Prof. Dr. Luka Cicin-Sain

Yu Z., Sasidharan-Nair V., Buchta T., Bonifacius A., Khan F., Pietzsch B., Ahmadi H., Beckstette M., Niemz J., Hilgendorf P., Mausberg P., Keller A., Falk C., Busch D.H., Schober K., Cicin-Sain L., Müller F., Brinkmann M.M., Eiz-Vesper B., ... , Floess S., Huehn J. (2024)

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells

PLoS.Pathog., 20 (9)

DOI: 10.1371/journal.ppat.1012581 HZI-Repositorium PubMed

Innocenti G., Obara M., Costa B., Jacobsen H., Katzmarzyk M., Cicin-Sain L., ... , Kalinke U., Galardini M. (2024)

Real-time identification of epistatic interactions in SARS-CoV-2 from large genome collections

Genome Biology, 25 (1)

DOI: 10.1186/s13059-024-03355-y HZI-Repositorium PubMed

Khan F., Müller T.R., Kasmapour B., Ynga-Durand M.A., Eiz-Vesper B., Von Einem J., ... , Busch D.H., Cicin-Sain L. (2024)

Dynamic monitoring of viral gene expression reveals rapid antiviral effects of CD8 T cells recognizing the HCMV-pp65 antigen

Frontiers in Immunology, 15

DOI: 10.3389/fimmu.2024.1439184 HZI-Repositorium PubMed

Metzdorf K., Jacobsen H., Kim Y., Teixeira Alves L.G., Kulkarni U., Brdovcak M.C., Materljan J., Eschke K., Chaudhry M.Z., Hoffmann M., Bertoglio F., Ruschig M., Hust M., Sustic M., Krmpotic A., Jonjic S., Widera M., Ciesek S., Pöhlmann S., ... , Landthaler M., Cicin-Sain L. (2024)

A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants

Frontiers in Immunology, 15

DOI: 10.3389/fimmu.2024.1383086 HZI-Repositorium PubMed

Winterhalter P.M., Warmuth L., Hilgendorf P., Schütz J.M., Dötsch S., Tonn T., Cicin-Sain L., ... , Busch D.H., Schober K. (2024)

HLA reduction of human T cells facilitates generation of immunologically multicompatible cellular products

Blood Advances, 8 (13)

DOI: 10.1182/bloodadvances.2023011496 PubMed

Santamorena M.M., Tischer-Zimmermann S., Bonifacius A., Mireisz C.N.-M., Costa B., Khan F., Kulkarni U., Lauruschkat C.D., Sampaio K.L., Stripecke R., Blasczyk R., Maecker-Kolhoff B., Kraus S., Schlosser A., Cicin-Sain L., ... , Kalinke U., Eiz-Vesper B. (2024)

Engineered HCMV-infected APCs enable the identification of new immunodominant HLA-restricted epitopes of anti-HCMV T-cell immunity

HLA, 103 (6)

DOI: 10.1111/tan.15541 HZI-Repositorium PubMed

Maaß H., Ynga-Durand M., Milosevic M., Krstanovic F., Matesic M.P., Zuza I., Jonjic S., Brizic I., Sustic A., Bloos F., SepNet Critical Care Trials Group, ... , Protic A., Cicin-Sain L. (2024)

Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants

Sci.Rep., 14 (1)

DOI: 10.1038/s41598-024-64384-y HZI-Repositorium PubMed

Becker B., Wottawa F., Bakr M., Koncina E., Mayr L., Kugler J., Yang G., Windross S.J., Neises L., Mishra N., Harris D., Tran F., Welz L., Schwärzler J., Banki Z., Stengel S.T., Ito G., Krötz C., Coleman O.I., Jaeger C., Haller D., Paludan S.R., Blumberg R., Kaser A., Cicin-Sain L., Schreiber S., Adolph T.E., Letellier E., Rosenstiel P., ... , Meiser J., Aden K. (2024)

Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut

iScience, 27 (3)

DOI: 10.1016/j.isci.2024.109173 HZI-Repositorium PubMed

Chaudhry M.Z., Borkner L., Kulkarni U., Berberich-Siebelt F., Cicin-Sain L. (2024)

NFAT signaling is indispensable for persistent memory responses of MCMV-specific CD8+ T cells

PLoS Pathogens, 20 (2 / February)

DOI: 10.1371/journal.ppat.1012025 HZI-Repositorium PubMed

Costa B., Becker J., Krammer T., Mulenge F., Duran V., Pavlou A., Gern O.L., Chu X., Li Y., Cicin-Sain L., Eiz-Vesper B., Messerle M., Dölken L., Saliba A.E., ... , Erhard F., Kalinke U. (2024)

Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells

Nat.Commun., 15 (1)

DOI: 10.1038/s41467-024-45614-3 HZI-Repositorium PubMed

Alfi O., Cohen M., Bar-On S., Hashimshony T., Levitt L., Raz Y., Blecher Y., Chaudhry M.Z., Cicin-Sain L., Ben-El R., Oiknine-Djian E., Lahav T., Vorontsov O., Cohen A., Zakay-Rones Z., Daniel L., Berger M., Mandel-Gutfreund Y., ... , Panet A., Wolf D.G. (2024)

Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface

Cell Rep., 43 (2)

DOI: 10.1016/j.celrep.2024.113698 HZI-Repositorium PubMed

Zhang L., Kempf A., Nehlmeier I., Cossmann A., Richter A., Bdeir N., Graichen L., Moldenhauer A.S., Dopfer-Jablonka A., Stankov M.V., Simon-Loriere E., Schulz S.R., Jäck H.M., Cicin-Sain L., Behrens G.M.N., Drosten C., ... , Hoffmann M., Pöhlmann S. (2024)

SARS-CoV-2 BA.2.86 enters lung cells and evades neutralizing antibodies with high efficiency

Cell, 187 (3)

DOI: 10.1016/j.cell.2023.12.025 HZI-Repositorium PubMed

Cicin-Sain L. (2023)

Effects and safety profile of childhood vaccines in the light of the biological basis of the immune response

Lijec.Vjesn., 145

DOI: 10.26800/LV-145-supl5-2 HZI-Repositorium

Katzmarzyk M., Clesle D.C., van den Heuvel J., Hoffmann M., Garritsen H., Pöhlmann S., ... , Jacobsen H., Cicin-Sain L. (2023)

