Prof. Dr. Michael Meyer-Hermann

Prof. Dr. Michael Meyer-Hermann
Forschungsgruppenleiter

Michael Meyer-Hermann ist seit 2010 Leiter der Abteilung System Immunologie am Helmholtz-Zentrum für Infektionsforschung in Braunschweig. Zunächst studierte er Physik, Mathematik und Philosophie in Frankfurt am Main und in Paris und promovierte anschließend in Frankfurt über Theoretische Elementarteilchenphysik.

Er baute dann in Dresden, Oxford (UK) und am Frankfurt Institute for Advanced Studies (FIAS) Arbeitsgruppen zur Systemimmunologie auf. Seine Forschung zielt neben der Entwicklung von neuen Methoden in der Theoretischen Zellbiologie auf grundsätzliche Fragen zur Funktionsweise des adaptiven Immunsystems sowie zur Wechselwirkung des Nerven- und des Immunsystems. Dazu möchte er mathematische Methoden als Standardwerkzeug in der biologischen und immunologischen Erforschung von Krankheiten und Therapien etablieren.

Publikationen
Merino Tejero E., Mao Q., Lashgari D., Garcia-Valiente R., Robert P.A., Meyer-Hermann M., Rodriguez Martinez M., Guikema J.E.J., ... , Hoefsloot H.H.C., Van Kampen A.H.C. (2022)
Multi-Scale Modeling Recapitulates the Effect of Genetic Alterations Associated With Diffuse Large B-Cell Lymphoma in the Germinal Center Dynamics
Front.Syst.Biol., 2 (4 / April 2022)

Lebedin M., Ratswohl C., Garg A., Schips M., Garcia C.V., Spatt L., Thibeault C., Obermayer B., Weiner J., Velasquez I.M., Gerhard C., Stubbemann P., Hanitsch L.G., Pischon T., Witzenrath M., Sander L.E., Kurth F., ... , Meyer-Hermann M., de la Rosa K. (2024)
Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses
iScience, 27 (3)

Betz P.K., Stoll J., Grappendorf V., Gilg J., Zeumer M., Klitz M., Spataro L., Klein A., Rothenhaeusler L., Bohnacker H., Kraemer H., Meyer-Hermann M., Somogyi S., ... , Gerndt A., Kuhn M.J. (2023)
ESID: Exploring the Design and Development of a Visual Analytics Tool for Epidemiological Emergencies

Robert P.A., Arulraj T., Meyer-Hermann M. (2023)
Germinal centers are permissive to subdominant antibody responses
Frontiers in Immunology, 14

Schips M., Mitra T., Bandyopadhyay A., Meyer-Hermann M. (2023)
Suppressive might of a few: T follicular regulatory cells impede auto-reactivity despite being outnumbered in the germinal centres
Front.Immunol., 14

Silva-Cayetano A., Fra-Bido S., Robert P.A., Innocentin S., Burton A.R., Watson E.M., Lee J.L., Webb L.M.C., Foster W.S., McKenzie R.C.J., Bignon A., Vanderleyden I., Alterauge D., Lemos J.P., Carr E.J., Hill D.L., Cinti I., Balabanian K., Baumjohann D., Espeli M., Meyer-Hermann M., ... , Denton A.E., Linterman M.A. (2023)
Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging
Nat.Immunol.

Garg A.K., Mitra T., Schips M., Bandyopadhyay A., Meyer-Hermann M. (2023)
Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study
Front.Immunol., 14

Grootveld A.K., Kyaw W., Panova V., Lau A.W.Y., Ashwin E., Seuzaret G., Dhenni R., Bhattacharyya N.D., Khoo W.H., Biro M., Mitra T., Meyer-Hermann M., Bertolino P., Tanaka M., Hume D.A., Croucher P.I., Brink R., Nguyen A., ... , Bannard O., Phan T.G. (2023)
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center
Cell, 186 (6)

García-Valiente R., Merino Tejero E., Stratigopoulou M., Balashova D., Jongejan A., Lashgari D., Pélissier A., Caniels T.G., Claireaux M.A.F., Musters A., van Gils M.J., Rodríguez Martínez M., de Vries N., Meyer-Hermann M., Guikema J.E.J., ... , Hoefsloot H., Van Kampen A.H.C. (2023)
Understanding repertoire sequencing data through a multiscale computational model of the germinal center
npj Syst.Bio.Appl., 9 (1)

Khailaie S., Robert P.A., Meyer-Hermann M. (2021)
An Agent-Based Model of T Helper Cell Fate Decisions in the Thymus
(2)

