Prof. Dr. Michael Meyer-Hermann

Merino Tejero E., Mao Q., Lashgari D., Garcia-Valiente R., Robert P.A., Meyer-Hermann M., Rodriguez Martinez M., Guikema J.E.J., ... , Hoefsloot H.H.C., Van Kampen A.H.C. (2022)

Multi-Scale Modeling Recapitulates the Effect of Genetic Alterations Associated With Diffuse Large B-Cell Lymphoma in the Germinal Center Dynamics

Front.Syst.Biol., 2 (4 / April 2022)

DOI: 10.3389/fsysb.2022.864690 HZI-Repositorium

Lebedin M., Ratswohl C., Garg A., Schips M., Garcia C.V., Spatt L., Thibeault C., Obermayer B., Weiner J., Velasquez I.M., Gerhard C., Stubbemann P., Hanitsch L.G., Pischon T., Witzenrath M., Sander L.E., Kurth F., ... , Meyer-Hermann M., de la Rosa K. (2024)

Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses

iScience, 27 (3)

DOI: 10.1016/j.isci.2024.109330 HZI-Repositorium PubMed

Betz P.K., Stoll J., Grappendorf V., Gilg J., Zeumer M., Klitz M., Spataro L., Klein A., Rothenhaeusler L., Bohnacker H., Kraemer H., Meyer-Hermann M., Somogyi S., ... , Gerndt A., Kuhn M.J. (2023)

ESID: Exploring the Design and Development of a Visual Analytics Tool for Epidemiological Emergencies

DOI: 10.1109/Vis4PandEmRes60343.2023.00007

Robert P.A., Arulraj T., Meyer-Hermann M. (2023)

Germinal centers are permissive to subdominant antibody responses

Frontiers in Immunology, 14

DOI: 10.3389/fimmu.2023.1238046 HZI-Repositorium PubMed

Schips M., Mitra T., Bandyopadhyay A., Meyer-Hermann M. (2023)

Suppressive might of a few: T follicular regulatory cells impede auto-reactivity despite being outnumbered in the germinal centres

Front.Immunol., 14

DOI: 10.3389/fimmu.2023.1253704 HZI-Repositorium PubMed

Silva-Cayetano A., Fra-Bido S., Robert P.A., Innocentin S., Burton A.R., Watson E.M., Lee J.L., Webb L.M.C., Foster W.S., McKenzie R.C.J., Bignon A., Vanderleyden I., Alterauge D., Lemos J.P., Carr E.J., Hill D.L., Cinti I., Balabanian K., Baumjohann D., Espeli M., Meyer-Hermann M., ... , Denton A.E., Linterman M.A. (2023)

Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging

Nat.Immunol.

DOI: 10.1038/s41590-023-01519-9 HZI-Repositorium PubMed

Garg A.K., Mitra T., Schips M., Bandyopadhyay A., Meyer-Hermann M. (2023)

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

Front.Immunol., 14

DOI: 10.3389/fimmu.2023.1080853 HZI-Repositorium PubMed

Grootveld A.K., Kyaw W., Panova V., Lau A.W.Y., Ashwin E., Seuzaret G., Dhenni R., Bhattacharyya N.D., Khoo W.H., Biro M., Mitra T., Meyer-Hermann M., Bertolino P., Tanaka M., Hume D.A., Croucher P.I., Brink R., Nguyen A., ... , Bannard O., Phan T.G. (2023)

Apoptotic cell fragments locally activate tingible body macrophages in the germinal center

Cell, 186 (6)

DOI: 10.1016/j.cell.2023.02.004 HZI-Repositorium PubMed

García-Valiente R., Merino Tejero E., Stratigopoulou M., Balashova D., Jongejan A., Lashgari D., Pélissier A., Caniels T.G., Claireaux M.A.F., Musters A., van Gils M.J., Rodríguez Martínez M., de Vries N., Meyer-Hermann M., Guikema J.E.J., ... , Hoefsloot H., Van Kampen A.H.C. (2023)

Understanding repertoire sequencing data through a multiscale computational model of the germinal center

npj Syst.Bio.Appl., 9 (1)

DOI: 10.1038/s41540-023-00271-y HZI-Repositorium PubMed

Khailaie S., Robert P.A., Meyer-Hermann M. (2021)

An Agent-Based Model of T Helper Cell Fate Decisions in the Thymus

(2)

DOI: 10.1007/978-3-030-57204-4_2

Mlynarczyk C., Teater M., Pae J., Chin C.R., Wang L., Arulraj T., Barisic D., Papin A., Hoehn K.B., Kots E., Ersching J., Bandyopadhyay A., Barin E., Poh H.X., Evans C.M., Chadburn A., Chen Z., Shen H., Isles H.M., Pelzer B., Tsialta I., Doane A.S., Geng H., Rehman M.H., Melnick J., Morgan W., Nguyen D.T.T., Elemento O., Kharas M.G., Jaffrey S.R., Scott D.W., Khelashvili G., Meyer-Hermann M., ... , Victora G.D., Melnick A. (2023)

BTG1 mutation yields supercompetitive B cells primed for malignant transformation

Sci., 379 (6629)

DOI: 10.1126/science.abj7412 HZI-Repositorium PubMed

Gurwicz N., Stoler-Barak L., Schwan N., Bandyopadhyay A., Meyer-Hermann M., Shulman Z. (2023)

Tingible body macrophages arise from lymph node-resident precursors and uptake B cells by dendrites

J Exp Med, 220 (4)

DOI: 10.1084/jem.20222173 HZI-Repositorium PubMed

Arulraj T., Binder S.C., Meyer-Hermann M. (2022)

Antibody Mediated Intercommunication of Germinal Centers

Cells, 11 (22)

