Prof. Dr. Susanne Häußler

Prof. Dr. Susanne Häußler
Forschungsgruppenleiterin

Susanne Häußler studierte Humanmedizin an der Medizinischen Fakultät der Universität zu Lübeck und der Medizinischen Hochschule Hannover (MHH), an der sie 1995 auch promovierte. Danach arbeitete sie ein Jahr in der Inneren Medizin im Marienhospital in Vechta und begann eine Ausbildung zur Fachärztin in der Medizinischen Mikrobiologie der MHH, die sie 2002 erfolgreich abschloss. Seit 2004 ist Susanne Häußler im Fach Medizinische Mikrobiologie und Infektionsepidemiologie habilitiert.

Ihr besonderes Forschungsinteresse gilt der Entstehung und Bekämpfung von akuten und chronischen Infektionen mit dem Bakterium Pseudomonas aeruginosa. An diesem Schwerpunkt arbeitete sie von 2003 bis 2004 als Projektleiterin im Bereich Zell- und Immunbiologie an der damaligen Gesellschaft für Biotechnologische Forschung (GBF). Von 2005 bis 2012 leitete sie am Helmholtz-Zentrum für Infektionsforschung (HZI) die Nachwuchsgruppe „Chronische Pseudomonas-Infektionen" mit enger Anbindung an die MHH.

Im Januar 2009 folgte Susanne Häußler außerdem einem Ruf auf die W2-Professur „Pathophysiologie bakterieller Biofilme" der MHH am TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung in Hannover. Seit 2012 ist sie Leiterin der Abteilung Molekulare Bakteriologie am HZI und W3 Professorin an der MHH. Seit August 2019 etabliert sie ein Novo Nordisk Foundation gefördertes Labor am Rigshospitalet in Kopenagen mit dem Ziel der Etablierung einer modernen molekularen Diagnostik zur Bekämpfung von bakterieller Multi-Resistenz.

Publikationen
Alpers K., Vatareck E., Gröbe L., Müsken M., Scharfe M., ... , Häußler S., Tomasch J. (2023)
Transcriptome Dynamics of Pseudomonas aeruginosa during Transition from Overlapping To Non-Overlapping Cell Cycles
mSystems.

Borgert S.R., Henke S., Witzgall F., Schmelz S., Zur Lage S., Hotop S.K., Stephen S., Lübken D., Krüger J., Gomez N.O., Van Ham M., Jänsch L., Kalesse M., Pich A., Brönstrup M., ... , Häußler S., Blankenfeldt W. (2022)
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa
Nat.Commun., 13 (1)

Koska M., Kordes A., Erdmann J., Willger S.D., Thöming J.G., ... , Bähre H., Häußler S. (2022)
Distinct Long- and Short-Term Adaptive Mechanisms in Pseudomonas aeruginosa
Microbiol.Spectr.

Thöming J.G., Häußler S. (2022)
Transcriptional Profiling of Pseudomonas aeruginosa Infections
, 1386 (11)

Weber C., Schultze T., Göttig S., Kessel J., Schröder A., Tietgen M., Besier S., Burbach T., Häußler S., Wichelhaus T.A., Hack D., ... , Kempf V.A.J., Hogardt M. (2022)
Antimicrobial Activity of Ceftolozane-Tazobactam, Ceftazidime-Avibactam, and Cefiderocol against Multidrug-Resistant Pseudomonas aeruginosa Recovered at a German University Hospital
Microbiol.Spectr., 10 (5)

Schwan M., Khaledi A., Willger S., Papenfort K., Glatter T., ... , Häußler S., Thormann K.M. (2022)
FlrA-independent production of flagellar proteins is required for proper flagellation in Shewanella putrefaciens
Mol.Microbiol.

Wang G., Brunel J.M., Preusse M., Mozaheb N., Willger S.D., Larrouy-Maumus G., Baatsen P., Häußler S., ... , Bolla J.M., Van Bambeke F. (2022)
The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence
Commun.Biol., 5 (1)

Bense S., Witte J., Preuße M., Koska M., Pezoldt L., Dröge A., Hartmann O., Müsken M., Schulze J., Fiebig T., Bähre H., Felgner S., ... , Pich A., Häußler S. (2022)
Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels
Molecular Microbiology

Neffe L., Abendroth L., Bautsch W., Häußler S., Tomasch J. (2022)
High plasmidome diversity of extended-spectrum beta-lactam-resistant Escherichia coli isolates collected during one year in one community hospital
Genomics

Thöming J.G., Häußler S. (2022)
Pseudomonas aeruginosa Is More Tolerant Under Biofilm Than Under Planktonic Growth Conditions: A Multi-Isolate Survey
Front Cell Infect Microbiol, 12

Jeske A., Arce-Rodriguez A., Thöming J.G., Tomasch J., Häußler S. (2022)
Evolution of biofilm-adapted gene expression profiles in lasR-deficient clinical Pseudomonas aeruginosa isolates
npj Biofilms and Microbiomes, 8 (1)

Arce-Rodríguez A., Pankratz D., Preusse M., Nikel P.I., Häußler S. (2022)
Dual Effect: High NADH Levels Contribute to Efflux-Mediated Antibiotic Resistance but Drive Lethality Mediated by Reactive Oxygen Species
MBio., 13 (1)

Brinkman F.S.L., Winsor G.L., Done R.E., Filloux A., Francis V. I, Goldberg J.B., Greenberg E.P., Han K., Hancock R.E.W., Haney C.H., Häußler S., Klockgether J., Lamont I.L., Levesque R.C., Lory S., Nikel P. I, Porter S.L., Scurlock M.W., Schweizer H.P., Tümmler B., ... , Wang M., Welch M. (2021)
The Pseudomonas aeruginosa whole genome sequence: A 20th anniversary celebration
(2)

Haag S., Häußler S. (2021)
Quo vadis clinical diagnostic microbiology?
Clin.Microbiol.Infect.

