Prof. Dr. Mark Brönstrup

Prof. Dr. Mark Brönstrup
Forschungsgruppenleiter
+49 531 6181-3400

Mark Brönstrup studierte Chemie an der Philipps-Universität Marburg und am Imperial College in London. 1999 promovierte er an der TU Berlin in organischer Chemie. Nach der Promotion arbeitete er von 2000 bis 2004 zunächst als Laborleiter für Massenspektrometrie beim Pharmakonzern Aventis, unterbrochen von einem Forschungs-Sabbatical 2003 an der Harvard Medical School.

Von 2005 bis 2010 leitete er bei Sanofi-Aventis die Naturstoff-Forschung in Frankfurt mit dem Ziel, Leitstrukturen aus natürlichen Quellen zu entdecken und diese über Strukturveränderungen zu klinischen Kandidaten zu optimieren.

Von 2010 bis 2013 beschäftigte er sich mit Translationsforschung als Leiter der Sektion Biomarker & Diagnostics in der Diabetes Division sowie als Domain Head für Biomarker, Bioimaging und Biological Assays bei Sanofi.

Seit Dezember 2013 leitet er die Abteilung für Chemische Biologie am Helmholtz-Zentrum für Infektionsforschung. Zudem hält er eine Professur (W3) an der Leibniz-Universität Hannover inne. 

Publikationen
Weber B.S., Ritchie N.E., Hilker S., Chan D.C.K., Peukert C., Deisinger J.P., Ives R., Ardal C., Burrows L.L., Brönstrup M., Magolan J., ... , Raivio T.L., Brown E.D. (2024)
High-Throughput Discovery of Synthetic Siderophores for Trojan Horse Antibiotics
ACS Infect.Dis.
DOI: 10.1021/acsinfecdis.4c00359 PubMed
Kohnhäuser D., Seedorf T., Cirnski K., Heimann D., Coetzee J., Sordello S., Richter J., Stappert M., Sabuco J.F., Corbett D., Bacque E., Rox K., Herrmann J., Vassort A., Müller R., ... , Kirschning A., Brönstrup M. (2024)
Optimization of the Central a[alpha]-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861
J.Med.Chem.
DOI: 10.1021/acs.jmedchem.4c00927 HZI-Repositorium PubMed
Mahdavi S.M., Bockfeld D., Esarev I.V., Lippmann P., Frank R., Brönstrup M., ... , Ott I., Tamm M. (2024)
Gold(i) and gold(iii) carbene complexes from the marine betaine norzooanemonin: inhibition of thioredoxin reductase, antiproliferative and antimicrobial activity
RSC Medicinal Chemistry
DOI: 10.1039/d4md00358f HZI-Repositorium PubMed
Rox K., Kühne A., Herrmann J., Jansen R., Hüttel S., Bernecker S., Hagos Y., Brönstrup M., Stadler M., ... , Hesterkamp T., Müller R. (2024)
Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters
ACS Pharm.Transl.Sci.
DOI: 10.1021/acsptsci.4c00183 HZI-Repositorium
Büssing R., Bublitz A., Karge B., Brönstrup M., Strowig T., Ott I. (2024)
An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile
J.Biol.Inorg.Chem.
DOI: 10.1007/s00775-024-02064-y HZI-Repositorium PubMed
Esarev I.V., Karge B., Zeng H., Lippmann P., Jones P.G., Schrey H., ... , Brönstrup M., Ott I. (2024)
Silver Organometallics that are Highly Potent Thioredoxin and Glutathione Reductase Inhibitors: Exploring the Correlations of Solution Chemistry with the Strong Antibacterial Effects
ACS infectious diseases, 10 (5)
DOI: 10.1021/acsinfecdis.4c00104 HZI-Repositorium PubMed
Li Q., Jansen H., Hansen G., Nurjadi D., Herrmann J., Stadler M., Brönstrup M., Müller R., He C., Graspeuntner S., ... , Rupp J., Shima K. (2024)
Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis
Int.J.Antimicrob.Agents
DOI: 10.1016/j.ijantimicag.2024.107132 PubMed
Jerye K., Lüken H., Steffen A., Schlawis C., Jänsch L., ... , Schulz S., Brönstrup M. (2024)
Activity-Based Protein Profiling Identifies Protein Disulfide-Isomerases as Target Proteins of the Volatile Salinilactones
Adv.Sci.