Systematical assessment of the impact of single spike mutations of SARS-CoV-2 Omicron sub-variants on the neutralization capacity of post-vaccination sera

Front.Immunol., 14

DOI: 10.3389/fimmu.2023.1288794 HZI-Repositorium PubMed

Abassi L., Bertoglio F., Macak Safranko Z, Schirrmann T., Greweling-Pils M., Seifert O., Khan F., Katzmarzyk M., Jacobsen H., Gödecke N., Heine P.A., Frenzel A., Nowack H., Dübel S., Kurolt I.C., Kontermann R.E., Markotic A., Schubert M., ... , Hust M., Cicin-Sain L. (2023)

Evaluation of the Neutralizing Antibody STE90-C11 against SARS-CoV-2 Delta Infection and Its Recognition of Other Variants of Concerns

Viruses, 15 (11)

DOI: 10.3390/v15112153 HZI-Repositorium PubMed

Jiang B., Schmitt M.J., Rand U., Company C., Dramaretska Y., Grossmann M., Serresi M., ... , Cicin-Sain L., Gargiulo G. (2023)

Pharmacological modulators of epithelial immunity uncovered by synthetic genetic tracing of SARS-CoV-2 infection responses

Sci.Adv., 9 (25)

DOI: 10.1126/sciadv.adf4975 HZI-Repositorium PubMed

Sitnik K.M., Krstanovic F., Gödecke N., Rand U., Kubsch T., Maaß H., Kim Y., ... , Brizic I., Cicin-Sain L. (2023)

Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo

Nat.Commun., 14 (1)

DOI: 10.1038/s41467-023-38449-x HZI-Repositorium PubMed

Metzdorf K., Jacobsen H., Greweling-Pils M.C., Hoffmann M., Lüddecke T., Miller F., Melcher L., Kempf A.M., Nehlmeier I., Bruder D., Widera M., Ciesek S., ... , Pöhlmann S., Cicin-Sain L. (2023)

TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection

Viruses, 15 (2)

DOI: 10.3390/v15020271 HZI-Repositorium PubMed

Dötsch S., Svec M., Schober K., Hammel M., Wanisch A., Gökmen F., Jarosch S., Warmuth L., Barton J., Cicin-Sain L., ... , D'Ippolito E., Busch D.H. (2023)

Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression

Proc.Natl.Acad.Sci.U.S.A., 120 (10)

DOI: 10.1073/pnas.2200626120

Schwerk J., Kemper L., Bussey K.A., Lienenklaus S., Weiss S., Cicin-Sain L., Kröger A., Kalinke U., Collins C.M., Speck S.H., Messerle M., Wirth D., Brinkmann M.M., ... , Hauser H., Köster M. (2022)

Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo

Pathogens, 11 (12)

DOI: 10.3390/pathogens11121554 HZI-Repositorium PubMed

Keller L., Oueis E., Kaur A., Safaei N., Kirsch S.H., Gunesch A.P., Haid S., Rand U., Cicin-Sain L., Fu C., Wink J., ... , Pietschmann T., Müller R. (2022)

Persicamidines - Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses

Angew.Chem.Int.Ed Engl.

DOI: 10.1002/anie.202214595 HZI-Repositorium PubMed

Jacobsen H., Strengert M., Maaß H., Ynga Durand M.A., Katzmarzyk M., Kessel B., Harries M., Rand U., Abassi L., Kim Y., Lüddecke T., Metzdorf K., Hernández P., Ortmann J., Heise J.K., Castell S., Gornyk D., Glöckner S., Melhorn V., Kemmling Y., Lange B., Dulovic A., Marsall P., Häring J., Junker D., Schneiderhan-Marra N., Hoffmann M., Pöhlmann S., ... , Krause G., Cicin-Sain L. (2022)

Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations

Sci.Rep., 12 (1)

DOI: 10.1038/s41598-022-22552-y HZI-Repositorium PubMed

Brlic P.K., Pavletic M., Lerga M., Krstanovic.F., Matesic M.P., Miklic K., Malic S., Miksa L., Pajcur M., Peruc D., Schubert M., Bertoglio F., Arapovic J., Protic A., Sustic A, Milosevic M, Cicin-Sain L., Jonjic S., ... , Lisnic V., Brizic I. (2022)

SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study

Viruses, 14 (9)

DOI: 10.3390/v14091966 HZI-Repositorium PubMed

Jacobsen H., Cobos Jiménez, Sitaras I., Bar-Zeev N., Cicin-Sain L., ... , Higdon M.M., Deloria-Knoll M. (2022)

Post-vaccination T cell immunity to omicron

Front.Immunol., 13

DOI: 10.3389/fimmu.2022.944713 HZI-Repositorium PubMed

Pardieck I.N., van der Sluis T.C., van der Gracht E.T.I., Veerkamp D.M.B., Behr F.M., van Duikeren S., Beyrend G., Rip J., Nadafi R., Beyranvand Nejad E., Mülling N., Brasem D.J., Camps M.G.M., Myeni S.K., Bredenbeek P.J., Kikkert M., Kim Y., Cicin-Sain L., Abdelaal T., van Gisbergen K.P.J.M., Franken K.L.M.C., Drijfhout J.W., Melief C.J.M., Zondag G.C.M., ... , Ossendorp F., Arens R. (2022)

A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection

Nat.Commun., 13 (1)

DOI: 10.1038/s41467-022-31721-6 HZI-Repositorium PubMed

Ynga-Durand M., Maaß H., Milosevic M., Krstanovic F., Pribanic Matesic M., Jonjic S., Protic A., Brizic I., ... , Sustic A., Cícín-Saín L. (2022)

SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes

Viruses., 14 (6)

DOI: 10.3390/v14061292 HZI-Repositorium PubMed

Ballmann R., Hotop S.K., Bertoglio F., Steinke S., Heine P.A., Chaudhry M.Z., Jahn D., Pucker B., Baldanti F., Piralla A., Schubert M., Cícín-Saín L., Brönstrup M., ... , Hust M., Dübel S. (2022)

ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein

Viruses., 14 (6)