DOI: 10.3390/cells11223680 HZI-Repositorium PubMed

Papaxenopoulou L.A., Zhao G., Khailaie S., Katsoulis-Dimitriou K., Schmitz I., Medina E., ... , Hatzikirou H., Meyer-Hermann M. (2022)

In silico predicted therapy against chronic Staphylococcus aureus infection leads to bacterial clearance in vivo

iScience, 25 (12)

DOI: 10.1016/j.isci.2022.105522 HZI-Repositorium PubMed

Arulraj T., Binder S.C., Meyer-Hermann M. (2022)

Investigating the Mechanism of Germinal Center Shutdown

Front.Immunol., 13

DOI: 10.3389/fimmu.2022.922318 HZI-Repositorium PubMed

Bandyopadhyay A., Schips M., Mitra T., Khailaie S., Binder S.C., Meyer-Hermann M. (2022)

Testing and isolation to prevent overloaded healthcare facilities and reduce death rates in the SARS-CoV-2 pandemic in Italy

Commun.Med.(Lond), 2

DOI: 10.1038/s43856-022-00139-y HZI-Repositorium PubMed

Arshad H., Siokis A., Franke R., Habib A., Alfonso J.C.L., Poliakova Y., Lücke E., Michaelis K., Brönstrup M., Meyer-Hermann M., Bilitewski U., Vila J., Abel L., Illig T., ... , Schreiber J., Pessler F. (2022)

Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease

Cells, 11 (15)

DOI: 10.3390/cells11152283 HZI-Repositorium PubMed

Zhao G., Straub R.H., Meyer-Hermann M. (2022)

The transition between acute and chronic infections in light of energy control: a mathematical model of energy flow in response to infection

J.R.Soc.Interface, 19 (191)

DOI: 10.1098/rsif.2022.0206 HZI-Repositorium PubMed

Lashgari D., Merino Tejero E., Meyer-Hermann M., Claireaux M.A.F., van Gils M.J., ... , Hoefsloot H.C.J., Van Kampen A.H.C. (2022)

From affinity selection to kinetic selection in Germinal Centre modelling

PLoS.Comput.Biol., 18 (6)

DOI: 10.1371/journal.pcbi.1010168 HZI-Repositorium PubMed

Mascheroni P., Savvopoulos S., Alfonso J.C.L., Meyer-Hermann M., Hatzikirou H. (2021)

Improving personalized tumor growth predictions using a Bayesian combination of mechanistic modeling and machine learning

Commun.Med.(Lond), 1

DOI: 10.1038/s43856-021-00020-4 HZI-Repositorium PubMed

Koslow W., Kühn M.J., Binder S., Klitz M., Abele D., ... , Basermann A., Meyer-Hermann M. (2022)

Appropriate relaxation of non-pharmaceutical interventions minimizes the risk of a resurgence in SARS-CoV-2 infections in spite of the Delta variant

PLoS.Comput.Biol., 18 (5)

DOI: 10.1371/journal.pcbi.1010054 HZI-Repositorium PubMed

Schlicker L., Zhao G., Dudek C.A., Boers H.M., Meyer-Hermann M., ... , Jacobs D.M., Hiller K. (2022)

Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase

Frontiers in Nutrition, 9

DOI: 10.3389/fnut.2022.785999 HZI-Repositorium PubMed

Kühn M.J., Abele D., Binder S., Rack K., Klitz M., Kleinert J., Gilg J., Spataro L., Koslow W., Siggel M., ... , Meyer-Hermann M., Basermann A. (2022)

Regional opening strategies with commuter testing and containment of new SARS-CoV-2 variants in Germany

BMC Infectious Diseases, 22 (1)

DOI: 10.1186/s12879-022-07302-9 HZI-Repositorium PubMed

Dorn F., Khailaie S., Stoeckli M., Binder S.C., Mitra T., Lange B., Lautenbacher S., Peichl A., Vanella P., Wollmershäuser T., ... , Fuest C., Meyer-Hermann M. (2022)

The common interests of health protection and the economy: evidence from scenario calculations of COVID-19 containment policies

Eur.J.Health Econ.

DOI: 10.1007/s10198-022-01452-y HZI-Repositorium PubMed

Long Z., Phillips B., Radtke D., Meyer-Hermann M., Bannard O. (2022)

Competition for refueling rather than cyclic reentry initiation evident in germinal centers

Sci Immunol, 7 (69)

DOI: 10.1126/sciimmunol.abm0775 HZI-Repositorium PubMed

Knabl L., Mitra T., Kimpel J., Rössler A., Volland A., Walser A., Ulmer H., Pipperger L., Binder S.C., Riepler L., Bates K., Bandyopadhyay A., Schips M., Ranjan M., Falkensammer B., Borena W., ... , Meyer-Hermann M., Von Laer D. (2021)

High SARS-CoV-2 seroprevalence in children and adults in the Austrian ski resort of Ischgl

Commun.Med.(London), 1 (1)

DOI: 10.1038/s43856-021-00007-1 HZI-Repositorium PubMed

Formaglio P., Alabdullah M., Siokis A., Handschuh J., Sauerland I., Fu Y., Krone A., Gintschel P., Stettin J., Heyde S., Mohr J., Philipsen L., Schröder A., Robert P.A., Zhao G., Khailaie S., Dudeck A., Bertrand J., Späth G.F., Kahlfuß S., Bousso P., Schraven B., Hühn J., Binder S., ... , Meyer-Hermann M., Müller A.J. (2021)

Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells

Immunity

DOI: 10.1016/j.immuni.2021.09.021 HZI-Repositorium PubMed

Siokis A., Robert P.A., Demetriou P., Kvalvaag A., Valvo S., Mayya V., ... , Dustin M.L., Meyer-Hermann M. (2021)

