Prof. Dr. Klemens Rottner

Prof. Dr. Klemens Rottner
Forschungsgruppenleiter

Klemens Rottner absolvierte sein Studium der Biologie/Zoologie an der Paris-Lodron-Universität in Salzburg und promovierte anschließend im Bereich Zellbiologie/Immunologie. Im Jahr 2000 entschied er sich für einen Forschungsaufenthalt in Braunschweig und arbeitete dort als Postdoc in der Gesellschaft für Biotechnologische Forschung. Im Anschluss übernahm er 2004 die Leitung der Forschungsgruppe Zytoskelett Dynamik.

2010 folgte er dem Ruf der Rheinischen Friedrich-Wilhelms-Universität in Bonn und übernahm eine Professur am Institut für Genetik. Im Jahr 2014 kehrte er nach Braunschweig zurück. Seither ist er als Professor am Institut für Zoologie der Technischen Universität tätig und leitet zudem die Arbeitsgruppe Molekulare Zellbiologie am Helmholtz-Zentrum für Infektionsforschung.

Publikationen
Sharafutdinov I., Friedrich B., Rottner K., Backert S., Tegtmeyer N. (2024)
Cortactin: A major cellular target of viral, protozoal, and fungal pathogens
Mol.Microbiol.

Jackson J., Hoffmann C., Scifo E., Wang H., Wischhof L., Piazzesi A., Mondal M., Shields H., Zhou X., Mondin M., Ryan E.B., Döring H., Prehn J.H.M., Rottner K., Giannone G., Nicotera P., Ehninger D., ... , Milovanovic D., Bano D. (2024)
Actin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology
Cell Death and Disease, 15 (4)

Rottner K., Bieling P. (2024)
Illuminating cortactin structure and function at actin filament branches
Nature Structural and Molecular Biology, 31 (5)

De Cicco T., Pezinski M., Wojcicka O., Pradhan B.S., Jablonska M., ... , Rottner K., Proszynski T.J. (2024)
Cortactin interacts with a[alpha]Dystrobrevin-1 and regulates murine neuromuscular junction morphology
European Journal of Cell Biology, 103 (2)

Sharafutdinov I., Harrer A., Müsken M., Rottner K., Sticht H., Täger C., Naumann M., ... , Tegtmeyer N., Backert S. (2024)
Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection
Cell Insight, 3 (3)

Kumar R., Rottner K., Rao G.N. (2024)
Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin in Retinal Neovascularization and Vascular Leakage
Arterioscler.Thromb.Vasc.Biol.

Kirchenwitz M., Halfen J., von Peinen K., Prettin S., Kollasser J., Zur Lage S., Blankenfeldt W., Brakebusch C., Rottner K., ... , Steffen A., Stradal T.E.B. (2023)
RhoB promotes Salmonella survival by regulating autophagy
Eur.J.Cell Biol., 102 (4)

Lambert C., Schmidt K., Karger M., Stadler M., Stradal T.E.B., Rottner K. (2023)
Cytochalasans and Their Impact on Actin Filament Remodeling
Biomolecules., 13 (8)

Gautreau A., Lappalainen P., Rottner K. (2023)
Editorial -
European Journal of Cell Biology

Lambert C., Shao L., Zeng H., Surup F., Saetang P., Aime M.C., Husbands D.R., Rottner K., ... , Stradal T.E.B., Stadler M. (2023)
Cytochalasans produced by Xylaria karyophthora and their biological activities
Mycologia

Bieling P., Rottner K. (2023)
From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly
Curr.Opin.Cell Biol., 80

Castellanos-Martinez R., Leon-Vega I.I., Guerrero-Fonseca I.M., Vargas-Robles H., Jimenez-Camacho K.E., Hernandez-Galicia G., Ortiz-Navarrete V.F., Rottner K., ... , Medina-Contreras O., Schnoor M. (2023)
T cell functions and organ infiltration by leukemic T cells require cortactin
J.Leukoc.Biol

Fäßler F., Javoor M.G., Datler J., Döring H., Hofer F.W., Dimchev G., Hodirnau V.-V., Faix J., ... , Rottner K., Schur F.K.M. (2023)
ArpC5 isoforms regulate Arp2/3 complex-dependent protrusion through differential Ena/VASP positioning
Science advances, 9 (3)

Yang S., Tang Y., Liu Y., Brown A.J., Schaks M., Ding B., Kramer D.A., Mietkowska M., Ding L., Alekhina O., Billadeau D.D., Chowdhury S., Wang J., ... , Rottner K., Chen B. (2022)
Arf GTPase activates the WAVE regulatory complex through a distinct binding site
Sci.Adv., 8 (50)

Pokrant T., Hein J.I., Körber S., Disanza A., Pich A., Scita G., ... , Rottner K., Faix J. (2023)
Ena/VASP clustering at microspike tips involves lamellipodin but not I-BAR proteins, and absolutely requires unconventional myosin-X
Proc Natl Acad Sci U S A, 120 (2)

Sharafutdinov I., Knorr J., Rottner K., Backert S., Tegtmeyer N. (2022)
Cortactin: A universal host cytoskeletal target of Gram-negative and Gram-positive bacterial pathogens
Mol.Microbiol.