DOI: 10.1002/advs.202309515 HZI-Repositorium PubMed
Zuffa S., Schmid R., Bauermeister A., Gomes P., Caraballo-Rodriguez A.M., El Abiead Y., Aron A.T., Gentry E.C., Zemlin J., Meehan M.J., Avalon N.E., Cichewicz R.H., Buzun E., Terrazas M.C., Hsu C.Y., Oles R., Ayala A.V., Zhao J., Chu H., Kuijpers M.C.M., Jackrel S.L., Tugizimana F., Nephali L.P., Dubery I.A., Madala N.E., Moreira E.A., Costa-Lotufo L.V., Lopes N.P., Rezende-Teixeira P., Jimenez P.C., Rimal B., Patterson A.D., Traxler M.F., Pessotti R.D.C., Alvarado-Villalobos D., Tamayo-Castillo G., Chaverri P., Escudero-Leyva E., Quiros-Guerrero L.M., Bory A.J., Joubert J., Rutz A., Wolfender J.L., Allard P.M., Sichert A., Pontrelli S., Pullman B.S., Bandeira N., Gerwick W.H., Gindro K., Massana-Codina J., Wagner B.C., Forchhammer K., Petras D., Aiosa N., Garg N., Liebeke M., Bourceau P., Kang K.B., Gadhavi H., Carvalho L.P.S., Silva dos Santos M., Perez-Lorente A.I., Molina-Santiago C., Romero D., Franke R., Brönstrup M., Vera-Ponce de Leon A., Pope P.B., La Rosa S.L., La Barbera G., Roager H.M., Laursen M.F., Hammerle F., Siewert B., Peintner U., Licona-Cassani C., Rodriguez-Orduna L., Rampler E., Hildebrand F., Koellensperger G., Schoeny H., Hohenwallner K., Panzenboeck L., Gregor R., O'Neill E.C., Roxborough E.T., Odoi J., Bale N.J., Ding S., Sinninghe Damste J.S., Guan X.L., Cui J.J., Ju K.S., Silva D.B., Silva F.M.R., da Silva G.F., Koolen H.H.F., Grundmann C., Clement J.A., Mohimani H., Broders K., McPhail K.L., Ober-Singleton S.E., Rath C.M., McDonald D., Knight R., ... , Wang M., Dorrestein P.C. (2024)
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
Nature microbiology, 9 (2)
DOI: 10.1038/s41564-023-01575-9 HZI-Repositorium PubMed
Pfütze S., Charria-Giron E., Schulzke E., Toshe R., Khonsanit A., Franke R., Surup F., ... , Brönstrup M., Stadler M. (2024)
Depicting the Chemical Diversity of Bioactive Meroterpenoids Produced by the Largest Organism on Earth
Angew.Chem.Int.Ed Engl.
DOI: 10.1002/anie.202318505 HZI-Repositorium PubMed
Haid S., Matthaei A., Winkler M., Sake S.M., Gunesch A.P., Milke V., Köhler N.M., Rückert J., Vieyres G., Kühl D., Nguyen T.-T., Göhl M., Lasswitz L., Zapatero-Belinchon F.J., Brogden G., Gerold G., Wiegmann B., Bilitewski U., Brown R.J.P., Brönstrup M., ... , Schulz T.F., Pietschmann T. (2024)
Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets
Antimicrob.Agents Chemother.