Characterization of mechanisms positioning costimulatory complexes in immune synapses

iScience., 24 (10)

DOI: 10.1016/j.isci.2021.103100 HZI-Repositorium PubMed

Robert P.A., Arulraj T., Meyer-Hermann M. (2021)

Ymir: A 3D structural affinity model for multi-epitope vaccine simulations

iScience., 24 (9)

DOI: 10.1016/j.isci.2021.102979 HZI-Repositorium PubMed

Merino Tejero E., Lashgari D., García-Valiente R., He J., Robert P.A., Meyer-Hermann M., Guikema J.E.J., ... , Hoefsloot H., Van Kampen A.H.C. (2021)

Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

Front.Immunol., 12

DOI: 10.3389/fimmu.2021.716240 HZI-Repositorium

Meyer-Hermann M. (2021)

A molecular theory of germinal center B cell selection and division

Cell Rep., 36 (8)

DOI: 10.1016/j.celrep.2021.109552 HZI-Repositorium PubMed

Arulraj T., Binder S.C., Meyer-Hermann M. (2021)

In Silico Analysis of the Longevity and Timeline of Individual Germinal Center Reactions in a Primary Immune Response

Cells, 10 (7)

DOI: 10.3390/cells10071736 HZI-Repositorium PubMed

Arulraj T., Binder S.C., Robert P.A., Meyer-Hermann M. (2021)

Germinal Centre Shutdown

Front Immunol., 12

DOI: 10.3389/fimmu.2021.705240 HZI-Repositorium PubMed

Priesemann V., Meyer-Hermann M., Pigeot I., Schöbel A. (2021)

Der Beitrag von epidemiologischen Modellen zur Beschreibung des Ausbruchsgeschehens der COVID-19-Pandemie [The contribution of epidemiological models to the description of the outbreak of the COVID-19 pandemic]

Bundesgesund.blatt.Gesund.forschung.Gesund.schutz., 64 (9)

DOI: 10.1007/s00103-021-03390-1 HZI-Repositorium PubMed

Kühn M.J., Abele D., Mitra T., Koslow W., Abedi M., Rack K., Siggel M., Khailaie S., Klitz M., Binder S., Spataro L., Gilg J., Kleinert J., Häberle M., Plötzke L., Spinner C.D., Stecher M., Zhu X.X., ... , Basermann A., Meyer-Hermann M. (2021)

Assessment of effective mitigation and prediction of the spread of SARS-CoV-2 in Germany using demographic information and spatial resolution

Math.Biosci., 339 (September 2021)

DOI: 10.1016/j.mbs.2021.108648 HZI-Repositorium PubMed

Tretter F., Wolkenhauer O., Meyer-Hermann M., Dietrich J.W., Green S., ... , Marcum J., Weckwerth W. (2021)

The Quest for System-Theoretical Medicine in the COVID-19 Era

Front.Med., 8

DOI: 10.3389/fmed.2021.640974 HZI-Repositorium PubMed

Linden M., Dehning J., Mohr S.B., Mohring J., Meyer-Hermann M., Pigeot I., ... , Schöbel A., Priesemann V. (2020)

Case numbers beyond contact tracing capacity are endangering the containment of COVID-19 / [Überschreitung der Kontaktnachverfolgungskapazität gefährdet die Eindämmung von COVID-19]

Dtsch.Arztebl.Inter., 117 (46)

DOI: 10.3238/arztebl.2020.0790 HZI-Repositorium PubMed

Barua A., Syga S., Mascheroni P., Kavallaris N., Meyer-Hermann M., ... , Deutsch A., Hatzikirou H. (2020)

Entropy-driven cell decision-making predicts 'fluid-to-solid' transition in multicellular systems

New J.Phys., 22 (12)

DOI: 10.1088/1367-2630/abcb2e HZI-Repositorium

Dorn F., Khailaie S., Stöckli M., Binder S., Lange B., Peichl A., Vanella P., Wollmershäuser T., ... , Fuest C., Meyer-Hermann M. (2020)

Das gemeinsame Interesse von Gesundheit und Wirtschaft: Eine Szenarienrechnung zur Eindämmung der Corona Pandemie

ifo Schnelldienst digital, 1/2020 (6)

DOI: - HZI-Repositorium

Merino Tejero E., Lashgari D., Garcia-Valiente R., Gao X., Crauste F., Robert P.A., Meyer-Hermann M., Martinez M., Rodriguez Martinez M., Van Ham S.M., Guikema J.E.J., ... , Hoefsloot H., Van Kampen A.H.C. (2021)

Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help

Front Immunol., 11

DOI: 10.3389/fimmu.2020.620716 HZI-Repositorium PubMed

Arulraj T., Binder S.C., Meyer-Hermann M. (2021)

Rate of Immune Complex Cycling in Follicular Dendritic Cells Determines the Extent of Protecting Antigen Integrity and Availability to Germinal Center B Cells

J.Immunol., 206 (7)

DOI: 10.4049/jimmunol.2001355 HZI-Repositorium PubMed

Elfaki Y., Robert P.A., Binz C., Falk C.S., Bruder D., Prinz I., Floess S., ... , Meyer-Hermann M., Hühn J. (2021)

Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice

Eur.J.Immunol.