DOI: 10.3390/v14061326 HZI-Repositorium PubMed

Khorenko M., Rand U., Cicin-Sain L., Feldmann C. (2022)

Foscarnet-Type Inorganic-Organic Hybrid Nanoparticles for Effective Antiviral Therapy

ACS Biomater.Sci Eng, 8 (4)

DOI: 10.1021/acsbiomaterials.2c00074 HZI-Repositorium PubMed

Hotop S.K., Reimering S., Shekhar A., Asgari E., Beutling U., Dahlke C., Fathi A., Khan F., Lütgehetmann M., Ballmann R., Gerstner A., Tegge W., Cicin-Sain L., Bilitewski U., ... , McHardy A.C., Brönstrup M. (2022)

Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2

Emerg.Microbes Infect, 11 (1)

DOI: 10.1080/22221751.2022.2057874 HZI-Repositorium PubMed

Cokaric Brdovcak M., Materljan J., Sustic M., Ravlic S., Ruzic T., Lisnic B., Miklic K., Brizic I., Matesic M.P., Lisnic V.J., Halassy B., Roncevic D., Knezevic Z., Stefan L., Bertoglio F., Schubert M., Cicin-Sain L., Markotic A., ... , Jonjic S., Krmpotic A. (2022)

ChAdOx1-S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination

Eur J Immunol

DOI: 10.1002/eji.202249823 HZI-Repositorium PubMed

Schubert M., Bertoglio F., Steinke S., Heine P.A., Ynga-Durand M.A., Maass H., Sammartino J.C., Cassaniti I., Zuo F., Du L., Korn J., Milosevic M., Wenzel E.V., Krstanovic F., Polten S., Pribanic-Matesic M., Brizic I., Baldanti F., Hammarström L., Dübel S., Sustic A, Marcotte H., Strengert M., Protic A., Piralla A., Pan-Hammarström Q., ... , Cicin-Sain L., Hust M. (2022)

Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant

BMC Med., 20 (1)

DOI: 10.1186/s12916-022-02312-5 HZI-Repositorium PubMed

Wöhrle F., Kerscher B., Cicin-Sain L., Bekeredjian-Ding I. (2022)

DGfI Study Group Vaccines - Annual Meeting 2022

Eur.J.Immunol., 52 (3)

DOI: 10.1002/eji.202270035 HZI-Repositorium PubMed

Baliu-Piqué M., Drylewicz J., Zheng X., Borkner L., Swain A.C., Otto S.A., de Boer R.J., Tesselaar K., ... , Cicin-Sain L., Borghans J.A.M. (2022)

Turnover of Murine Cytomegalovirus-Expanded CD8(+) T Cells Is Similar to That of Memory Phenotype T Cells and Independent of the Magnitude of the Response

J.Immunol., 208 (4)

DOI: 10.4049/jimmunol.2100883 HZI-Repositorium PubMed

Kim Y., Zheng X., Eschke K., Chaudhry M.Z., Bertoglio F., Tomic A., Krmpotic A., Hoffmann M., Bar-On Y., Boehme J., Bruder D., Ebensen T., Brunotte L., Ludwig S., Messerle M., Guzmán C., Mandelboim O., Hust M., Pöhlmann S., ... , Jonjic S., Cicin-Sain L. (2022)

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

Cell Mol.Immunol., 19 (2)

DOI: 10.1038/s41423-021-00814-5 HZI-Repositorium PubMed

Chaudhry M.Z., Eschke K., Hoffmann M., Grashoff M., Abassi L., Kim Y., Brunotte L., Ludwig S., Kröger A., Klawonn F., ... , Pöhlmann S.H., Cicin-Sain L. (2022)

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases

J.Virol.

DOI: 10.1128/jvi.02186-21 HZI-Repositorium PubMed

Cossarizza A., Chang H.D., Radbruch A., Abrignani S., Addo R., Akdis M., Andrä I., Andreata F., Annunziato F., Arranz E., Bacher P., Bari S., Barnaba V., Barros-Martins J., Baumjohann D., Beccaria C.G., Bernardo D., Boardman D.A., Borger J., Böttcher C., Brockmann L., Burns M., Busch D.H., Cameron G., Cammarata I., Cassotta A., Chang Y., Chirdo F.G., Christakou E., Cicin-Sain L., Cook L., Corbett A.J., Cornelis R., Cosmi L., Davey M.S., De Biasi S., De Simone G., Del Zotto G., Delacher M., Di Rosa F., Santo J.D., Diefenbach A., Dong J., Dörner T., Dress R.J., Dutertre C.A., Eckle S.B.G., Eede P., Evrard M., Falk C.S., Feuerer M., Fillatreau S., Fiz-Lopez A., Follo M., Foulds G.A., Fröbel J., Gagliani N., Galletti G., Gangaev A., Garbi N., Garrote J.A., Geginat J., Gherardin N.A., Gibellini L., Ginhoux F., Godfrey D.I., Gruarin P., Haftmann C., Hansmann L., Harpur C.M., Hayday A.C., Heine G., Hernandez D.C., Herrmann M., Hoelsken O., Huang Q., Huber S., Huber J.E., Hühn J., Hundemer M., Hwang W.Y.K., Iannacone M., Ivison S.M., Jäck H.M., Jani P.K., Keller B., Kessler N., Ketelaars S., Knop L., Knopf J., Koay H.F., Kobow K., Kriegsmann K., Kristyanto H., Krueger A., Kuehne J.F., Kunze-Schumacher H., Kvistborg P., Kwok I., Latorre D., Lenz D., Levings M.K., Lino A.C., Liotta F., Long H.M., Lugli E., MacDonald K.N., Maggi L., Maini M.K., Mair F., Manta C., Manz R.A., Mashreghi M.F., Mazzoni A., McCluskey J., Mei H.E., Melchers F., Melzer S., Mielenz D., Monin L., Moretta L., Multhoff G., Munoz L.E., Munoz-Ruiz M., Muscate F., Natalini A., Neumann K., Ng L.G., Niedobitek A., Niemz J., Almeida L.N., Notarbartolo S., Ostendorf L., Pallett L.J., Patel A.A., Percin G.I., Peruzzi G., Pinti M., Pockley A.G., Pracht K., Prinz I., Pujol-Autonell I., Pulvirenti N., Quatrini L., Quinn K.M., Radbruch H., Rhys H., Rodrigo M.B., Romagnani C., Saggau C., Sakaguchi S., Sallusto F., Sanderink L., Sandrock I., Schauer C., Scheffold A., Scherer H.U., Schiemann M., Schildberg F.A., Schober K., Schoen J., Schuh W., ler T., Schulz A.R., Schulz S., Schulze J., Simonetti S., Singh J., Sitnik K.M., Stark R., Starossom S., Stehle C., Szelinski F., Tan L., Tarnok A., Tornack J., Tree T.I.M., van Beek J.J.P., van de Veen W., van Gisbergen K., Vasco C., Verheyden N.A., von Borstel A., Ward-Hartstonge K.A., Warnatz K., Waskow C., Wiedemann A., Wilharm A., Wing J., Wirz O., Wittner J., ... , Yang J.H.M., Yang J. (2021)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Eur.J.Immunol., 51 (12)

