Prof. Dr. Thomas Pietschmann

Hartmann C.R., Khan R., Schöning J., Richter M., Willers M., Pirr S., Heckmann J., Dirks J., Morbach H., Konrad M., Fries E., Winkler M., Büchel J., Seidenspinner S., Fischer J., Vollmuth C., Meinhardt M., Marissen J., Schmolke M., Haid S., Pietschmann T., Backes S., Dölken L., Löber U., Keil T., Heuschmann P.U., Wöckel A., Ulas T., Forslund-Startceva S.K., ... , Härtel C., Viemann D. (2024)

A clinical protocol for a German birth cohort study of the Maturation of Immunity Against respiratory viral Infections (MIAI)

Front.Immunol., 15

DOI: 10.3389/fimmu.2024.1443665 HZI-Repositorium PubMed

Reichert I., Lee J.Y., Weber L., Fuh M.M., Schlaeger L., Kinast V., Schlienkamp S., Conradi J., Vondran F.W.R., Pfaender S., Scaturro P., Steinmann E., Bartenschlager R., Pietschmann T., ... , Heeren J., Lauber C. (2024)

The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle

PLoS Pathog., 20 (9)

DOI: 10.1371/journal.ppat.1012509 HZI-Repositorium PubMed

Garcia R., Popoff A., Bader C.D., Löhr J., Walesch S., Walt C., Boldt J., Bunk B., Haeckl F.P.J., Gunesch A.P., Birkelbach J., Nübel U., Pietschmann T., ... , Bach T., Müller R. (2024)

Discovery of the Pendulisporaceae: An extremotolerant myxobacterial family with distinct sporulation behavior and prolific specialized metabolism

Chem, 10

DOI: 10.1016/j.chempr.2024.04.019 HZI-Repositorium

Lauber C., Zhang X., Vaas J., Klingler F., Mutz P., Dubin A., Pietschmann T., Roth O., Neuman B.W., Gorbalenya A.E., ... , Bartenschlager R., Seitz S. (2024)

Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates

PLoS Pathogens, 20 (4/ April)

DOI: 10.1371/journal.ppat.1012163 HZI-Repositorium PubMed

Frericks N., Brown R.J.P., Reinecke B.M., Herrmann M., Brüggemann Y., Todt D., Miskey C., Vondran F.W.R., Steinmann E., ... , Pietschmann T., Sheldon J. (2024)

Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes

J.Virol., 98 (3)

DOI: 10.1128/jvi.01921-23 HZI-Repositorium PubMed

Sake S.M., Zhang X., Rajak M.K., Urbanek-Quaing M., Carpentier A., Gunesch A.P., Grethe C., Matthaei A., R++ckert J., Galloux M., Larcher T., Le Goffic R., Hontonnou F., Chatterjee A.K., Johnson K., Morwood K., Rox K., Elgaher W.A.M., Huang J., Wetzke M., Hansen G., Fischer N., El+®ou+½t J.F., Rameix-Welti M.A., Hirsch A.K.H., Herold E., Empting M., Lauber C., Schulz T.F., Krey T., ... , Haid S., Pietschmann T. (2024)

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Nature Communications, 15 (1)

DOI: 10.1038/s41467-024-45241-y HZI-Repositorium PubMed

Haid S., Matthaei A., Winkler M., Sake S.M., Gunesch A.P., Milke V., Köhler N.M., Rückert J., Vieyres G., Kühl D., Nguyen T.-T., Göhl M., Lasswitz L., Zapatero-Belinchon F.J., Brogden G., Gerold G., Wiegmann B., Bilitewski U., Brown R.J.P., Brönstrup M., ... , Schulz T.F., Pietschmann T. (2024)

Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets

Antimicrob.Agents Chemother.

DOI: 10.1128/aac.01210-23 HZI-Repositorium PubMed

Matthaei A., Joecks S., Frauenstein A., Bruening J., Bankwitz D., Friesland M., Gerold G., Vieyres G., Kaderali L., ... , Meissner F., Pietschmann T. (2024)

Landscape of protein-protein interactions during hepatitis C virus assembly and release

Microbiol.Spectr., 12 (2)

DOI: 10.1128/spectrum.02562-22 HZI-Repositorium PubMed

Pink I., Hennigs J.K., Ruhl L., Sauer A., Boblitz L., Huwe M., Fuge J., Falk C.S., Pietschmann T., de Zwaan M., Prasse A., Kluge S., Klose H., ... , Hoeper M.M., Welte T. (2023)

Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19

Infection

DOI: 10.1007/s15010-023-02114-8 HZI-Repositorium PubMed

Meister T.L., Friesland M., Frericks N., Wetzke M., Haid S., Steinmann J., Todt D., ... , Pietschmann T., Steinmann E. (2023)

Virucidal activity of oral, hand, and surface disinfectants against respiratory syncytial virus

J.Hosp.Infect., 141 (Nov 2023)

DOI: 10.1016/j.jhin.2023.08.009 HZI-Repositorium PubMed

Liang T.J., Law J.L.M., Pietschmann T., Ray S.C., Bukh J., Bull R., Chung R.T., Tyrrell D.L., ... , Houghton M., Rice C.M. (2023)

Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model

Clin.Infect.Dis., 77

DOI: 10.1093/cid/ciad336 HZI-Repositorium PubMed

Stahl Y., Kabar I., Heinzow H., Maasoumy B., Bremer B., Wedemeyer H., Schmidt H.H.-J., Pietschmann T., ... , Schlevogt B., Behrendt P. (2023)

Enhanced monitoring and detection of recent genotype 3 hepatitis E virus infection through urine antigen testing

Emerg.Microbes Infect., 12 (2)

DOI: 10.1080/22221751.2023.2251598 HZI-Repositorium PubMed

Zhang Y., Kinast V., Sheldon J., Frericks N., Todt D., Zimmer M., Caliskan N., Brown R.J.P., ... , Steinmann E., Pietschmann T. (2023)

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Microbiol.Spectr.

DOI: 10.1128/spectrum.01284-23 HZI-Repositorium PubMed

Lange F., Garn J., Anagho H.A., Vondran F.W.R., von Hahn T., ... , Pietschmann T., Carpentier A. (2023)

Hepatitis D virus infection, innate immune response and antiviral treatments in stem cell-derived hepatocytes

Liver Int.

DOI: 10.1111/liv.15655 HZI-Repositorium PubMed

Vieyres G., Pietschmann T. (2023)

The role of human lipoproteins for hepatitis C virus persistence

Current Opinion in Virology, 60

DOI: 10.1016/j.coviro.2023.101327 PubMed

Sake S.M., Kosch C., Blockus S., Haid S., Gunesch A.P., Zhang X., Friesland M., Trummer S.B., Grethe C., Kühnel A., Rückert J., Duprex W.P., Huang J., Rameix-Welti M.A., Empting M., Fischer N., Hirsch A.K.H., ... , Schulz T.F., Pietschmann T. (2022)

Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages

Antimicrob.Agents Chemother.