Mlynarczyk C., Teater M., Pae J., Chin C.R., Wang L., Arulraj T., Barisic D., Papin A., Hoehn K.B., Kots E., Ersching J., Bandyopadhyay A., Barin E., Poh H.X., Evans C.M., Chadburn A., Chen Z., Shen H., Isles H.M., Pelzer B., Tsialta I., Doane A.S., Geng H., Rehman M.H., Melnick J., Morgan W., Nguyen D.T.T., Elemento O., Kharas M.G., Jaffrey S.R., Scott D.W., Khelashvili G., Meyer-Hermann M., ... , Victora G.D., Melnick A. (2023)
BTG1 mutation yields supercompetitive B cells primed for malignant transformation
Sci., 379 (6629)

Gurwicz N., Stoler-Barak L., Schwan N., Bandyopadhyay A., Meyer-Hermann M., Shulman Z. (2023)
Tingible body macrophages arise from lymph node-resident precursors and uptake B cells by dendrites
J Exp Med, 220 (4)

Arulraj T., Binder S.C., Meyer-Hermann M. (2022)
Antibody Mediated Intercommunication of Germinal Centers
Cells, 11 (22)

Papaxenopoulou L.A., Zhao G., Khailaie S., Katsoulis-Dimitriou K., Schmitz I., Medina E., ... , Hatzikirou H., Meyer-Hermann M. (2022)
In silico predicted therapy against chronic Staphylococcus aureus infection leads to bacterial clearance in vivo
iScience, 25 (12)

Arulraj T., Binder S.C., Meyer-Hermann M. (2022)
Investigating the Mechanism of Germinal Center Shutdown
Front.Immunol., 13

Bandyopadhyay A., Schips M., Mitra T., Khailaie S., Binder S.C., Meyer-Hermann M. (2022)
Testing and isolation to prevent overloaded healthcare facilities and reduce death rates in the SARS-CoV-2 pandemic in Italy
Commun.Med.(Lond), 2

Arshad H., Siokis A., Franke R., Habib A., Alfonso J.C.L., Poliakova Y., Lücke E., Michaelis K., Brönstrup M., Meyer-Hermann M., Bilitewski U., Vila J., Abel L., Illig T., ... , Schreiber J., Pessler F. (2022)
Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease
Cells, 11 (15)

Zhao G., Straub R.H., Meyer-Hermann M. (2022)
The transition between acute and chronic infections in light of energy control: a mathematical model of energy flow in response to infection
J.R.Soc.Interface, 19 (191)

Lashgari D., Merino Tejero E., Meyer-Hermann M., Claireaux M.A.F., van Gils M.J., ... , Hoefsloot H.C.J., Van Kampen A.H.C. (2022)
From affinity selection to kinetic selection in Germinal Centre modelling
PLoS.Comput.Biol., 18 (6)

Mascheroni P., Savvopoulos S., Alfonso J.C.L., Meyer-Hermann M., Hatzikirou H. (2021)
Improving personalized tumor growth predictions using a Bayesian combination of mechanistic modeling and machine learning
Commun.Med.(Lond), 1

Koslow W., Kühn M.J., Binder S., Klitz M., Abele D., ... , Basermann A., Meyer-Hermann M. (2022)
Appropriate relaxation of non-pharmaceutical interventions minimizes the risk of a resurgence in SARS-CoV-2 infections in spite of the Delta variant
PLoS.Comput.Biol., 18 (5)

Schlicker L., Zhao G., Dudek C.A., Boers H.M., Meyer-Hermann M., ... , Jacobs D.M., Hiller K. (2022)
Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase
Frontiers in Nutrition, 9

Kühn M.J., Abele D., Binder S., Rack K., Klitz M., Kleinert J., Gilg J., Spataro L., Koslow W., Siggel M., ... , Meyer-Hermann M., Basermann A. (2022)
Regional opening strategies with commuter testing and containment of new SARS-CoV-2 variants in Germany
BMC Infectious Diseases, 22 (1)

Dorn F., Khailaie S., Stoeckli M., Binder S.C., Mitra T., Lange B., Lautenbacher S., Peichl A., Vanella P., Wollmershäuser T., ... , Fuest C., Meyer-Hermann M. (2022)
The common interests of health protection and the economy: evidence from scenario calculations of COVID-19 containment policies
Eur.J.Health Econ.