Kirchenwitz M., Stahnke S., Grunau K., Melcher L., Van Ham M., Rottner K., ... , Steffen A., Stradal T.E.B. (2022)
The autophagy inducer SMER28 attenuates microtubule dynamics mediating neuroprotection
Sci.Rep., 12 (1)

Ding B., Yang S., Schaks M., Liu Y., Brown A.J., Rottner K., ... , Chowdhury S., Chen B. (2022)
Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase
Nat.Commun., 13 (1)

Kage F., Döring H., Mietkowska M., Schaks M., Grüner F., Stahnke S., Steffen A., Müsken M., ... , Stradal T.E.B., Rottner K. (2022)
Lamellipodia-like actin networks in cells lacking WAVE regulatory complex
J Cell Sci, 135 (15)

Lartey N.L., Vargas-Robles H., Guerrero-Fonseca I.M., García-Ponce A., Salinas-Lara C., ... , Rottner K., Schnoor M. (2022)
The Actin-Binding Protein Cortactin Promotes Sepsis Severity by Supporting Excessive Neutrophil Infiltration into the Lung
Biomedicines, 10 (5)

Kirchenwitz M., Stahnke S., Prettin S., Borowiak M., Menke L., Sieben C., Birchmeier C., Rottner K., ... , Stradal T.E.B., Steffen A. (2022)
SMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta
Cells, 11 (10)

Petersen L., Stroh S., Schöttelndreier D., Grassl G.A., Rottner K., Brakebusch C., ... , Fahrer J., Genth H. (2022)
The Essential Role of Rac1 Glucosylation in Clostridioides difficile Toxin B-Induced Arrest of G1-S Transition
Front Microbiol, 13

Kummer D., Steinbacher T., Thölmann S., Schwietzer M.F., Hartmann C., Horenkamp S., Demuth S., Peddibhotla S.S.D., Brinkmann F., Kemper B., Schnekenburger J., Brandt M., Betz T., Liashkovich I., Kouzel I.U., Shahin V., Corvaia N., Rottner K., Tarbashevich K., Raz E., Greune L., Schmidt M.A., ... , Gerke V., Ebnet K. (2022)
A JAM-A-tetraspanin- anb
J Cell Biol., 221 (4)

Fung T.S., Chakrabarti R., Kollasser J., Rottner K., Stradal T.E.B., ... , Kage F., Higgs H.N. (2022)
Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
Curr.Biol., 32 (7)

Faix J., Rottner K. (2022)
Ena/VASP proteins in cell edge protrusion, migration and adhesion
J Cell Sci, 135 (6)

Rottner K., Stradal T.E.B. (2022)
WASP stings into matrix to lead immune cell migration
J.Cell Biol., 221 (2)

Mehidi A., Kage F., Karatas Z., Cercy M., Schaks M., Polesskaya A., Sainlos M., Gautreau A.M., Rossier O., ... , Rottner K., Giannone G. (2021)
Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration
Nature Cell Biology, 23 (11)

Funk J., Merino F., Schaks M., Rottner K., Raunser S., Bieling P. (2021)
A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
Nat.Commun., 12 (1)

Tegtmeyer N., Harrer A., Rottner K., Backert S. (2021)
Helicobacter pylori caga induces cortactin y-470 phosphorylation-dependent gastric epithelial cell scattering via abl, vav2 and rac1 activation
Cancers, 13 (16)

Cornelius J., Rottner K., Korte M., Michaelsen-Preusse K. (2021)
Cortactin Contributes to Activity-Dependent Modulation of Spine Actin Dynamics and Spatial Memory Formation
Cells, 10 (7)

Knorr J., Sharafutdinov I., Fiedler F., Esmaeili D.S., Rohde M., Rottner K., ... , Backert S., Tegtmeyer N. (2021)
Cortactin is required for efficient fak, src and abl tyrosine kinase activation and phosphorylation of helicobacter pylori caga
Int.J.Mol.Sci., 22 (11)