DOI: 10.1128/aac.01032-22 HZI-Repositorium PubMed

Keller L., Oueis E., Kaur A., Safaei N., Kirsch S.H., Gunesch A.P., Haid S., Rand U., Cicin-Sain L., Fu C., Wink J., ... , Pietschmann T., Müller R. (2022)

Persicamidines - Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses

Angew.Chem.Int.Ed Engl.

DOI: 10.1002/anie.202214595 HZI-Repositorium PubMed

Haack P.A., Harmrolfs K., Bader C.D., Garcia R., Gunesch A.P., Haid S., Popoff A., Voltz A., Kim H., Bartenschlager R., ... , Pietschmann T., Müller R. (2022)

Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors

Angew.Chem.Int.Ed Engl.

DOI: 10.1002/anie.202212946 HZI-Repositorium PubMed

Baier C., Huang J., Reumann K., Indenbirken D., Thol F., Koenecke C., Ebadi E., Heim A., Bange F.C., Haid S., ... , Pietschmann T., Fischer N. (2022)

Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients

Antimicrob.Resist.Infect.Control, 11 (1)

DOI: 10.1186/s13756-022-01120-z HZI-Repositorium PubMed

Reinecke B., Frericks N., Lauber C., Dinkelborg K., Matthaei A., Vondran F.W.R., Behrendt P., Haid S., ... , Brown R.J.P., Pietschmann T. (2022)

The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection

J Virol.

DOI: 10.1128/jvi.01995-21 HZI-Repositorium PubMed

Gömer A., Brown R.J.P., Pfaender S., Deterding K., Reuter G., Orton R., Seitz S., Bock C.T., Cavalleri J.M.V., Pietschmann T., Wedemeyer H., ... , Steinmann E., Todt D. (2022)

Intra-host analysis of hepaciviral glycoprotein evolution reveals signatures associated with viral persistence and clearance

Virus Evol., 8 (1)

DOI: 10.1093/ve/veac007 HZI-Repositorium PubMed

Wetzke M., Funken D., Lange M., Bejo L., Haid S., Monteiro J.G.T., Schütz K., Happle C., Schulz T.F., Seidenberg J., ... , Pietschmann T., Hansen G. (2022)

IRIS: Infection with RespIratory Syncytial Virus in infants-a prospective observational cohort study

BMC Pulm Med, 22 (1)

DOI: 10.1186/s12890-022-01842-1 HZI-Repositorium PubMed

Schuhenn J., Meister T.L., Todt D., Bracht T., Schork K., Billaud J.N., Elsner C., Heinen N., Karakoese Z., Haid S., Kumar S., Brunotte L., Eisenacher M., Di Y., Lew J., Falzarano D., Chen J., Yuan Z., Pietschmann T., Wiegmann B., Uebner H., Taube C., Le-Trilling V.T.K., Trilling M., Krawczyk A., Ludwig S., Sitek B., Steinmann E., Dittmer U., Lavender K.J., ... , Sutter K., Pfaender S. (2022)

Differential interferon- a

Proc.Natl.Acad.Sci.U.S.A., 119 (8)

DOI: 10.1073/pnas.2111600119 HZI-Repositorium PubMed

Paulsen M., Zychlinsky Scharff A., de Cassan K., Sugianto R.I., Blume C., Blume H., Christmann M., Hauß C., Illig T., Jonczyk R., Klopp N., Kopfnagel V., Lichtinghagen R., Lucas H., Luhr A., Mutschler F., Pietschmann T., Pott P.C., Prokein J., Schaefer P., Stahl F., Stanislawski N., von der Born J., Schmidt B.M.W., Heiden S., Stiesch M., ... , Memaran N., Melk A. (2021)

Children and Adolescents' Behavioral Patterns in Response to Escalating COVID-19 Restriction Reveal Sex and Age Differences

J.Adolesc.Health

DOI: 10.1016/j.jadohealth.2021.11.021 HZI-Repositorium PubMed

Weber T., Potthoff J., Bizu S., Labuhn M., Dold L., Schoofs T., Horning M., Ercanoglu M.S., Kreer C., Gieselmann L., Vanshylla K., Langhans B., Janicki H., Ströh L.J., Knops E., Nierhoff D., Spengler U., Kaiser R., Bjorkman P.J., Krey T., Bankwitz D., Pfeifer N., Pietschmann T., ... , Flyak A.I., Klein F. (2021)

Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization

Immunity., 55 (2)

DOI: 10.1016/j.immuni.2021.12.003 HZI-Repositorium PubMed

Bader C.D., Panter F., Garcia R., Tchesnokov E.P., Haid S., Walt C., Spröer C., Kiefer A.F., Götte M., Overmann J., ... , Pietschmann T., Müller R. (2022)

Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium

Chemistry.

DOI: 10.1002/chem.202104484 HZI-Repositorium PubMed

Bankwitz D., Krey T., Pietschmann T. (2022)

[Development approaches for vaccines against hepatitis C virus infections] / Entwicklungsansätze für Impfstoffe gegen Hepatitis-C-Virus-Infektionen

Bundesgesundheitsblatt.Gesundheitsforschung.Gesundheitsschutz. (Jan)

DOI: 10.1007/s00103-021-03477-9 HZI-Repositorium PubMed

Zapatero-Belinchón F.J., Moeller R., Lasswitz L., Van Ham M., Becker M., Brogden G., Rosendal E., Bi W., Carriquí-Madronal B., Islam K., Lenman A., Gunesch A.P., Kirui J., Pietschmann T., Överby A.K., ... , Jänsch L., Gerold G. (2021)

Fluvastatin mitigates SARS-CoV-2 infection in human lung cells

iScience, 24 (12)

DOI: 10.1016/j.isci.2021.103469 HZI-Repositorium PubMed

Nicolay W., Moeller R., Kahl S., Vondran F.W.R., Pietschmann T., ... , Kunz S., Gerold G. (2021)

Characterization of rna sensing pathways in hepatoma cell lines and primary human hepatocytes

Cells, 10 (11)

DOI: 10.3390/cells10113019 HZI-Repositorium PubMed

Ricke-Hoch M., Stelling E., Lasswitz L., Gunesch A.P., Kasten M., Zapatero-Belinchon F.J., Brogden G., Gerold G., Pietschmann T., Montiel V., Balligand J.L., Facciotti F., Hirsch E., Gausepohl T., Elbahesh H., Rimmelzwaan G.F., Höfer A., Kühnel M.P., Jonigk D., Eigendorf J., Tegtbur U., Mink L., Scherr M., Illig T., Schambach A., Pfeffer T.J., Hilfiker A., ... , Haverich A., Hilfiker-Kleiner D. (2021)

Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease

PLoS ONE, 16 (8)

DOI: 10.1371/journal.pone.0255335 HZI-Repositorium PubMed

Risso-Ballester J., Galloux M., Cao J., Le Goffic R., Hontonnou F., Jobart-Malfait A., Desquesnes A., Sake S.M., Haid S., Du M., Zhang X., Zhang H., Wang Z., Rincheval V., Zhang Y., Pietschmann T., Eléouet J.F., ... , Rameix-Welti M.A., Altmeyer R. (2021)