Long Z., Phillips B., Radtke D., Meyer-Hermann M., Bannard O. (2022)
Competition for refueling rather than cyclic reentry initiation evident in germinal centers
Sci Immunol, 7 (69)

Knabl L., Mitra T., Kimpel J., Rössler A., Volland A., Walser A., Ulmer H., Pipperger L., Binder S.C., Riepler L., Bates K., Bandyopadhyay A., Schips M., Ranjan M., Falkensammer B., Borena W., ... , Meyer-Hermann M., Von Laer D. (2021)
High SARS-CoV-2 seroprevalence in children and adults in the Austrian ski resort of Ischgl
Commun.Med.(London), 1 (1)

Formaglio P., Alabdullah M., Siokis A., Handschuh J., Sauerland I., Fu Y., Krone A., Gintschel P., Stettin J., Heyde S., Mohr J., Philipsen L., Schröder A., Robert P.A., Zhao G., Khailaie S., Dudeck A., Bertrand J., Späth G.F., Kahlfuß S., Bousso P., Schraven B., Hühn J., Binder S., ... , Meyer-Hermann M., Müller A.J. (2021)
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells
Immunity

Siokis A., Robert P.A., Demetriou P., Kvalvaag A., Valvo S., Mayya V., ... , Dustin M.L., Meyer-Hermann M. (2021)
Characterization of mechanisms positioning costimulatory complexes in immune synapses
iScience., 24 (10)

Robert P.A., Arulraj T., Meyer-Hermann M. (2021)
Ymir: A 3D structural affinity model for multi-epitope vaccine simulations
iScience., 24 (9)

Merino Tejero E., Lashgari D., García-Valiente R., He J., Robert P.A., Meyer-Hermann M., Guikema J.E.J., ... , Hoefsloot H., Van Kampen A.H.C. (2021)
Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center
Front.Immunol., 12

Meyer-Hermann M. (2021)
A molecular theory of germinal center B cell selection and division
Cell Rep., 36 (8)

Arulraj T., Binder S.C., Meyer-Hermann M. (2021)
In Silico Analysis of the Longevity and Timeline of Individual Germinal Center Reactions in a Primary Immune Response
Cells, 10 (7)

Arulraj T., Binder S.C., Robert P.A., Meyer-Hermann M. (2021)
Germinal Centre Shutdown
Front Immunol., 12

Priesemann V., Meyer-Hermann M., Pigeot I., Schöbel A. (2021)
Der Beitrag von epidemiologischen Modellen zur Beschreibung des Ausbruchsgeschehens der COVID-19-Pandemie [The contribution of epidemiological models to the description of the outbreak of the COVID-19 pandemic]
Bundesgesund.blatt.Gesund.forschung.Gesund.schutz., 64 (9)

Kühn M.J., Abele D., Mitra T., Koslow W., Abedi M., Rack K., Siggel M., Khailaie S., Klitz M., Binder S., Spataro L., Gilg J., Kleinert J., Häberle M., Plötzke L., Spinner C.D., Stecher M., Zhu X.X., ... , Basermann A., Meyer-Hermann M. (2021)
Assessment of effective mitigation and prediction of the spread of SARS-CoV-2 in Germany using demographic information and spatial resolution
Math.Biosci., 339 (September 2021)

Tretter F., Wolkenhauer O., Meyer-Hermann M., Dietrich J.W., Green S., ... , Marcum J., Weckwerth W. (2021)
The Quest for System-Theoretical Medicine in the COVID-19 Era
Front.Med., 8

Linden M., Dehning J., Mohr S.B., Mohring J., Meyer-Hermann M., Pigeot I., ... , Schöbel A., Priesemann V. (2020)
Case numbers beyond contact tracing capacity are endangering the containment of COVID-19 / [Überschreitung der Kontaktnachverfolgungskapazität gefährdet die Eindämmung von COVID-19]
Dtsch.Arztebl.Inter., 117 (46)

Barua A., Syga S., Mascheroni P., Kavallaris N., Meyer-Hermann M., ... , Deutsch A., Hatzikirou H. (2020)
Entropy-driven cell decision-making predicts 'fluid-to-solid' transition in multicellular systems
New J.Phys., 22 (12)

Dorn F., Khailaie S., Stöckli M., Binder S., Lange B., Peichl A., Vanella P., Wollmershäuser T., ... , Fuest C., Meyer-Hermann M. (2020)
Das gemeinsame Interesse von Gesundheit und Wirtschaft: Eine Szenarienrechnung zur Eindämmung der Corona Pandemie
ifo Schnelldienst digital, 1/2020 (6)

Merino Tejero E., Lashgari D., Garcia-Valiente R., Gao X., Crauste F., Robert P.A., Meyer-Hermann M., Martinez M., Rodriguez Martinez M., Van Ham S.M., Guikema J.E.J., ... , Hoefsloot H., Van Kampen A.H.C. (2021)
Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help
Front Immunol., 11

Arulraj T., Binder S.C., Meyer-Hermann M. (2021)
Rate of Immune Complex Cycling in Follicular Dendritic Cells Determines the Extent of Protecting Antigen Integrity and Availability to Germinal Center B Cells
J.Immunol., 206 (7)

Elfaki Y., Robert P.A., Binz C., Falk C.S., Bruder D., Prinz I., Floess S., ... , Meyer-Hermann M., Hühn J. (2021)
Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice
Eur.J.Immunol.