DOI: 10.1128/aac.01210-23 HZI-Repositorium PubMed
Eggert A., Schuppe K.T., Fuchs H.L.S., Brönstrup M., Kalesse M. (2023)
Total Synthesis of Acanthodoral Using a Rearrangement Strategy
Organic Letters
DOI: 10.1021/acs.orglett.3c03717 HZI-Repositorium PubMed
Mahdavi S.M., Bockfeld D., Büssing R., Karge B., Bannenberg T., Frank R., Brönstrup M., ... , Ott I., Tamm M. (2024)
Synthesis of N-heterocyclic carbene gold(i) complexes from the marine betaine 1,3-dimethylimidazolium-4-carboxylate
Dalton Transactions
DOI: 10.1039/d3dt04135b HZI-Repositorium PubMed
Rox K., Jansen R., Lukezic T., Greweling-Pils M., Herrmann J., Miethke M., Hüttel S., Hennessen F., Abou Fayad A., Holzhausen C., Lundberg C.V., Teague J., Sudarman E., Bülter L., Hesterkamp T., Stadler M., ... , Brönstrup M., Müller R. (2024)
Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models
Microbiol.Spectr., 12 (1)
DOI: 10.1128/spectrum.01289-23 HZI-Repositorium PubMed
Charria-Giron E., Marin-Felix Y., Beutling U., Franke R., Brönstrup M., Vasco-Palacios A.M., ... , Caicedo N.H., Surup F. (2023)
Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes
Microbiol.Spectr.
DOI: 10.1128/spectrum.02743-23 HZI-Repositorium PubMed
Schwitalla J.W., Le N.T.H., Um S., Schalk F., Brönstrup M., ... , Baunach M., Beemelmanns C. (2023)
Heterologous expression of the cryptic mdk gene cluster and structural revision of maduralactomycin A
RSC Adv., 13 (48)
DOI: 10.1039/d3ra05931f HZI-Repositorium PubMed
Schneider I., Fetz V., Prochnow H.P., Brönstrup M. (2023)
Artificial Siderophores with a Trihydroxamate-DOTAM Scaffold Deliver Iron and Antibiotic Cargo into the Bacterial Pathogen Escherichia coli
Isr.J.Chem., 63 (7-8)
DOI: 10.1002/ijch.202300057 HZI-Repositorium
Jian L., Zscherp R., Beutling U., Shen X., Xu S., Zhang X., Brönstrup M., ... , Klahn P., Sun Q. (2023)
Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors
J.Med.Chem.
DOI: 10.1021/acs.jmedchem.3c00549 PubMed
Wu Y., Zoller B.G.E., Kamal M.A.M., Hotop S.K., Lehr C.M., Brönstrup M., ... , Dersch P., Empting M. (2023)
Establishment of an In Bacterio assay for the Assessment of Carbon Storage Regulator A (CsrA) inhibitors
Chembiochem.
DOI: 10.1002/cbic.202300369 HZI-Repositorium PubMed
Allartz P., Hotop S.K., Muntau B., Schlaphof A., Thome-Bolduan C., Gabriel M., Petersen N., Lintzel M., Behrens C., Eggert P., Pörtner K., Steiner J., ... , Brönstrup M., Tappe D. (2023)
Detection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study
Infection
DOI: 10.1007/s15010-023-02048-1 HZI-Repositorium PubMed
Friederich J., Xu C., Raunft P., Fuchs H.L.S., Brönstrup M. (2023)
Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin
Chem.Commun., 59 (48)
DOI: 10.1039/d3cc01334k PubMed
Peukert C., Vetter A.C., Fuchs H.L.S., Harmrolfs K., Karge B., ... , Stadler M., Brönstrup M. (2023)
Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant E. coli
Chem.Sci., 14
DOI: 10.1039/d2sc06850h HZI-Repositorium
Cedeno-Sanchez M., Charria-Giron E., Lambert C., Luangsa-ard J.J., Decock C., Franke R., ... , Brönstrup M., Stadler M. (2023)
Segregation of the genus Parahypoxylon (Hypoxylaceae, Xylariales) from Hypoxylon by a polyphasic taxonomic approach
MycoKeys, 95
DOI: 10.3897/MYCOKEYS.95.98125 HZI-Repositorium
Zapol'skii V.A., Kaul S., Karge B., Brönstrup M., Gjikaj M., Kaufmann D.E. (2023)
A New Way to 2,3,4-Trisubstituted Benzo[h]quinolines: Synthesis, Consecutive Reactions and Cellular Activities â 