DOI: 10.1002/eji.202170126 HZI-Repositorium PubMed

Pezoldt J., Wiechers C., Erhard F., Rand U., Bulat T., Beckstette M., Brendolan A., Hühn J., Kalinke U., Mueller M., Strobl B., Deplancke B., ... , Cicin-Sain L., Sitnik K.M. (2021)

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Commun.Biolog., 4 (1)

DOI: 10.1038/s42003-021-02882-9 HZI-Repositorium PubMed

Zimmer M.M., Kibe A., Rand U., Pekarek L., Ye L., Buck S., Smyth R.P., ... , Cicin-Sain L., Caliskan N. (2021)

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Nat.Commun., 12 (1)

DOI: 10.1038/s41467-021-27431-0 HZI-Repositorium PubMed

Olbrich L., Stockdale L., Basu Roy R., Song R., Cicin-Sain L., Whittaker E., Prendergast A.J., ... , Fletcher H., Seddon J.A. (2021)

Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward

PLoS.Pathog., 17 (12)

DOI: 10.1371/journal.ppat.1010061 HZI-Repositorium PubMed

Flommersfeld S., Böttcher J.P., Ersching J., Flossdorf M., Meiser P., Pachmayr L.O., Leube J., Hensel I., Jarosch S., Zhang Q., Chaudhry M.Z., Andrae I., Schiemann M., Busch D.H., Cicin-Sain L., Sun J.C., Gasteiger G., Victora G.D., Höfer T., ... , Buchholz V.R., Grassmann S. (2021)

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Immunity.

DOI: 10.1016/j.immuni.2021.08.002 HZI-Repositorium PubMed

Müller T.R., Jarosch S., Hammel M., Leube J., Grassmann S., Bernard B., Effenberger M., Andrä I., Chaudhry M.Z., Käuferle T., Malo A., Cicin-Sain L., Steinberger P., Feuchtinger T., Protzer U., Schumann K., Neuenhahn M., ... , Schober K., Busch D.H. (2021)

Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy

Cell Rep.Med., 2 (8)

DOI: 10.1016/j.xcrm.2021.100374 HZI-Repositorium PubMed

Rand U., Kupke S.Y., Shkarlet H., Hein M.D., Hirsch T., Marichal-Gallardo P., Cicin-Sain L., ... , Reichl U., Bruder D. (2021)

Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity

Cells, 10 (7)

DOI: 10.3390/cells10071756 HZI-Repositorium PubMed

Bertoglio F., Fühner V., Ruschig M., Heine P.A., Abassi L., Klünemann T., Rand U., Meier D., Langreder N., Steinke S., Ballmann R., Schneider K., Roth K.D.R., Kuhn P., Riese P., Schäckermann D., Korn J., Koch A., Chaudhry M.Z., Eschke K., Kim Y., Zock-Emmenthal S., Becker M., Scholz M., Moreira G.M.S.G., Wenzel E.V., Russo G., Garritsen H.S.P., Casu S., Gerstner A., Roth G., Adler J., Trimpert J., Hermann A., Schirrmann T., Dübel Stefan, Frenzel A., van den Heuvel J., Cicin-Sain L., ... , Schubert M., Hust M. (2021)

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations

Cell Rep., 36 (4)

DOI: 10.1016/j.celrep.2021 HZI-Repositorium PubMed

Pommerenke C., Rand U., Uphoff C.C., Nagel S., Zaborski M., Hauer V., Kaufmann M., Meyer C., Denkmann S.A., Riese P., Eschke K., Kim Y., Safranko Z.M., Kurolt I.C., Markotic A., ... , Cicin-Sain L., Steenpass L. (2021)

Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies

PLoS ONE, 16 (8)

DOI: 10.1371/journal.pone.0255622 HZI-Repositorium PubMed

Baasch S., Giansanti P., Kolter J., Riedl A., Forde A.J., Runge S., Zenke S., Elling R., Halenius A., Brabletz S., Hengel H., Kuster B., Brabletz T., Cicin-Sain L., Arens R., Vlachos A., Rohr J.C., Stemmler M.P., Kopf M., ... , Ruzsics Z., Henneke P. (2021)

Cytomegalovirus subverts macrophage identity

Cell, 184 (14)

DOI: 10.1016/j.cell.2021.05.009 PubMed

Bertoglio F., Meier D., Langreder N., Steinke S., Rand U., Simonelli L., Heine P.A., Ballmann R., Schneider K.T., Roth K.D.R., Ruschig M., Riese P., Eschke K., Kim Y., Schäckermann D., Pedotti M., Kuhn P., Zock-Emmenthal S., Wöhrle J., Kilb N., Herz T., Becker M., Grasshoff M., Wenzel E.V., Russo G., Kröger A., Brunotte L., Ludwig S., Fühner V., Krämer S.D., Dübel S., Varani L., Roth G., Cicin-Sain L., ... , Schubert M., Hust M. (2021)

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

Nat.Commun., 12 (1)

DOI: 10.1038/s41467-021-21609-2 HZI-Repositorium PubMed

Chaudhry M.Z., Messerle M., Cicin-Sain L (2021)

Construction of Human Cytomegalovirus Mutants with Markerless BAC Mutagenesis

Methods Mol.Biol., 2244 (8)

DOI: 10.1007/978-1-0716-1111-1_8 PubMed

Rand U., Kubsch T., Kasmapour B., Cicin-Sain L. (2021)