A condensate-hardening drug blocks RSV replication in vivo

Nature, 595 (7868)

DOI: 10.1038/s41586-021-03703-z HZI-Repositorium PubMed

Martin-Benlloch X., Lanfranchi D.A., Haid S., Pietschmann T., Davioud-Charvet E., Elhabiri M. (2021)

Magnesium Complexes of Ladanein: A Beneficial Strategy for Stabilizing Polyphenolic Antivirals

European Journal of Inorganic Chemistry

DOI: 10.1002/ejic.202100341 HZI-Repositorium

Jo W.K., Schadenhofer A., Habierski A., Kaiser F.K., Saletti G., Ganzenmueller T., Hage E., Haid S., Pietschmann T., Hansen G., Schulz T.F., Rimmelzwaan G.F., ... , Osterhaus A.D.M.E., Ludlow M. (2021)

Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants

Proc.Natl.Acad.Sci.U.S.A., 118 (14)

DOI: 10.1073/pnas.2026558118 HZI-Repositorium PubMed

Zapatero-Belinchón F.J., Dietzel E., Dolnik O., Döhner K., Costa R., Hertel B., Veselkova B., Kirui J., Klintworth A., Manns M.P., P÷hlmann S., Pietschmann T., Krey T., Ciesek S., Gerold G., Sodeik B., ... , Becker S., von Hahn T. (2019)

Characterization of the filovirus-resistant cell line SH-SY5Y reveals redundant role of cell surface entry factors

Viruses, 11 (3)

DOI: 10.3390/v11030275 HZI-Repositorium PubMed

Tegtmeyer B., Vieyres G., Todt D., Lauber C., Ginkel C., Engelmann M., Herrmann M., Pfaller C.K., Vondran F.W.R., Broering R., Vafadarnejad E., Saliba A.E., Puff C., Baumgärtner W., Miskey C., Ivics Z., Steinmann E., ... , Pietschmann T., Brown R.J.P. (2021)

Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements

J.Virol., 95 (10)

DOI: 10.1128/JVI.00245-21 HZI-Repositorium PubMed

Bankwitz D., Bahai A., Labuhn M., Doepke M., Ginkel C., Khera T., Todt D., Ströh L.J., Dold L., Klein F., Klawonn F., Krey T., Behrendt P., Cornberg M., ... , McHardy A.C., Pietschmann T. (2021)

Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies

GUT

DOI: 10.1136/gutjnl-2020-321190 HZI-Repositorium PubMed

Brown R.J.P., Tegtmeyer B., Sheldon J., Khera T., Anggakusuma, Todt D., Vieyres G., Weller R., Joecks S., Zhang Y., Sake S., Bankwitz D., Welsch K., Ginkel C., Engelmann M., Gerold G., Steinmann E., Yuan Q., Ott M., Vondran F.W.R., Krey T., Ströh L.J., Miskey C., Ivics Z., Herder V., Baumgärtner W., Lauber C., Seifert M., Tarr A.W., Mcclure C.P., Randall G., Baktash Y., Ploss A., Thi V.L.D., Michailidis E., Saeed M., Verhoye L., Meuleman P., Goedecke N., Wirth D., ... , Rice C.M., Pietschmann T. (2020)

Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice

Sci Adv, 6 (45)

DOI: 10.1126/sciadv.abd3233 HZI-Repositorium PubMed

Tran H.T.L., Morikawa K., Anggakusuma, Zibi R., Thi V.L.D., Penin F., Heim M.H., Quadroni M., Pietschmann T., ... , Gouttenoire J., Moradpour D. (2020)

OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease

PLoS ONE, 15 (7)

DOI: 10.1371/journal.pone.0236447 HZI-Repositorium PubMed

Wahlicht T., Vieyres G., Bruns S.A., Meumann N., Büning H., Hauser H., Schmitz I., ... , Pietschmann T., Wirth D. (2020)

Controlled Functional Zonation of Hepatocytes in Vitro by Engineering of Wnt Signaling

ACS Synth.Biol., 9 (7)

DOI: 10.1021/acssynbio.9b00435 PubMed

Haid S., Grethe C., Bankwitz D., Grunwald T., Pietschmann T. (2020)

Erratum: Correction for Haid et al., "Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System" (Journal of virology (2015) 90 6 (3065-3073) PII: e01690-19)

J.Virol., 94 (14)

DOI: 10.1128/JVI.01690-19 HZI-Repositorium PubMed

Vieyres G., Reichert I., Carpentier A., Vondran F.W.R., Pietschmann T. (2020)

The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly

PLoS.Pathog., 16 (6)

DOI: 10.1371/journal.ppat.1008554 HZI-Repositorium PubMed

Gunesch A.P., Zapatero-Belinchon F.J., Pinkert L., Steinmann E., Manns M.P., Schneider G., Pietschmann T., ... , Brönstrup M., von Hahn T. (2020)

Filovirus antiviral activity of cationic amphiphilic drugs is associated with lipophilicity and ability to induce phospholipidosis

Antimicrob.Agents Chemother., 64 (8)

DOI: 10.1128/AAC.00143-20 HZI-Repositorium PubMed

Alberione M.P., Moeller R., Kirui J., Ginkel C., Doepke M., Ströh L.J., Machtens J.P., ... , Pietschmann T., Gerold G. (2020)

Single-nucleotide variants in human CD81 influence hepatitis C virus infection of hepatoma cells

Med.Microbiol.Immunol., 209 (4)

DOI: 10.1007/s00430-020-00675-1 HZI-Repositorium PubMed

Kinast V., Plociennikowska A., Anggakusuma, Bracht T., Todt D., Brown R.J., Boldanova T., Zhang Y., Brueggemann Y., Friesland M., Engelmann M., Vieyres G., Broering R., Vondran F.W.R., Heim M.H., Sitek B., Bartenschlager R., ... , Pietschmann T., Steinmann E. (2020)

C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle

J.Hepatol., 73 (3)

DOI: 10.1016/j.jhep.2020.03.047 HZI-Repositorium PubMed

Köllmann C., Sake S.M., Jones P.G., Pietschmann T., Werz D.B. (2020)

Protecting-Group-Mediated Diastereoselective Synthesis of C4-Methylated Uridine Analogs and Their Activity against the Human Respiratory Syncytial Virus

J.Org.Chem., 85 (6)

DOI: 10.1021/acs.joc.9b03425 HZI-Repositorium PubMed

Blockus S., Sake S.M., Wetzke M., Grethe C., Graalmann T., Pils M., Le Goffic R., Galloux M., Prochnow H., Rox K., Huttel S., Rupcic Z., Wiegmann B., Dijkman R., Rameix-Welti M.A., Eleouet J.F., Duprex W.P., Thiel V., Hansen G., Brönstrup M., ... , Haid S., Pietschmann T. (2020)

Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry

Antiviral Res., 177 (May)

DOI: 10.1016/j.antiviral.2020.104774 HZI-Repositorium PubMed

Carpentier A., Sheldon J., Vondran F.W.R., Brown R.J.P., Pietschmann T. (2020)

Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus

GUT, 69 (9)