Grischke J., Szafranski S.P., Muthukumarasamy U., Häußler S., Stiesch M. (2021)
Removable denture is a risk indicator for peri-implantitis and facilitates expansion of specific periodontopathogens: a cross-sectional study
BMC Oral Health, 21 (1)

Hirschmann S., Gómez-Mejia A., Mäder U., Karsunke J., Driesch D., Rohde M., Häußler S., ... , Burchhardt G., Hammerschmidt S. (2021)
The two-component system 09 regulates pneumococcal carbohydrate metabolism and capsule expression
Microorg., 9 (3)

Bunk B., Jakóbczak B., Florian V., Dittmar D., Mäder U., Jarek M., Häußler S., Baums C.G., ... , Völker U., Michalik S. (2021)
Complete Genome Sequences of Streptococcus suis Pig-Pathogenic Strains 10, 13-00283-02, and 16085/3b
Microbiol.Resour.Announc., 10 (2)

Schinner S., Engelhardt F., Preusse M., Thöming J.G., Tomasch J., Häußler S. (2020)
Genetic determinants of Pseudomonas aeruginosa fitness during biofilm growth
Biofilm., 2 (December 2020)

Hartmann R., Jeckel H., Jelli E., Singh P.K., Vaidya S., Bayer M., Rode D.K.H., Vidakovic L., Diaz-Pascual F., Fong J.C.N., Dragos A., Lamprecht O., Thöming J.G., Netter N., Häußler S., Nadell C.D., Sourjik V., Kovícs - T., ... , Yildiz F.H., Drescher K. (2021)
Quantitative image analysis of microbial communities with BiofilmQ
Nat.Microbiol., 6 (2)

Hartmann R., Jeckel H., Jelli E., Singh P.K., Vaidya S., Bayer M., Rode D.K.H., Vidakovic L., Diaz-Pascual F., Fong J.C.N., Dragos A., Lamprecht O., Thöming J.G., Netter N., Häußler S., Nadell C.D., Sourjik V., Kovícs - T., ... , Yildiz F.H., Drescher K. (2021)
Publisher Correction: Quantitative image analysis of microbial communities with BiofilmQ (Nature Microbiology, (2021), 10.1038/s41564-020-00817-4)
Nat.Microbiol., 270 (6)

Donnert M., Elsheikh S., Arce-Rodriguez A., Pawar V., Braubach P., Jonigk D., Haverich A., Weiss S., ... , Müsken M., Häußler S. (2020)
Targeting bioenergetics is key to counteracting the drug-tolerant state of biofilm-grown bacteria
PLoS.Pathog., 16 (12)

Grekov I., Thöming J.G., Kordes A., Häußler S. (2021)
Evolution of Pseudomonas aeruginosa toward higher fitness under standard laboratory conditions
ISME J., 15 (4)

Engelhardt F., Tomasch J., Häußler S. (2020)
Organism-specific depletion of highly abundant RNA species from bacterial total RNA
Access.Microbiol., 2 (10)

Schinner S., Preusse M., Kesthely C., Häußler S. (2020)
Analysis of the organization and expression patterns of the convergent pseudomonas aeruginosa lasr/rsal gene pair uncovers mutual influence
Mol.Microbiol.

Stressmann F.A., Bernal-Bayard J., Perez-Pascual D., Audrain B., Rendueles O., Briolat V., Bruchmann S., Volant S., Ghozlane A., Häußler S., Duchaud E., ... , Levraud J.P., Ghigo J.M. (2021)
Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection
ISME J., 15 (3)

Depke T., Häußler S., Brönstrup M. (2020)
The peptide chain release factor methyltransferase prmc influences the pseudomonas aeruginosa pa14 endo-and exometabolome
Metabolites, 10 (10)

Seupt A., Schniederjans M., Tomasch J., Häußler S. (2021)
Expression of the MexXY aminoglycoside efflux pump and presence of an aminoglycoside modifying enzyme in clinical Pseudomonas aeruginosa isolates are highly correlated
Antimicrob.Agents Chemother., 65 (1)

Felgner S., Preusse M., Beutling U., Stahnke S., Pawar V., Rohde M., Brönstrup M., ... , Stradal T., Häußler S. (2020)
Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake
Elife., 9 (September)

Muthukumarasamy U., Preusse M., Kordes A., Koska M., Schniederjans M., ... , Khaledi A., Häußler S. (2020)
Single-nucleotide polymorphism-based genetic diversity analysis of clinical Pseudomonas aeruginosa isolates
Genome Biol.Evol., 12 (4)

Khaledi A., Weimann A., Schniederjans M., Asgari E., Kuo T.H., Oliver A., Cabot G., Kola A., Gastmeier P., Hogardt M., Jonas D., Mofrad M.R., Bremges A., ... , McHardy A.C., Häußler S. (2020)
Predicting antimicrobial resistance in Pseudomonas aeruginosa with machine learning-enabled molecular diagnostics
EMBO Mol.Med., 12 (3)

