Prof. Dr. Jochen Hühn

Zhang B., Zhang Z., Koeken V.A.C.M., Kumar S., Aillaud M., Tsay H.C., Liu Z., Kraft A.R.M., Soon C.F., Odak I., Bosnjak B., Vlot A., Swertz M.A., Ohler U., Geffers R., Illig T., Hühn J., Saliba A.E., Sander L.E., Förster R., Xu C.J., Cornberg M., Schulte L.N., ... , Li Y., Deutsche C.O.V.I. (2023)

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

Cell Genom.

DOI: 10.1016/j.xgen.2022.100232 HZI-Repositorium PubMed

Braband K.L., Kaufmann T., Floess S., Zou M., Hühn J., Delacher M. (2022)

Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells

Front.Immunol., 13

DOI: 10.3389/fimmu.2022.1082055 HZI-Repositorium PubMed

Pezoldt J., Wiechers C., Zou M., Litovchenko M., Biocanin M., Beckstette M., Sitnik K., Palatella M., van Mierlo G., Chen W., Gardeux V., Floess S., Ebel M., Russeil J., Arampatzi P., Vafardanejad E., Saliba A.E., ... , Deplancke B., Hühn J. (2022)

Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets

Nat.Commun., 13 (1)

DOI: 10.1038/s41467-022-34868-4 HZI-Repositorium PubMed

Shaikh H., Pezoldt J., Mokhtari Z., Gamboa Vargas J., Le D.D., Pena Mosca J., Arellano-Viera E., Kern M.A., Graf C., Beyersdorf N., Lutz M.B., Riedel A., Büttner-Herold M., Zernecke A., Einsele H., Saliba A.E., Ludewig B., ... , Hühn J., Beilhack A. (2022)

Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells

JCI.Insight.

DOI: 10.1172/jci.insight.154250 HZI-Repositorium PubMed

Yang J., Zou M., Chu X., Floess S., Li Y., ... , Delacher M., Hühn J. (2022)

Inflammatory perturbations in early life long-lastingly shape the transcriptome and TCR repertoire of the first wave of regulatory T cells

Front.Immunol., 13

DOI: 10.3389/fimmu.2022.991671 HZI-Repositorium PubMed

Beckstette M., Lu C.W., Herppich S., Diem E.C., Ntalli A., Ochel A., Kruse F., Pietzsch B., Neumann K., Hühn J., ... , Floess S., Lochner M. (2022)

Profiling of epigenetic marker regions in murine ILCs under homeostatic and inflammatory conditions

J Exp Med, 219 (10)

DOI: 10.1084/jem.20210663 HZI-Repositorium PubMed

Ataide M.A., Knöpper K., Cruz de Casas P., Ugur M., Eickhoff S., Zou M., Shaikh H., Trivedi A., Grafen A., Yang T., Prinz I., Ohlsen K., Gomez de Agüero M., Beilhack A., Hühn J., Gaya M., Saliba A.E., ... , Gasteiger G., Kastenmüller W. (2022)

Lymphatic migration of unconventional Tcells promotes site-specific immunity in distinct lymph nodes

Immunity.

DOI: 10.1016/j.immuni.2022.07.019 PubMed

Palatella M., Guillaume S.M., Linterman M.A., Hühn J. (2022)

The dark side of Tregs during aging

Front Immunol., 13

DOI: 10.3389/fimmu.2022.940705 HZI-Repositorium PubMed

Nair V.S., Heredia M., Samsom J., Hühn J. (2022)

Impact of gut microenvironment on epigenetic signatures of intestinal T helper cell subsets

Immunol.Lett., 246 (June 2022)

DOI: 10.1016/j.imlet.2022.04.006 PubMed

Laubert M., Bonifacius A., Dragon A.C., Mangare C., Blasczyk R., ... , Hühn J., Eiz-Vesper B. (2022)

Enhancement of Antiviral T-Cell Responses by Vitamin C Suggests New Strategies to Improve Manufacturing of Virus-Specific T Cells for Adoptive Immunotherapy

Biology, 11 (4)

DOI: 10.3390/biology11040536 HZI-Repositorium PubMed

Cossarizza A., Chang H.D., Radbruch A., Abrignani S., Addo R., Akdis M., Andrä I., Andreata F., Annunziato F., Arranz E., Bacher P., Bari S., Barnaba V., Barros-Martins J., Baumjohann D., Beccaria C.G., Bernardo D., Boardman D.A., Borger J., Böttcher C., Brockmann L., Burns M., Busch D.H., Cameron G., Cammarata I., Cassotta A., Chang Y., Chirdo F.G., Christakou E., Cicin-Sain L., Cook L., Corbett A.J., Cornelis R., Cosmi L., Davey M.S., De Biasi S., De Simone G., Del Zotto G., Delacher M., Di Rosa F., Santo J.D., Diefenbach A., Dong J., Dörner T., Dress R.J., Dutertre C.A., Eckle S.B.G., Eede P., Evrard M., Falk C.S., Feuerer M., Fillatreau S., Fiz-Lopez A., Follo M., Foulds G.A., Fröbel J., Gagliani N., Galletti G., Gangaev A., Garbi N., Garrote J.A., Geginat J., Gherardin N.A., Gibellini L., Ginhoux F., Godfrey D.I., Gruarin P., Haftmann C., Hansmann L., Harpur C.M., Hayday A.C., Heine G., Hernandez D.C., Herrmann M., Hoelsken O., Huang Q., Huber S., Huber J.E., Hühn J., Hundemer M., Hwang W.Y.K., Iannacone M., Ivison S.M., Jäck H.M., Jani P.K., Keller B., Kessler N., Ketelaars S., Knop L., Knopf J., Koay H.F., Kobow K., Kriegsmann K., Kristyanto H., Krueger A., Kuehne J.F., Kunze-Schumacher H., Kvistborg P., Kwok I., Latorre D., Lenz D., Levings M.K., Lino A.C., Liotta F., Long H.M., Lugli E., MacDonald K.N., Maggi L., Maini M.K., Mair F., Manta C., Manz R.A., Mashreghi M.F., Mazzoni A., McCluskey J., Mei H.E., Melchers F., Melzer S., Mielenz D., Monin L., Moretta L., Multhoff G., Munoz L.E., Munoz-Ruiz M., Muscate F., Natalini A., Neumann K., Ng L.G., Niedobitek A., Niemz J., Almeida L.N., Notarbartolo S., Ostendorf L., Pallett L.J., Patel A.A., Percin G.I., Peruzzi G., Pinti M., Pockley A.G., Pracht K., Prinz I., Pujol-Autonell I., Pulvirenti N., Quatrini L., Quinn K.M., Radbruch H., Rhys H., Rodrigo M.B., Romagnani C., Saggau C., Sakaguchi S., Sallusto F., Sanderink L., Sandrock I., Schauer C., Scheffold A., Scherer H.U., Schiemann M., Schildberg F.A., Schober K., Schoen J., Schuh W., ler T., Schulz A.R., Schulz S., Schulze J., Simonetti S., Singh J., Sitnik K.M., Stark R., Starossom S., Stehle C., Szelinski F., Tan L., Tarnok A., Tornack J., Tree T.I.M., van Beek J.J.P., van de Veen W., van Gisbergen K., Vasco C., Verheyden N.A., von Borstel A., Ward-Hartstonge K.A., Warnatz K., Waskow C., Wiedemann A., Wilharm A., Wing J., Wirz O., Wittner J., ... , Yang J.H.M., Yang J. (2021)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Eur.J.Immunol., 51 (12)