Walch P., Selkrig J., Knodler L.A., Rettel M., Stein F., Fernandez K., Viéitez C., Potel C.M., Scholzen K., Geyer M., Rottner K., Steele-Mortimer O., Savitski M.M., ... , Holden D.W., Typas A. (2021)
Global mapping of Salmonella enterica-host protein-protein interactions during infection
Cell Host.Microbe

Rottner K., Stradal T.E.B., Chen B. (2021)
WAVE regulatory complex
Curr.Biol., 31 (10)

Rottner K., Vicente-Manzanares M. (2021)
European Journal of Cell Biology - Editorial
Eur.J.Cell Biol., 100 (4)

Stahnke S., Döring H., Kusch C., De Gorter D.J.J., Dütting S., Guledani A., Pleines I., Schnoor M., Sixt M., Geffers R., Rohde M., Müsken M., Kage F., Steffen A., Faix J., Nieswandt B., ... , Rottner K., Stradal T.E.B. (2021)
Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion
Curr.Biol., 31 (5 / May)

Dimchev V., Lahmann I., Koestler S.A., Kage F., Dimchev G., Steffen A., Stradal T.E.B., Vauti F., ... , Arnold H.H., Rottner K. (2021)
Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation
Front.Cell Dev.Biol., 9

Leithner A., Altenburger L.M., Hauschild R., Assen F.P., Rottner K., Stradal T.E.B., Diz-Munoz A., ... , Stein J.V., Sixt M. (2021)
Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse
J.Cell Biol., 220 (4)

Papalazarou V., Swaminathan K., Jaber-Hijazi F., Spence H., Lahmann I., Nixon C., Salmeron-Sanchez M., Arnold H.H., ... , Rottner K., Machesky L.M. (2020)
The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts
Development, 147 (22)

Wang C., Lambert C., Hauser M., Deuschmann A., Zeilinger C., Rottner K., Stradal T.E.B., Stadler M., ... , Skellam E.J., Cox R.J. (2020)
Diversely Functionalised Cytochalasins through Mutasynthesis and Semi-Synthesis
Chem.Eur.J., 26 (60)

Singh S.P., Thomason P.A., Lilla S., Schaks M., Tang Q., Goode B.L., Machesky L.M., ... , Rottner K., Insall R.H. (2020)
Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime
PLoS Biol, 18 (8)

Tang Q., Schaks M., Koundinya N., Yang C., Pollard L.W., Svitkina T.M., ... , Rottner K., Goode B.L. (2020)
WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge
Mol.Biol Cell, 31 (20)

Salzer E., Zoghi S., Kiss M.G., Kage F., Rashkova C., Stahnke S., Haimel M., Platzer R., Caldera M., Ardy R.C., Hoeger B., Block J., Medgyesi D., Sin C., Shahkarami S., Kain R., Ziaee V., Hammerl P., Bock C., Menche J., Dupré L., Huppa J.B., Sixt M., Lomakin A., Rottner K., Binder C.J., Stradal T.E.B., ... , Rezaei N., Boztug K. (2020)
The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity
Sci.Immunol., 5 (49)

Damiano-Guercio J., Kurzawa L., Mueller J., Dimchev G., Schaks M., Nemethova M., Pokrant T., Brühmann S., Linkner J., Blanchoin L., Sixt M., ... , Rottner K., Faix J. (2020)
Loss of ENA/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion
eLife, 9

Schaks M., Reinke M., Witke W., Rottner K. (2020)
Molecular Dissection of Neurodevelopmental Disorder-Causing Mutations in CYFIP2
Cells, 9 (6)

Dimchev G., Amiri B., Humphries A.C., Schaks M., Dimchev V., Stradal T.E.B., Faix J., Krause M., Way M., ... , Falcke M., Rottner K. (2020)
Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation
J.Cell Sci., 133 (7)

Samus M., Li Y.T., Sorokin L., Rottner K., Vestweber D. (2020)
Actin-binding protein cortactin promotes pathogenesis of experimental autoimmune encephalomyelitis by supporting leukocyte infiltration into the central nervous system
J.Neurosci., 40 (7)

Kage F., Steffen A., Ellinger A., Ranftler C., Gehre C., Brakebusch C., Pavelka M., ... , Stradal T., Rottner K. (2019)
Author Correction: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42
Sci Rep., 9 (1)

Rottner K., Schaks M. (2019)
N-WASP Guides Cancer Cells toward LPA
Dev.Cell, 51 (4)

Taha M., Aldirawi M., März S., Seebach J., Odenthal-Schnittler M., Bondareva O., Bojovic V., Schmandra T., Wirth B., Mietkowska M., ... , Rottner K., Schnittler H. (2019)
EPLIN-a[alpha] and -b[beta] Isoforms Modulate Endothelial Cell Dynamics through a Spatiotemporally Differentiated Interaction with Actin
Cell Rep., 29 (4)