Thöming J.G., Tomasch J., Preusse M., Koska M., Grahl N., Pohl S., Willger S.D., Kaever V., ... , Müsken M., Häußler S. (2020)
Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype
NPJ.Biofilms.Microbiomes., 6 (1)

Felgner S., Spöring I., Pawar V., Kocijancic D., Preusse M., Falk C., Rohde M., Häußler S., ... , Weiss S., Erhardt M. (2020)
The immunogenic potential of bacterial flagella for Salmonella-mediated tumor therapy
Int.J.Cancer, 147 (2)

Pylaeva E., Bordbari S., Spyra I., Decker A.S., Häußler S., Vybornov V., ... , Lang S., Jablonska J. (2019)
Detrimental Effect of Type I IFNs During Acute Lung Infection With Pseudomonas aeruginosa Is Mediated Through the Stimulation of Neutrophil NETosis
Front.Immunol., 10

Erdmann J., Thöming J.G., Pohl S., Pich A., Lenz C., Häußler S. (2019)
The Core Proteome of Biofilm-Grown Clinical Pseudomonas aeruginosa Isolates
Cells, 8 (10)

Kordes A., Preusse M., Willger S.D., Braubach P., Jonigk D., Haverich A., ... , Warnecke G., Häußler S. (2019)
Genetically diverse Pseudomonas aeruginosa populations display similar transcriptomic profiles in a cystic fibrosis explanted lung
Nat.Commun., 10 (1)

Bolard A., Schniederjans M., Häußler S., Triponney P., Valot B., ... , Plesiat P., Jeannot K. (2019)
Production of norspermidine contributes to aminoglycoside resistance in pmrAB mutants of Pseudomonas aeruginosa
Antimicrob.Agents Chemother., 63 (10)

Arce-Rodriguez A., Volke D.C., Bense S., Häußler S., Nikel P.I. (2019)
Non-invasive, ratiometric determination of intracellular pH in Pseudomonas species using a novel genetically encoded indicator
Microb.Biotechnol., 12 (4)

Kordes A., Grahl N., Koska M., Preusse M., Arce-Rodriguez A., Abraham W.R., ... , Kaever V., Häußler S. (2019)
Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host
ISME J., 13 (8)

Bense S., Bruchmann S., Steffen A., Stradal T.E.B., Häußler S., Düvel J. (2019)
Spatiotemporal control of FlgZ activity impacts Pseudomonas aeruginosa flagellar motility
Mol.Microbiol., 111 (6)

Hong Z., Bolard A., Giraud C., Prévost S., Genta-Jouve G., Deregnaucourt C., Häußler S., ... , Jeannot K., Li Y. (2019)
Azetidine-Containing Alkaloids Produced by a Quorum-Sensing Regulated Nonribosomal Peptide Synthetase Pathway in Pseudomonas aeruginosa
Angewandte Chemie - International Edition, 58 (10)

Hengge R., Häußler S., Pruteanu M., Stülke J., Tschowri N., Turgay K. (2019)
Recent Advances and Current Trends in Nucleotide Second Messenger Signaling in Bacteria
J Mol Biol., 431 (5)

Grobe S., Doberenz S., Ferreira K., Krueger J., Brönstrup M., ... , Kaever V., Häußler S. (2019)
Identification and quantification of (t)RNA modifications in Pseudomonas aeruginosa by liquid chromatography-tandem mass spectrometry
Chembiochem., 20 (11)

Erdmann J., Preusse M., Khaledi A., Pich A., Häußler S. (2018)
Environment-driven changes of mRNA and protein levels in Pseudomonas aeruginosa
Environ.Microbiol., 20 (11)

Lorenz A., Preusse M., Bruchmann S., Pawar V., Grahl N., Pils M.C., Nolan L.M., Filloux A., ... , Weiss S., Häußler S. (2019)
Importance of flagella in acute and chronic Pseudomonas aeruginosa infections
Environ.Microbiol., 21 (3)

Müsken M., Pawar V., Schwebs T., Bähre H., Felgner S., ... , Weiss S., Häußler S. (2018)
Breaking the vicious cycle of antibiotic killing and regrowth of biofilm-residing Pseudomonas aeruginosa
Antimicrob.Agents Chemother., 62 (12)

Hornischer K., Khaledi A., Pohl S., Schniederjans M., Pezoldt L., Casilag F., Muthukumarasamy U., Bruchmann S., Thöming J., ... , Kordes A., Häußler S. (2019)
BACTOME : a reference database to explore the sequence- and gene expression-variation landscape of Pseudomonas aeruginosa clinical isolates
Nucleic Acids Res., 47 (1, D1)

Müller L., Murgia X., Siebenbürger L., Börger C., Schwarzkopf K., Sewald K., Häußler S., Braun A., Lehr C.M., ... , Hittinger M., Wronski S. (2018)
Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin
J.Antimicrob.Chemother., 73 (10)

Spöring I., Felgner S., Preusse M., Eckweiler D., Rohde M., Häußler S., ... , Weiss S., Erhardt M. (2018)
Regulation of Flagellum Biosynthesis in Response to Cell Envelope Stress in Salmonella enterica Serovar Typhimurium
MBio., 9 (3)

Eckweiler D., Häußler S. (2018)
Antisense transcription in Pseudomonas aeruginosa
Microbiology, 164 (6)