A Novel Triple-Fluorescent HCMV Strain Reveals Gene Expression Dynamics and Anti-Herpesviral Drug Mechanisms

Front.Cell.Infect.Microbiol., 10

DOI: 10.3389/fcimb.2020.536150 HZI-Repositorium PubMed

Seelbinder B., Wallstabe J., Marischen L., Weiss E., Wurster S., Page L., Löffler C., Bussemer L., Schmitt A.L., Wolf T., Linde J., Cicin-Sain L., Becker J., Kalinke U., Vogel J., Panagiotou G., Einsele H., Westermann A.J., ... , Schäuble S., Loeffler J. (2020)

Triple RNA-Seq Reveals Synergy in a Human Virus-Fungus Co-infection Model

Cell Rep., 33 (7)

DOI: 10.1016/j.celrep.2020.108389 HZI-Repositorium PubMed

Gödecke N., Riedel J., Herrmann S., Behme S., Rand U., Kubsch T., Cicin-Sain L., Hauser H., ... , Köster M., Wirth D. (2020)

Synthetic rewiring and boosting type I interferon responses for visualization and counteracting viral infections

Nucleic Acids Res., 48 (20)

DOI: 10.1093/nar/gkaa961 HZI-Repositorium PubMed

Grassmann S., Mihatsch L., Mir J., Kazeroonian A., Rahimi R., Flommersfeld S., Schober K., Hensel I., Leube J., Pachmayr L.O., Kretschmer L., Zhang Q., Jolly A., Chaudhry M.Z., Schiemann M., Cicin-Sain L., Höfer T., Busch D.H., ... , Flossdorf M., Buchholz V.R. (2020)

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection

Nat.Immunol., 21 (12)

DOI: 10.1038/s41590-020-00807-y HZI-Repositorium PubMed

Abassi L., Cicin-Sain L. (2020)

The avid competitors of memory inflation

Curr.Opin.Virol., 44 (October)

DOI: 10.1016/j.coviro.2020.08.007 HZI-Repositorium PubMed

Zeeb M., Kerrinnes T., Cicin-Sain L., Guzmán C.A., Puppe W., Schulz T.F., Peters A., Berger K., ... , Castell S., Karch A. (2020)

Seropositivity for pathogens associated with chronic infections is a risk factor for all-cause mortality in the elderly: findings from the Memory and Morbidity in Augsburg Elderly (MEMO) Study

Geroscience., 42 (5)

DOI: 10.1007/s11357-020-00216-x HZI-Repositorium PubMed

Chaudhry M.Z., Casalegno-Garduno R., Sitnik K.M., Kasmapour B., Pulm A.K., Brizic I., Eiz-Vesper B., Moosmann A., Jonjic S., ... , Mocarski E.S., Cicin-Sain L. (2020)

Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells

Proc.Natl.Acad.Sci.U.S.A, 117 (23)

DOI: 10.1073/pnas.1914667117 HZI-Repositorium PubMed

Welten S.P.M., Yermanos A., Baumann N.S., Wagen F., Oetiker N., Sandu I., Pedrioli A., Oduro J.D., Reddy S.T., Cicin-Sain L., ... , Held W., Oxenius A. (2020)

Tcf1+ cells are required to maintain the inflationary T cell pool upon MCMV infection

Nat.Commun., 11 (1)

DOI: 10.1038/s41467-020-16219-3 HZI-Repositorium PubMed

Schober K., Voit F., Grassmann S., Müller T.R., Eggert J., Jarosch S., Weißbrich B., Hoffmann P., Borkner L., Nio E., Fanchi L., Clouser C.R., Radhakrishnan A., Mihatsch L., Lückemeier P., Leube J., Dössinger G., Klein L., Neuenhahn M., Oduro J.D., Cicin-Sain L., ... , Buchholz V.R., Busch D.H. (2020)

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection

Nat.Immunol., 21 (4)

DOI: 10.1038/s41590-020-0628-2 PubMed

Nikolich-Zugich J., Cicin-Sain L., Collins-McMillen D., Jackson S., Oxenius A., Sinclair J., Snyder C., ... , Wills M., Lemmermann N. (2020)

Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging

Geroscience., 42 (2)