DOI: 10.1136/gutjnl-2019-319354 HZI-Repositorium PubMed

Prochnow H., Rox K., Birudukota N.V.S., Weichert L., Hotop S.K., Klahn P., Mohr K., Franz S., Banda D.H., Blockus S., Schreiber J., Haid S., Oeyen M., Martinez J.P., Süssmuth R.D., Wink J., Meyerhans A., Goffinet C., Messerle M., Schulz T.F., Kröger A., Schols D., ... , Pietschmann T., Brönstrup M. (2020)

Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis

J.Virol., 94 (2)

DOI: 10.1128/JVI.01471-19 HZI-Repositorium PubMed

Köllmann C., Wiechert S.M., Jones P.G., Pietschmann T., Werz D.B. (2019)

Synthesis of 4'/5'-Spirocyclopropanated Uridine and d-Xylouridine Derivatives and Their Activity against the Human Respiratory Syncytial Virus

Org.Lett., 21 (17)

DOI: 10.1021/acs.orglett.9b02555 HZI-Repositorium PubMed

Gerold G., Moeller R., Pietschmann T. (2020)

Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion

Cold Spring Harb.Perspect.Med., 10 (2)

DOI: 10.1101/cshperspect.a036830 HZI-Repositorium PubMed

Gottschick C., Raupach-Rosin H., Langer S., Hassan L., Horn J., Dorendorf E., Caputo M., Bittner M., Beier L., Rübsamen N., Schlinkmann K., Zoch B., Guzmán C.A., Hansen G., Heselich V., Holzapfel E., Hübner J., Pietschmann T., Pieper D.H., Pletz M., Riese P., Schmidt-Pokrzywniak A., Hartwig S., Von Kaisenberg C., Aydogdu M., Buhles M., Dressler F., Eberl W., Haase R., von Koch F.E., Feidicker S., Frambach T., Franz H.G.B., Guthmann F., Koch H.G., Seeger S., Oberhoff C., Pauker W., Petry K.U., Schild R.L., Tchirikov M., Röhrig E., ... , Karch A., Mikolajczyk R. (2019)

Erratum: Cohort profile: The LoewenKIDS Study - Life-course perspective on infections, the microbiome and the development of the immune system in early childhood (International Journal of Epidemiology (2019) DOI: 10.1093/ije/dyz001)

Int.J.Epidemiol., 48 (4)

DOI: 10.1093/ije/dyz069 PubMed

Kinast V., Leber S.L., Brown R.J.P., Vieyres G., Behrendt P., Essbach C., Strnad P., Vondran F.W.R., Cornberg M., Wex C., Pietschmann T., Haybaeck J., ... , Todt D., Steinmann E. (2019)

Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver

Cells, 8 (6)

DOI: 10.3390/cells8060610 HZI-Repositorium PubMed

Martin-Benlloch X., Haid S., Novodomska A., Rominger F., Pietschmann T., ... , Davioud-Charvet E., Elhabiri M. (2019)

Physicochemical Properties Govern the Activity of Potent Antiviral Flavones

ACS Omega, 4 (3)

DOI: 10.1021/acsomega.8b03332 HZI-Repositorium PubMed

Vieyres G., Pietschmann T. (2019)

HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit

Cells, 8 (3)

DOI: 10.3390/cells8030233 HZI-Repositorium

Pietschmann T., Brown R.J.P. (2019)

Hepatitis C Virus

Trends in Microbiology, 27 (4)

DOI: 10.1016/j.tim.2019.01.001 HZI-Repositorium PubMed

Gottschick C., Raupach-Rosin H., Langer S., Hassan L., Horn J., Dorendorf E., Caputo M., Bittner M., Beier L., Rübsamen N., Schlinkmann K., Zoch B., Guzmán C.A., Hansen G., Heselich V., Holzapfel E., Hübner J., Pietschmann T., Pieper D.H., Pletz M., Riese P., Schmidt-Pokrzywniak A., Hartwig S., von Kaisenberg C., Aydogdu M., Buhles M., Dressler F., Eberl W., Haase R., Edler von Koch F., Feidicker S., Frambach T., Franz H.G.B., Guthmann F., Koch H.G., Seeger S., Oberhoff C., Pauker W., Petry K.U., Schild R.L., Tchirikov M., ... , Röhrig E., Mikolajczyk R. (2019)

Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood

Int.J.Epidemiol., 48 (4)

DOI: 10.1093/ije/dyz001 HZI-Repositorium PubMed

Banda D.H., Perin P.M., Brown R.J.P., Todt D., Solodenko W., Hoffmeyer P., Sahu K.K., Houghton M., Meuleman P., Müller R., ... , Kirschning A., Pietschmann T. (2019)

A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors

J.Hepatol., 70 (6)

DOI: 10.1016/j.jhep.2019.01.033 HZI-Repositorium PubMed

Khera T., Behrendt P., Bankwitz D., Brown R.J.P., Todt D., Doepke M., Khan A.G., Schulze K., Law J., Logan M., Hockman D., Wong J.A.J.-X., Dold L., Gonzalez-Motos V., Spengler U., Viejo-Borbolla A., Ströh L., Krey T., Tarr A.W., Steinmann E., Manns M.P., Klein F., Guzmán C.A., Marcotrigiano J., ... , Houghton M., Pietschmann T. (2019)

Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants

J.Hepatol., 70 (4)

DOI: 10.1016/j.jhep.2018.11.003 HZI-Repositorium PubMed

Garcia-Nicolas O., V'kovski P., Vielle N.J., Ebert N., Züst R., Portmann J., Stalder H., Gaschen V., Vieyres G., Stoffel M., Schweizer M., Summerfield A., Engler O., Pietschmann T., Todt D., Alves M.P., ... , Thiel V., Pfaender S. (2018)

The small compound inhibitor K22 displays broad antiviral activity against different members of the family Flaviviridae and offers potential as pan-viral inhibitor

Antimicrob.Agents Chemother., 62 (11)

DOI: 10.1128/AAC.01206-18 HZI-Repositorium

Bruening J., Lasswitz L., Banse P., Kahl S., Marinach C., Vondran F.W., Kaderali L., Silvie O., Pietschmann T., ... , Meissner F., Gerold G. (2018)

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB

PLoS Pathog., 14 (7)

DOI: 10.1371/journal.ppat.1007111 HZI-Repositorium

Banse P., Moeller R., Bruening J., Lasswitz L., Kahl S., Khan A.G., Marcotrigiano J., ... , Pietschmann T., Gerold G. (2018)

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells

Viruses., 10 (4)

DOI: 10.3390/v10040207 HZI-Repositorium PubMed

Bartenschlager R., Baumert T.F., Bukh J., Houghton M., Lemon S.M., Lindenbach B.D., Lohmann V., Moradpour D., Pietschmann T., Rice C.M., ... , Thimme R., Wakita T. (2018)

Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: considerations for scientists and funding agencies

Virus Res., 248 (March)

DOI: 10.1016/j.virusres.2018.02.016 HZI-Repositorium PubMed

Baier C., Haid S., Beilken A., Behnert A., Wetzke M., Brown R.J.P., Schmitt C., Ebadi E., Hansen G., Schulz T.F., ... , Pietschmann T., Bange F.C. (2018)

Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease

Antimicrob.Resist.Infect.Control, 7 (1)

DOI: 10.1186/s13756-018-0316-2 HZI-Repositorium PubMed

Knegendorf L., Drave S.A., Dao Thi V, Debing Y., Brown R.J.P., Vondran F.W.R., Resner K., Friesland M., Khera T., Engelmann M., Bremer B., Wedemeyer H., Behrendt P., Neyts J., Pietschmann T., ... , Todt D., Steinmann E. (2018)

Hepatitis E virus replication and interferon responses in human placental cells

Hepatol.Commun., 2 (2)

DOI: 10.1002/hep4.1138 HZI-Repositorium

Riber C.F., Andersen A.H.F., Gajda P., Lovschall K.B., Dagnaes-Hansen F., Banda D.H., ... , Pietschmann T., Tolstrup M. (2017)

Synthetic Polymer with a Structure-Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells

ACS Macro Lett., 6 (9)

DOI: 10.1021/acsmacrolett.7b00471

Behrendt P., Perin P., Menzel N., Banda D., Pfaender S., Alves M.P., Thiel V., Meulemann P., Colpitts C.C., Schang L.M., Vondran F.W.R., Anggakusuma, Manns M.P., ... , Steinmann E., Pietschmann T. (2017)

Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry

Antiviral Res., 147 (November)

DOI: 10.1016/j.antiviral.2017.09.006 HZI-Repositorium PubMed

Weller R., Hueging K., Brown R.J.P., Todt D., Joecks S., ... , Vondran F.W.R., Pietschmann T. (2017)

Hepatitis C virus strain-dependent usage of apolipoprotein E modulates assembly efficiency and specific infectivity of secreted virions

J.Virol., 91 (18)

DOI: 10.1128/JVI.00422-17 HZI-Repositorium PubMed

Bartenschlager R., Cornberg M., Pietschmann T. (2017)

[Personalized treatment of viral hepatitis of the present and the future : Hepatitis B, C, delta, and E]

Internist (Berl), 58 (7)

DOI: 10.1007/s00108-017-0262-8 PubMed

Vasiliauskaite I., Owsianka A., England P., Khan A.G., Cole S., Bankwitz D., Foung S.K.H., Pietschmann T., Marcotrigiano J., Rey F.A., ... , Patel A.H., Krey T. (2017)

Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2

MBio., 8 (3)

DOI: 10.1128/mBio.00382-17 HZI-Repositorium PubMed

Anggakusuma, Romero-Brey I., Berger C., Colpitts C.C., Boldanova T., Engelmann M., Todt D., Perin P.M., Behrendt P., Vondran F.W.R., Xu S., Goffinet C., Schang L.M., Heim M.H., Bartenschlager R., ... , Pietschmann T., Steinmann E. (2015)

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation

Hepatology, 62 (3)

DOI: 10.1002/hep.27913 PubMed

Bankwitz D., Doepke M., Hueging K., Weller R., Bruening J., Behrendt P., Lee J.Y., Vondran F.W.R., Manns M.P., ... , Bartenschlager R., Pietschmann T. (2017)

Maturation of secreted HCV particles by incorporation of secreted apoE protects from antibodies by enhancing infectivity

J.Hepatol., 67 (3)

DOI: 10.1016/j.jhep.2017.04.010 HZI-Repositorium PubMed

Pfaender S., Walter S., Grabski E., Todt D., Bruening J., Romero-Brey I., Gather T., Brown R.J., Hahn K., Puff C., Pfankuche V.M., Hansmann F., Postel A., Becher P., Thiel V., Kalinke U., Wagner B., Bartenschlager R., Baumgartner W., Feige K., Pietschmann T., ... , Cavalleri J.M., Steinmann E. (2017)

Immune protection against reinfection with nonprimate hepacivirus

Proc.Natl.Acad.Sci U.S A, 114 (12)

DOI: 10.1073/pnas.1619380114 HZI-Repositorium PubMed

Siddharta A., Pfaender S., Vielle N.J., Dijkman R., Friesland M., Becker B., Yang J., Engelmann M., Todt D., Windisch M.P., Brill F.H., Steinmann J., Steinmann J., Becker S., Alves M.P., Pietschmann T., Eickmann M., ... , Thiel V., Steinmann E. (2017)

Virucidal activity of WHO-recommended formulations against enveloped viruses including Zika, Ebola and emerging Coronaviruses

J Infect.Dis., 215 (6)

DOI: 10.1093/infdis/jix046 HZI-Repositorium PubMed

Gerold G., Bruening J., Pietschmann T. (2016)

Decoding protein networks during virus entry by quantitative proteomics

Virus Res., 218

DOI: 10.1016/j.virusres.2015.09.006 HZI-Repositorium PubMed

Pietschmann T. (2017)

Clinically approved ion channel inhibitors close gates for hepatitis C virus and open doors for drug repurposing in infectious viral diseases

J.Virol., 91 (2)

DOI: 10.1128/JVI.01914-16 HZI-Repositorium PubMed

Khera T., Todt D., Steinmann E., Pietschmann T., Brown R.J.P., Vercauteren K., Verhoye L., Farhoudi A., Meuleman P., Mcclure C.P., Bhuju S., Geffers R., Baumert T.F., Baumert T.F., ... , Baumert T.F., Pietschmann T. (2017)

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Antiviral Res., 139

DOI: 10.1016/j.antiviral.2017.01.001 HZI-Repositorium PubMed

Gerold G., Bruening J., Weigel B., Pietschmann T. (2017)

Protein interactions during the flavivirus and hepacivirus life cycle

Mol.Cell Proteomics, 16 (4)

DOI: 10.1074/mcp.R116.065649 HZI-Repositorium PubMed

Anggakusuma, Brown R.J.P., Banda D.H., Todt D., Vieyres G., ... , Steinmann E., Pietschmann T. (2016)

Hepacivirus NS3/4A proteases interfere with MAVS signaling in both their cognate animal hosts and humans: Implications for zoonotic transmission

J.Virol., 90 (23)

DOI: 10.1128/JVI.01634-16 HZI-Repositorium PubMed

von Schaewen M., Dorner M., Hueging K., Foquet L., Gerges S., Hrebikova G., Heller B., Bitzegeio J., Doerrbecker J., Horwitz J.A., Gerold G., Suerbaum S., Rice C.M., Meuleman P., ... , Pietschmann T., Ploss A. (2016)

Expanding the Host Range of Hepatitis C Virus through Viral Adaptation

MBio., 7 (6)

DOI: 10.1128/mBio.01915-16 HZI-Repositorium PubMed

Xu S., Ducroux A., Ponnurangam A., Vieyres G., Franz S., Musken M., Zillinger T., Malassa A., Ewald E., Hornung V., Barchet W., Häußler S., ... , Pietschmann T., Goffinet C. (2016)

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites

Cell Host.Microbe, 20 (4)