DOI: 10.1002/eji.202048981 HZI-Repositorium PubMed

Volk V., Theobald S.J., Danisch S., Khailaie S., Kalbarczyk M., Schneider A., Bialek-Waldmann J., Krönke N., Deng Y., Eiz-Vesper B., Dragon A.C., Von Kaisenberg C., Lienenklaus S., Bleich A., Keck J., Meyer-Hermann M., Klawonn F., Hammerschmidt W., Delecluse H.J., Münz C., ... , Feuerhake F., Stripecke R. (2021)

PD-1 Blockade Aggravates Epstein-Barr Virus(+) Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4(+) T Cell Dysregulations

Front Oncol., 10

DOI: 10.3389/fonc.2020.614876 HZI-Repositorium PubMed

Khailaie S., Mitra T., Bandyopadhyay A., Schips M., Mascheroni P., Vanella P., Lange B., ... , Binder S.C., Meyer-Hermann M. (2021)

Development of the reproduction number from coronavirus SARS-CoV-2 case data in Germany and implications for political measures

BMC.Med., 19 (1)

DOI: 10.1186/s12916-020-01884-4 HZI-Repositorium PubMed

Nakagawa R., Toboso-Navasa A., Schips M., Young G., Bhaw-Rosun L., Llorian-Sopena M., Chakravarty P., Sesay A.K., Kassiotis G., ... , Meyer-Hermann M., Calado D.P. (2021)

Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth

Proc.Natl.Acad.Sci.U.S.A, 118 (2)

DOI: 10.1073/pnas.2016425118 HZI-Repositorium PubMed

Wübbolding M., Lopez Alfonso J.C., Lin C.Y., Binder S., Falk C., Debarry J., Gineste P., Kraft A.R.M., Chien R.N., Maasoumy B., Wedemeyer H., Jeng W.J., Meyer-Hermann M., ... , Cornberg M., Höner zu Siederdissen C. (2021)

Pilot Study Using Machine Learning to Identify Immune Profiles for the Prediction of Early Virological Relapse After Stopping Nucleos(t)ide Analogues in HBeAg-Negative CHB

Hepatol.Commun., 5 (1)

DOI: 10.1002/hep4.1626 HZI-Repositorium PubMed

Barua A., Nava-Sedeno J.M., Meyer-Hermann M., Hatzikirou H. (2020)

A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms

Sci.Rep., 10 (1)

DOI: 10.1038/s41598-020-79119-y HZI-Repositorium PubMed

Pae J., Ersching J., Castro T.B.R., Schips M., Mesin L., Allon S.J., Ordovas-Montanes J., Mlynarczyk C., Melnick A., Efeyan A., Shalek A.K., ... , Meyer-Hermann M., Victora G.D. (2021)

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

J.Exp.Med., 218 (4)

DOI: 10.1084/jem.20201699 HZI-Repositorium PubMed

Rastogi A., Robert P.A., Halle S., Meyer-Hermann M. (2020)

Evaluation of CD8 T cell killing models with computer simulations of 2-photon imaging experiments

PLoS.Comput.Biol., 16 (12)

DOI: 10.1371/journal.pcbi.1008428 HZI-Repositorium PubMed

Demetriou P., Abu-Shah E., Valvo S., McCuaig S., Mayya V., Kvalvaag A., Starkey T., Korobchevskaya K., Lee L.Y.W., Friedrich M., Mann E., Kutuzov M.A., Morotti M., Wietek N., Rada H., Yusuf S., Afrose J., Siokis A., Allan P., Ambrose T., Arancibia C., Bailey A., Barnes E., Bird-Lieberman E., Bornschein J., Brain O., Braden B., Collier J., Cobbold J., Culver E., East J., Howarth L., Klenerman P., Leedham S., Palmer R., Pavlides M., Powrie F., Rodrigues A., Satsangi J., Simmons A., Sullivan P., Uhlig H., Walsh A., Meyer-Hermann M., Ahmed A.A., Depoil D., ... , Dustin M.L., Oxford IBD Cohort I (2020)

Author Correction: A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals (Nature Immunology, (2020), 21, 10, (1232-1243), 10.1038/s41590-020-0770-x)

Nat.Immunol., 22 (1)

DOI: 10.1038/s41590-020-00825-w HZI-Repositorium

Khailaie S., Montaseri G., Meyer-Hermann M. (2020)

An Adaptive Control Scheme for Interleukin-2 Therapy

iScience, 23 (11)

DOI: 10.1016/j.isci.2020.101663 HZI-Repositorium PubMed

Demetriou P., Abu-Shah E., Valvo S., McCuaig S., Mayya V., Kvalvaag A., Starkey T., Korobchevskaya K., Lee L.Y.W., Friedrich M., Mann E., Kutuzov M.A., Morotti M., Wietek N., Rada H., Yusuf S., Afrose J., Siokis A., Allan P., Ambrose T., Arancibia C., Bailey A., Barnes E., Bird-Lieberman E., Bornschein J., Brain O., Braden B., Collier J., Cobbold J., Culver E., East J., Howarth L., Klenerman P., Leedham S., Palmer R., Pavlides M., Powrie F., Rodrigues A., Satsangi J., Simmons A., Sullivan P., Uhlig H., Walsh A., Meyer-Hermann M., Ahmed A.A., Depoil D., ... , Dustin M.L., Oxford IBD Cohort I (2020)

A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals

Nat.Immunol., 21 (10)

DOI: 10.1038/s41590-020-0770-x HZI-Repositorium PubMed

Siokis A., Robert P.A., Meyer-Hermann M. (2020)

Agent-Based Modeling of T Cell Receptor Cooperativity

Int.J.Mol.Sci., 21 (18)

DOI: 10.3390/ijms21186473 HZI-Repositorium PubMed

Hoore M., Khailaie S., Montaseri G., Mitra T., Meyer-Hermann M. (2020)

Mathematical Model Shows How Sleep May Affect Amyloid-b[beta] Fibrillization

Biophys.J., 119 (4)