Molecules., 28 (6)
DOI: 10.3390/molecules28062479 HZI-Repositorium PubMed
Maingot M., Bourotte M., Vetter A.C., Schellhorn B., Antraygues K., Scherer H., Gitzinger M., Kemmer C., Dale G.E., Defert O., Lociuro S., Brönstrup M., ... , Willand N., Trebosc V. (2023)
Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against Acinetobacter baumannii
Eur.J.Med.Chem., 252
DOI: 10.1016/j.ejmech.2023.115257 PubMed
Lai Y.H., Franke R., Pinkert L., Overwin H., Brönstrup M. (2023)
Molecular Signatures of the Eagle Effect Induced by the Artificial Siderophore Conjugate LP-600 in E. coli
ACS Infect.Dis., 9 (3)
DOI: 10.1021/acsinfecdis.2c00567 HZI-Repositorium PubMed
Peukert C., Rox K., Karge B., Hotop S.K., Brönstrup M. (2023)
Synthesis and Characterization of DOTAM-Based Sideromycins for Bacterial Imaging and Antimicrobial Therapy
ACS Infect.Dis., 9 (2)
DOI: 10.1021/acsinfecdis.2c00523 HZI-Repositorium PubMed
Wimmer S., Hoff K., Martin B., Grewer M., Denni L., Lascorz Massanet R., Raimondi M.V., Bülbül E.F., Melesina J., Hotop S.K., Haupenthal J., Rohde H., Heisig P., Hirsch A.K.H., Brönstrup M., ... , Sippl W., Holl R. (2022)
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors
Bioorg.Chem., 131
DOI: 10.1016/j.bioorg.2022.106331 PubMed
Borgert S.R., Henke S., Witzgall F., Schmelz S., Zur Lage S., Hotop S.K., Stephen S., Lübken D., Krüger J., Gomez N.O., Van Ham M., Jänsch L., Kalesse M., Pich A., Brönstrup M., ... , Häußler S., Blankenfeldt W. (2022)
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa
Nat.Commun., 13 (1)
DOI: 10.1038/s41467-022-35030-w HZI-Repositorium PubMed
Peukert C., Gasser V., Orth T., Fritsch S., Normant V., Cunrath O., ... , Schalk I.J., Brönstrup M. (2022)
Trojan Horse Siderophore Conjugates Induce Pseudomonas aeruginosa Suicide and Qualify the TonB Protein as a Novel Antibiotic Target
J.Med.Chem., 66 (1)
DOI: 10.1021/acs.jmedchem.2c01489 HZI-Repositorium PubMed
Kruck D., Bode H., Krusche J., Beck C., Ohlsen K., Sander J., Römling U., Burrichter A., Varo J.G., ... , Charoenpattarapreeda J., Brönstrup M. (2022)
Journal Club : [u.a.] Gesteuerter Abbau von Proteinen in Bakterien durch BacPROTAC-Wirkstoffe [etc.]
Biospektrum, 28 (7)
DOI: 10.1007/s12268-022-1853-z
Fiorini F., Bajerski F., Jeske O., Lepleux C., Overmann J., Brönstrup M. (2022)
A Metabolomics-Based Toolbox to Assess and Compare the Metabolic Potential of Unexplored, Difficult-to-Grow Bacteria
Mar Drugs, 20 (11)
DOI: 10.3390/md20110713 HZI-Repositorium PubMed
Cooper M.S., Zhang L., Ibrahim M., Zhang K., Sun X., Röske J., Göhl M., Brönstrup M., Cowell J.K., Sauerhering L., Becker S., Vangeel L., Jochmans D., Neyts J., Rox K., Marsh G.P., ... , Maple H.J., Hilgenfeld R. (2022)
Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease
J.Med.Chem., 65 (19)
DOI: 10.1021/acs.jmedchem.2c01131 HZI-Repositorium PubMed
Suo H., Hochnadel I., Petriv N., Franke R., Schmidt J., Limanska N., Tugai A., Jedicke N., Brönstrup M., ... , Manns M.P., Yevsa T. (2022)
Elucidating the mechanism behind and investigating the efficacy of Traditional Chinese Medicine and Traditional Tibetan Medicine in combination with standard therapeutics in hepatocellular carcinoma and cholangiocarcinoma in vitro
Front Pharmacol., 13
DOI: 10.3389/fphar.2022.906468 HZI-Repositorium PubMed
Testolin G., Richter J., Ritter A., Prochnow H., Köhnke J., Brönstrup M. (2022)
Optical Modulation of Antibiotic Resistance by Photoswitchable Cystobactamids
Chem.Eur.J.