Schaks M., Giannone G., Rottner K. (2019)
Actin dynamics in cell migration
Essays Biochem., 63 (5)

Schaks M., Döring H., Kage F., Steffen A., Klünemann T., Blankenfeldt W., ... , Stradal T., Rottner K. (2021)
RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding
Small Gtpases., 12 (2)

Mehidi A., Rossier O., Schaks M., Chazeau A., Biname F., Remorino A., Coppey M., Karatas Z., Sibarita J.B., Rottner K., ... , Moreau V., Giannone G. (2019)
Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion
Curr.Biol., 29 (17)

Kunschmann T., Puder S., Fischer T., Steffen A., Rottner K., Mierke C.T. (2019)
The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices
Sci.Rep., 9 (1)

Kugelmann D., Rotzer V., Walter E., Egu D.T., Fuchs M.T., Vielmuth F., Vargas-Robles H., Schnoor M., Hertl M., Eming R., Rottner K., Schmidt A., ... , Spindler V., Waschke J. (2019)
Role of Src and Cortactin in Pemphigus Skin Blistering
Front Immunol, 10

Litschko C., Brühmann S., Csiszar A., Stephan T., Dimchev V., Damiano-Guercio J., Junemann A., Körber S., Winterhoff M., Nordholz B., Ramalingam N., Peckham M., Rottner K., ... , Merkel R., Faix J. (2019)
Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins
Proc.Natl.Acad.Sci.U.S.A, 116 (9)

Velázquez-Avila M., Balandrán J.C., Ramirez-Ramirez D., Velázquez-Avila M., Sandoval A., Felipe-López A., Nava P., Alvarado-Moreno J.A., Dozal D., Prieto-Chávez J.L., Schaks M., Rottner K., Dorantes-Acosta E., López-Martinez B., ... , Schnoor M., Pelayo R. (2019)
High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse
Leukemia, 33 (6)

Schaks M., Singh S.P., Kage F., Thomason P., Klünemann T., Steffen A., Blankenfeldt W., Stradal T.E., ... , Insall R.H., Rottner K. (2018)
Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo
Curr.Biol., 28 (11)

Rottner K., Schaks M. (2019)
Assembling actin filaments for protrusion
Curr.Opin.Cell Biol., 56 (Februar)

Dolati S., Kage F., Mueller J., Müsken M., Kirchner M., Dittmar G., Sixt M., ... , Rottner K., Falcke M. (2018)
On the relation between filament density, force generation and protrusion rate in mesenchymal cell motility
Mol.Biol.Cell, 29 (22)

Beer L.A., Tatge H., Reich N., Tenspolde M., Olling A., Goy S., Rottner K., ... , Alekov A.K., Gerhard R. (2018)
Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate
Cell Microbiol., 20 (10)

Ge J., Burnier L., Adamopoulou M., Kwa M.Q., Schaks M., ... , Rottner K., Brakebusch C. (2018)
RhoA, Rac1, and Cdc42 differentially regulate SMA and collagen i expression in mesenchymal stem cells
J.Biol.Chem., 293 (24)

Dimchev G., Rottner K. (2018)
Micromanipulation Techniques Allowing Analysis of Morphogenetic Dynamics and Turnover of Cytoskeletal Regulators
J.Vis.Exp. (135)

Steffen A., Kage F., Rottner K. (2018)
Imaging the Molecular Machines That Power Cell Migration
Methods Mol.Biol., 1749 (19)

Rottner K., Kage F. (2017)
Actin Networks: Adapting to Load through Geometry
Curr.Biol., 27 (23)

Schnoor M., Stradal T.E., Rottner K. (2017)
Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein
Trends Cell Biol., 28 (2)

Rottner K., Faix J., Bogdan S., Linder S., Kerkhoff E. (2017)
Actin assembly mechanisms at a glance
J.Cell Sci., 130 (20)

Böttcher R.T., Veelders M., Rombaut P., Faix J., Theodosiou M., Stradal T.E., Rottner K., Zent R., ... , Herzog F., Fassler R. (2017)
Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading
J.Cell Biol., 216 (11)

Litschko C., Linkner J., Bruhmann S., Stradal T.E.B., Reinl T., Jänsch L., ... , Rottner K., Faix J. (2017)
Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes
Eur.J.Cell Biol., 96 (8)

Steffen A., Stradal T.E., Rottner K. (2017)
Signalling Pathways Controlling Cellular Actin Organization
Handb.Exp.Pharmacol., 235