DOI: 10.1016/j.bpj.2020.07.011 HZI-Repositorium PubMed

Theobald S.J., Kreer C., Khailaie S., Bonifacius A., Eiz-Vesper B., Figueiredo C., MacH M., Backovic M., Ballmaier M., Koenig J., Olbrich H., Schneider A., Volk V., Danisch S., Gieselmann L., Ercanoglu M.S., Messerle M., Kaisenberg C.V., Witte T., Klawonn F., Meyer-Hermann M., ... , Klein F., Stripecke R. (2020)

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV

PLoS Pathog., 16 (7)

DOI: 10.1371/journal.ppat.1008560 HZI-Repositorium PubMed

Reimer D., Meyer-Hermann M., Rakhymzhan A., Steinmetz T., Tripal P., Thomas J., Boettcher M., Mougiakakos D., Schulz S.R., Urbanczyk S., Hauser A.E., ... , Niesner R.A., Mielenz D. (2020)

B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2

Cell Rep., 32 (6)

DOI: 10.1016/j.celrep.2020.108030 HZI-Repositorium PubMed

Mascheroni P., Meyer-Hermann M., Hatzikirou H. (2020)

Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors

Front.Microbiol., 11

DOI: 10.3389/fmicb.2020.01083 HZI-Repositorium PubMed

Schaadt N.S., Schönmeyer R., Forestier G., Brieu N., Braubach P., Nekolla K., ... , Meyer-Hermann M., Feuerhake F. (2020)

Graph-based description of tertiary lymphoid organs at single-cell level

PLoS.Comput.Biol., 16 (2)

DOI: 10.1371/journal.pcbi.1007385 HZI-Repositorium PubMed

Alfonso J.C.L., Papaxenopoulou L.A., Mascheroni P., Meyer-Hermann M., Hatzikirou H. (2020)

On the Immunological Consequences of Conventionally Fractionated Radiotherapy

iScience, 23 (3)

DOI: 10.1016/j.isci.2020.100897 HZI-Repositorium PubMed

Montaseri G., Alfonso J.C.L., Hatzikirou H., Meyer-Hermann M. (2020)

A minimal modeling framework of radiation and immune system synergy to assist radiotherapy planning

J.Theor.Biol., 486 (February)

DOI: 10.1016/j.jtbi.2019.110099 PubMed

Arshad H., Alfonso J.C.L., Franke R., Michaelis K., Araujo L., Habib A., Zboromyrska Y., Lucke E., Strungaru E., Akmatov M.K., Hatzikirou H., Meyer-Hermann M., Petersmann A., Nauck M., Brönstrup M., Bilitewski U., Abel L., Sievers J., Vila J., Illig T., ... , Schreiber J., Pessler F. (2019)

Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia

J.Transl.Med., 17 (1)

DOI: 10.1186/s12967-019-2112-z HZI-Repositorium PubMed

Meyer-Hermann M. (2019)

Injection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies

Cell Reports, 29 (5)

DOI: 10.1016/j.celrep.2019.09.058 HZI-Repositorium PubMed

Arulraj T., Binder S.C., Robert P.A., Meyer-Hermann M. (2019)

Synchronous germinal center onset impacts the efficiency of antibody responses

Front.Immunol., 10

DOI: 10.3389/fimmu.2019.02116 HZI-Repositorium PubMed

Roco J.A., Mesin L., Binder S.C., Nefzger C., Gonzalez-Figueroa P., Canete P.F., Ellyard J., Shen Q., Robert P.A., Cappello J., Vohra H., Zhang Y., Nowosad C.R., Schiepers A., Corcoran L.M., Toellner K.M., Polo J.M., Meyer-Hermann M., ... , Victora G.D., Vinuesa C.G. (2019)

Class-Switch Recombination Occurs Infrequently in Germinal Centers

Immunity., 51 (2)

DOI: 10.1016/j.immuni.2019.07.001 HZI-Repositorium PubMed

Canete P.F., Sweet R.A., Gonzalez-Figueroa P., Papa I., Ohkura N., Bolton H., Roco J.A., Cuenca M., Bassett K.J., Sayin I., Barry E., Lopez A., Canaday D.H., Meyer-Hermann M., Doglioni C., Fazekas de St Groth B., Sakaguchi S., ... , Cook M.C., Vinuesa C.G. (2019)

Regulatory roles of IL-10-producing human follicular T cells

J.Exp.Med., 216 (8)

DOI: 10.1084/jem.20190493 HZI-Repositorium PubMed

Mascheroni P., Lopez Alfonso J.C., Kalli M., Stylianopoulos T., Meyer-Hermann M., Hatzikirou H. (2019)

On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas

Cancers.(Basel), 11 (5)

DOI: 10.3390/cancers11050716 HZI-Repositorium PubMed

Schlicker L., Boers H.M., Dudek C.A., Zhao G., Barua A., Trezzi J.P., Meyer-Hermann M., ... , Jacobs D.M., Hiller K. (2019)

Postprandial Metabolic Effects of Fiber Mixes Revealed by in vivo Stable Isotope Labeling in Humans

Metabolites., 9 (5)

DOI: 10.3390/metabo9050091 HZI-Repositorium PubMed

Theobald S.J., Khailaie S., Meyer-Hermann M., Volk V., Olbrich H., Danisch S., Gerasch L., Schneider A., Sinzger C., Schaudien D., Lienenklaus S., Riese P., Guzmán C.A., Figueiredo C., Von Kaisenberg C., Spineli L.M., Glaesener S., Meyer-Bahlburg A., Ganser A., Schmitt M., MacH M., ... , Messerle M., Stripecke R. (2018)

Signatures of T and B cell development, functional responses and PD-1 upregulation after HCMV latent infections and reactivations in Nod.Rag.Gamma mice humanized with cord blood CD34+cells

Front.Immunol., 9 (NOV)

DOI: 10.3389/fimmu.2018.02734 HZI-Repositorium PubMed

Meyer-Hermann M., Binder S.C., Mesin L., Victora G.D. (2018)

Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers

Front Immunol, 9 (September)

DOI: 10.3389/fimmu.2018.02020 HZI-Repositorium PubMed

Khailaie S., Rowshanravan B., Robert P.A., Waters E., Halliday N., Badillo Herrera J.D., Walker L.S.K., ... , Sansom D.M., Meyer-Hermann M. (2018)

Characterization of CTLA4 Trafficking and Implications for Its Function

Biophys.J., 115 (7)

DOI: 10.1016/j.bpj.2018.08.020 HZI-Repositorium PubMed

Meyer-Hermann M. (2018)

Estimation of the cancer risk induced by therapies targeting stem cell replication and treatment recommendations

Sci.Rep., 8 (1)

DOI: 10.1038/s41598-018-29967-6 HZI-Repositorium PubMed

Siokis A., Robert P.A., Demetriou P., Dustin M.L., Meyer-Hermann M. (2018)

F-Actin-Driven CD28-CD80 Localization in the Immune Synapse

Cell Rep., 24 (5)

DOI: 10.1016/j.celrep.2018.06.114 HZI-Repositorium PubMed

Montaseri G., Boianelli A., Hernandez-Vargas E.A., Meyer-Hermann M. (2018)

PK/PD-based adaptive tailoring of oseltamivir doses to treat within-host influenza viral infections

Prog.Biophys.Mol.Biol.

DOI: 10.1016/j.pbiomolbio.2018.07.007 HZI-Repositorium

Robert P.A., Marschall A.L., Meyer-Hermann M. (2018)

Induction of broadly neutralizing antibodies in Germinal Centre simulations

Curr.Opin.Biotechnol., 51 (June)

DOI: 10.1016/j.copbio.2018.01.006 PubMed

Volk V., Reppas A.I., Robert P.A., Spineli L.M., Sundarasetty B.S., Theobald S.J., Schneider A., Gerasch L., Roth C.D., Kl÷ss S., Koehl U., Von Kaisenberg C., Figueiredo C., Hatzikirou H., ... , Meyer-Hermann M., Stripecke R. (2017)

Multidimensional analysis integrating human t-cell signatures in lymphatic tissues with sex of humanized mice for prediction of responses after dendritic cell immunization

Front.Immunol., 8 (DEC)

DOI: 10.3389/fimmu.2017.01709 HZI-Repositorium PubMed

Zhao G., Wirth D., Schmitz I., Meyer-Hermann M. (2017)

A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance

Nat.Commun., 8 (1)

DOI: 10.1038/s41467-017-01627-9 HZI-Repositorium PubMed

Papa I., Saliba D., Ponzoni M., Bustamante S., Canete P.F., Gonzalez-Figueroa P., McNamara H.A., Valvo S., Grimbaldeston M., Sweet R.A., Vohra H., Cockburn I.A., Meyer-Hermann M., Dustin M.L., ... , Doglioni C., Vinuesa C.G. (2017)

TFH-derived dopamine accelerates productive synapses in germinal centres

Nature, 547 (7663)

DOI: 10.1038/nature23013 HZI-Repositorium PubMed

Robert P.A., Rastogi A., Binder S.C., Meyer-Hermann M. (2017)

How to Simulate a Germinal Center

Methods Mol.Biol., 1623

DOI: 10.1007/978-1-4939-7095-7_22

Hatzikirou H., Alfonso J.C.L., Leschner S., Weiss S., Meyer-Hermann M. (2017)

Therapeutic potential of bacteria against solid tumors

Cancer Res., 77 (7)

DOI: 10.1158/0008-5472.CAN-16-1621 HZI-Repositorium PubMed

Siokis A., Robert P.A., Meyer-Hermann M. (2017)

Mathematical Modeling of Synaptic Patterns

Methods Mol.Biol., 1584 (12)

DOI: 10.1007/978-1-4939-6881-7_12 HZI-Repositorium PubMed

Binder S.C., Meyer-Hermann M. (2016)

Implications of intravital imaging of murine germinal centers on the control of B cell selection and division

Front.Immunol., 7 (DEC)

DOI: 10.3389/fimmu.2016.00593 HZI-Repositorium PubMed

Montaseri G., Meyer-Hermann M. (2016)

Diversity of coupled oscillators can enhance their synchronization

Phys.Rev.E Stat.Nonlinear Soft Matter Phys., 94 (4-1)

DOI: 10.1103/PhysRevE.94.042213 HZI-Repositorium PubMed

Mziaut H., Mulligan B., Hoboth P., Otto O., Ivanova A., Herbig M., Schumann D., Hildebrandt T., Dehghany J., Sonmez A., Munster C., Meyer-Hermann M., Guck J., ... , Kalaidzidis Y., Solimena M. (2016)

The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512

Mol.Metab, 5 (8)

DOI: 10.1016/j.molmet.2016.05.015 HZI-Repositorium PubMed

Ghanbari A., Dehghany J., Schwebs T., Musken M., Häußler S., Meyer-Hermann M. (2016)

Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms

Sci Rep., 6

DOI: 10.1038/srep32097 HZI-Repositorium PubMed

Meyer-Hermann M., Kempf H. (2011)

Mathematical model of tumour irradiation with heavy ions

DOI: -

Beyer T., Meyer-Hermann M. (2011)

Delaunay-Object-Dynamics for tissues involving highly motile cells

(15)

DOI: 10.1111/mmi.12733 HZI-Repositorium

Meyer-Hermann M., Straub R.H. (2011)

Optimised cortisol treatment of rheumatoid arthritis based on the circadian rhythm of key factors

Clin.Exp.Rheumatol., 29 (1)

DOI: - HZI-Repositorium

Figge M.T., Meyer-Hermann M. (2011)