DOI: 10.1007/s11357-020-00170-8 HZI-Repositorium PubMed

Cossarizza A., Chang H.D., Radbruch A., Acs A., Adam D., dam-Klages S., Agace W.W., Aghaeepour N., Akdis M., Allez M., Almeida L.N., Alvisi G., Anderson G., Annunziato F., Anselmo A., Bacher P., Baldari C.T., Bari S., Barnaba V., Barros-Martins J., Battistini L., Bauer W., Baumgart S., Baumgarth N., Baumjohann D., Baying B., Bebawy M., Becher B., Beisker W., Benes V., Beyaert R., Blanco A., Boardman D.A., Bogdan C., Borger J.G., Borsellino G., Boulais P.E., Bradford J.A., Brenner D., Brinkman R.R., Brooks A.E.S., Busch D.H., Büscher M., Bushnell T.P., Calzetti F., Cameron G., Cammarata I., Cao X., Cardell S.L., Casola S., Cassatella M.A., Cavani A., Celada A., Chatenoud L., Chattopadhyay P.K., Chow S., Christakou E., Cicin-Sain L., Clerici M., Colombo F.S., Cook L., Cooke A., Cooper A.M., Corbett A.J., Cosma A., Cosmi L., Coulie P.G., Cumano A., Cvetkovic L., Dang V.D., ng-Heine C., Davey M.S., Davies D., De Biasi S., Del Zotto G., Dela Cruz G.V., Delacher M., Della Bella S., Dellabona P., Deniz G., Dessing M., Di Santo J.P., Diefenbach A., Dieli F., Dolf A., Dörner T., Dress R.J., Dudziak D., Dustin M., Dutertre C.A., Ebner F., Eckle S.B.G., Edinger M., Eede P., Ehrhardt G.R.A., Eich M., Engel P., Engelhardt B., Erdei A., Esser C., Everts B., Evrard M., Falk C.S., Fehniger T.A., Felipo-Benavent M., Ferry H., Feuerer M., Filby A., Filkor K., Fillatreau S., Follo M., Förster I., Foster J., Foulds G.A., Frehse B., Frenette P.S., Frischbutter S., Fritzsche W., Galbraith D.W., Gangaev A., Garbi N., Gaudilliere B., Gazzinelli R.T., Geginat J., Gerner W., Gherardin N.A., Ghoreschi K., Gibellini L., Ginhoux F., Goda K., Godfrey D.I., Goettlinger C., Goodyear C.S., Gori A., Grogan J.L., Grummitt D., Grützkau A., Haftmann C., Hahn J., Hammad H., Hämmerling G., Hansmann L., Hansson G., Harpur C.M., Hartmann S., Hauser A., Hauser A.E., Haviland D.L., Hedley D., Hernandez D.C., Herrera G., Herrmann M., Hess C., Höfer T., Hoffmann P., Hogquist K., Holland T., Höllt T., Holmdahl R., Hombrink P., Houston J.P., Hoyer B.F., Huang B., Huang F.P., Huber J.E., Hühn J., Hundemer M., Hunter C.A., Hwang W.Y.K., Iannone A., Ingelfinger F., Ivison S.M., Jäck H.M., Jani P.K., Jbvega B., Kaiser T., Kalina T., Kamradt T., Kaufmann S.H.E., Keller B., Ketelaars S.L.C., Khalilnezhad A., Khan S., Kisielow J., Klenerman P., Knopf J., Koay H.F., Kobow K., Kolls J.K., Kong W.T., Kopf M., Korn T., Kriegsmann K., Kristyanto H., Kroneis T., Krueger A., Kühne J., Kukat C., Kunkel D., Kunze-Schumacher H., Kurosaki T., Kurts C., Kvistborg P., Kwok I., Landry J., Lantz O., Lanuti P., LaRosa F., Lehuen A., LeibundGut-Landmann S., Leipold M.D., Leung L.Y.T., Levings M.K., Lino A.C., Liotta F., Litwin V., Liu Y., Ljunggren H.G., Lohoff M., Lombardi G., Lopez L., Lopez-Botet M., Lovett-Racke A.E., Lubberts E., Luche H., Ludewig B., Lugli E., Lunemann S., Maecker H.T., Maggi L., Maguire O., Mair F., Mair K.H., Mantovani A., Manz R.A., Marshall A.J., Martinez-Romero A., Martrus G., Marventano I., Maslinski W., Matarese G., Mattioli A.V., Maueröder C., Mazzoni A., McCluskey J., McGrath M., McGuire H.M., McInnes I.B., Mei H.E., ... , Melchers F., Melzer S. (2019)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Eur.J.Immunol., 49 (10)

DOI: 10.1002/eji.201970107 HZI-Repositorium PubMed

Ynga-Durand M.A., Dekhtiarenko I., Cicin-Sain L. (2019)

Vaccine Vectors Harnessing the Power of Cytomegaloviruses

Vaccines.(Basel), 7 (4)

DOI: 10.3390/vaccines7040152 HZI-Repositorium PubMed

Zheng X., Oduro J.D., Boehme J.D., Borkner L., Ebensen T., Heise U., Gereke M., Pils M.C., Krmpotic A., Guzmán C.A., ... , Bruder D., Cicin-Sain L. (2019)

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge

PLoS Pathog., 15 (9)

DOI: 10.1371/journal.ppat.1008036 HZI-Repositorium PubMed

Contreras N.A., Sitnik K.M., Jeftic I., Coplen C.P., Cicin-Sain L., Nikolich-Zugich J. (2019)

Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia

PLoS.Pathog., 15 (6)

DOI: 10.1371/journal.ppat.1007890 HZI-Repositorium PubMed

Baumann N.S., Welten S.P.M., Torti N., Pallmer K., Borsa M., Barnstorf I., Oduro J.D., ... , Cicin-Sain L., Oxenius A. (2019)

Early primed KLRG1- CMV-specific T cells determine the size of the inflationary T cell pool

PLoS.Pathog., 15 (5)

DOI: 10.1371/journal.ppat.1007785 HZI-Repositorium PubMed

Grassmann S., Pachmayr L.O., Leube J., Mihatsch L., Andrae I., Flommersfeld S., Oduro J., Cicin-Sain L., Schiemann M., ... , Flossdorf M., Buchholz V.R. (2019)

Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection

Immunity., 50 (6)

DOI: 10.1016/j.immuni.2019.04.015 PubMed

Cicin-Sain L. (2019)

Cytomegalovirus memory inflation and immune protection

Med.Microbiol Immunol, 208 (3-4)

DOI: 10.1007/s00430-019-00607-8

Beyranvand Nejad E., Ratts R.B., Panagioti E., Meyer C., Oduro J.D., Cicin-Sain L., Früh K., ... , Van Der Burg S.H., Arens R. (2019)

Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection

J.Immunother.Cancer, 7 (1)

DOI: 10.1186/s40425-019-0500-9 HZI-Repositorium PubMed

Keib A., Mei Y.F., Cicin-Sain L., Busch D.H., Dennehy K.M. (2019)

Measuring Antiviral Capacity of T Cell Responses to Adenovirus

J.Immunol., 202 (2)

DOI: 10.4049/jimmunol.1801003 PubMed

Becker J., Kinast V., Döring M., Lipps C., Duran V., Spanier J., Tegtmeyer P.K., Wirth D., Cicin-Sain L., ... , Alcami A., Kalinke U. (2018)

Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines

Virulence., 9 (1)

DOI: 10.1080/21505594.2018.1535785 HZI-Repositorium

Cicin-Sain L., Arens R. (2018)

Exhaustion and Inflation at Antipodes of T Cell Responses to Chronic Virus Infection

Trends Microbiol., 26 (6)

DOI: 10.1016/j.tim.2017.11.012 HZI-Repositorium PubMed

Reichel A., Stilp A.C., Scherer M., Reuter N., Lukassen S., Kasmapour B., Schreiner S., Cicin-Sain L., ... , Winterpacht A., Stamminger T. (2018)

The chromatin remodeling factor SPOC1 acts as a cellular restriction factor against human cytomegalovirus by repressing the major immediate-early promoter

J.Virol., 92 (14)

