss of epigenetic modification driven by the foxp3 transcription factor leads to regulatory T cell insufficiency
Immunity, 36 (5)

O'Connor R.A., Floess S., Hühn J., Jones S.A., Anderton S.M. (2012)
Foxp3(+) Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production
European Journal of Immunology, 42 (5)

Berod L., Puttur F., Hühn Jochen, Sparwasser Tim* (2012)
Tregs in infection and vaccinology: heroes or traitors?
Microbial Biotechnology, 5 (2)

Hinz D., Bauer M., Roder S., Olek S., Hühn Jochen, Sack U., Borte M., Simon J.C., ... , Lehmann I., Herberth G. (2012)
Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year
Allerg: European Journal of Allergy and Clinical Immunology, 67 (3)

Miyao T., Floess S., Setoguchi R., Luche H., Fehling H.J., Waldmann H., ... , Hühn J., Hori S. (2012)
Plasticity of foxp3(+) T cells reflects promiscuous foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
Immunity, 36 (2)

Blankenhaus B., Klemm U., Eschbach M.L., Sparwasser T., Hühn Jochen*, Kuhl A.A., Loddenkemper C., ... , Jacobs T., Breloer M. (2011)
Strongyloides ratti infection induces expansion of Foxp3(+) regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice
Journal of Immunology, 186 (7)

Steinfelder S., Floess S., Engelbert D., Haeringer B., Baron U., Rivino L., Steckel B., Gruetzkau A., Olek S., Geginat J., ... , Hühn J., Hamann A. (2011)
Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells
Blood, 117 (10)

Toker A., Hühn Jochen* (2011)
To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
Science Signaling, 4 (158)

Mayer C.T., Floess S., Baru A.M., Lahl K., Hühn J., Sparwasser T. (2011)
CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity
European Journal of Immunology, 41 (3)

Hubert S., Rissiek B., Klages K., Hühn Jochen*, Sparwasser T., Haag F., Koch-Nolte F., Boyer O., ... , Seman M., Adriouch S. (2010)
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway
Journal of Experimental Medicine, 207 (12)

Polansky J.K., Schreiber L., Thelemann C., Ludwig L., Kruger M., Baumgrass R., Cording S., Floess S., ... , Hamann A., Hühn J. (2010)
Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
Journal of Molecular Medicine, 88 (10)

Klages K., Mayer C.T., Lahl K., Loddenkemper C., Teng M.W., Ngiow S.F., Smyth M.J., Hamann A., ... , Hühn Jochen*, Sparwasser T. (2010)
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
Cancer Research, 70 (20)

Menning A., Loddenkemper C., Westendorf A.M., Szilagyi B., Buer J., Siewert C., ... , Hamann A., Hühn Jochen* (2010)
Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation
European Journal of Immunology, 40 (9)

Lahl K., Mayer C.T., Bopp T., Hühn Jochen*, Loddenkemper C., Eberl G., Wirnsberger G., Dornmair K., Geffers Robert*, Schmitt E., ... , Buer J., Sparwasser T. (2009)
Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice
Journal of Immunology, 183 (9)

Humrich J.Y., Morbach H., Undeutsch R., Enghard P., Rosenberger S., Weigert O., Kloke L., Heimann J., Gaber T., Brandenburg S., Scheffold A., Hühn Jochen*, Radbruch A., ... , Burmester G.R., Riemekasten G. (2010)
Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus
Proceedings of the National Academy of Sciences of the United States of America, 107 (1)

Rausch S., Hühn Jochen*, Loddenkemper C., Hepworth M.R., Klotz C., Sparwasser T., Hamann A., ... , Lucius R., Hartmann S. (2009)
Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) cells
Europen Journal of Immunology, 39 (11)

Koenecke C., Czeloth N., Bubke A., Schmitz S., Kissenpfennig A., Malissen B., Hühn Jochen*, Ganser A., ... , Forster R., Prinz I. (2009)
Alloantigen-specific de novo-induced Foxp3(+) Treg revert in vivo and do not protect from experimental GVHD
European Journal of Immunology, 39 (11)

Lahl K., Loddenkemper C., Drouin C., Freyer J., Arnason J., Eberl G., Hamann A., Wagner H., ... , Hühn Jochen*, Sparwasser T. (2007)
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
Journal of Experimental Medicine, 204 (1)

Siewert C., Menning A., Dudda J., Siegmund K., Lauer U., Floess S., Campbell D.J., ... , Hamann A., Hühn J. (2007)
Induction of organ-selective CD4+ regulatory T cell homing
European Journal of Immunology, 37 (4)

Menning A., Hopken U.E., Siegmund K., Lipp M., Hamann A., Hühn Jochen* (2007)
Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets
European Journal of Immunology, 37 (6)

Baron U., Floess S., Wieczorek G., Baumann K., Grutzkau A., Dong J., Thiel A., Boeld T.J., Hoffmann P., Edinger M., Turbachova I., Hamann A., ... , Olek S., Hühn J. (2007)
DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
European Journal of Immunology, 37 (9)

Polansky J.K., Hühn Jochen* (2007)
[To be or not to be a Treg: epigenetic regulation of Foxp3 expression in regulatory T cells]
Zeitschrift für Rheumatologie, 66 (5)

Doebis C., Siegmund K., Loddenkemper C., Lowe J.B., Issekutz A.C., Hamann A., ... , Hühn Jochen*, Syrbe U. (2008)
Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction
American Journal of Pathology, 173 (4)

Apostolou I., Verginis P., Kretschmer K., Polansky J., Hühn Jochen*, von Boehmer H. (2008)
Peripherally induced Treg: mode, stability, and role in specific tolerance
Journal of Clinical Immunology, 28 (6)

Hoffmann P., Boeld T.J., Eder R., Hühn J., Floess S., Wieczorek G., Olek S., Dietmaier W., ... , Andreesen R., Edinger M. (2009)
Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation
European Journal of Immunology, 39 (4)

Loddenkemper C., Hoffmann C., Stanke J., Nagorsen D., Baron U., Olek S., Hühn Jochen*, Ritz J.P., Stein H., Kaufmann A.M., ... , Schneider A., Cichon G. (2009)
Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer
Cancer Science, 100 (6)

Schaub B., Liu J., Hoppler S., Schleich I., Hühn Jochen*, Olek S., Wieczorek G., ... , Illi S., von Mutius E. (2009)
Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
Journal of Allergy and Clinical Immunology, 123 (4)

Wieczorek G., Asemissen A., Model F., Turbachova I., Floess S., Liebenberg V., Baron U., Stauch D., Kotsch K., Pratschke J., Hamann A., Loddenkemper C., Stein H., Volk H.D., Hoffmuller U., Grutzkau A., Mustea A., Hühn J., ... , Scheibenbogen C., Olek S. (2009)
Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue
Cancer Research, 69 (2)

Hühn Jochen*, Polansky J.K., Hamann A. (2009)
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
Nature Reviews Immunology, 9 (2)

Hansen W., Loser K., Westendorf Astrid M.*, Bruder Dunja*, Pförtner S., Siewert C., Hühn J., ... , Beissert S., Buer Jan* (2006)
GPR83-overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo
Journal of Immunology, 177

Hühn J., Siegmund K., Lehmann J.C.U., Siewert C., Haubold U., Feuerer M., Debes G.F., Lauber J., Frey O., Przybylski G.K., Niesner U., de la Rosa M., Schmidt C.A., Bräuer R., Buer J., ... , Scheffold A., Hamann A. (2004)
Developmental stage, phenotype and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells
Journal of Experimental Medicine, 199