Kage F., Steffen A., Ellinger A., Ranftler C., Gehre C., Brakebusch C., Pavelka M., ... , Stradal T., Rottner K. (2017)
FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42
Sci.Rep., 7 (1)

Dimchev G., Steffen A., Kage F., Dimchev V., Pernier J., ... , Carlier M.F., Rottner K. (2017)
Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly
Mol.Biol.Cell, 28 (10)

Citalan-Madrid A.F., Vargas-Robles H., Garcia-Ponce A., Shibayama M., Betanzos A., Nava P., Salinas-Lara C., Rottner K., ... , Mennigen R., Schnoor M. (2017)
Cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe DSS-induced colitis
Mucosal.Immunol., 10 (5)

Kage F., Winterhoff M., Dimchev V., Mueller J., Thalheim T., Freise A., Bruhmann S., Kollasser J., Block J., Dimchev G., Geyer M., Schnittler H.J., Brakebusch C., Stradal T.E., Carlier M.F., Sixt M., Kas J., ... , Faix J., Rottner K. (2017)
FMNL formins boost lamellipodial force generation
Nat.Commun., 8

Leithner A., Eichner A., Muller J., Reversat A., Brown M., Schwarz J., Merrin J., de Gorter D.J., Schur F., Bayerl J., de Vries I, Wieser S., Hauschild R., Lai F.P., Moser M., Kerjaschki D., Rottner K., Small J.V., ... , Stradal T.E., Sixt M. (2016)
Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes
Nat.Cell Biol., 18 (11)

Andritschke D., Dilling S., Emmenlauer M., Welz T., Schmich F., Misselwitz B., Ramo P., Rottner K., Kerkhoff E., Wada T., Penninger J.M., Beerenwinkel N., Horvath P., ... , Dehio C., Hardt W.D. (2016)
A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion
PLoS ONE, 11 (9)

Ponce A.G., Citalan Madrid A.F., Vargas Robles H., Chanez Paredes S., Nava P., Betanzos A., Zarbock A., Rottner K., ... , Vestweber D., Schnoor M. (2016)
Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility
Sci Rep., 6

Rottner K. (2016)
CELL BIOLOGY. Formin' filaments at a faster CLIP
Science, 352 (6288)

Wollscheid H.P., Biancospino M., He F., Magistrati E., Molteni E., Lupia M., Soffientini P., Rottner K., Cavallaro U., Pozzoli U., Mapelli M., ... , Walters K.J., Polo S. (2016)
Diverse functions of myosin VI elucidated by an isoform-specific a[alpha]-helix domain
Nat.Struct.Mol.Biol., 23 (4)

Rottner K., Stradal T.E.B. (2016)
How distinct Arp2/3 complex variants regulate actin filament assembly
Nat.Cell Biol., 18 (1)

Kuhn S., Erdmann C., Kage F., Block J., Schwenkmezger L., Steffen A., ... , Rottner K., Geyer M. (2015)
The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation
Nat.Commun., 6

Chazeau A., Mehidi A., Nair D., Gautier J.J., Leduc C., Chamma I., Kage F., Kechkar A., Thoumine O., Rottner K., Choquet D., Gautreau A., ... , Sibarita J.B., Giannone G. (2014)
Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion
Embo Journal, 33

May M., Schelle I., Brakebusch C., Rottner K., Genth H. (2014)
Rac1-dependent recruitment of PAK2 to G phase centrosomes and their roles in the regulation of mitotic entry
Cell Cycle, 13 (14)

Steffen A., Koestler S.A., Rottner K. (2014)
Requirements for and consequences of Rac-dependent protrusion
Europan Journal of Cell Biology, 93 (5-6)

Duplan M.B., Zalli D., Stephens S., Zenger S., Neff L., Oelkers J.M., Lai F.P.L.L., Horne W., ... , Rottner K., Baron R. (2014)
Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and src
Molecular and Cellular Biology, 34 (1)

Huelsenbeck S.C., Roggenkamp D., May M., Huelsenbeck J., Brakebusch C., Rottner K., Ladwein M., Just I., Fritz G., ... , Schmidt G., Genth H. (2013)
Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1
International Journal of Biochemistry and Cell Biology, 45 (8)

Dang I., Gorelik R., Sousa-Blin C., Derivery E., Guerin C., Linkner J., Nemethova M., Dumortier J.G., Giger F.A., Chipysheva T.A., Ermilova V.D., Vacher S., Campanacci V., Herrada I., Planson A.G., Fetics S., Henriot V., David V., Oguievetskaia K., Lakisic G., Pierre F., Steffen A., Boyreau A., Peyrieras N., Rottner K., Zinn-Justin S., Cherfils J., Bieche I., Alexandrova A.Y., David N.B., Small J.V., Faix J., ... , Blanchoin L., Gautreau A. (2013)
Inhibitory signalling to the Arp2/3 complex steers cell migration
Nature, 503 (7475)