DOI: 10.1128/JVI.00342-18 HZI-Repositorium

Baumann N.S., Torti N., Welten S.P.M., Barnstorf I., Borsa M., Pallmer K., Oduro J.D., Cicin-Sain L., Ikuta K., ... , Ludewig B., Oxenius A. (2018)

Tissue maintenance of CMV-specific inflationary memory T cells by IL-15

PLoS Pathog., 14 (4)

DOI: 10.1371/journal.ppat.1006993 HZI-Repositorium PubMed

Redeker A., Remmerswaal E.B.M., van der Gracht E.T.I., Welten S.P.M., Höllt T., Koning F., Cicin-Sain L., Nikolich-Zugich J., Ten Berge I, van Lier R.A.W., ... , van Unen V, Arens R. (2017)

The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose

Front Immunol., 8

DOI: 10.3389/fimmu.2017.01953 HZI-Repositorium PubMed

Kutle I., Sengstake S., Templin C., Glass M., Kubsch T., Keyser K.A., Binz A., Bauerfeind R., Sodeik B., Cicin-Sain L., ... , Dezeljin M., Messerle M. (2017)

The M25 gene products are critical for the cytopathic effect of mouse cytomegalovirus

Sci.Rep., 7 (1)

DOI: 10.1038/s41598-017-15783-x HZI-Repositorium

Subramanian N., Wu Z., Reister F., Sampaio K.L., Frascaroli G., ... , Cicin-Sain L., Mertens T. (2017)

Naive T cells are activated by autologous HCMV-infected endothelial cells through NKG2D and can control HCMV transmission in vitro

J.Gen.Virol., 98 (12)

DOI: 10.1099/jgv.0.000976

Kasmapour B., Kubsch T., Rand U., Eiz-Vesper B., Messerle M., Vondran F.W.R., Wiegmann B., ... , Haverich A., Cicin-Sain L. (2017)

Myeloid dendritic cells repress human cytomegalovirus gene expression and spread by releasing interferon-unrelated soluble antiviral factors

J.Virol., 92 (1)

DOI: 10.1128/JVI.01138-17 HZI-Repositorium

Chaudhry M.Z., Kasmapour B., Plaza-Sirvent C., Bajagic M., Garduno R.C., Borkner L., Rovis T.L., Scrima A., Jonjic S., ... , Schmitz I., Cicin-Sain L. (2017)

UL36 rescues apoptosis inhibition and in vivo replication of a chimeric MCMV lacking the M36 gene

Front.Cell.Infect.Microbiol., 7 (JUL)

DOI: 10.3389/fcimb.2017.00312 HZI-Repositorium PubMed

Borkner L., Sitnik K.M., Dekhtiarenko I., Pulm A.K., Tao R., ... , Drexler I., Cicin-Sain L. (2017)

Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope

J.Immunol., 199 (5)

DOI: 10.4049/jimmunol.1602115

Jackson S.E., Redeker A., Arens R., van Baarle D., van den Berg S.P.H., Benedict C.A., Cicin-Sain L., ... , Hill A.B., Wills M.R. (2017)

CMV immune evasion and manipulation of the immune system with aging

Geroscience., 39 (3)

DOI: 10.1007/s11357-017-9986-6 HZI-Repositorium PubMed

Popovic B., Golemac M., Podlech J., Zeleznjak J., Bilic-Zulle L., Lukic M.L., Cicin-Sain L., Reddehase M.J., Sparwasser T., ... , Krmpotic A., Jonjic S. (2017)

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection

PLoS.Pathog., 13 (4)

DOI: 10.1371/journal.ppat.1006345 HZI-Repositorium PubMed

Thiel N., Keyser K.A., Lemmermann N.A., Oduro J.D., Wagner K., Elsner C., Halenius A., Lenac Rovis T., Brinkmann M.M., Jonjic S., ... , Cicin-Sain L., Messerle M. (2016)

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages

PLoS Pathog., 12 (12)

DOI: 10.1371/journal.ppat.1006057 HZI-Repositorium PubMed

Dekhtiarenko I., Ratts R.B., Blatnik R., Lee L.N., Fischer S., Borkner L., Oduro J.D., Marandu T.F., Hoppe S., Ruzsics Z., Sonnemann J.K., Mansouri M., Meyer C., Lemmermann N.A., Holtappels R., Arens R., Klenerman P., Fruh K., Reddehase M.J., ... , Riemer A.B., Cicin-Sain L. (2016)

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

PLoS Pathog., 12 (12)

DOI: 10.1371/journal.ppat.1006072 HZI-Repositorium PubMed

Puttur F., Francozo M., Solmaz G., Bueno C., Lindenberg M., Gohmert M., Swallow M., Tufa D., Jacobs R., Lienenklaus S., Kuhl A.A., Borkner L., Cicin-Sain L., Holzmann B., Wagner H., ... , Berod L., Sparwasser T. (2016)

Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling

Cell Rep., 17 (4)

DOI: 10.1016/j.celrep.2016.09.055 HZI-Repositorium PubMed

Oduro J.D., Redeker A., Lemmermann N.A., Ebermann L., Marandu T.F., Dekhtiarenko I., Holzki J.K., Busch D., ... , Arens R., Cicin-Sain L. (2015)

Murine cytomegalovirus infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection

J Gen.Virol., 97

DOI: 10.1099/jgv.0.000339 HZI-Repositorium PubMed

Venturi V., Nzingha K., Amos T.G., Charles W.C., Dekhtiarenko I., Cicin-Sain L., ... , Davenport M.P., Rudd B.D. (2016)

The Neonatal CD8+ T Cell Repertoire Rapidly Diversifies during Persistent Viral Infection

J Immunol., 196

DOI: 10.4049/jimmunol.1501867

Marandu T.F., Oduro J.D., Borkner L., Dekhtiarenko I., Uhrlaub J., Drabig A., Kroger A., ... , Nikolich-Zugich J., Cicin-Sain L. (2015)

Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections

J Virol., 89

DOI: 10.1128/JVI.01989-15 HZI-Repositorium PubMed

Holzki J.K., Dag F., Dekhtiarenko I., Rand U., Casalegno-Garduno R., Trittel S., May T., ... , Riese P., Cicin-Sain L. (2015)

Type I IFN released by Myeloid Dendritic Cells reversibly impairs Cytomegalovirus replication by inhibiting immediate early gene expression

J Virol., 89

DOI: 10.1128/JVI.01459-15 HZI-Repositorium PubMed

Welten S.P., Redeker A., Franken K.L., Oduro J.D., Ossendorp F., Cicin-Sain L., Melief C.J., ... , Aichele P., Arens R. (2015)

The viral context instructs the redundancy of costimulatory pathways in driving CD8 T cell expansion

Elife., 4

DOI: 10.7554/eLife.07486.