DOI: 10.1002/eji.202170126 HZI-Repositorium PubMed

Haftmann C., Zwicky P., Ingelfinger F., Mair F., Floess S., Riedel R., Durek P., Spalinger M.R., Friebel E., Leung B.P., Lutz M., Puertas N., Amorim A., Schürli S., Becher B., Kisielow J., Waisman A., Mashreghi M.F., ... , Hühn J., Becher B. (2021)

Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development

Sci.Immunol., 6 (65)

DOI: 10.1126/sciimmunol.abf3111 HZI-Repositorium PubMed

Pezoldt J., Wiechers C., Erhard F., Rand U., Bulat T., Beckstette M., Brendolan A., Hühn J., Kalinke U., Mueller M., Strobl B., Deplancke B., ... , Cicin-Sain L., Sitnik K.M. (2021)

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Commun.Biolog., 4 (1)

DOI: 10.1038/s42003-021-02882-9 HZI-Repositorium PubMed

Formaglio P., Alabdullah M., Siokis A., Handschuh J., Sauerland I., Fu Y., Krone A., Gintschel P., Stettin J., Heyde S., Mohr J., Philipsen L., Schröder A., Robert P.A., Zhao G., Khailaie S., Dudeck A., Bertrand J., Späth G.F., Kahlfuß S., Bousso P., Schraven B., Hühn J., Binder S., ... , Meyer-Hermann M., Müller A.J. (2021)

Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells

Immunity

DOI: 10.1016/j.immuni.2021.09.021 HZI-Repositorium PubMed

Ruck T., Bock S., Pfeuffer S., Schroeter C.B., Cengiz D., Marciniak P., Lindner M., Herrmann A., Liebmann M., Kovac S., Gola L., Rolfes L., Pawlitzki M., Opel N., Hahn T., Dannlowski U., Pap T., Luessi F., Schreiber J.A., Wünsch B., Kuhlmann T., Seebohm G., Tackenberg B., Seja P., Döring F., Wischmeyer E., Chasan A.I., Roth J., Klotz L., Meyer Zu Hörste G., Wiendl H., Marschall T., Floess S., Hühn J., Budde T., Bopp T., ... , Bittner S., Meuth S.G. (2021)

K2P18.1 translates T cell receptor signals into thymic regulatory T cell development

Cell Research

DOI: 10.1038/s41422-021-00580-z HZI-Repositorium PubMed

Herppich S., Beckstette M., Hühn J. (2021)

The thymic microenvironment gradually modulates the phenotype of thymus-homing peripheral conventional dendritic cells

Immunity, Inflammation and Disease

DOI: 10.1002/iid3.559 HZI-Repositorium PubMed

Elfaki Y., Yang J., Boehme J., Schultz K., Bruder D., Falk C.S., ... , Hühn J., Floess S. (2021)

Tbx21 and foxp3 are epigenetically stabilized in t-bet+ tregs that transiently accumulate in influenza a virus-infected lungs

Int.J.Mol.Sci., 22 (14)

DOI: 10.3390/ijms22147522 HZI-Repositorium PubMed

Shaikh H., Vargas J.G., Mokhtari Z., Jarick K.J., Ulbrich M., Mosca J.P., Viera E.A., Graf C., Le D.D., Heinze K.G., Büttner-Herold M., Rosenwald A., Pezoldt J., ... , Hühn J., Beilhack A. (2021)

Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract

Front.Immunol., 12

DOI: 10.3389/fimmu.2021.689896 HZI-Repositorium PubMed

Ciurkiewicz M., Floess S., Beckstette M., Kummerfeld M., Baumgärtner W., ... , Hühn J., Beineke A. (2021)

Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination

Brain Pathology

DOI: 10.1111/bpa.13000 HZI-Repositorium PubMed

Floess S., Hühn J. (2021)

Generation of Sequencing Libraries for Building Immune Cell Methylomes

Methods Mol.Biol., 2285 (21)

DOI: 10.1007/978-1-0716-1311-5_21 HZI-Repositorium PubMed

Delacher M., Simon M., Sanderink L., Hotz-Wagenblatt A., Wuttke M., Schambeck K., Schmidleithner L., Bittner S., Pant A., Ritter U., Hehlgans T., Riegel D., Schneider V., Groeber-Becker F.K., Eigenberger A., Gebhard C., Strieder N., Fischer A., Rehli M., Hoffmann P., Edinger M., Strowig T., Hühn J., Schmidl C., Werner J.M., Prantl L., Brors B., ... , Imbusch C.D., Feuerer M. (2021)

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

Immunity, 54 (4)

DOI: 10.1016/j.immuni.2021.03.007 HZI-Repositorium PubMed

Zou M., Wiechers C., Hühn J. (2021)

Lymph node stromal cell subsets-Emerging specialists for tailored tissue-specific immune responses

Int.J.Med.Microbiol., 311 (3)

DOI: 10.1016/j.ijmm.2021.151492 HZI-Repositorium PubMed

Elfaki Y., Robert P.A., Binz C., Falk C.S., Bruder D., Prinz I., Floess S., ... , Meyer-Hermann M., Hühn J. (2021)

Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice

Eur.J.Immunol.