Volk V., Theobald S.J., Danisch S., Khailaie S., Kalbarczyk M., Schneider A., Bialek-Waldmann J., Krönke N., Deng Y., Eiz-Vesper B., Dragon A.C., Von Kaisenberg C., Lienenklaus S., Bleich A., Keck J., Meyer-Hermann M., Klawonn F., Hammerschmidt W., Delecluse H.J., Münz C., ... , Feuerhake F., Stripecke R. (2021)
PD-1 Blockade Aggravates Epstein-Barr Virus(+) Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4(+) T Cell Dysregulations
Front Oncol., 10

Khailaie S., Mitra T., Bandyopadhyay A., Schips M., Mascheroni P., Vanella P., Lange B., ... , Binder S.C., Meyer-Hermann M. (2021)
Development of the reproduction number from coronavirus SARS-CoV-2 case data in Germany and implications for political measures
BMC.Med., 19 (1)

Nakagawa R., Toboso-Navasa A., Schips M., Young G., Bhaw-Rosun L., Llorian-Sopena M., Chakravarty P., Sesay A.K., Kassiotis G., ... , Meyer-Hermann M., Calado D.P. (2021)
Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth
Proc.Natl.Acad.Sci.U.S.A, 118 (2)

Wübbolding M., Lopez Alfonso J.C., Lin C.Y., Binder S., Falk C., Debarry J., Gineste P., Kraft A.R.M., Chien R.N., Maasoumy B., Wedemeyer H., Jeng W.J., Meyer-Hermann M., ... , Cornberg M., Höner zu Siederdissen C. (2021)
Pilot Study Using Machine Learning to Identify Immune Profiles for the Prediction of Early Virological Relapse After Stopping Nucleos(t)ide Analogues in HBeAg-Negative CHB
Hepatol.Commun., 5 (1)

Barua A., Nava-Sedeno J.M., Meyer-Hermann M., Hatzikirou H. (2020)
A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms
Sci.Rep., 10 (1)

Pae J., Ersching J., Castro T.B.R., Schips M., Mesin L., Allon S.J., Ordovas-Montanes J., Mlynarczyk C., Melnick A., Efeyan A., Shalek A.K., ... , Meyer-Hermann M., Victora G.D. (2021)
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells
J.Exp.Med., 218 (4)

Rastogi A., Robert P.A., Halle S., Meyer-Hermann M. (2020)
Evaluation of CD8 T cell killing models with computer simulations of 2-photon imaging experiments
PLoS.Comput.Biol., 16 (12)

Demetriou P., Abu-Shah E., Valvo S., McCuaig S., Mayya V., Kvalvaag A., Starkey T., Korobchevskaya K., Lee L.Y.W., Friedrich M., Mann E., Kutuzov M.A., Morotti M., Wietek N., Rada H., Yusuf S., Afrose J., Siokis A., Allan P., Ambrose T., Arancibia C., Bailey A., Barnes E., Bird-Lieberman E., Bornschein J., Brain O., Braden B., Collier J., Cobbold J., Culver E., East J., Howarth L., Klenerman P., Leedham S., Palmer R., Pavlides M., Powrie F., Rodrigues A., Satsangi J., Simmons A., Sullivan P., Uhlig H., Walsh A., Meyer-Hermann M., Ahmed A.A., Depoil D., ... , Dustin M.L., Oxford IBD Cohort I (2020)
Author Correction: A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals (Nature Immunology, (2020), 21, 10, (1232-1243), 10.1038/s41590-020-0770-x)
Nat.Immunol., 22 (1)

Khailaie S., Montaseri G., Meyer-Hermann M. (2020)
An Adaptive Control Scheme for Interleukin-2 Therapy
iScience, 23 (11)

Demetriou P., Abu-Shah E., Valvo S., McCuaig S., Mayya V., Kvalvaag A., Starkey T., Korobchevskaya K., Lee L.Y.W., Friedrich M., Mann E., Kutuzov M.A., Morotti M., Wietek N., Rada H., Yusuf S., Afrose J., Siokis A., Allan P., Ambrose T., Arancibia C., Bailey A., Barnes E., Bird-Lieberman E., Bornschein J., Brain O., Braden B., Collier J., Cobbold J., Culver E., East J., Howarth L., Klenerman P., Leedham S., Palmer R., Pavlides M., Powrie F., Rodrigues A., Satsangi J., Simmons A., Sullivan P., Uhlig H., Walsh A., Meyer-Hermann M., Ahmed A.A., Depoil D., ... , Dustin M.L., Oxford IBD Cohort I (2020)
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals
Nat.Immunol., 21 (10)