Modeling intravital two-photon data of lymphocyte migration and interaction

(6)

DOI: 10.1007/978-1-4419-7725-0 HZI-Repositorium

Hernandez-Vargas E.A., Meyer-Hermann M. (2012)

Innate immune system dynamics to influenza virus

IFAC Proceedings Volumes (IFAC-PapersOnline)

DOI: 10.3182/20120829-3-HU-2029.00029

Tas J.M., Mesin L., Pasqual G., Targ S., Jacobsen J.T., Mano Y.M., Chen C.S., Weill J.C., Reynaud C.A., Browne E.P., ... , Meyer-Hermann M., Victora G.D. (2016)

Visualizing antibody affinity maturation in germinal centers

Science, 351

DOI: 10.1126/science.aad3439 HZI-Repositorium PubMed

Binder S.C., Eckweiler D., Schulz S., Bielecka A., Nicolai T., Franke R., ... , Häußler S., Meyer-Hermann M. (2016)

Functional modules of sigma factor regulons guarantee adaptability and evolvability

Sci Rep., 6

DOI: 10.1038/srep22212 HZI-Repositorium PubMed

Halle S., Keyser K.A., Stahl F.R., Busche A., Marquardt A., Zheng X., Galla M., Heissmeyer V., Heller K., Boelter J., Wagner K., Bischoff Y., Martens R., Braun A., Werth K., Uvarovskii A., Kempf H., Meyer-Hermann M., Arens R., Kremer M., Sutter G., ... , Messerle M., Forster R. (2016)

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

Immunity, 44 (2)

DOI: 10.1016/j.immuni.2016.01.010 HZI-Repositorium PubMed

Nakagawa R., Leyland R., Meyer-Hermann M., Lu D., Turner M., Arbore G., Phan T.G., ... , Brink R., Vigorito E. (2016)

MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis

J.Clin.Invest., 126 (1)

DOI: 10.1172/JCI82914 HZI-Repositorium PubMed

Hatzikirou H., Alfonso J.C.L., Mühle S., Stern C., Weiss S., Meyer-Hermann M. (2015)

Cancer therapeutic potential of combinatorial immuno- and vasomodulatory interventions

J.R.Soc.Interface, 12 (112)

DOI: 10.1098/rsif.2015.0439 HZI-Repositorium PubMed

Jiao Y., Lau T., Hatzikirou H., Meyer-Hermann M., Joseph C.Corbo, Torquato S. (2014)

Avian photoreceptor patterns represent a disordered hyperuniform solution to a multiscale packing problem

Phys.Rev.E.Stat.Nonlin.Soft.Matter Phys., 89 (2)

Boianelli A., Nguyen V.K., Ebensen T., Schulze K., Wilk E., Sharma N., Stegemann-Koniszewski S., Bruder D., Toapanta F.R., Guzmán C.A., ... , Meyer-Hermann M., Hernandez-Vargas E.A. (2015)

Modeling influenza virus infection: A roadmap for influenza research

Viruses, 7 (10)

DOI: 10.3390/v7102875 HZI-Repositorium PubMed

Sukhorukov V.M., Meyer-Hermann M. (2015)

Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton

Sci.Rep., 5

DOI: 10.1038/srep13924 HZI-Repositorium PubMed

Kempf H., Bleicher M., Meyer-Hermann M. (2015)

Spatio-Temporal Dynamics of Hypoxia during Radiotherapy

PLoS ONE, 10 (8)

DOI: 10.1371/journal.pone.0133357 HZI-Repositorium PubMed

Dehghany J., Hoboth P., Ivanova A., Mziaut H., Muller A., Kalaidzidis Y., ... , Solimena M., Meyer-Hermann M. (2015)

A Spatial Model of Insulin-Granule Dynamics in Pancreatic b[beta]-Cells

Traffic, 16 (8)

DOI: 10.1111/tra.12286 HZI-Repositorium PubMed

Nguyen V.K., Binder S.C., Boianelli A., Meyer-Hermann M., Hernandez-Vargas E.A. (2015)

Ebola virus infection modeling and identifiability problems

Front Microbiol., 6

DOI: 10.3389/fmicb.2015.00257 HZI-Repositorium PubMed

Binder S.C., Hernandez-Vargas E.A., Meyer-Hermann M. (2015)

Reducing complexity: An iterative strategy for parameter determination in biological networks

Comput Phys Commun, 190

Milanez-Almeida P., Klawonn F., Meyer-Hermann M., Hühn J. (2014)

Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen

Eur.J Microbiol.Immunol.(Bp), 4 (3)

Hoboth P., Muller A., Ivanova A., Mziaut H., Dehghany J., Sonmez A., Lachnit M., Meyer-Hermann M., ... , Kalaidzidis Y., Solimena M. (2015)

Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies

Proc.Natl.Acad.Sci U.S A, 112 (7)

DOI: 10.1073/pnas.1409542112 HZI-Repositorium PubMed

Khailaie S., Robert P.A., Toker A., Hühn J., Meyer-Hermann M. (2014)

A signal integration model of thymic selection and natural regulatory T cell commitment

Journal of Immunology, 193 (12)

Milanez-Almeida P., Meyer-Hermann M., Toker A., Khailaie S., Hühn J. (2014)

Foxp3 regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen

European Journal of Immunology, 45

Meyer-Hermann M. (2014)

Overcoming the Dichotomy of Quantity and Quality in Antibody Responses

Journal of Immunology, 193 (11)

Zhao G., Dharmadhikari G., Maedler K., Meyer-Hermann M. (2014)

Possible Role of Interleukin-1beta in Type 2 Diabetes Onset and Implications for Anti-inflammatory Therapy Strategies

PLoS Computational Biology, 10 (8)