DOI: 10.1002/eji.202048981 HZI-Repositorium PubMed

Permanyer M., Bosnjak B., Glage S., Friedrichsen M., Floess S., Hühn J., Patzer G.E., Odak I., Eckert N., Zargari R., Ospina-Quintero L., ... , Georgiev H., Förster R. (2021)

Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool

Cell Mol.Immunol, 18 (2)

DOI: 10.1038/s41423-020-00599-z HZI-Repositorium PubMed

Bonifacius A., Goldmann O., Floess S., Holtfreter S., Robert P.A., Nordengrün M., Kruse F., Lochner M., Falk C.S., Schmitz I., Bröker B.M., ... , Medina E., Hühn J. (2020)

Staphylococcus aureus Alpha-Toxin Limits Type 1 While Fostering Type 3 Immune Responses

Front Immunol., 11

DOI: 10.3389/fimmu.2020.01579 HZI-Repositorium PubMed

Zou M., Yang J., Wiechers C., Hühn J. (2020)

Acute neonatal Listeria monocytogenes infection causes long-term, organ-specific changes in immune cell subset composition

Eur.J.Microbiol.Immunol.(Bp)

DOI: 10.1556/1886.2020.00007 HZI-Repositorium PubMed

Matthias J., Heink S., Picard F.S., Zeiträg J., Kolz A., Chao Y.Y., Soll D., de Almeida G.P., Glasmacher E., Jacobsen I.D., Riedel T., Peters A., Floess S., Hühn J., Baumjohann D., Huber M., ... , Korn T., Zielinski C.E. (2020)

Salt generates anti-inflammatory Th17 cells but amplifies their pathogenicity in pro-inflammatory cytokine microenvironments

J.Clin.Invest, 130 (9)

DOI: 10.1172/JCI137786 HZI-Repositorium PubMed

Kouakanou L., Peters C., Sun Q., Floess S., Bhat J., ... , Hühn J., Kabelitz D. (2020)

Vitamin C supports conversion of human g[gamma]d[delta] T cells into FOXP3-expressing regulatory cells by epigenetic regulation

Sci.Rep., 10 (1)

DOI: 10.1038/s41598-020-63572-w HZI-Repositorium PubMed

Nikolouli E., Elfaki Y., Herppich S., Schelmbauer C., Delacher M., Falk C., Mufazalov I.A., Waisman A., ... , Feuerer M., Hühn J. (2021)

Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions

Cell.Mol.Immunol, 18 (1)

DOI: 10.1038/s41423-019-0352-8 HZI-Repositorium PubMed

Maluski M., Ghosh A., Herbst J., Scholl V., Baumann R., Hühn J., Geffers R., Meyer J., Maul H., Eiz-Vesper B., Krueger A., Schambach A., ... , van den Brink M.R.M., Sauer M.G. (2019)

Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development

J.Clin.Invest., 129 (12)

DOI: 10.1172/JCI126350 HZI-Repositorium PubMed

Andersen L., Gülich A.F., Alteneder M., Preglej T., Orola M.J., Dhele N., Stolz V., Schebesta A., Hamminger P., Hladik A., Floess S., Krausgruber T., Faux T., Andrabi S.B.A., Hühn J., Knapp S., Sparwasser T., Bock C., Laiho A., Elo L.L., Rasool O., Lahesmaa R., ... , Sakaguchi S., Ellmeier W. (2019)

The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells

Cell Rep., 29 (13)

DOI: 10.1016/j.celrep.2019.11.089 HZI-Repositorium PubMed

Herppich S., Toker A., Pietzsch B., Kitagawa Y., Ohkura N., Miyao T., Floess S., Hori S., ... , Sakaguchi S., Hühn J. (2019)

Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells

Front.Immunol., 10

DOI: 10.3389/fimmu.2019.02382 HZI-Repositorium PubMed

Cossarizza A., Chang H.D., Radbruch A., Acs A., Adam D., dam-Klages S., Agace W.W., Aghaeepour N., Akdis M., Allez M., Almeida L.N., Alvisi G., Anderson G., Annunziato F., Anselmo A., Bacher P., Baldari C.T., Bari S., Barnaba V., Barros-Martins J., Battistini L., Bauer W., Baumgart S., Baumgarth N., Baumjohann D., Baying B., Bebawy M., Becher B., Beisker W., Benes V., Beyaert R., Blanco A., Boardman D.A., Bogdan C., Borger J.G., Borsellino G., Boulais P.E., Bradford J.A., Brenner D., Brinkman R.R., Brooks A.E.S., Busch D.H., Büscher M., Bushnell T.P., Calzetti F., Cameron G., Cammarata I., Cao X., Cardell S.L., Casola S., Cassatella M.A., Cavani A., Celada A., Chatenoud L., Chattopadhyay P.K., Chow S., Christakou E., Cicin-Sain L., Clerici M., Colombo F.S., Cook L., Cooke A., Cooper A.M., Corbett A.J., Cosma A., Cosmi L., Coulie P.G., Cumano A., Cvetkovic L., Dang V.D., ng-Heine C., Davey M.S., Davies D., De Biasi S., Del Zotto G., Dela Cruz G.V., Delacher M., Della Bella S., Dellabona P., Deniz G., Dessing M., Di Santo J.P., Diefenbach A., Dieli F., Dolf A., Dörner T., Dress R.J., Dudziak D., Dustin M., Dutertre C.A., Ebner F., Eckle S.B.G., Edinger M., Eede P., Ehrhardt G.R.A., Eich M., Engel P., Engelhardt B., Erdei A., Esser C., Everts B., Evrard M., Falk C.S., Fehniger T.A., Felipo-Benavent M., Ferry H., Feuerer M., Filby A., Filkor K., Fillatreau S., Follo M., Förster I., Foster J., Foulds G.A., Frehse B., Frenette P.S., Frischbutter S., Fritzsche W., Galbraith D.W., Gangaev A., Garbi N., Gaudilliere B., Gazzinelli R.T., Geginat J., Gerner W., Gherardin N.A., Ghoreschi K., Gibellini L., Ginhoux F., Goda K., Godfrey D.I., Goettlinger C., Goodyear C.S., Gori A., Grogan J.L., Grummitt D., Grützkau A., Haftmann C., Hahn J., Hammad H., Hämmerling G., Hansmann L., Hansson G., Harpur C.M., Hartmann S., Hauser A., Hauser A.E., Haviland D.L., Hedley D., Hernandez D.C., Herrera G., Herrmann M., Hess C., Höfer T., Hoffmann P., Hogquist K., Holland T., Höllt T., Holmdahl R., Hombrink P., Houston J.P., Hoyer B.F., Huang B., Huang F.P., Huber J.E., Hühn J., Hundemer M., Hunter C.A., Hwang W.Y.K., Iannone A., Ingelfinger F., Ivison S.M., Jäck H.M., Jani P.K., Jbvega B., Kaiser T., Kalina T., Kamradt T., Kaufmann S.H.E., Keller B., Ketelaars S.L.C., Khalilnezhad A., Khan S., Kisielow J., Klenerman P., Knopf J., Koay H.F., Kobow K., Kolls J.K., Kong W.T., Kopf M., Korn T., Kriegsmann K., Kristyanto H., Kroneis T., Krueger A., Kühne J., Kukat C., Kunkel D., Kunze-Schumacher H., Kurosaki T., Kurts C., Kvistborg P., Kwok I., Landry J., Lantz O., Lanuti P., LaRosa F., Lehuen A., LeibundGut-Landmann S., Leipold M.D., Leung L.Y.T., Levings M.K., Lino A.C., Liotta F., Litwin V., Liu Y., Ljunggren H.G., Lohoff M., Lombardi G., Lopez L., Lopez-Botet M., Lovett-Racke A.E., Lubberts E., Luche H., Ludewig B., Lugli E., Lunemann S., Maecker H.T., Maggi L., Maguire O., Mair F., Mair K.H., Mantovani A., Manz R.A., Marshall A.J., Martinez-Romero A., Martrus G., Marventano I., Maslinski W., Matarese G., Mattioli A.V., Maueröder C., Mazzoni A., McCluskey J., McGrath M., McGuire H.M., McInnes I.B., Mei H.E., ... , Melchers F., Melzer S. (2019)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Eur.J.Immunol., 49 (10)