Tata M., Amman F., Pawar V., Wolfinger M.T., Weiss S., ... , Häußler S., Bläsi U. (2017)
The anaerobically induced sRNA PaiI affects denitrification in Pseudomonas aeruginosa PA14
Front.Microbiol., 8 (NOV)

Müsken M., Klimmek K., Sauer-Heilborn A., Donnert M., Sedlacek L., ... , Suerbaum S., Häußler S. (2017)
Towards individualized diagnostics of biofilm-associated infections: a case study
NPJ.Biofilms.Microbiomes., 3 (22)

Schniederjans M., Koska M., Häußler S. (2017)
Transcriptional and mutational profiling of an aminoglycoside resistant Pseudomonas aeruginosa small colony variant
Antimicrob.Agents Chemother., 61 (11)

van Duuren J.B.J.H., Müsken M., Karge B., Tomasch J., Wittmann C., ... , Häußler S., Brönstrup M. (2017)
Use of Single-Frequency Impedance Spectroscopy to Characterize the Growth Dynamics of Biofilm Formation in Pseudomonas aeruginosa
Sci.Rep., 7 (1)

Doberenz S., Eckweiler D., Reichert O., Jensen V., Bunk B., Sproer C., Kordes A., Frangipani E., Luong K., Korlach J., Heeb S., Overmann J., ... , Kaever V., Häußler S. (2017)
Identification of a Pseudomonas aeruginosa PAO1 DNA methyltransferase, its targets, and physiological roles
MBio, 8 (1)

Kommerein N., Stumpp S.N., Musken M., Ehlert N., Winkel A., Häußler S., Behrens P., ... , Buettner F.F.R., Stiesch M. (2017)
An oral multispecies biofilm model for high content screening applications
PLoS ONE, 12 (3)

Pusic P., Tata M., Wolfinger M.T., Sonnleitner E., Häußler S., Bläsi U. (2016)
Cross-regulation by CrcZ RNA controls anoxic biofilm formation in Pseudomonas aeruginosa
Sci.Rep., 6

Xu S., Ducroux A., Ponnurangam A., Vieyres G., Franz S., Musken M., Zillinger T., Malassa A., Ewald E., Hornung V., Barchet W., Häußler S., ... , Pietschmann T., Goffinet C. (2016)
cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites
Cell Host.Microbe, 20 (4)

Lorenz A., Pawar V., Häußler S., Weiss S. (2016)
Insights into host-pathogen interactions from state-of-the-art animal models of respiratory Pseudomonas aeruginosa infections
FEBS Lett., 590 (21)

Felgner S., Frahm M., Kocijancic D., Rohde M., Eckweiler D., Bielecka A., Bueno E., Cava F., Abraham W.R., Curtiss R. III, Häußler S., ... , Erhardt M., Weiss S. (2016)
aroA-Deficient Salmonella enterica Serovar Typhimurium Is More Than a Metabolically Attenuated Mutant
MBio., 7 (5)

Ghanbari A., Dehghany J., Schwebs T., Musken M., Häußler S., Meyer-Hermann M. (2016)
Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms
Sci Rep., 6

Hornischer K., Häußler S. (2016)
Diagnostics and Resistance Profiling of Bacterial Pathogens
Curr Top.Microbiol.Immunol., 398

Sommer R., Wagner S., Varrot A., Nycholat C.M., Khaledi A., Häußler S., Paulson J.C., ... , Imberty A., Titz A. (2016)
The virulence factor LecB varies in clinical isolates: Consequences for ligand binding and drug discovery
Chem.Sci., 7 (8)

Krueger J., Pohl S., Preusse M., Kordes A., Rugen N., Schniederjans M., ... , Pich A., Häußler S. (2016)
Unravelling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa
Environ.Microbiol., 18

Khaledi A., Schniederjans M., Pohl S., Rainer R., Bodenhofer U., Xia B., Klawonn F., Bruchmann S., Preusse M., Eckweiler D., ... , Dötsch A., Häußler S. (2016)
Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa
Antimicrobial Agents Chemother., 60 (8)

Eckweiler D., Bunk B., Spröer C., Overmann J., Häußler Susanne (2014)
Complete Genome Sequence of Highly Adherent Pseudomonas aeruginosa Small-Colony Variant SCV20265
Genome Announcement, 2 (1)

Claus R., Häußler S., Lacorn M. (2007)
Rise of testosterone, nortestosterone, and 17¯-estradiol concentrations in peripheral blood plasma of pigs after sublingual application in vivo
Food Chem.Toxicol., 45 (2)

Römling U., Häußler S. (2008)
Regulatory Networks in Pseudomonas aeruginosa: Role of Cyclic-di(3',5')-Guanylic Acid
(8)

Borrero-de Acuna J.M., Bielecka A., Häußler S., Schobert M., Jahn M., Wittmann C., ... , Jahn D., Poblete-Castro I. (2014)
Production of medium chain length polyhydroxyalkanoate in metabolic flux optimized Pseudomonas putida
Microb.Cell Fact., 13 (1)

Perez F., Hujer A.M., Marshall S.H., Ray A.J., Rather P.N., Suwantarat N., Dumford D. III, O'Shea P., Domitrovic T.N.J., Salata R.A., Chavda K.D., Chen L., Kreiswirth B.N., Vila A.J., Häußler S., ... , Jacobs M.R., Bonomo R.A. (2014)
Extensively drug-resistant Pseudomonas aeruginosa isolates containing bla<inf>VIM-2</inf>and elements of Salmonella genomic island 2: A new genetic resistance determinant in northeast Ohio
Antimicrob.Agents Chemother., 58 (10)