Siokis A., Robert P.A., Meyer-Hermann M. (2020)
Agent-Based Modeling of T Cell Receptor Cooperativity
Int.J.Mol.Sci., 21 (18)

Hoore M., Khailaie S., Montaseri G., Mitra T., Meyer-Hermann M. (2020)
Mathematical Model Shows How Sleep May Affect Amyloid-b[beta] Fibrillization
Biophys.J., 119 (4)

Theobald S.J., Kreer C., Khailaie S., Bonifacius A., Eiz-Vesper B., Figueiredo C., MacH M., Backovic M., Ballmaier M., Koenig J., Olbrich H., Schneider A., Volk V., Danisch S., Gieselmann L., Ercanoglu M.S., Messerle M., Kaisenberg C.V., Witte T., Klawonn F., Meyer-Hermann M., ... , Klein F., Stripecke R. (2020)
Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV
PLoS Pathog., 16 (7)

Reimer D., Meyer-Hermann M., Rakhymzhan A., Steinmetz T., Tripal P., Thomas J., Boettcher M., Mougiakakos D., Schulz S.R., Urbanczyk S., Hauser A.E., ... , Niesner R.A., Mielenz D. (2020)
B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2
Cell Rep., 32 (6)

Mascheroni P., Meyer-Hermann M., Hatzikirou H. (2020)
Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors
Front.Microbiol., 11

Schaadt N.S., Schönmeyer R., Forestier G., Brieu N., Braubach P., Nekolla K., ... , Meyer-Hermann M., Feuerhake F. (2020)
Graph-based description of tertiary lymphoid organs at single-cell level
PLoS.Comput.Biol., 16 (2)

Alfonso J.C.L., Papaxenopoulou L.A., Mascheroni P., Meyer-Hermann M., Hatzikirou H. (2020)
On the Immunological Consequences of Conventionally Fractionated Radiotherapy
iScience, 23 (3)

Montaseri G., Alfonso J.C.L., Hatzikirou H., Meyer-Hermann M. (2020)
A minimal modeling framework of radiation and immune system synergy to assist radiotherapy planning
J.Theor.Biol., 486 (February)

Arshad H., Alfonso J.C.L., Franke R., Michaelis K., Araujo L., Habib A., Zboromyrska Y., Lucke E., Strungaru E., Akmatov M.K., Hatzikirou H., Meyer-Hermann M., Petersmann A., Nauck M., Brönstrup M., Bilitewski U., Abel L., Sievers J., Vila J., Illig T., ... , Schreiber J., Pessler F. (2019)
Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia
J.Transl.Med., 17 (1)

Meyer-Hermann M. (2019)
Injection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies
Cell Reports, 29 (5)

Arulraj T., Binder S.C., Robert P.A., Meyer-Hermann M. (2019)
Synchronous germinal center onset impacts the efficiency of antibody responses
Front.Immunol., 10

Roco J.A., Mesin L., Binder S.C., Nefzger C., Gonzalez-Figueroa P., Canete P.F., Ellyard J., Shen Q., Robert P.A., Cappello J., Vohra H., Zhang Y., Nowosad C.R., Schiepers A., Corcoran L.M., Toellner K.M., Polo J.M., Meyer-Hermann M., ... , Victora G.D., Vinuesa C.G. (2019)
Class-Switch Recombination Occurs Infrequently in Germinal Centers
Immunity., 51 (2)

Canete P.F., Sweet R.A., Gonzalez-Figueroa P., Papa I., Ohkura N., Bolton H., Roco J.A., Cuenca M., Bassett K.J., Sayin I., Barry E., Lopez A., Canaday D.H., Meyer-Hermann M., Doglioni C., Fazekas de St Groth B., Sakaguchi S., ... , Cook M.C., Vinuesa C.G. (2019)
Regulatory roles of IL-10-producing human follicular T cells
J.Exp.Med., 216 (8)

Mascheroni P., Lopez Alfonso J.C., Kalli M., Stylianopoulos T., Meyer-Hermann M., Hatzikirou H. (2019)
On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas
Cancers.(Basel), 11 (5)

Schlicker L., Boers H.M., Dudek C.A., Zhao G., Barua A., Trezzi J.P., Meyer-Hermann M., ... , Jacobs D.M., Hiller K. (2019)
Postprandial Metabolic Effects of Fiber Mixes Revealed by in vivo Stable Isotope Labeling in Humans
Metabolites., 9 (5)