DOI: 10.1002/eji.201970107 HZI-Repositorium PubMed

Schuster M., Plaza-Sirvent C., Visekruna A., Hühn J., Schmitz I. (2019)

Generation of Foxp3+CD25- regulatory T-cell precursors requires c-rel and IkBNS

Front.Immunol., 10 (JULY)

DOI: 10.3389/fimmu.2019.01583 HZI-Repositorium PubMed

Pezoldt J., Yang J., Zou M., Hühn J. (2018)

Microbiome and gut immunity: T cells

(9)

DOI: 10.1007/978-3-319-90545-7_9 PubMed

Pandiyan P., Bhaskaran N., Zou M., Schneider E., Jayaraman S., Hühn J. (2019)

Microbiome Dependent Regulation of T regs and Th17 Cells in Mucosa

Front Immunol, 10

DOI: 10.3389/fimmu.2019.00426 HZI-Repositorium PubMed

Lyszkiewicz M., Winter S.J., Witzlau K., Fohse L., Brownlie R., Puchalka J., Verheyden N.A., Kunze-Schumacher H., Imelmann E., Blume J., Raha S., Sekiya T., Yoshimura A., Frueh J.T., Ullrich E., Hühn J., Weiss S., Gutierrez M.G., Prinz I., Zamoyska R., ... , Zietara N., Krueger A. (2019)

miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity

PLoS.Biol., 17 (3)

DOI: 10.1371/journal.pbio.2006716 HZI-Repositorium PubMed

Garg G., Muschaweckh A., Moreno H., Vasanthakumar A., Floess S., Lepennetier G., Oellinger R., Zhan Y., Regen T., Hiltensperger M., Peter C., Aly L., Knier B., Palam L.R., Kapur R., Kaplan M.H., Waisman A., Rad R., Schotta G., Hühn J., ... , Kallies A., Korn T. (2019)

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Cell Rep., 26 (7)

DOI: 10.1016/j.celrep.2019.01.070 HZI-Repositorium PubMed

Elfiky A., Bonifacius A., Pezoldt J., Pasztoi M., Chaoprasid P., Sadana P., El-Sherbeeny N., Hagras M., Scrima A., ... , Dersch P., Hühn J. (2018)

Yersinia Pseudotuberculosis Modulates Regulatory T Cell Stability via Injection of Yersinia Outer Proteins in a Type III Secretion System-Dependent Manner

Eur.J.Microbiol.Immunol.(Bp), 8 (4)

DOI: 10.1556/1886.2018.00015 HZI-Repositorium

Ludwig R., Hühn J. (2018)

Already ENLIGHT-TENed? Equipping young immunologists with a combination of research-related and transferrable competencies

Eur.J.Immunol., 48 (12)

DOI: 10.1002/eji.201870145

Yang J., Zou M., Pezoldt J., Zhou X., Hühn J. (2018)

Thymus-derived Foxp3(+) regulatory T cells upregulate RORg[gamma]t expression under inflammatory conditions

J.Mol.Med.(Berl), 96 (12)

DOI: 10.1007/s00109-018-1706-x PubMed

Prajeeth C.K., Dittrich-Breiholz O., Talbot S.R., Robert P.A., Hühn J., Stangel M. (2018)

IFN-g[gamma] producing Th1 cells induce different transcriptional profiles in microglia and astrocytes

Front.Cell.Neurosci., 12

DOI: 10.3389/fncel.2018.00352 HZI-Repositorium PubMed

Pezoldt J., Pasztoi M., Zou M., Wiechers C., Beckstette M., Thierry G.R., Vafadarnejad E., Floess S., Arampatzi P., Buettner M., Schweer J., Fleissner D., Vital M., Pieper D.H., Basic M., Dersch P., Strowig T., Hornef M., Bleich A., Bode U., Pabst O., Bajenoff M., ... , Saliba A.E., Hühn J. (2018)

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

Nat.Commun., 9 (1)

DOI: 10.1038/s41467-018-06423-7 HZI-Repositorium

Kyburz A., Fallegger A., Zhang X., Altobelli A., Artola-Boran M., Borbet T., Urban S., Paul P., Münz C., Floess S., Hühn J., Cover T.L., Blaser M.J., ... , Taube C., Müller A. (2018)

Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells

J.Allergy Clin.Immunol., 143 (4)

DOI: 10.1016/j.jaci.2018.07.046 HZI-Repositorium PubMed

Schmidl C., Delacher M., Hühn J., Feuerer M. (2018)

Epigenetic mechanisms regulating T-cell responses

J.Allergy Clin.Immunol., 142 (3)

DOI: 10.1016/j.jaci.2018.07.014

Prajeeth C.K., Hühn J., Stangel M. (2018)

Regulation of neuroinflammatory properties of glial cells by T cell effector molecules

Neural Regen.Res., 13 (2)

DOI: 10.4103/1673-5374.226385 HZI-Repositorium

Uhde A.K., Ciurkiewicz M., Herder V., Khan M.A., Hensel N., Claus P., Beckstette M., Teich R., Floess S., Baumgartner W., Jung K., ... , Hühn J., Beineke A. (2018)

Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice

Sci.Rep., 8 (1)

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Sadana P., Geyer R., Pezoldt J., Helmsing S., Hühn J., Hust M., ... , Dersch P., Scrima A. (2018)

The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine

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Lipps C., Klein F., Wahlicht T., Seiffert V., Butueva M., Zauers J., Truschel T., Luckner M., Köster M., MacLeod R., Pezoldt J., Hühn J., Yuan Q., Muller P.P., Kempf H., Zweigerdt R., Dittrich-Breiholz O., Pufe T., Beckmann R., Drescher W., Riancho J., Sanudo C., Korff T., Opalka B., Rebmann V., Gothert J.R., Alves P.M., Ott M., Schucht R., Hauser H., ... , Wirth D., May T. (2018)

Expansion of functional personalized cells with specific transgene combinations

Nat.Commun., 9 (1)

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Schmoeckel K., Mrochen D.M., Hühn J., Pötschke C., Bröker B.M. (2018)

Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree

PLoS ONE, 13 (2)

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Essig K., Hu D., Guimaraes J.C., Alterauge D., Edelmann S., Raj T., Kranich J., Behrens G., Heiseke A., Floess S., Klein J., Maiser A., Marschall S., Hrabe de Angelis M., Leonhardt H., Calkhoven C.F., Noessner E., Brocker T., Hühn J., Krug A.B., Zavolan M., ... , Baumjohann D., Heissmeyer V. (2017)

Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

Immunity, 47 (6)

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Prajeeth C.K., Kronisch J., Khorooshi R., Knier B., Toft-Hansen H., Gudi V., Floess S., Hühn J., Owens T., ... , Korn T., Stangel M. (2017)

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties

J.Neuroinflammation., 14 (1)

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Ranjan S., Goihl A., Kohli S., Gadi I., Pierau M., Shahzad K., Gupta D., Bock F., Wang H., Shaikh H., Kahne T., Reinhold D., Bank U., Zenclussen A.C., Niemz J., Schnoder T.M., Brunner-Weinzierl M., Fischer T., Kalinski T., Schraven B., Luft T., Hühn J., Naumann M., ... , Heidel F.H., Isermann B. (2017)

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

Nat.Commun., 8 (1)

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Van Ham M., Teich R., Philipsen L., Niemz J., Amsberg N., Wissing J., Nimtz M., Grobe L., Kliche S., Thiel N., Klawonn F., Hubo M., Jonuleit H., Reichardt P., Muller A.J., ... , Hühn J., Jänsch L. (2017)

TCR signalling network organization at the immunological synapses of murine regulatory T cells

Eur.J.Immunol., 47 (12)

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Pasztoi M., Pezoldt J., Beckstette M., Lipps C., Wirth D., Rohde M., Paloczi K., ... , Buzas E.I., Hühn J. (2017)

Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells

Eur.J.Immunol., 47 (12)

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Kyburz A., Urban S., Altobelli A., Floess S., Hühn J., ... , Cover T.L., Muller A. (2017)

Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy

Clin.Exp.Allergy

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Szilagyi B.A., Triebus J., Kressler C., de Almeida M., Tierling S., Durek P., Mardahl M., Szilagyi A., Floess S., Hühn J., Syrbe U., Walter J., ... , Polansky J.K., Hamann A. (2017)

Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells

Mucosal.Immunol., 10 (6)

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Nikolouli E., Hardtke-Wolenski M., Hapke M., Beckstette M., Geffers R., Floess S., ... , Jaeckel E., Hühn J. (2017)

Alloantigen-induced regulatory t cells generated in presence of vitamin c display enhanced stability of foxp3 expression and promote skin allograft acceptance

Front.Immunol., 8 (748)

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Schuster M., Plaza-Sirvent C., Matthies A.M., Heise U., Jeron A., Bruder D., Visekruna A., ... , Hühn J., Schmitz I. (2017)

c-REL and IkappaBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors

J.Immunol., 199 (3)

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Niemz J., Kliche S., Pils M.C., Morrison E., Manns A., Freund C., Crittenden J.R., Graybiel A.M., Galla M., ... , Jänsch L., Hühn J. (2017)

The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells

Eur.J.Microbiol.Immunol.(Bp), 7 (2)

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Ciurkiewicz M., Herder V., Khan M.A., Uhde A.K., Teich R., Floess S., Baumgartner W., ... , Hühn J., Beineke A. (2017)

Cytotoxic CD8+ T cells ablation enhances the capacity of regulatory T cells to delay viral elimination in Theiler's murine encephalomyelitis

Brain Pathol., 28 (3)

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Pasztoi M., Bonifacius A., Pezoldt J., Kulkarni D., Niemz J., Yang J., Teich R., Hajek J., Pisano F., Rohde M., ... , Dersch P., Hühn J. (2017)

Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling

Cell Mol.Life Sci., 74 (15)

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Garg G., Nikolouli E., Hardtke-Wolenski M., Toker A., Ohkura N., Beckstette M., Miyao T., Geffers R., Floess S., Gerdes N., Lutgens E., Osterloh A., Hori S., Sakaguchi S., ... , Jaeckel E., Hühn J. (2017)

Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells

Oncotarget., 8 (22)

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Pezoldt J., Pisano F., Heine W., Pasztoi M., Rosenheinrich M., Nuss A.M., Pils M.C., Prinz I., Forster R., ... , Hühn J., Dersch P. (2017)

Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection

J Infect.Dis., 216 (6)

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Beyer M., Hühn J. (2017)

Epigenetic orchestration of thymic T reg cell development

Nat.Immunol., 18 (2)

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Noyan F., Zimmermann K., Hardtke-Wolenski M., Knoefel A., Schulde E., Geffers R., Hust M., Hühn J., Galla M., Morgan M., Jokuszies A., ... , Manns M.P., Jaeckel E. (2016)

Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor

Am J Transplant., 17 (4)

DOI: 10.1111/ajt.14175 HZI-Repositorium PubMed

Pezoldt J., Hühn J. (2016)

Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4+ T Cell Differentiation

Eur.J Microbiol.Immunol.(Bp), 6 (3)

DOI: 10.1556/1886.2016.00018

Uhde A.K., Herder V., Akram Khan M., Ciurkiewicz M., Schaudien D., Teich R., Floess S., Baumgartner W., ... , Hühn J., Beineke A. (2016)

Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice

PLoS ONE, 11 (9)

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Goldstein J.D., Burlion A., Zaragoza B., Sendeyo K., Polansky J.K., Hühn J., Piaggio E., ... , Salomon B.L., Marodon G. (2016)

Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression

PLoS ONE, 11 (4)

DOI: 10.1371/journal.pone.0153682 HZI-Repositorium PubMed

Polansky J.K., Floess S., Freyer J., Hamann A., Hühn J. (2009)

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells

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Milanez-Almeida P., Ulas T., Pasztoi M., Glage S., Schughart K., Lutz M.B., ... , Schultze J.L., Hühn J. (2015)

CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice

Eur.J Microbiol.Immunol.(Bp), 5 (4)

DOI: 10.1556/1886.2015.00038 HZI-Repositorium PubMed

Pasztoi M., Pezoldt J., Hühn J. (2015)

Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells

Prog.Mol.Biol.Transl.Sci, 136

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Klysz D., Tai X., Robert P.A., Craveiro M., Cretenet G., Oburoglu L., Mongellaz C., Flöß S., Fritz V., Matias M.I., Yong C., Surh N., Marie J.C., Hühn J., Zimmermann V., Kinet S., ... , Dardalhon V., Taylor N. (2015)

Glutamine-dependent a[alpha]-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

Sci Signal, 8 (396)

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Yang B.H., Hagemann S., Mamareli P., Lauer U., Hoffmann U., Beckstette M., Fohse L., Prinz I., Pezoldt J., Suerbaum S., Sparwasser T., Hamann A., Floess S., ... , Hühn J., Lochner M. (2016)

Foxp3+ T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

Mucosal.Immunol., 9

DOI: 10.1038/mi.2015.74 HZI-Repositorium PubMed

Braun A., Dewert N., Brunnert F., Schnabel V., Hardenberg J.H., Richter B., Zachmann K., Cording S., Classen A., Brans R., Hamann A., ... , Hühn J., Schon M.P. (2015)

Integrin a[alpha]E(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity

J Invest Dermatol.

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Roesner L.M., Flöß S., Witte T., Olek S., Hühn J., Werfel T. (2015)

Foxp3 regulatory T cells are expanded in severe atopic dermatitis patients

Allergy: European Journal of Allergy and Clinical Immunology, 70 (12)

DOI: 10.1111/all.12712 PubMed

Hühn J., Beyer M. (2015)

Epigenetic and transcriptional control of Foxp3 regulatory T cells

Semin.Immunol., 27 (1)

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Hühn J., Floess S., Ohkura N., Sakaguchi S. (2015)

Comment on "cutting edge: Epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory t cells in tumors from mice and humans"

J.Immunol., 194 (8)

Prajeeth C.K., Beineke A., Iskandar C., Gudi V., Herder V., Gerhauser I., Haist V., Teich R., Hühn J., ... , Baumgartner W., Stangel M. (2014)

Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice

J Neuroinflammation., 11 (1)

DOI: 10.1186/s12974-014-0180-9 HZI-Repositorium

Milanez-Almeida P., Klawonn F., Meyer-Hermann M., Hühn J. (2014)

Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen

Eur.J Microbiol.Immunol.(Bp), 4 (3)

Delacher M., Schreiber L., Richards D.M., Farah C., Feuerer M., Hühn J. (2014)

Transcriptional control of regulatory T cells

Curr Top.Microbiol.Immunol., 381

Yang B.H., Flöß S., Hagemann S., Deyneko I.V., Gröbe L., Pezoldt J., Sparwasser T., ... , Lochner M., Hühn J. (2015)

Development of a unique epigenetic signature during in vivo Th17 differentiation

Nucleic Acids Res, 43 (3)

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Mayer Christian T., Lahl K., Milanez-Almeida P., Watts D., Dittmer U., Fyhrquist N., Hühn Jochen, Kopf M., Kretschmer K., ... , Rouse B., Sparwasser Tim (2014)

Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice

Immunity, Inflammation and Disease, 2 (3)

DOI: 10.1002/iid3.33 HZI-Repositorium PubMed

Franckaert D., Dooley J., Roos E., Flöß S., Hühn J., Luche H., Fehling H.J., Liston A., ... , Linterman M.A., Schlenner S.M. (2014)

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3 and Foxp3 T cells

Immunology and Cell Biology, 93 (4)

DOI: 10.1038/icb.2014.108 HZI-Repositorium PubMed

Tebartz C., Horst Sarah A., Sparwasser Tim, Hühn Jochen, Beineke A., ... , Peters G., Medina Eva (2014)

A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection

Journal of Immunology, 194 (3)

Khailaie S., Robert P.A., Toker A., Hühn J., Meyer-Hermann M. (2014)

A signal integration model of thymic selection and natural regulatory T cell commitment

Journal of Immunology, 193 (12)

Milanez-Almeida P., Meyer-Hermann M., Toker A., Khailaie S., Hühn J. (2014)

Foxp3 regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen

European Journal of Immunology, 45

Berod L., Friedrich C., Nandan A., Freitag J., Hagemann S., Harmrolfs K., Sandouk A., Hesse C., Castro C.N., Bahre H., Tschirner S.K., Gorinski N., Gohmert M., Mayer C.T., Hühn Jochen, Ponimaskin E., Abraham Wolf-Rainer, Müller Rolf, ... , Lochner M., Sparwasser Tim (2014)

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

Nature medicine, 20

Blankenhaus B., Reitz M., Brenz Y., Eschbach M.L., Hartmann W., Haben I., Sparwasser Tim, Hühn J., Kühl A., Feyerabend T.B., ... , Rodewald H.R., Breloer M. (2014)

Foxp3+ Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice

PLoS Pathogens, 10 (2)

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Schreiber L., Pietzsch B., Flöß S., Farah C., Jänsch L., ... , Schmitz I., Hühn J. (2014)

The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-?B signaling

PLoS ONE, 9 (2)

DOI: 10.1371/journal.pone.0088318 HZI-Repositorium PubMed

Khailaie Sahamoddin, Bahrami F., Janahmadi M., Milanez-Almeida P., Hühn J., Meyer-Hermann M. (2013)

A mathematical model of immune activation with a unified self-nonself concept

Frontiers in Immunology, 4

DOI: 10.3389/fimmu.2013.00474 HZI-Repositorium PubMed

Prajeeth C.K., Lohr K., Flöß S., Zimmermann J., Ulrich R., Gudi V., Beineke A., Baumgartner W., Muller M., ... , Hühn J., Stangel M. (2014)

Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia

Brain, Behavior, and Immunity, 37

DOI: 10.1016/j.bbi.2014.01.001 HZI-Repositorium PubMed

Cording S., Fleißner Diana, Heimesaat M.M., Bereswill S., Loddenkemper C., Uematsu S., Akira S., ... , Hamann A., Hühn Jochen (2013)

Commensal microbiota drive proliferation of conventional and Foxp3 regulatory CD4 T cells in mesenteric lymph nodes and Peyer's patches

European Journal of Microbiology and Immunology, 3 (1)

Cording S., Wahl B., Kulkarni D., Chopra H., Pezoldt Jörn, Buettner M., Dummer A., Hadis U., Heimesaat M., Bereswill S., Falk C., Bode U., Hamann A., Fleissner D., ... , Hühn Jochen, Pabst O. (2014)

The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes

Mucosal Immunology, 7 (2)

DOI: 10.1038/mi.2013.54 PubMed

Schweer J., Kulkarni D., Kochut A., Pezoldt J., Pisano F., Pils M.C., Genth H., ... , Hühn J., Dersch P. (2013)

The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases

PLoS Pathogens, 9 (11)

DOI: 10.1371/journal.ppat.1003746 HZI-Repositorium PubMed

Huang Yi-Ju, Haist V., Baumgartner W., Fohse L., Prinz I., Suerbaum S., ... , Flöß S., Hühn J. (2013)

Induced and thymus-derived Foxp3 regulatory T cells share a common niche

European Journal of Immunology, 44 (2)

DOI: 10.1002/eji.201343463

Kühlhorn F., Rath M., Schmoeckel K., Cziupka K., Nguyen H.H., Hildebrandt P., Hünig T., Sparwasser Tim, Hühn Jochen, ... , Pötschke C., Bröker B.M. (2013)

Foxp3+ Regulatory T Cells Are Required for Recovery from Severe Sepsis

PLoS ONE, 8 (5)

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Toker A., Engelbert D., Garg G., Polansky J.K., Floess S., Miyao T., Baron U., Düber S., Geffers R., Giehr P., Schallenberg S., Kretschmer K., Olek S., Walter J., Weiss S., Hori S., ... , Hamann A., Hühn J. (2013)

Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus

Journal of Immunology, 190 (7)

Weiss J.M., Bilate A.M., Gobert M., Ding Y., de Lafaille M.A.C., Parkhurst C.N., Xiong H., Dolpady J., Frey A.B., Ruocco M.G., Yang Y., Flöß S., Hühn J., Oh S., Li M.O., Niec R.E., Rudensky A.Y., Dustin M.L., ... , Littman D.R., Lafaille J.J. (2012)

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosagenerated induced Foxp3+ T reg cells

Journal of Experimental Medicine, 209 (10)

DOI: 10.1084/jem.20120914 HZI-Repositorium PubMed

Schuster M., Glauben R., Plaza-Sirvent C., Schreiber L., Annemann M., Floess S., Kuhl A.A., Clayton L.K., Sparwasser T., Schulze-Osthoff K., Pfeffer K., Hühn J., ... , Siegmund B., Schmitz I. (2012)

IkappaB(NS) Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor

Immunity, 37 (6)

DOI: 10.1016/j.immuni.2012.08.023 HZI-Repositorium PubMed

Ohkura N., Hamaguchi M., Morikawa H., Sugimura K., Tanaka A., Ito Y., Osaki M., Tanaka Y., Yamashita R., Nakano N., Hühn Jochen, Fehling H.J., Sparwasser Tim*, ... , Nakai K., Sakaguchi S. (2012)

T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for treg cell development

Immunity, 37 (5)

DOI: 10.1016/j.immuni.2012.09.010 HZI-Repositorium PubMed

Koenecke C., Lee C.W., Thamm K., Fohse L., Schafferus M., Mittrucker H.W., Floess S., Hühn J., Ganser A., ... , Forster R., Prinz I. (2012)

IFN-gamma Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease

Journal of Immunology, 189 (6)

DOI: 10.4049/jimmunol.1200413 PubMed

König S., Probst-Kepper M., Reinl T., Jeron A., Hühn Jochen, ... , Schraven B., Jänsch Lothar (2012)

First insight into the kinome of human regulatory T cells

PLoS ONE, 7 (7)

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Herder V., Gerhauser I., Klein S.K., Almeida P., Kummerfeld M., Ulrich R., Seehusen F., Rohn K., Schaudien D., Baumgartner W., ... , Hühn Jochen, Beineke A. (2012)

Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis

Journal of Neuroimmunology, 249 (1-2)

Bettini M.L., Pan F., Bettini M., Finkelstein D., Rehg J.E., Floess S., Bell B.D., Ziegler S.F., Hühn J., ... , Pardoll D.M., Vignali D.A. (2012)

Loss of epigenetic modification driven by the foxp3 transcription factor leads to regulatory T cell insufficiency

Immunity, 36 (5)

O'Connor R.A., Floess S., Hühn J., Jones S.A., Anderton S.M. (2012)

Foxp3(+) Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production

European Journal of Immunology, 42 (5)

Berod L., Puttur F., Hühn Jochen, Sparwasser Tim* (2012)

Tregs in infection and vaccinology: heroes or traitors?

Microbial Biotechnology, 5 (2)

Hinz D., Bauer M., Roder S., Olek S., Hühn Jochen, Sack U., Borte M., Simon J.C., ... , Lehmann I., Herberth G. (2012)

Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year

Allerg: European Journal of Allergy and Clinical Immunology, 67 (3)

Miyao T., Floess S., Setoguchi R., Luche H., Fehling H.J., Waldmann H., ... , Hühn J., Hori S. (2012)

Plasticity of foxp3(+) T cells reflects promiscuous foxp3 expression in conventional T cells but not reprogramming of regulatory T cells

Immunity, 36 (2)

Blankenhaus B., Klemm U., Eschbach M.L., Sparwasser T., Hühn Jochen*, Kuhl A.A., Loddenkemper C., ... , Jacobs T., Breloer M. (2011)

Strongyloides ratti infection induces expansion of Foxp3(+) regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice

Journal of Immunology, 186 (7)

Steinfelder S., Floess S., Engelbert D., Haeringer B., Baron U., Rivino L., Steckel B., Gruetzkau A., Olek S., Geginat J., ... , Hühn J., Hamann A. (2011)

Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells

Blood, 117 (10)

DOI: 10.1182/blood-2010-06-293027 HZI-Repositorium PubMed

Toker A., Hühn Jochen* (2011)

To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms

Science Signaling, 4 (158)