Binder S.C., Eckweiler D., Schulz S., Bielecka A., Nicolai T., Franke R., ... , Häußler S., Meyer-Hermann M. (2016)
Functional modules of sigma factor regulons guarantee adaptability and evolvability
Sci Rep., 6

Schulz S., Häußler S. (2014)
Chromatin immunoprecipitation for ChIP-chip and ChIP-seq
Methods Mol.Biol., 1149

Tata M., Wolfinger M.T., Amman F., Roschanski N., Dotsch A., Sonnleitner E., ... , Häußler S., Blasi U. (2016)
RNASeq Based Transcriptional Profiling of Pseudomonas aeruginosa PA14 after Short- and Long-Term Anoxic Cultivation in Synthetic Cystic Fibrosis Sputum Medium
PLoS ONE, 11 (1)

Casilag F., Lorenz A., Kruger J., Klawonn F., Weiss S., Häußler S. (2015)
The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition
Infect.Immun., 84

Düvel J., Bense S., Möller S., Bertinetti D., Schwede F., Morr M., Eckweiler D., Genieser H.G., Jänsch L., Herberg F.W., ... , Frank R., Häußler S. (2016)
Application of synthetic peptide arrays to uncover cyclic Di-GMP binding motifs
J Bacteriol., 198

Dötsch A., Schniederjans M., Khaledi A., Hornischer K., Schulz S., Bielecka A., Eckweiler D., ... , Pohl S., Häußler S. (2015)
The Pseudomonas aeruginosa transcriptional landscape is shaped by environmental heterogeneity and genetic variation
MBio, 6 (4)

Bruchmann S., Muthukumarasamy U., Pohl S., Preusse M., Bielecka A., Nicolai T., Hamann I., Hillert R., Kola A., Gastmeier P., ... , Eckweiler D., Häußler S. (2015)
Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain- and sequence type-specific adaptation
Environ.Microbiol., 17

Bielecki P., Jensen V., Schulze W., Godeke J., Strehmel J., Eckweiler D., Nicolai T., Bielecka A., Wille T., ... , Gerlach R.G., Häußler S. (2015)
Cross talk between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa
Nucleic Acids Res, 43

Lassak J., Keilhauer E.C., Furst M., Wuichet K., Godeke J., Starosta A.L., Chen J.M., Sogaard-Andersen L., Rohr J., Wilson D.N., Häußler S., ... , Mann M., Jung K. (2015)
Arginine-rhamnosylation as new strategy to activate translation elongation factor P
Nat.Chem.Biol., 11 (4)

Pawar V., Komor U., Kasnitz N., Bielecki P., Pils M.C., Gocht B., Moter A., Rohde M., ... , Weiss S., Häußler S. (2015)
In vivo efficacy of antimicrobials against biofilm producing Pseudomonas aeruginosa
Antimicrob.Agents Chemother., 59 (8)

Bielecki P., Muthukumarasamy U., Eckweiler D., Bielecka A., Pohl S., Schanz A., Niemeyer U., Oumeraci T., von Neuhoff N., ... , Ghigo J.M., Häußler S. (2014)
In vivo mRNA profiling of uropathogenic Escherichia coli from diverse phylogroups reveals common and group-specific gene expression profiles
MBio, 5 (4)

Häußler S., Blanka A., VanHook A.M. (2015)
Science signaling podcast: 14 April 2015
Sci.Signal., 8 (372)

Blanka A., Düvel J., Dötsch A., Klinkert B., Abraham W.R., Kaever V., Ritter C., ... , Narberhaus F., Häußler S. (2015)
Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition
Sci.Signal., 8 (372)

Schulz S., Eckweiler D., Bielecka A., Nicolai T., Franke R., Dötsch A., Hornischer K., Bruchmann S., ... , Düvel J., Häußler S. (2015)
Elucidation of Sigma Factor-Associated Networks in Pseudomonas aeruginosa Reveals a Modular Architecture with Limited and Function-Specific Crosstalk
PLoS Pathog., 11 (3)

Vercammen K., Wei Q., Charlier D., Dötsch A., Häußler S., Schulz S., Salvi F., Gadda G., Spain J., Rybtke M.L., Tolker-Nielsen T., Dingemans J., ... , Ye L., Cornelis P. (2015)
Pseudomonas aeruginosa LysR PA4203 Regulator NmoR Acts as a Repressor of the PA4202 nmoA Gene, Encoding a Nitronate Monooxygenase
J Bacteriol., 197 (6)

Oumeraci T., Jensen V., Talbot S.R., Hofmann W., Kostrzewa M., Schlegelberger B., ... , von Neuhoff N., Häußler Susanne (2015)
Comprehensive MALDI-TOF Biotyping of the Non-Redundant Harvard Pseudomonas aeruginosa PA14 Transposon Insertion Mutant Library
PLoS ONE, 10 (2)

Brouwer Stephan, Pustelny Christian, Ritter Christiane, Klinkert B., Narberhaus F., Häußler Susanne (2014)
The PqsR and RhlR transcriptional regulators determine the level of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa by producing two different pqsABCDE mRNA Isoforms
Journal of Bacterioliology, 196 (23)

Pustelny C., Komor U., Pawar V., Lorenz A., Bielecka A., Moter A., Gocht B., Eckweiler D., Grothe C., Lünsdorf H., ... , Weiss S., Häußler S. (2014)
Contribution of Veillonella parvula to Pseudomonas aeruginosa mediated pathogenicity in a murine tumor model system
Infection and Immunity, 83