DOI: 10.1371/journal.pcbi.1003798 HZI-Repositorium PubMed

Haering M., Hördt A., Meyer-Hermann M., Hernandez-Vargas E.A. (2014)

Computational study to determine when to initiate and alternate therapy in HIV infection

BioMed Research International, 2014

DOI: 10.1155/2014/472869 HZI-Repositorium PubMed

Hernandez-Vargas E.A., Wilk E., Canini L., Toapanta F.R., Binder S.C., Uvarovskii A., Ross T.M., Guzmán C.A., ... , Perelson A.S., Meyer-Hermann M. (2014)

Effects of aging on influenza virus infection dynamics

Journal of Virology, 88 (8)

Jain H.V., Richardson A., Meyer-Hermann M., Byrne H.M. (2014)

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas

PLoS ONE, 9

DOI: 10.1371/journal.pone.0081582 HZI-Repositorium PubMed

Khailaie Sahamoddin, Bahrami F., Janahmadi M., Milanez-Almeida P., Hühn J., Meyer-Hermann M. (2013)

A mathematical model of immune activation with a unified self-nonself concept

Frontiers in Immunology, 4

DOI: 10.3389/fimmu.2013.00474 HZI-Repositorium PubMed

He J.-S., Meyer-Hermann M., Xiangying D., Zuan L.Y., Jones L.A., Ramakrishna L., de Vries V, Dolpady J., Aina H., Joseph S., Narayanan S., Subramaniam S., Puthia M., Wong G., Xiong H., Poidinger M., Urban J.F., ... , Lafaille J.J., Curotto de Lafaille M.A. (2013)

The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response

Journal of Experimental Medicine, 210 (12)

DOI: 10.1084/jem.20131539 HZI-Repositorium PubMed

Meyer-Hermann M., Beyer T. (2012)

Models of cell migration

DOI: 10.1002/3527600906.mcb.201100040 HZI-Repositorium

Zhang Y., Meyer-Hermann M., George L.A., Figge M.T., Khan M., Goodall M., Young S.P., Reynolds A., Falciani F., Waisman A., Notley C.A., Ehrenstein M.R., ... , Kosco-Vilbois M., Toellner K.M. (2013)

Germinal center B cells govern their own fate via antibody feedback

Journal of Experimental Medicine, 210 (3)

Kempf H., Hatzikirou H., Bleicher M., Meyer-Hermann M. (2013)

In silico analysis of cell cycle synchronisation effects in radiotherapy of tumour spheroids

PLoS Computational Biology, 9 (11)

DOI: 10.1371/journal.pcbi.1003295 HZI-Repositorium PubMed

Schmeitz C., Hernandez-Vargas E.A., Fliegert R., Guse A.H., Meyer-Hermann M. (2013)

A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties

Frontiers in Immunology, 4

DOI: 10.3389/fimmu.2013.00277 HZI-Repositorium PubMed

Binder Sebastian C., Telschow A., Meyer-Hermann M. (2012)

Population dynamics of Borrelia burgdorferi in Lyme disease

Frontiers in Microbiology, 3 (MAR)

DOI: 10.3389/fmicb.2012.00104 HZI-Repositorium PubMed

Sukhorukov V.M., Dikov D., Reichert A.S., Meyer-Hermann M. (2012)

Emergence of the mitochondrial reticulum from fission and fusion dynamics

PLoS Computational Biology, 8 (10)

DOI: 10.1371/journal.pcbi.1002745 HZI-Repositorium PubMed

Figge M.T., Reichert A.S., Meyer-Hermann M., Osiewacz H.D. (2012)

Deceleration of fusion-fission cycles improves mitochondrial quality control during aging

PLoS Computational Biology, 8 (6)

DOI: 10.1371/journal.pcbi.1002576 HZI-Repositorium PubMed

Meyer-Hermann M., Mohr E., Pelletier N., Zhang Y., Victora G.D., Toellner K.M. (2012)

A theory of germinal center B cell selection, division, and exit

Cell Reports, 2 (1)

Fava E., Dehghany J., Ouwendijk J., Muller A., Niederlein A., Verkade P., ... , Meyer-Hermann Michael*, Solimena M. (2012)

Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

Diabetologia, 55 (4)

DOI: 10.1007/s00125-011-2438-4 HZI-Repositorium PubMed

Dustin M.L., Meyer-Hermann M. (2012)

Immunology. Antigen feast or famine

Science, 335 (6067)

DOI: 10.1126/science.1218165 HZI-Repositorium PubMed

Jain H.V., Meyer-Hermann Michael* (2011)

The Molecular Basis of Synergism between Carboplatin and ABT-737 Therapy Targeting Ovarian Carcinomas

Cancer Research, 71 (3)

DOI: 10.1158/0008-5472.CAN-10-3174. Epub 2010 Dec 17. HZI-Repositorium PubMed

Grise G., Meyer-Hermann Michael* (2011)

Surface reconstruction using Delaunay triangulation for applications in life sciences

Computer Physics Communications, 182 (4)

Victora G.D., Schwickert T.A., Fooksman D.R., Kamphorst A.O., Meyer-Hermann Michael*, ... , Dustin M.L., Nussenzweig M.C. (2010)

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter

Cell, 143 (4)

Kempf H., Bleicher M., Meyer-Hermann Michael* (2010)

Spatio-temporal cell dynamics in tumour spheroid irradiation

European Physical Journal D, 60 (1)

Garin A., Meyer-Hermann Michael*, Contie M., Figge M.T., Buatois V., Gunzer Matthias*, Toellner K.M., ... , Elson G., Kosco-Vilbois M.H. (2010)

Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation

Immunity, 33 (1)

Prof. Dr. Michael Meyer-Hermann

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