Theobald S.J., Khailaie S., Meyer-Hermann M., Volk V., Olbrich H., Danisch S., Gerasch L., Schneider A., Sinzger C., Schaudien D., Lienenklaus S., Riese P., Guzmán C.A., Figueiredo C., Von Kaisenberg C., Spineli L.M., Glaesener S., Meyer-Bahlburg A., Ganser A., Schmitt M., MacH M., ... , Messerle M., Stripecke R. (2018)
Signatures of T and B cell development, functional responses and PD-1 upregulation after HCMV latent infections and reactivations in Nod.Rag.Gamma mice humanized with cord blood CD34+cells
Front.Immunol., 9 (NOV)

Meyer-Hermann M., Binder S.C., Mesin L., Victora G.D. (2018)
Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers
Front Immunol, 9 (September)

Khailaie S., Rowshanravan B., Robert P.A., Waters E., Halliday N., Badillo Herrera J.D., Walker L.S.K., ... , Sansom D.M., Meyer-Hermann M. (2018)
Characterization of CTLA4 Trafficking and Implications for Its Function
Biophys.J., 115 (7)

Meyer-Hermann M. (2018)
Estimation of the cancer risk induced by therapies targeting stem cell replication and treatment recommendations
Sci.Rep., 8 (1)

Siokis A., Robert P.A., Demetriou P., Dustin M.L., Meyer-Hermann M. (2018)
F-Actin-Driven CD28-CD80 Localization in the Immune Synapse
Cell Rep., 24 (5)

Montaseri G., Boianelli A., Hernandez-Vargas E.A., Meyer-Hermann M. (2018)
PK/PD-based adaptive tailoring of oseltamivir doses to treat within-host influenza viral infections
Prog.Biophys.Mol.Biol.

Robert P.A., Marschall A.L., Meyer-Hermann M. (2018)
Induction of broadly neutralizing antibodies in Germinal Centre simulations
Curr.Opin.Biotechnol., 51 (June)

Volk V., Reppas A.I., Robert P.A., Spineli L.M., Sundarasetty B.S., Theobald S.J., Schneider A., Gerasch L., Roth C.D., Kl÷ss S., Koehl U., Von Kaisenberg C., Figueiredo C., Hatzikirou H., ... , Meyer-Hermann M., Stripecke R. (2017)
Multidimensional analysis integrating human t-cell signatures in lymphatic tissues with sex of humanized mice for prediction of responses after dendritic cell immunization
Front.Immunol., 8 (DEC)

Zhao G., Wirth D., Schmitz I., Meyer-Hermann M. (2017)
A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
Nat.Commun., 8 (1)

Papa I., Saliba D., Ponzoni M., Bustamante S., Canete P.F., Gonzalez-Figueroa P., McNamara H.A., Valvo S., Grimbaldeston M., Sweet R.A., Vohra H., Cockburn I.A., Meyer-Hermann M., Dustin M.L., ... , Doglioni C., Vinuesa C.G. (2017)
TFH-derived dopamine accelerates productive synapses in germinal centres
Nature, 547 (7663)

Robert P.A., Rastogi A., Binder S.C., Meyer-Hermann M. (2017)
How to Simulate a Germinal Center
Methods Mol.Biol., 1623

Hatzikirou H., Alfonso J.C.L., Leschner S., Weiss S., Meyer-Hermann M. (2017)
Therapeutic potential of bacteria against solid tumors
Cancer Res., 77 (7)

Siokis A., Robert P.A., Meyer-Hermann M. (2017)
Mathematical Modeling of Synaptic Patterns
Methods Mol.Biol., 1584 (12)

Binder S.C., Meyer-Hermann M. (2016)
Implications of intravital imaging of murine germinal centers on the control of B cell selection and division
Front.Immunol., 7 (DEC)

Montaseri G., Meyer-Hermann M. (2016)
Diversity of coupled oscillators can enhance their synchronization
Phys.Rev.E Stat.Nonlinear Soft Matter Phys., 94 (4-1)

Mziaut H., Mulligan B., Hoboth P., Otto O., Ivanova A., Herbig M., Schumann D., Hildebrandt T., Dehghany J., Sonmez A., Munster C., Meyer-Hermann M., Guck J., ... , Kalaidzidis Y., Solimena M. (2016)
The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512
Mol.Metab, 5 (8)

Ghanbari A., Dehghany J., Schwebs T., Musken M., Häußler S., Meyer-Hermann M. (2016)
Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms
Sci Rep., 6

Meyer-Hermann M., Kempf H. (2011)
Mathematical model of tumour irradiation with heavy ions

Beyer T., Meyer-Hermann M. (2011)
Delaunay-Object-Dynamics for tissues involving highly motile cells
(15)