Steffen A., Ladwein M., Dimchev G.A., Hein A., Schwenkmezger L., Arens S., Ladwein K.I., Holleboom J.M., Schur F., Small J.V., Schwarz J., Gerhard R., Faix J., Stradal Theresia E.B., ... , Brakebusch C., Rottner K. (2013)
Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation
Journal of Cell Science, 126 (20)

Koestler S.A., Steffen A., Nemethova M., Winterhoff M., Luo N., Holleboom J.Margit, Krupp J., Jacob S., Vinzenz M., Schur F., Schluter K., Gunning P.W., Winkler C., Schmeiser C., Faix J., Stradal T.E., ... , Small J.V., Rottner K. (2013)
Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin1
Molecular Biology of the Cell, 24 (18)

Wolters M., Boyle E.C., Lardong K., Trulzsch K., Steffen A., Rottner K., ... , Ruckdeschel K., Aepfelbacher M. (2013)
Cytotoxic necrotizing factor-y boosts yersinia effector translocation by activating rac protein
Journal of Biological Chemistry, 288 (32)

Junemann A., Winterhoff M., Nordholz B., Rottner K., Eichinger L., ... , Graf R., Faix J. (2013)
ForC lacks canonical formin activity but bundles actin filaments and is required for multicellular development of Dictyostelium cells
European Journal of Cell Biology, 92 (6-7)

Thoss F., Dietrich F., Punkt K., Illenberger S., Rottner K., ... , Himmel M., Ziegler W.H. (2013)
Metavinculin: New insights into functional properties of a muscle adhesion protein
Biochemical and Biophysical Research Communications, 430 (1)

Block J., Breitsprecher D., Kuhn S., Winterhoff M., Kage F., Geffers R., Duwe P., Rohn J.L., Baum B., Brakebusch C., Geyer M., Stradal T.E., ... , Faix J., Rottner K. (2012)
FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42
Current biology, 22 (11)

Hanisch J., Stradal T.E., Rottner K. (2012)
A novel contractility pathway operating in Salmonella invasion
Virulence, 3 (1)

Breitsprecher D., Koestler S.A., Chizhov I., Nemethova M., Mueller J., Goode B.L., Small J.V., ... , Rottner K., Faix J. (2011)
Cofilin cooperates with fascin to disassemble filopodial actin filaments
Journal of Cell Science, 124 (Pt 19)

Rottner K., Stradal T.E. (2011)
Actin dynamics and turnover in cell motility
Current Opinion in Cell Biology, 23 (5)

Schnoor M., Lai F.P., Zarbock A., Klaver R., Polaschegg C., Schulte D., Weich H.A., Oelkers J.M., ... , Rottner K., Vestweber D. (2011)
Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo
Journal of Experimental Medicine, 208 (8)

Williams M.J., Rottner K. (2010)
Introduction to Small GTPases
Small Gtpases., 1 (1)

Oelkers J.M., Vinzenz M., Nemethova M., Jacob S., Lai F.P., Block J., Szczodrak M., Kerkhoff E., Backert S., Schluter K., Stradal T.E., Small J.V., ... , Koestler S.A., Rottner K. (2011)
Microtubules as platforms for assaying actin polymerization in vivo
PLoS ONE, 6 (5)

Dubielecka P.M., Ladwein K.I., Xiong X., Migeotte I., Chorzalska A., Anderson K.V., Sawicki J.A., Rottner K., ... , Stradal T.E., Kotula L. (2011)
Essential role for Abi1 in embryonic survival and WAVE2 complex integrity
Proceedings of the National Academy of Sciences USA, 108 (17)

Hänisch J., Kolm R., Wozniczka M., Bumann D., Rottner K., Stradal T.E. (2011)
Activation of a RhoA/Myosin II-Dependent but Arp2/3 Complex-Independent Pathway Facilitates Salmonella Invasion
Cell Host and Microbe, 9 (4)

Jackson B., Peyrollier K., Pedersen E., Basse A., Karlsson R., Wang Z., Lefever T., Ochsenbein A.M., Schmidt G., Aktories K., Stanley A., Quondamatteo F., Ladwein M., Rottner K., ... , van Hengel J., Brakebusch C. (2011)
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes
Molecular Biology of the Cell, 22 (5)

Rottner K., Hanisch J., Campellone K.G. (2010)
WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond
Trends in Cell Biology, 20 (11)