Espinoza Mora M.D.R., Steeg C., Tartz S., Häußler Susanne, Sparwasser Tim, Link A., ... , Fleischer B., Jacobs T. (2014)
Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory
PLoS ONE, 9 (8)

Cabot G., Bruchmann Sebastian, Mulet X., Zamorano L., Juan C., Häußler Susanne (2014)
Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of ampc
Antimicrobial Agents and Chemotherapy, 58 (6)

Vidigal P.G., Müsken M., Becker K.A., Häußler S., Wingender J., Steinmann Eike, Kehrmann J., Gulbins E., Buer J., ... , Rath P.M., Steinmann J. (2014)
Effects of Green Tea Compound Epigallocatechin-3-Gallate against Stenotrophomonas maltophilia Infection and Biofilm
PLoS ONE, 9 (4)

Schmidt A., Belaaouaj A., Bissinger R., Koller G., Malleret L., D'Orazio C., Facchinelli M., Schulte-Hubbert B., Molinaro A., Holst O., Hammermann J., Schniederjans M., Meyer K.C., Damkiaer S., Piacentini G., Assael B., Bruce K., Häußler Susanne, Lipuma J.J., Seelig J., ... , Worlitzsch D., Doring G. (2014)
Neutrophil elastase-mediated increase in airway temperature during inflammation
Journal of Cystic Fibrosis, 13 (6)

Pawar V., Crull K., Komor U., Kasnitz N., Frahm M., Kocijancic D., Westphal K., Leschner S., Wolf K., Loessner H., Rohde M., ... , Häußler S., Weiss S. (2014)
Murine solid tumours as a novel model to study bacterial biofilm formation in vivo
Journal of International Medicine, 276

Pohl S., Klockgether J., Eckweiler D., Khaledi A., Schniederjans M., Chouvarine P., ... , Tummler B., Häußler S. (2014)
The extensive set of accessory Pseudomonas aeruginosa genomic components
Fems Microbiology Letters, 356 (2)

Fleige H., Ravens S., Moschovakis G.L., Bölter J., Willenzon S., Sutter G., Häußler Susanne, Kalinke Ulrich, ... , Prinz I., Förster R. (2014)
IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs
Journal of Experimental Medicine, 211 (4)

Blanka A., Schulz S., Eckweiler D., Franke R., Bielecka A., Nicolai T., Casilag F., Düvel J., Abraham W.R., ... , Kaever V., Häußler S. (2014)
Identification of the alternative sigma factor SigX regulon and its implications for pseudomonas aeruginosa pathogenicity
Journal of Bacteriology, 196 (2)

Häußler Susanne, Fuqua C. (2013)
Biofilms 2012: New discoveries and significant wrinkles in a dynamic field
Journal of Bacteriology, 195 (13)

Gödeke J., Pustelny C., Häußler Susanne* (2013)
Recycling of peptidyl-tRNAs by peptidyl-tRNA hydrolase counteracts azithromycin-mediated effects on Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy, 57 (4)

Bielecki P., Komor U., Bielecka A., Musken M., Puchalka J., Pletz M.W., Ballmann M., Martins dos Santos V, ... , Weiss Siegfried, Häußler Susanne (2013)
Ex vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites
Environmental Microbiology, 15 (2)

Bruchmann S., Dötsch A., Nouri B., Chaberny I.F., Häußler Susanne* (2013)
Quantitative contributions of target alteration and decreased drug accumulation to pseudomonas aeruginosa fluoroquinolone resistance
Antimicrobial Agents and Chemotherapy, 57 (3)

Pustelny C., Brouwer S., Musken M., Bielecka A., Dotsch A., ... , Nimtz Manfred, Häußler Susanne (2013)
The peptide chain release factor methyltransferase PrmC is essential for pathogenicity and environmental adaptation of Pseudomonas aeruginosa PA14
Environmental Microbiology, 15 (2)

Wei Q., Minh P.N., Dotsch A., Hildebrand F., Panmanee W., Elfarash A., Schulz S., Plaisance S., Charlier D., Hassett D., ... , Häußler Susanne*, Cornelis P. (2012)
Global regulation of gene expression by OxyR in an important human opportunistic pathogen
Nucleic Acids Research, 40 (10)

Bielecki P., Lukat P., Husecken K., Dotsch A., Steinmetz Heinrich, Hartmann Rolf W., ... , Müller Rolf, Häußler Susanne (2012)
Mutation in Elongation Factor G Confers Resistance to the Antibiotic Argyrin in the Opportunistic Pathogen Pseudomonas aeruginosa
ChemBioChem, 13 (16)

Storz M.P., Maurer C.K., Zimmer C., Wagner N., Brengel C., De Jong J.C., Lucas S., Musken M., Häußler Susanne, ... , Steinbach A., Hartmann Rolf W. (2012)
Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa
Journal of the American Chemical Society, 134 (39)

Komor U., Bielecki P., Loessner H., Rohde Manfred, Wolf K., Westphal K., ... , Weiss Siegfried, Häußler Susanne (2012)
Biofilm formation by Pseudomonas aeruginosa
Microbes and Infection, 14 (11)

Malone J.G., Jaeger T., Manfredi P., Dotsch A., Blanka A., Bos R., Cornelis G.R., ... , Häußler Susanne*, Jenal U. (2012)
The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways
PLoS Pathogens, 8 (6)