Meyer-Hermann M., Straub R.H. (2011)
Optimised cortisol treatment of rheumatoid arthritis based on the circadian rhythm of key factors
Clin.Exp.Rheumatol., 29 (1)

Figge M.T., Meyer-Hermann M. (2011)
Modeling intravital two-photon data of lymphocyte migration and interaction
(6)

Hernandez-Vargas E.A., Meyer-Hermann M. (2012)
Innate immune system dynamics to influenza virus
IFAC Proceedings Volumes (IFAC-PapersOnline)

Tas J.M., Mesin L., Pasqual G., Targ S., Jacobsen J.T., Mano Y.M., Chen C.S., Weill J.C., Reynaud C.A., Browne E.P., ... , Meyer-Hermann M., Victora G.D. (2016)
Visualizing antibody affinity maturation in germinal centers
Science, 351

Binder S.C., Eckweiler D., Schulz S., Bielecka A., Nicolai T., Franke R., ... , Häußler S., Meyer-Hermann M. (2016)
Functional modules of sigma factor regulons guarantee adaptability and evolvability
Sci Rep., 6

Halle S., Keyser K.A., Stahl F.R., Busche A., Marquardt A., Zheng X., Galla M., Heissmeyer V., Heller K., Boelter J., Wagner K., Bischoff Y., Martens R., Braun A., Werth K., Uvarovskii A., Kempf H., Meyer-Hermann M., Arens R., Kremer M., Sutter G., ... , Messerle M., Forster R. (2016)
In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity
Immunity, 44 (2)

Nakagawa R., Leyland R., Meyer-Hermann M., Lu D., Turner M., Arbore G., Phan T.G., ... , Brink R., Vigorito E. (2016)
MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis
J.Clin.Invest., 126 (1)

Hatzikirou H., Alfonso J.C.L., Mühle S., Stern C., Weiss S., Meyer-Hermann M. (2015)
Cancer therapeutic potential of combinatorial immuno- and vasomodulatory interventions
J.R.Soc.Interface, 12 (112)

Jiao Y., Lau T., Hatzikirou H., Meyer-Hermann M., Joseph C.Corbo, Torquato S. (2014)
Avian photoreceptor patterns represent a disordered hyperuniform solution to a multiscale packing problem
Phys.Rev.E.Stat.Nonlin.Soft.Matter Phys., 89 (2)

Boianelli A., Nguyen V.K., Ebensen T., Schulze K., Wilk E., Sharma N., Stegemann-Koniszewski S., Bruder D., Toapanta F.R., Guzmán C.A., ... , Meyer-Hermann M., Hernandez-Vargas E.A. (2015)
Modeling influenza virus infection: A roadmap for influenza research
Viruses, 7 (10)

Sukhorukov V.M., Meyer-Hermann M. (2015)
Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton
Sci.Rep., 5

Kempf H., Bleicher M., Meyer-Hermann M. (2015)
Spatio-Temporal Dynamics of Hypoxia during Radiotherapy
PLoS ONE, 10 (8)

Dehghany J., Hoboth P., Ivanova A., Mziaut H., Muller A., Kalaidzidis Y., ... , Solimena M., Meyer-Hermann M. (2015)
A Spatial Model of Insulin-Granule Dynamics in Pancreatic b[beta]-Cells
Traffic, 16 (8)

Nguyen V.K., Binder S.C., Boianelli A., Meyer-Hermann M., Hernandez-Vargas E.A. (2015)
Ebola virus infection modeling and identifiability problems
Front Microbiol., 6

Binder S.C., Hernandez-Vargas E.A., Meyer-Hermann M. (2015)
Reducing complexity: An iterative strategy for parameter determination in biological networks
Comput Phys Commun, 190

Milanez-Almeida P., Klawonn F., Meyer-Hermann M., Hühn J. (2014)
Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen
Eur.J Microbiol.Immunol.(Bp), 4 (3)

Hoboth P., Muller A., Ivanova A., Mziaut H., Dehghany J., Sonmez A., Lachnit M., Meyer-Hermann M., ... , Kalaidzidis Y., Solimena M. (2015)
Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies
Proc.Natl.Acad.Sci U.S A, 112 (7)

Khailaie S., Robert P.A., Toker A., Hühn J., Meyer-Hermann M. (2014)
A signal integration model of thymic selection and natural regulatory T cell commitment
Journal of Immunology, 193 (12)

Milanez-Almeida P., Meyer-Hermann M., Toker A., Khailaie S., Hühn J. (2014)
Foxp3 regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen
European Journal of Immunology, 45

Meyer-Hermann M. (2014)
Overcoming the Dichotomy of Quantity and Quality in Antibody Responses
Journal of Immunology, 193 (11)