DOI: 10.1016/j.chom.2016.09.003

Bankwitz D., Pietschmann T. (2016)

Hepatitis C virus plays hide and seek with neutralizing antibodies

Hepatology, 64 (6)

DOI: 10.1002/hep.28760 HZI-Repositorium PubMed

Weller R., Todt D., Engelmann M., Friesland M., Wedemeyer H., ... , Pietschmann T., Steinmann E. (2016)

Apolipoprotein E polymorphisms and their protective effect on Hepatitis E virus replication

Hepatology, 64 (6)

DOI: 10.1002/hep.28788 HZI-Repositorium PubMed

Pfaender S., Grabski E., Detje C.N., Riebesehl N., Lienenklaus S., Steinmann E., ... , Kalinke U., Pietschmann T. (2016)

Hepatitis C Virus Stimulates Murine CD8a[alpha]-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner

PLoS Pathog., 12 (7)

DOI: 10.1371/journal.ppat.1005736 HZI-Repositorium PubMed

Vieyres G., Welsch K., Gerold G., Gentzsch J., Kahl S., Vondran F.W., ... , Kaderali L., Pietschmann T. (2016)

ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production

PLoS Pathog., 12 (4)

DOI: 10.1371/journal.ppat.1005568 HZI-Repositorium PubMed

Walter S., Bollenbach A., Doerrbecker J., Pfaender S., Brown R.J., Vieyres G., Scott C., Foster R., Kumar A., Zitzmann N., Griffin S., Penin F., ... , Pietschmann T., Steinmann E. (2016)

Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7

J Virol., 90 (10)

DOI: 10.1128/JVI.00132-16

Todt D., Francois C., Anggakusuma, Behrendt P., Engelmann M., Knegendorf L., Vieyres G., Wedemeyer H., Hartmann R., Pietschmann T., ... , Duverlie G., Steinmann E. (2016)

Antiviral activity of different interferon (sub-) types against hepatitis E virus replication

Antimicrob.Agents Chemother., 60 (4)

DOI: 10.1128/AAC.02427-15

Haid S., Grethe C., Bankwitz D., Grunwald T., Pietschmann T. (2015)

Identification of a human respiratory syncytial virus (hRSV) cell entry inhibitor by using a novel lentiviral pseudotype (hRSVpp) system

J Virol., 90 (6)

DOI: 10.1128/JVI.03074-15 HZI-Repositorium PubMed

Walker A., Skibbe K., Steinmann E., Pfaender S., Kuntzen T., Megger D.A., Groten S., Sitek B., Lauer G.M., Kim A.Y., Pietschmann T., ... , Allen T.M., Timm J. (2015)

Distinct escape pathway by HCV genotype 1a from a dominant CD8+ T cell response by selection of altered epitope processing

J Virol., 90

DOI: 10.1128/JVI.01993-15 HZI-Repositorium PubMed

Vercauteren K., Brown R.J., Mesalam A.A., Doerrbecker J., Bhuju S., Geffers R., Van Den Eede N., Mcclure C.P., Troise F., Verhoye L., Baumert T., Farhoudi A., Cortese R., Ball J.K., Leroux-Roels G., Pietschmann T., ... , Nicosia A., Meuleman P. (2015)

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice

GUT, 65

DOI: 10.1136/gutjnl-2014-309045 PubMed

Gerold G., Meissner F., Bruening J., Welsch K., Perin P.M., Baumert T.F., Vondran F.W., Kaderali L., Marcotrigiano J., Khan A.G., Mann M., ... , Rice C.M., Pietschmann T. (2015)

Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry

Cell Rep., 12 (5)

DOI: 10.1016/j.celrep.2015.06.063 HZI-Repositorium PubMed

Hueging K., Weller R., Doepke M., Vieyres G., Todt D., Wolk B., Vondran F.W., Geffers R., Lauber C., Kaderali L., ... , Penin F., Pietschmann T. (2015)

Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses

PLoS ONE, 10 (7)

DOI: 10.1371/journal.pone.0134529 HZI-Repositorium PubMed

Perin P.M., Haid S., Brown R.J., Doerrbecker J., Schulze K., Zeilinger C., von Schaewen M., Heller B., Vercauteren K., Luxenburger E., Baktash Y.M., Vondran F.W., Speerstra S., Awadh A., Mukhtarov F., Schang L.M., Kirschning A., Müller R., Guzmán C.A., Kaderali L., Randall G., Meuleman P., ... , Ploss A., Pietschmann T. (2016)

Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1

Hepatology, 63

DOI: 10.1002/hep.28111 HZI-Repositorium PubMed

Lump E., Castellano L.M., Meier C., Seeliger J., Erwin N., Sperlich B., Sturzel C.M., Usmani S., Hammond R.M., von Einem J., Gerold G., Kreppel F., Bravo-Rodriguez K., Pietschmann T., Holmes V.M., Palesch D., Zirafi O., Weissman D., Sowislok A., Wettig B., Heid C., Kirchhoff F., Weil T., Klarner F.G., Schrader T., Bitan G., Sanchez-Garcia E., Winter R., ... , Shorter J., Munch J. (2015)

A molecular tweezer antagonizes seminal amyloids and HIV infection

Elife., 4

DOI: 10.7554/eLife.05397. HZI-Repositorium PubMed

Tarr A.W., Khera T., Hueging K., Sheldon J., Steinmann E., ... , Pietschmann T., Brown R.J. (2015)

Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design

Viruses., 7 (7)

DOI: 10.3390/v7072809 HZI-Repositorium PubMed

Lauber C., Vieyres G., Terczynska-Dyla E., Anggakusuma, Dijkman R., Gad H.H., Akhtar H., Geffers R., Vondran F.W., Thiel V., Kaderali L., ... , Pietschmann T., Hartmann R. (2015)

Transcriptome analysis reveals a classical interferon signature induced by IFNlambda4 in human primary cells

Genes Immun., 16 (6)

DOI: 10.1038/gene.2015.23 HZI-Repositorium PubMed

Koutsoudakis G., Romero-Brey I., Berger C., Perez-Vilaro G., Perin P.M., Vondran F.W., Kalesse M., Harmrolfs K., Müller R., Martinez J.P., Pietschmann T., Bartenschlager R., Bronstrup M., ... , Meyerhans A., Diez J. (2015)

Soraphen A: a broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity

J Hepatol., 63 (4)

DOI: 10.1016/j.jhep.2015.06.002 HZI-Repositorium PubMed

Pfaender S., Walter S., Todt D., Behrendt P., Doerrbecker J., Woelk B., Engelmann M., Gravemann U., Seltsam A., Steinmann J., Burbelo P.D., Klawonn F., Feige K., Pietschmann T., ... , Cavalleri J.M., Steinmann E. (2015)

Assessment of cross-species transmission of hepatitis C-related non-primate hepacivirus in a population of humans at high risk of exposure

J Gen.Virol., 96 (9)

DOI: 10.1099/vir.0.000208 HZI-Repositorium PubMed

Anggakusuma, Frentzen A., Gürlevik E., Yuan Q., Steinmann E., Ott M., Staeheli P., Schmid-Burgk J., Schmidt T., Hornung V., ... , Kuehnel F., Pietschmann T. (2015)

Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons

J.Virol., 89 (7)

DOI: 10.1128/JVI.03129-14 HZI-Repositorium PubMed

Vercauteren K., Van Den Eede N., Mesalam A.A., Belouzard S., Catanese M.T., Bankwitz D., Wong-Staal F., Cortese R., Dubuisson J., Rice C.M., Pietschmann T., Leroux-Roels G., ... , Nicosia A., Meuleman P. (2014)

Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents

Hepatology, 60 (5)

Pfaender S., Brinkmann J., Todt D., Riebesehl N., Steinmann J., Steinmann J., ... , Pietschmann T., Steinmann E. (2015)

Mechanisms of methods for hepatitis C virus inactivation

Appl.Environ.Microbiol., 81 (5)

DOI: 10.1128/AEM.03580-14 HZI-Repositorium PubMed

Hedenstierna M., Weiland O., Brass A., Bankwitz D., Behrendt P., Uhnoo I., Aleman S., Cardell K., Fryden A., Norkrans G., Eilard A., Glaumann H., Pietschmann T., ... , Sällberg M., Brenndörfer E.D. (2015)

Long-term follow-up of successful hepatitis C virus therapy: Waning immune responses and disappearance of liver disease are consistent with cure

Aliment.Pharmacol.Ther., 41 (6)

Grabski E., Wappler I., Pfaender S., Steinmann E., Haid S., Dzionek A., ... , Pietschmann T., Kalinke U. (2014)

Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus induced interferon-alpha responses of plasmacytoid dendritic cells

Journal of Virology, 89

DOI: 10.1128/JVI.03229-14 HZI-Repositorium PubMed

Pfaender S., Cavalleri J.M., Walter S., Doerrbecker J., Campana B., Brown R.J., Burbelo P.D., Postel A., Hahn K., Kusuma A., Riebesehl N., Baumgartner W., Becher P., Heim M.H., Pietschmann T., ... , Feige K., Steinmann E. (2014)

Clinical course of infection and viral tissue tropism of hepatitis C virus-like non-primate hepaciviruses in horses

Hepatology, 61 (2)

DOI: 10.1002/hep.27440 PubMed

Bankwitz D., Vieyres G., Hueging K., Bitzegeio J., Doepke M., Chhatwal P., Haid S., Catanese M.T., Zeisel M.B., Nicosia A., Baumert T.F., ... , Kaderali L., Pietschmann Thomas (2014)

Role of the hypervariable region 1 (HVR1) for the interplay of hepatitis C virus with entry factors and lipoproteins

Journal of Virologie, 88

Pietschmann Thomas (2014)

In sero veritas: What serum markers teach us about HCV infection of primary human hepatocytes

GUT, 63 (9)

Irving W.L., Rupp D., Mcclure C.P., Than L.M., Titman A., Ball J.K., Steinmann Eike, Bartenschlager R., ... , Pietschmann Thomas, Brown Richard J.P. (2014)

Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region

Antiviral Research, 110 (1)

DOI: 10.1016/j.antiviral.2014.07.009 HZI-Repositorium PubMed

Gerold Gisa, Pietschmann Thomas (2014)

The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets

Digestive Diseases, 32 (5)

DOI: 10.1159/000360830 HZI-Repositorium PubMed

Lange M., Fiedler M., Bankwitz D., Osburn W., Viazov S., Brovko O., Zekri A.R., Khudyakov Y., Nassal M., Pumpens P., Pietschmann Thomas, Timm J., ... , Roggendorf M., Walker A. (2014)

Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-neutralizing antibodies

PLoS ONE, 9 (7)

DOI: 10.1371/journal.pone.0102235 HZI-Repositorium PubMed

Doerrbecker J., Friesland M., Riebesehl N., Ginkel C., Behrendt P., Brown R.J., Ciesek S., Wedemeyer H., Sarrazin C., Kaderali L., ... , Pietschmann T., Steinmann E. (2014)

Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles

Hepatology, 60

Pfaender S., Brown R.J., Pietschmann T., Steinmann E. (2014)

Natural reservoirs for homologs of hepatitis C virus

Emerging Microbes and Infections, 3

DOI: 10.1038/emi.2014.19 HZI-Repositorium PubMed

Vieyres G., Dubuisson J., Pietschmann Thomas (2014)

Incorporation of hepatitis C virus e1 and e2 glycoproteins: the keystones on a peculiar virion

Viruses, 6 (3)

Brown R.J.P., Koutsoudakisu G., Urbanowicz R.A., Mirza D., Ginkel C., Riebesehl N., Calland N., Albecka A., Price L., Hudson N., Descamps V., Backx M., Patrick McClure C., Duverlie G., Pecheur E.I., Dubuisson J., Perez-Del-Pulgar S., Forns X., Steinmann Eike, Tarr A.W., ... , Pietschmann Thomas, Ball J.K. (2014)

Analysis of serine codon conservation reveals diverse phenotypic constraints on hepatitis C virus glycoprotein evolution

Journal of Virology, 88 (1)

Steinmann Eike, Pietschmann Thomas (2013)

Cell culture systems for hepatitis C virus

Current Topics in Microbiology and Immunology, 369

Gerold G., Pietschmann Thomas (2013)

A circuit of paracrine signals between liver sinusoid endothelial cells and hepatocytes regulates hepatitis C virus replication

Hepatology, 59

Gerold Gisa, Pietschmann Thomas (2013)

Hepatitis C virus NS5B polymerase primes innate immune signaling

Hepatology, 57 (3)

Steinmann J., Buer J., Pietschmann Thomas, Steinmann Eike (2013)

Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea

British Journal of Pharmacology, 168 (5)

DOI: 10.1111/bph.12009 HZI-Repositorium PubMed

Hamming O.J., Terczynska-Dyla E., Vieyres G., Dijkman R., Jorgensen S.E., Akhtar H., Siupka P., Pietschmann T., ... , Thiel V., Hartmann R. (2013)

Interferon lambda 4 signals via the IFNambda receptor to regulate antiviral activity against HCV and coronaviruses

Embo Journal, 32 (23)

DOI: 10.1038/emboj.2013.232 HZI-Repositorium PubMed

Hüging K., Döpke M., Vieyres G., Bankwitz D., Frentzen A., Dörrbecker J., Gumz F., Haid S., Wölk B., ... , Kaderali L., Pietschmann T. (2013)

Apolipoprotein E co-determines tissue-tropism of hepatitis C virus and it is crucial for viral cell-to-cell transmission by contributing to a post-envelopment step of assembly

Journal of Virology, 88 (3)

Pfaender S., Heyden J., Friesland M., Ciesek S., Ejaz A., Steinmann J., Steinmann J., Malarski A., Stoiber H., Tsiavaliaris G., Bader W., Jahreis G., ... , Pietschmann T., Steinmann E. (2013)

Inactivation of Hepatitis C Virus Infectivity by Human Breast Milk

Journal of Infectious Diseases, 208 (12)