Selezska K., Kazmierczak M., Musken M., Garbe J., Schobert M., Häußler Susanne*, Wiehlmann L., ... , Rohde C., Sikorski J. (2012)
Pseudomonas aeruginosa population structure revisited under environmental focus: impact of water quality and phage pressure
Environmental Microbiology, 14 (8)

Lu C., Kirsch B., Zimmer C., De Jong J.C., Henn C., Maurer C.K., Müsken M., Häußler Susanne*, ... , Steinbach A., Hartmann Rolf W. (2012)
Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone- dependent quorum sensing in Pseudomonas aeruginosa
Chemistry and Biology, 19 (3)

Dötsch A., Eckweiler D., Schniederjans M., Zimmermann A., Jensen V., Scharfe M., ... , Geffers Robert, Häußler Susanne (2012)
The Pseudomonas aeruginosa
PLoS ONE, 7 (2)

Düvel J., Bertinetti D., Moller S., Schwede F., Morr M., Wissing J., Radamm L., Zimmermann B., Genieser H.G., Jänsch Lothar, ... , Herberg F.W., Häußler Susanne (2012)
A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa
Journal of Microbiological Methods, 88 (2)

Zaoui C., Overhage J., Lons D., Zimmermann A., Musken M., Bielecki P., Pustelny C., Becker T., ... , Nimtz Manfred, Häußler Susanne (2012)
An orphan sensor kinase controls quinolone signal production via MexT in Pseudomonas aeruginosa
Molecular Microbiology, 83 (3)

Pommerenke C., Friedrich B., Johl T., Jänsch Lothar, Häußler Susanne, Klawonn F. (2012)
A modified apriori algorithm for analysing high-dimensional gene data
LNCS, 6936

Wei Q., Tarighi S., Dotsch A., Häußler Susanne*, Musken M., Wright V.J., Camara M., Williams P., Haenen S., Boerjan B., Bogaerts A., Vierstraete E., Verleyen P., Schoofs L., Willaert R., De Groote V, Michiels J., Vercammen K., ... , Crabbe A., Cornelis P. (2011)
Phenotypic and Genome-Wide Analysis of an Antibiotic-Resistant Small Colony Variant (SCV) of Pseudomonas aeruginosa
PLoS ONE, 6 (12)

Schmidt J., Musken M., Becker T., Magnowska Z., Bertinetti D., Moller S., Zimmermann B., Herberg F.W., ... , Jansch L., Häußler Susanne* (2011)
The Pseudomonas aeruginosa Chemotaxis Methyltransferase CheR1 Impacts on Bacterial Surface Sampling
PLoS ONE, 6 (3)

Haddad A., Jensen V., Becker T., Häußler Susanne* (2009)
The Pho regulon influences biofilm formation and type three secretion in Pseudomonas aeruginosa
Environmental Microbiology Reports, 1 (6)

Häußler Susanne* (2010)
Multicellular signalling and growth of Pseudomonas aeruginosa
International Journal of Medical Microbiology, 300 (8)

Dötsch A., Klawonn F., Jarek M., Scharfe M., Blöcker Helmut*, Häußler Susanne* (2010)
Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa
BMC GENOMICS, 11

Pommerenke C., Musken M., Becker T., Dotsch A., Klawonn Frank*, Häußler Susanne* (2010)
Global genotype-phenotype correlations in Pseudomonas aeruginosa
PLoS Pathogens, 6 (8)

Müsken M., Di Fiore S., Römling U., Häußler Susanne* (2010)
A 96-well-plate-based optical method for the quantitative and qualitative evaluation of Pseudomonas aeruginosa biofilm formation and its application to susceptibility testing
Nature Protocols, 5 (8)

Häußler Susanne*, Parsek M.R. (2010)
Biofilms 2009: new perspectives at the heart of surface-associated microbial communities
Journal of Bacteriology, 192 (12)

Musken M., Di Fiore S., Dotsch A., Fischer R., Häußler Susanne* (2010)
Genetic determinants of Pseudomonas aeruginosa biofilm establishment
Microbiology, 156 (Pt 2)

Yu S., Jensen V., Seeliger J., Feldmann I., Weber S., Schleicher E., ... , Häußler Susanne*, Blankenfeldt W. (2009)
Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein
Biochemistry, 48 (43)

Dötsch A., Becker T., Pommerenke C., Magnowska Z., Jänsch Lothar*, Häußler Susanne* (2009)
Genomewide identification of genetic determinants of antimicrobial drug resistance in Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy, 53 (6)

Dötsch A., Pommerenke C., Bredenbruch F., Geffers Robert*, Häußler Susanne* (2009)
Evaluation of a microarray-hybridization based method applicable for discovery of single nucleotide polymorphisms (SNPs) in the Pseudomonas aeruginosa genome
BMC GENOMICS, 10

Moya B., Dötsch A., Juan C., Blazquez J., Zamorano L., ... , Häußler S., Oliver A. (2009)
Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein
PLoS Pathog, 5 (3)

Bohn Y.S., Brandes G., Rakhimova E., Horatzek S., Salunkhe P., Munder A., van Barneveld A., Jordan D., Bredenbruch F., Häußler Susanne*, Riedel K., Eberl L., Jensen P.O., Bjarnsholt T., Moser C., Hoiby N., ... , Tummler B., Wiehlmann L. (2009)
Multiple roles of Pseudomonas aeruginosa
Molecular Microbiology, 71 (3)