Brinkmann M.M., Daq F., Hengel H., Messerle M., Kalinke U., Cicin-Sain L. (2015)

Cytomegalovirus immune evasion of myeloid lineage cells

Med.Microbiol.Immunol., 204

Riese P., Trittel S., May T., Cicin-Sain L., Chambers B.J., Guzmán C.A. (2015)

Activated NKT cells imprint NK-cell differentiation, functionality and education

Eur.J Immunol., 45 (6)

Tsuda Y., Parkins C.J., Caposio P., Feldmann F., Botto S., Ball S., Messaoudi I., Cicin-Sain L., ... , Feldmann H., Jarvis M.A. (2015)

A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

Vaccine, 33 (19)

Döring M., Lessin I., Frenz T., Spanier J., Kessler A., Tegtmeyer P., Dag F., Thiel N., Trilling M., Lienenklaus S., Weiss S., Scheu S., Messerle M., Cicin-Sain L., ... , Hengel H., Kalinke U. (2014)

M27 expressed by cytomegalovirus counteracts effective type I IFN induction of myeloid cells, but not of plasmacytoid dendritic cells

Journal of Virology, 88 (23)

PubMed

Marandu T.F., Finsterbusch K., Kroger A., Cicin-Sain L. (2014)

Mouse CMV infection delays antibody class switch upon an unrelated virus challenge

Experimental Gerontology, 54

DOI: 10.1016/j.exger.2014.01.017 HZI-Repositorium PubMed

Sansoni P., Vescovini R., Fagnoni F.F., Akbar A., Arens R., Chiu Y.L., Cicin-Sain L., Dechanet-Merville J., Derhovanessian E., Ferrando-Martinez S., Franceschi C., Frasca D., Fulop T., Furman D., Gkrania-Klotsas E., Goodrum F., Grubeck-Loebenstein B., Hurme M., Kern F., Lilleri D., Lopez-Botet M., Maier A.B., Marandu T., Marchant A., Mathei C., Moss P., Muntasell A., Remmerswaal E.B., Riddell N.E., Rothe K., Sauce D., Shin E.C., Simanek A.M., Smithey M.J., Soderberg-Naucler C., Solana R., Thomas P.G., van Lier R., ... , Pawelec G., Nikolich-Zugich J. (2014)

New advances in CMV and immunosenescence

Exp.Gerontol., 55C

PubMed

Dekhtiarenko I., Cicin-Sain L., Messerle M. (2014)

Use of recombinant approaches to construct human cytomegalovirus mutants

Methods in Molecular Biology, 1119

PubMed

Dag F., Dolken L., Holzki J., Drabig A., Weingartner A., Schwerk J., Lienenklaus S., Conte I., Geffers R., Davenport C., Rand U., Köster M., Weiss S., Adler B., Wirth D., Messerle M., ... , Hauser H., Cicin-Sain L. (2014)

Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency

PLoS Pathogens, 10 (2)

DOI: 10.1371/journal.ppat.1003962 HZI-Repositorium PubMed

Dekhtiarenko I., Jarvis M.A., Ruzsics Z., Cicin-Sain L. (2013)

The context of gene expression defines the immunodominance hierarchy of cytomegalovirus antigens

Journal of Immunology, 190 (7)

Solana R., Tarazona R., Aiello A.E., Akbar A.N., Appay V., Beswick M., Bosch J.A., Campos C., Cantisan S., Cicin-Sain L., Derhovanessian E., Ferrando-Martinez S., Frasca D., Fulöp T., Govind S., Grubeck-Loebenstein B., Hill A., Hurme M., Kern F., Larbi A., Lopez-Botet M., Maier A.B., McElhaney J.E., Moss P., Naumova E., Nikolich-Zugich J., Pera A., Rector J.L., Riddell N., Sanchez-Correa B., Sansoni P., Sauce D., van Lier R., Wang G.C., Wills M.R., ... , Zielinski M., Pawelec G. (2012)

CMV and Immunosenescence: From basics to clinics

Immunity and Ageing, 9 (1)

DOI: 10.1186/1742-4933-9-23 HZI-Repositorium PubMed

Ebermann L., Ruzsics Z., Guzmán C.A., Van Rooijen N., Casalegno-Garduno R., ... , Koszinowski U., Cicin-Sain L. (2012)

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient host

PLoS Pathogens, 8 (12)

DOI: 10.1371/journal.ppat.1003062 HZI-Repositorium PubMed

Cicin-Sain L., Brien J.D., Uhrlaub J.L., Drabig A., Marandu T.F., Nikolich-Zugich J. (2012)

Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging

PLoS Pathogens, 8 (8)

DOI: 10.1371/journal.ppat.1002849 HZI-Repositorium PubMed

Cicin-Sain L., Sylwester A.W., Hagen S.I., Siess D.C., Currier N., Legasse A.W., Fischer M.B., Koudelka C.W., Axthelm M.K., ... , Nikolich-Zugich J., Picker L.J. (2011)

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques

Journal of Immunology, 187 (4)

Tsuda Y., Caposio P., Parkins C.J., Botto S., Messaoudi I., Cicin-Sain Luka*, ... , Feldmann H., Jarvis M.A. (2011)

A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus

PLoS Neglected Tropical Diseases, 5 (8)

DOI: 10.1371/journal.pntd.0001275 HZI-Repositorium PubMed

Cicin-Sain L., Smyk-Pearson S., Currier N., Byrd L., Koudelka C., Robinson T., Swarbrick G., Tackitt S., Legasse A., Fischer M., Nikolich-Zugich D., Park B., Hobbs T., Doane C.J., Mori M., Axthelm M.K., ... , Lewinsohn D.A., Nikolich-Zugich J. (2010)

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates

Journal of Immunology, 184 (12)

Prof. Dr. Dr. Luka Cicin-Sain

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