DOI: 10.1002/chem.202201297 HZI-Repositorium PubMed
Göhl M., Zhang L., El Kilani H., Sun X., Zhang K., ... , Brönstrup M., Hilgenfeld R. (2022)
From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease G
Molecules, 27 (13)
DOI: 10.3390/molecules27134292 HZI-Repositorium PubMed
Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C. (2022)
Correction for Suerbaum et al., "Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model"
MBio.
DOI: 10.1128/mbio.02301-22 HZI-Repositorium PubMed
Arshad H., Siokis A., Franke R., Habib A., Alfonso J.C.L., Poliakova Y., Lücke E., Michaelis K., Brönstrup M., Meyer-Hermann M., Bilitewski U., Vila J., Abel L., Illig T., ... , Schreiber J., Pessler F. (2022)
Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease
Cells, 11 (15)
DOI: 10.3390/cells11152283 HZI-Repositorium PubMed
Brauer M., Hotop S.K., Wurster M., Herrmann J., Miethke M., Schlüter R., Dittmann S., Zühlke D., Brönstrup M., Lalk M., Müller R., Sievers S., ... , Bernhardt J., Riedel K. (2022)
Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress
mSphere
DOI: 10.1128/msphere.00302-22 HZI-Repositorium PubMed
Ballmann R., Hotop S.K., Bertoglio F., Steinke S., Heine P.A., Chaudhry M.Z., Jahn D., Pucker B., Baldanti F., Piralla A., Schubert M., Cícín-Saín L., Brönstrup M., ... , Hust M., Dübel S. (2022)
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein
Viruses., 14 (6)
DOI: 10.3390/v14061326 HZI-Repositorium PubMed
Fritsch S., Gasser V., Peukert C., Pinkert L., Kuhn L., Perraud Q., Normant V., ... , Brönstrup M., Schalk I.J. (2022)
Uptake Mechanisms and Regulatory Resfponses to MECAM- and DOTAM-Based Artificial Siderophores and Their Antibiotic Conjugates in Pseudomonas aeruginosa
ACS Infect.Dis., 8 (6)
DOI: 10.1021/acsinfecdis.2c00049 HZI-Repositorium PubMed
Peukert C., Popat Gholap S., Green O., Pinkert L., van den Heuvel J., Van Ham M., ... , Shabat D., Brönstrup M. (2022)
Enzyme-Activated, Chemiluminescent Siderophore-Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens
Angew.Chem.Int.Ed Engl.
DOI: 10.1002/anie.202201423 HZI-Repositorium PubMed
Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C. (2022)
Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model
MBio., 13 (2)
DOI: 10.1128/mbio.03755-21 HZI-Repositorium PubMed
Hotop S.K., Reimering S., Shekhar A., Asgari E., Beutling U., Dahlke C., Fathi A., Khan F., Lütgehetmann M., Ballmann R., Gerstner A., Tegge W., Cicin-Sain L., Bilitewski U., ... , McHardy A.C., Brönstrup M. (2022)
Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2
Emerg.Microbes Infect, 11 (1)
DOI: 10.1080/22221751.2022.2057874 HZI-Repositorium PubMed
Arisetti N., Fuchs H.L.S., Coetzer J., Orozco M., Ruppelt D., Bauer A., Heimann D., Kuhnert E., Bhamidimarri S.P., Bafna J.A., Hinkelmann B., Eckel K., Sieber S.A., Müller P.P., Herrmann J., Müller R., Winterhalter M., ... , Steinem C., Brönstrup M. (2021)
Total synthesis and mechanism of action of the antibiotic armeniaspirol A
Chem.Sci., 12 (48)
DOI: 10.1039/d1sc04290d HZI-Repositorium PubMed
Ahsendorf H.P., Diesterbeck U.S., Hotop S.K., Winkler M., Brönstrup M., Czerny C.P. (2022)
Characterisation of an Anti-Vaccinia Virus F13 Single Chain Fragment Variable from a Human Anti-Vaccinia Virus-Specific Recombinant Immunoglobulin Library
Viruses, 14 (2)
DOI: 10.3390/v14020197 HZI-Repositorium PubMed