Zhao G., Dharmadhikari G., Maedler K., Meyer-Hermann M. (2014)
Possible Role of Interleukin-1beta in Type 2 Diabetes Onset and Implications for Anti-inflammatory Therapy Strategies
PLoS Computational Biology, 10 (8)

Haering M., Hördt A., Meyer-Hermann M., Hernandez-Vargas E.A. (2014)
Computational study to determine when to initiate and alternate therapy in HIV infection
BioMed Research International, 2014

Hernandez-Vargas E.A., Wilk E., Canini L., Toapanta F.R., Binder S.C., Uvarovskii A., Ross T.M., Guzmán C.A., ... , Perelson A.S., Meyer-Hermann M. (2014)
Effects of aging on influenza virus infection dynamics
Journal of Virology, 88 (8)

Jain H.V., Richardson A., Meyer-Hermann M., Byrne H.M. (2014)
Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas
PLoS ONE, 9

Khailaie Sahamoddin, Bahrami F., Janahmadi M., Milanez-Almeida P., Hühn J., Meyer-Hermann M. (2013)
A mathematical model of immune activation with a unified self-nonself concept
Frontiers in Immunology, 4

He J.-S., Meyer-Hermann M., Xiangying D., Zuan L.Y., Jones L.A., Ramakrishna L., de Vries V, Dolpady J., Aina H., Joseph S., Narayanan S., Subramaniam S., Puthia M., Wong G., Xiong H., Poidinger M., Urban J.F., ... , Lafaille J.J., Curotto de Lafaille M.A. (2013)
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response
Journal of Experimental Medicine, 210 (12)

Meyer-Hermann M., Beyer T. (2012)
Models of cell migration

Zhang Y., Meyer-Hermann M., George L.A., Figge M.T., Khan M., Goodall M., Young S.P., Reynolds A., Falciani F., Waisman A., Notley C.A., Ehrenstein M.R., ... , Kosco-Vilbois M., Toellner K.M. (2013)
Germinal center B cells govern their own fate via antibody feedback
Journal of Experimental Medicine, 210 (3)

Kempf H., Hatzikirou H., Bleicher M., Meyer-Hermann M. (2013)
In silico analysis of cell cycle synchronisation effects in radiotherapy of tumour spheroids
PLoS Computational Biology, 9 (11)

Schmeitz C., Hernandez-Vargas E.A., Fliegert R., Guse A.H., Meyer-Hermann M. (2013)
A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties
Frontiers in Immunology, 4

Binder Sebastian C., Telschow A., Meyer-Hermann M. (2012)
Population dynamics of Borrelia burgdorferi in Lyme disease
Frontiers in Microbiology, 3 (MAR)

Sukhorukov V.M., Dikov D., Reichert A.S., Meyer-Hermann M. (2012)
Emergence of the mitochondrial reticulum from fission and fusion dynamics
PLoS Computational Biology, 8 (10)

Figge M.T., Reichert A.S., Meyer-Hermann M., Osiewacz H.D. (2012)
Deceleration of fusion-fission cycles improves mitochondrial quality control during aging
PLoS Computational Biology, 8 (6)

Meyer-Hermann M., Mohr E., Pelletier N., Zhang Y., Victora G.D., Toellner K.M. (2012)
A theory of germinal center B cell selection, division, and exit
Cell Reports, 2 (1)

Fava E., Dehghany J., Ouwendijk J., Muller A., Niederlein A., Verkade P., ... , Meyer-Hermann Michael*, Solimena M. (2012)
Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling
Diabetologia, 55 (4)

Dustin M.L., Meyer-Hermann M. (2012)
Immunology. Antigen feast or famine
Science, 335 (6067)

Jain H.V., Meyer-Hermann Michael* (2011)
The Molecular Basis of Synergism between Carboplatin and ABT-737 Therapy Targeting Ovarian Carcinomas
Cancer Research, 71 (3)

Grise G., Meyer-Hermann Michael* (2011)
Surface reconstruction using Delaunay triangulation for applications in life sciences
Computer Physics Communications, 182 (4)

Victora G.D., Schwickert T.A., Fooksman D.R., Kamphorst A.O., Meyer-Hermann Michael*, ... , Dustin M.L., Nussenzweig M.C. (2010)
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
Cell, 143 (4)

Kempf H., Bleicher M., Meyer-Hermann Michael* (2010)
Spatio-temporal cell dynamics in tumour spheroid irradiation
European Physical Journal D, 60 (1)

Garin A., Meyer-Hermann Michael*, Contie M., Figge M.T., Buatois V., Gunzer Matthias*, Toellner K.M., ... , Elson G., Kosco-Vilbois M.H. (2010)
Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation
Immunity, 33 (1)