Marg S., Winkler U., Sestu M., Himmel M., Schonherr M., Bar J., Mann A., Moser M., Mierke C.T., Rottner K., Blessing M., ... , Hirrlinger J., Ziegler W.H. (2010)
The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin
PLoS ONE, 5 (7)

Hertzog M., Milanesi F., Hazelwood L., Disanza A., Liu H., Perlade E., Malabarba M.G., Pasqualato S., Maiolica A., Confalonieri S., Le Clainche C., Offenhauser N., Block J., Rottner K., Di Fiore P.P., Carlier M.F., Volkmann N., ... , Hanein D., Scita G. (2010)
Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping
PLoS Biology, 8 (6)

Klink B.U., Barden S., Heidler T.V., Borchers C., Ladwein M., Stradal T.B., ... , Rottner K., Heinz D.W. (2010)
Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry
Journal of Biological Chemistry, 285 (22)

Hänisch J., Ehinger J., Ladwein M., Rohde M., Derivery E., Bosse T., Steffen A., Bumann D., Misselwitz B., Hardt W.D., Gautreau A., ... , Stradal T.E., Rottner K. (2010)
Molecular dissection of Salmonella-induced membrane ruffling versus invasion
Cellular Microbiology, 12 (1)

Rottner K., Stradal Theresia E.* (2009)
Poxviruses taking a ride on actin: new users of known hardware
Cell Host and Microbe, 6 (6)

Lai F.P., Szczodrak M., Oelkers J.M., Ladwein M., Acconcia F., Benesch S., Auinger S., Faix J., Small J.V., Polo S., ... , Stradal T.E., Rottner K. (2009)
Cortactin Promotes Migration and PDGF-induced Actin Reorganization by Signaling to Rho-GTPases
Molecular Biology of the Cell, 20 (14)

Himmel M., Ritter A., Rothemund S., Pauling B.V., Rottner K., ... , Gingras A.R., Ziegler W.H. (2009)
Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions
Journal of Biolical Chemistry, 284 (20)

Faix J., Breitsprecher D., Stradal T.E.B., Rottner K. (2009)
Filopodia: Complex models for simple rods
The International Journal of Biochemistry and Cell Biology, 41 (8-9)

Koestler S.A., Rottner K., Lai F., Block J., Vinzenz M., Small J.V. (2009)
F- and G-actin concentrations in lamellipodia of moving cells
PLoS ONE, 4 (3)

Weiss S.M., Ladwein M., Schmidt D., Ehinger J., Lommel S., Städing K., Beutling U., Disanza A., Frank R., Jänsch L., Scita G., Gunzer F., ... , Rottner K., Stradal T.E. (2009)
IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation
Cell Host and Microbe, 5 (3)

Halabi-Cabezon I., Huelsenbeck J., May M., Ladwein M., Rottner K., ... , Just I., Genth H. (2008)
Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1
Febs Letters, 582 (27)

Block J., Stradal T.E.B., Hanisch J., Geffers R., Kostler S.A., Urban E., Small J.V., ... , Rottner K., Faix J. (2008)
Filopodia formation induced by active mDia2/Drf3
Journal of Microscopy, 231 (3)

Ladwein M., Rottner K. (2008)
On the Rho'd: The regulation of membrane protrusions by Rho-GTPases
Febs Letters, 582 (14)

Steffen A., Le Dez G., Poincloux R., Recchi C., Nassoy P., Rottner K., ... , Galli T., Chavrier P. (2008)
MT1-MMP-Dependent Invasion Is Regulated by TI-VAMP/VAMP7
Current biology, 18 (12)

Koestler S.A., Auinger S., Vinzenz M., Rottner K., Small J.V. (2008)
Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front
Nature Cell Biology, 10 (3)

Bosse T., Ehinger J., Czuchra A., Benesch S., Steffen A., Wu X., Schloen K., Niemann H.H., Scita G., Stradal T.E.B., ... , Brakebusch C., Rottner K. (2007)
Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways
Molecular and Cellular Biology, 27 (19)

Müller-Taubenberger A., Vos M.J., Böttger A., Lasi M., Lai F.P.L., ... , Fischer M., Rottner K. (2006)
Monomeric red fluorescent protein variants used for imaging studies in different species
European Journal of Cell Biology, 85 (9-10)

Caspani E.M., Echevarria D., Rottner K., Small J.V. (2006)
Live imaging of glioblastoma cells in brain tissue shows requirement of actin bundles for migration
Neuron Glia Biology, 2 (2)

Faix J., Rottner K. (2006)
The making of filopodia
Current Opinion in Cell Biology, 18 (1)