Hotop S.K., Abd El Wahed A., Beutling U., Czerny F., Sievers C., Diederichsen U., Frank R., Stahl-Hennig C., ... , Brönstrup M., Fritz H.J. (2019)
Serological Analysis of Herpes B Virus at Individual Epitope Resolution: From Two-Dimensional Peptide Arrays to Multiplex Bead Flow Assays
Anal.Chem., 91 (17)
DOI: 10.1021/acs.analchem.9b01291 PubMed
Roche B., Garcia-Rivera M.A., Normant V., Kuhn L., Hammann P., Brönstrup M., ... , Mislin G.L.A., Schalk I.J. (2021)
A role for PchHI as the ABC transporter in iron acquisition by the siderophore pyochelin in Pseudomonas aeruginosa
Environmental Microbiology
DOI: 10.1111/1462-2920.15811 HZI-Repositorium PubMed
Jimidar C.C., Grunenberg J., Karge B., Fuchs H.L.S., Brönstrup M., Klahn P. (2021)
Masked Amino Trimethyl Lock (H2N-TML) Systems: New Molecular Entities for the Development of Turn-On Fluorophores and Their Application in Hydrogen Sulfide (H2S) Imaging in Human Cells
Chemistry - A European Journal
DOI: 10.1002/chem.202103525 HZI-Repositorium PubMed
Becker K., Cao S., Nilsson A., Erlandsson M., Hotop S.K., Kuka J., Hansen J., Haldimann K., Grinberga S., Berruga-Fernández T., Huseby D.L., Shariatgorji R., Lindmark E., Platzack B., Böttger E.C., Crich D., Friberg L.E., Vingsbo Lundberg C., Hughes D., Brönstrup M., Andrén P.E., ... , Liepinsh E., Hobbie S.N. (2021)
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
EBioMedicine, 73 (November 2021)
DOI: 10.1016/j.ebiom.2021.103652 HZI-Repositorium PubMed
Pinkert L., Lai Y.H., Peukert C., Hotop S.K., Karge B., Schulze L.M., ... , Grunenberg J., Brönstrup M. (2021)
Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens
J.Med.Chem.
DOI: 10.1021/acs.jmedchem.1c01482 PubMed
Rox K., Heyner M., Krull J., Harmrolfs K., Rinne V., Hokkanen J., Perez Vilaro G., Díez J., Müller R., Kröger A., ... , Sugiyama Y., Brönstrup M. (2021)
Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A
ACS Pharm.Transl.Sci., 4 (5)
DOI: 10.1021/acsptsci.1c00078 HZI-Repositorium PubMed
Rath S., Rox K., Kleine Bardenhorst S., Schminke U., Dörr M., Mayerle J., Frost F., Lerch M.M., Karch A., Brönstrup M., ... , Pieper D.H., Vital M. (2021)
Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
mSystems.
DOI: 10.1128/mSystems.00945-21 HZI-Repositorium PubMed
Miethke M., Pieroni M., Weber T., Brönstrup M., Hammann P., Halby L., Arimondo P.B., Glaser P., Aigle B., Bode H.B., Moreira R., Li Y., Luzhetskyy A., Medema M.H., Pernodet J.L., Stadler M., Tormo J.R., Genilloud O., Truman A.W., Weissman K.J., Takano E., Sabatini S., Stegmann E., Brötz-Oesterhelt H., Wohlleben W., Seemann M., Empting M., Hirsch A.K.H., Loretz B., Lehr C.M., Titz A., Herrmann J., Jaeger T., Alt S., Hesterkamp T., Winterhalter M., Schiefer A., Pfarr K., Hoerauf A., Graz H., Graz M., Lindvall M., Ramurthy S., Karlen A., van Dongen M., Petkovic H., Keller A., Peyrane F., Donadio S., Fraisse L., Piddock L.J.V., Gilbert I.H., ... , Moser H.E., Müller R. (2021)
Towards the sustainable discovery and development of new antibiotics
Nat.Rev.Chem.
DOI: 10.1038/s41570-021-00313-1 HZI-Repositorium PubMed
Peukert C., Langer L.N.B., Wegener S.M., Tutov A., Bankstahl J.P., Karge B., Bengel F.M., ... , Ross T.L., Brönstrup M. (2021)
Optimization of Artificial Siderophores as (68)Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections
J.Med.Chem., 64 (16)
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