DOI: 10.1126/scisignal.2001783 HZI-Repositorium PubMed

Mayer C.T., Floess S., Baru A.M., Lahl K., Hühn J., Sparwasser T. (2011)

CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity

European Journal of Immunology, 41 (3)

DOI: 10.1002/eji.201040913 HZI-Repositorium PubMed

Hubert S., Rissiek B., Klages K., Hühn Jochen*, Sparwasser T., Haag F., Koch-Nolte F., Boyer O., ... , Seman M., Adriouch S. (2010)

Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway

Journal of Experimental Medicine, 207 (12)

DOI: 10.1084/jem.20091154 HZI-Repositorium PubMed

Polansky J.K., Schreiber L., Thelemann C., Ludwig L., Kruger M., Baumgrass R., Cording S., Floess S., ... , Hamann A., Hühn J. (2010)

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells

Journal of Molecular Medicine, 88 (10)

Klages K., Mayer C.T., Lahl K., Loddenkemper C., Teng M.W., Ngiow S.F., Smyth M.J., Hamann A., ... , Hühn Jochen*, Sparwasser T. (2010)

Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma

Cancer Research, 70 (20)

Menning A., Loddenkemper C., Westendorf A.M., Szilagyi B., Buer J., Siewert C., ... , Hamann A., Hühn Jochen* (2010)

Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation

European Journal of Immunology, 40 (9)

Lahl K., Mayer C.T., Bopp T., Hühn Jochen*, Loddenkemper C., Eberl G., Wirnsberger G., Dornmair K., Geffers Robert*, Schmitt E., ... , Buer J., Sparwasser T. (2009)

Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice

Journal of Immunology, 183 (9)

Humrich J.Y., Morbach H., Undeutsch R., Enghard P., Rosenberger S., Weigert O., Kloke L., Heimann J., Gaber T., Brandenburg S., Scheffold A., Hühn Jochen*, Radbruch A., ... , Burmester G.R., Riemekasten G. (2010)

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

Proceedings of the National Academy of Sciences of the United States of America, 107 (1)

Rausch S., Hühn Jochen*, Loddenkemper C., Hepworth M.R., Klotz C., Sparwasser T., Hamann A., ... , Lucius R., Hartmann S. (2009)

Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) cells

Europen Journal of Immunology, 39 (11)

Koenecke C., Czeloth N., Bubke A., Schmitz S., Kissenpfennig A., Malissen B., Hühn Jochen*, Ganser A., ... , Forster R., Prinz I. (2009)

Alloantigen-specific de novo-induced Foxp3(+) Treg revert in vivo and do not protect from experimental GVHD

European Journal of Immunology, 39 (11)

Lahl K., Loddenkemper C., Drouin C., Freyer J., Arnason J., Eberl G., Hamann A., Wagner H., ... , Hühn Jochen*, Sparwasser T. (2007)

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

Journal of Experimental Medicine, 204 (1)

Siewert C., Menning A., Dudda J., Siegmund K., Lauer U., Floess S., Campbell D.J., ... , Hamann A., Hühn J. (2007)

Induction of organ-selective CD4+ regulatory T cell homing

European Journal of Immunology, 37 (4)

Menning A., Hopken U.E., Siegmund K., Lipp M., Hamann A., Hühn Jochen* (2007)

Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets

European Journal of Immunology, 37 (6)

Baron U., Floess S., Wieczorek G., Baumann K., Grutzkau A., Dong J., Thiel A., Boeld T.J., Hoffmann P., Edinger M., Turbachova I., Hamann A., ... , Olek S., Hühn J. (2007)

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells

European Journal of Immunology, 37 (9)

DOI: 10.3390/md8122976 HZI-Repositorium PubMed

Polansky J.K., Hühn Jochen* (2007)

[To be or not to be a Treg: epigenetic regulation of Foxp3 expression in regulatory T cells]

Zeitschrift für Rheumatologie, 66 (5)

Doebis C., Siegmund K., Loddenkemper C., Lowe J.B., Issekutz A.C., Hamann A., ... , Hühn Jochen*, Syrbe U. (2008)

Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction

American Journal of Pathology, 173 (4)

Apostolou I., Verginis P., Kretschmer K., Polansky J., Hühn Jochen*, von Boehmer H. (2008)

Peripherally induced Treg: mode, stability, and role in specific tolerance

Journal of Clinical Immunology, 28 (6)

Hoffmann P., Boeld T.J., Eder R., Hühn J., Floess S., Wieczorek G., Olek S., Dietmaier W., ... , Andreesen R., Edinger M. (2009)

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation

European Journal of Immunology, 39 (4)

DOI: 10.1002/eji.200838904 PubMed

Loddenkemper C., Hoffmann C., Stanke J., Nagorsen D., Baron U., Olek S., Hühn Jochen*, Ritz J.P., Stein H., Kaufmann A.M., ... , Schneider A., Cichon G. (2009)

Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer

Cancer Science, 100 (6)

DOI: 10.1111/j.1349-7006.2009.01153.x PubMed

Schaub B., Liu J., Hoppler S., Schleich I., Hühn Jochen*, Olek S., Wieczorek G., ... , Illi S., von Mutius E. (2009)

Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells

Journal of Allergy and Clinical Immunology, 123 (4)

DOI: 10.1016/j.jaci.2009.01.056 HZI-Repositorium PubMed

Wieczorek G., Asemissen A., Model F., Turbachova I., Floess S., Liebenberg V., Baron U., Stauch D., Kotsch K., Pratschke J., Hamann A., Loddenkemper C., Stein H., Volk H.D., Hoffmuller U., Grutzkau A., Mustea A., Hühn J., ... , Scheibenbogen C., Olek S. (2009)

Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue

Cancer Research, 69 (2)

Hühn Jochen*, Polansky J.K., Hamann A. (2009)

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Nature Reviews Immunology, 9 (2)

DOI: 10.1038/nri2474

Hansen W., Loser K., Westendorf Astrid M.*, Bruder Dunja*, Pförtner S., Siewert C., Hühn J., ... , Beissert S., Buer Jan* (2006)

GPR83-overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo

Journal of Immunology, 177

Hühn J., Siegmund K., Lehmann J.C.U., Siewert C., Haubold U., Feuerer M., Debes G.F., Lauber J., Frey O., Przybylski G.K., Niesner U., de la Rosa M., Schmidt C.A., Bräuer R., Buer J., ... , Scheffold A., Hamann A. (2004)

Developmental stage, phenotype and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells

Journal of Experimental Medicine, 199

Prof. Dr. Jochen Hühn

Forschungsgruppe

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