Rottner K., Kaverina I.N., Stradal Theresia E.B.* (2006)
Cytoskeleton proteins
, 3rd

Steffen A., Faix J., Resch G.P., Linkner J., Wehland J., Small J.V., ... , Rottner K., Stradal T.E.B. (2006)
Filopodia formation in the absence of functional WAVE- and Arp2/3-complex
Molecular Biology of the Cell, 17

Stamm L., Pak M.A., Morisaki J.H., Snapper S.B., Rottner K., ... , Lommel S., Brown E.J. (2005)
Role of the WASP family proteins for Mycobacterium marinum actin tail formation
Proceedings of the National Academy of Sciences of the United States of America, 102 (41)

Czuchra A., Wu X., Meyer H., Van Hengel J., Schroeder T., Geffers R., ... , Rottner K., Brakebusch C. (2005)
Cdc42 is not essential for filopodium formation, directed migration, cell polarization and mitosis in fibroblastoid cells
Molecular Biology of the Cell, 16 (10)

Disanza A., Steffen A., Hertzog M., Frittoli E., Rottner K., Scita G. (2005)
Actin polymerization machinery: the finish line of signalling networks, the starting point of cellular movement
Cellular and Molecular Life Sciences, 62

Innocenti M., Gerboth S., Rottner K., Lai Frank P.L., Hertzog M., Stradal T.E.B., Frittoli E., Didry D., Polo S., Disanza A., Benesch S., Di Fiore P.P., ... , Carlier M.-F., Scita G. (2005)
Abi1regulates the activity of N-WASP and WAVE in distinct actin-based processes
Nature Cell Biology, 7 (10)

Benesch S., Polo S., Lai F.P.L., Anderson K.I., Stradal T.E.B., ... , Wehland J., Rottner K. (2005)
N-WASP deficiency impairs EGF internalization and actin assembly at clathrin coated pits
Journal of Cell Science, 118

Rottner K., Stradal T.E.B., Wehland J. (2005)
Bacteria - host cell interactions at the plasma membrane: stories on actin cytoskeleton subversion
Developmental Cell, 9

Stradal T.E.B., Lommel S., Wehland J., Rottner K. (2005)
Host-pathogen interactions and cell motility: learning from bacteria
(12)

Wang Y.L., Burridge K., Dembo M., Gabbiani G., Hanks S.K., Hosoya H., Janmey P., Karlsson R., Lindberg U., Mabuchi I., Otey C., Rottner K., Small J.V., ... , Wang C.L., Zigmond S. (2004)
Biomedical research publication system
Science, 303

Rottner K., Lommel S., Wehland J., Stradal T.E.B. (2004)
Pathogen-induced actin filament rearrangement in infectious diseases
Journal of Pathology, 204

Pacholsky D., Himmel M., Löw T., Stradal T.E.B., Rottner K., ... , Fürst D.O., Van der Ven P.F. (2004)
Xin repeats define a novel actin binding motif
Journal of Cell Science, 117

Stradal T.E.B., Rottner K., Disanza A., Confalonieri S., Innocenti M., Scita G. (2004)
Regulation of actin dynamics by WASF and WAVE family proteins
Trends in Cell Biology, 14

Steffen A., Rottner K., Ehinger J., Innocenti M., Scita G., ... , Wehland J., Stradal T.E.B. (2004)
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation
Embo Journal, 23 (4)

Stradal T.B., Sechi A.S., Wehland J., Rottner K. (2003)
The cytoskeleton

Breitbach K., Rottner K., Klocke S., Rohde M., Jenzora A., ... , Wehland J., Steinmetz I. (2003)
Actin-based motility of Burkholderia pseudomallei
Cellular Microbiology, 5 (6)

Small J.V., Stradal T., Vignal E., Rottner K. (2002)
The lamellipodium: Where motility begins.
Trends in Cell Biology, 12

Benesch S., Lommel S., Steffen A., Stradal T.E., Scaplehorn N., Way M., ... , Wehland J., Rottner K. (2002)
Phosphatidylinositol 4,5-Biphosphate (PIP2)-induced Vesicle Movement Depends on N-WASP and Involves Nck, WIP, and Grb2*210
Journal of Biological Chemistry, 277 (40)

Stradal T.B., Courtney K., Rottner K., Hahne P., Small J.V., Pendergast A.M. (2001)
The Abl-interactor (Abi) proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.
Current biology, 11

Rottner K., Krause M., Gimona M., Small J.V., Wehland J. (2001)
Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions
Molecular Biology of the Cell, 12 (10)

Lommel S., Benesch S., Rottner K., Franz T., Wehland J., Kühn R. (2001)
Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP- defective cells
EMBO Reports, 2 (9)