Häußler Susanne*, Becker T. (2008)
The pseudomonas quinolone signal (PQS) balances life and death in Pseudomonas aeruginosa
PLoS Pathogens, 4 (9)

Balke B., Schmoldt S., Häußler Susanne*, Suerbaum S., Heesemann J., Hogardt M. (2008)
A German external quality survey of diagnostic microbiology of respiratory tract infections in patients with cystic fibrosis
Journal of Cystic Fibrosis, 7 (1)

Meissner A., Wild V., Simm R., Rohde Manfred*, Erck C., Bredenbruch F., Morr Michael*, ... , Römling U., Häußler Susanne* (2007)
Pseudomonas aeruginosa
Environmental Microbiology, 9 (10)

Jensen V., Löns D., Zaoui C., Bredenbruch F., Meissner A., Dieterich G., ... , Münch R., Häußler Susanne* (2006)
RhIR expression in Pseudomonas aeruginosa
Journal of Bacteriology, 188

Häußler Susanne* (2006)
"Sociomicrobiology" - New approaches to understand chronic infectious diseases [Das "sozialverhalten" von bakterien - Ein neuer ansatz zum verständnis chronischer infektionen]
Medizinische Welt, 57 (10)

Balke B., Hogardt M., Schmoldt S., Hoy L., Weissbrodt H., Häußler Susanne* (2006)
Evaluation of the E test for the assessment of synergy of antibiotic combinations against multiresistant Pseudomonas aueruginosa
European Journal of Clinical Microbiology & Infectious Diseases, 25

Nalca Y., Jänsch Lothar*, Bredenbruch F., Geffers Robert*, Buer Jan*, Häußler Susanne* (2006)
Quorum-sensing antagonistic activities of azithromycin in Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy, 50

Vonberg R.P., Häußler Susanne*, Vandamme P., Steinmetz I. (2006)
Identification of Burkholderia cepacia
Journal of Medical Microbiology, 55

Bredenbruch F., Geffers Robert*, Nimtz Manfred*, Buer Jan*, Häußler Susanne* (2006)
The Pseudomonas aeruginosa
Environmental Microbiology, 8

Romero-Tabarez M., Jansen R., Sylla M., Lünsdorf H., Häußler S., Santosa D.A., ... , Timmis K.N., Molinari G. (2006)
7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis
Antimicrobial Agents and Chemotherapy, 50 (5)

Bredenbruch F., Nimtz M., Wray V., Morr M., Müller R., Häußler S. (2005)
Biosynthetic pathway of Pseudomonas aeruginosa
Journal of Bacteriology, 187

Balke B., Hoy L., Weissbrodt H., Häußler S. (2004)
Comparison of standard agar dilution with the Merlin, Micronaut System for automated broth microtiter antimicrobial susceptibility testing of mucoid and non-mucoid Pseudomonas aeruginosa isolates from cystic fibrosis patients
European Journal of Clinical Microbiology and Infectious Diseases, 23 (10)

Häußler S. (2004)
Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa
Environmental Microbiology, 6

Von Goetz F., Häußler S., Jordan D., Saravanamuthu S., Wehmhöner D., Strüßmann A., Lauber J., Attree I., Buer J., ... , Tümmler B., Steinmetz I. (2004)
Expression analysis of a highly adherent and cytotoxic small colony variant of Pseudomonas aeruginosa isolated from a cystic fibrosis lung
Journal of Bacteriology, 186

Häußler S., Rohde M., von Neuhoff N., Nimtz M., Steinmetz I. (2003)
Structural and functional cellular changes induced by Burholderia pseudomallei
Infection and Immunity, 71

Wehmhöner D., Häußler S., Tümmler B., Jänsch L., Wehland J., Steinmetz.I. (2003)
Inter - and intraclonal diversity of Pseudomonas aeruginosa proteome manifests within the secretome.
Journal of Bacteriology, 185 (19)

Häußler S., Ziesing S., Rademacher G., Hoy L., Weißbrodt H. (2003)
Evaluation of the MERLIN, micronaut system for automated antimicrobial susceptibility testing of Pseudomonas aeruginosa and Burkholderia species isolated from cystic fribrosis patients
European Journal of Clinical Microbiology and Infectious Diseases, 22

Häußler S., Lehmann C., Breselge C., Rohde M., Claßen M., Tümmler B., ... , Vandamme P., Steinmetz I. (2003)
Fatal outcome of lung transplantation in cystic fibrosis due to serum resistant Burkholderia cepacia comlex small colony variants
European Journal of Clinical Microbiology and Infectious Diseases, 22

Häußler S., Ziegler I., Löttel A., Von Götz F., Rohde M., Wehmhöner D., Saravanamuthu S., ... , Tümmler B., Steinmetz I. (2003)
Highly adherent small colony variants of Pseudomonas aeruginosa
Journal of Medical Microbiology, 52

Häußler S. (2003)
Morphologische Varianten bakterieller Erreger und chronische Infektionen
Gelbe Hefte, 42

Häußler S. (2003)
Chronic infections by small colony variants of pathogenic bacteria
Biomedical Progress, 16

Breuer K., Häußler S., Kapp A., Werfel T. (2002)
Staphylococcus aureus : colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis
British Journal of Dermatology, 147

Steinmetz I., Nimtz M., Häußler Susanne*, Reganzerowski A., Brenneke B. (2000)
Exopolysaccharides of Burkholderia pseudomallei
Acta tropica., 74 (2-3)