DOI: 10.1093/infdis/jit519 PubMed

Steinmann Eike, Doerrbecker Juliane, Friesland Martina, Riebesehl Nina, Ginkel Corinne, Hillung Julia, Gentzsch Juliane, Lauber C., Brown Richard, ... , Frentzen Anne, Pietschmann Tim (2013)

Characterization of hepatitis C virus intra- and inter-genotypic chimeras reveals a role of the glycoproteins in virus envelopment

Journal of Virology, 52

Behrendt P., Doerrbecker J., Riebesehl N., Wilhelm C., Ciesek S., Erichsen T.J., Steinmann J., Ott M., Manns M.P., ... , Pietschmann T., Steinmann E. (2013)

Stability and transmission of hepatitis C virus in different anesthetic agents

American Journal of Infection Control, 41 (10)

DOI: 10.1016/j.ajic.2013.01.016 HZI-Repositorium PubMed

Zahid M.N., Turek M., Xiao F., Dao Thi V, Guerin M., Fofana I., Bachellier P., Thompson J., Delang L., Neyts J., Bankwitz D., Pietschmann Thomas*, Dreux M., Cosset F.L., Grunert F., ... , Baumert T.F., Zeisel M.B. (2013)

The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination

Hepatology, 57 (2)

DOI: 10.1002/hep.26097 HZI-Repositorium PubMed

Steinmann E., Gravemann U., Friesland M., Doerrbecker J., Muller T.H., ... , Pietschmann Thomas*, Seltsam A. (2013)

Two pathogen reduction technologies-methylene blue plus light and shortwave ultraviolet light-effectively inactivate hepatitis C virus in blood products

Transfusion, 53 (5)

DOI: 10.1111/j.1537-2995.2012.03858.x PubMed

Nandakumar R., Finsterbusch K., Lipps C., Neumann B., Grashoff M., Nair S., Hochnadel I., Lienenklaus S., Wappler I., Steinmann E., Hauser H., ... , Pietschmann T., Kröger A. (2013)

Hepatitis C Virus Replication in Mouse Cells is Restricted by IFN-Dependent and -Independent Mechanisms

Gastroenterology, 145 (6)

DOI: 10.1053/j.gastro.2013.08.037 HZI-Repositorium PubMed

Anggakusuma, Colpitts C.C., Schang L.M., Rachmawati H., Frentzen A., Pfaender S., Behrendt P., Brown R.J., Bankwitz D., Steinmann J., Ott M., Meuleman P., Rice C.M., Ploss A., ... , Pietschmann T., Steinmann E. (2013)

Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells

GUT, 63

DOI: 10.1136/gutjnl-2012-304299 HZI-Repositorium PubMed

Frentzen Anne, Kusuma Angga, Guerlevik E., Hueging Kathrin, Knocke S., Ginkel Corinne, Brown Richard J.P., Heim M., Dill M.T., Kröger Andrea, Kalinke Ulrich, Kaderali L., ... , Kuehnel F., Pietschmann Thomas (2013)

Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells

Hepatology

DOI: 10.1002/hep.26626 HZI-Repositorium PubMed

Haid S., Grethe C., Dill M.T., Heim M., Kaderali L., Pietschmann T. (2013)

Isolate-dependent use of Claudins for cell entry by hepatitis C virus

Hepatology, 59 (1)

Doerrbecker J., Meuleman P., Kang J., Riebesehl N., Wilhelm C., Friesland M., Pfaender S., Steinmann J., ... , Pietschmann T., Steinmann E. (2013)

Thermostability of seven hepatitis C virus genotypes in vitro and in vivo

Journal of Viral Hepatitis, 20 (7)

DOI: 10.1111/jvh.12055 HZI-Repositorium PubMed

Gentzsch J., Brohm C., Steinmann Eike, Friesland M., Menzel N., Vieyres G., Perin P.M., Frentzen Anne, ... , Kaderali L., Pietschmann Thomas (2013)

Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment

PLoS Pathogens, 9 (5)

DOI: 10.1371/journal.ppat.1003355 HZI-Repositorium PubMed

Westhaus S., Bankwitz D., Ernst S., Rohrmann K., Wappler I., Agne C., Luchtefeld M., Schieffer B., Sarrazin C., Manns M.P., Pietschmann T., ... , Ciesek S., von Hahn T. (2013)

Characterization of the inhibition of hepatitis C virus entry by In vitro-generated and patient-derived oxidized low-density lipoprotein

Hepatology, 57 (5)

DOI: 10.1002/hep.26190 HZI-Repositorium PubMed

Vieyres G., Pietschmann Thomas (2013)

Entry and replication of recombinant hepatitis C viruses in cell culture

Methods, 59 (2)

DOI: 10.1016/j.ymeth.2012.09.005 HZI-Repositorium PubMed

Fofana I., Fafi-Kremer S., Carolla P., Fauvelle C., Zahid M.N., Turek M., Heydmann L., Cury K., Hayer J., Combet C., Cosset F.L., Pietschmann Thomas*, Hiet M.S., Bartenschlager R., Habersetzer F., Doffoel M., Keck Z.Y., Foung S.K., Zeisel M.B., ... , Stoll-Keller F., Baumert T.F. (2012)

Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies1

Gastroenterology, 143 (1)

DOI: 10.1053/j.gastro.2012.04.006 HZI-Repositorium PubMed

Doerrbecker J., Behrendt P., Mateu-Gelabert P., Ciesek S., Riebesehl N., Wilhelm C., Steinmann J.*, ... , Pietschmann Thomas*, Steinmann E.* (2013)

Transmission of hepatitis C virus among people who inject drugs: viral stability and association with drug preparation equipment

Journal of Infectious Diseases, 207 (2)

DOI: 10.1093/infdis/jis677

Vieyres G., Brohm C., Friesland M., Gentzsch J., Wolk B., Roingeard P., ... , Steinmann E., Pietschmann Thomas* (2013)

Subcellular Localization and Function of an Epitope-Tagged p7 Viroporin in Hepatitis C Virus-Producing Cells

Journal of Virology, 87 (3)

DOI: 10.1128/JVI.02782-12 HZI-Repositorium PubMed

Kugler J., Schmelz S., Gentzsch J., Haid S., Pollmann E., van den Heuvel Joop, Franke R., Pietschmann Thomas, ... , Heinz Dirk W., Collins J. (2012)

High Affinity Peptide Inhibitors of the Hepatitis C Virus NS3-4A Protease Refractory to Common Resistant Mutants

Journal of Biological Chemistry, 287 (46)

DOI: 10.1074/jbc.M112.393843 HZI-Repositorium PubMed

Frentzen A., Hueging K., Bitzegeio J., Pietschmann Thomas*, Steinmann E. (2012)

Two methods of heterokaryon formation to discover HCV restriction factors2

Journal of Visualized Experiments (65)

Ejaz A., Steinmann E., Bánki Z., Anggakusuma, Khalid S., Lengauer S., Wilhelm C., Zoller H., Schloegl A., Steinmann J., Grabski E., Kleines M., ... , Pietschmann Thomas*, Stoiber H. (2012)

Specific Acquisition of Functional CD59 but Not CD46 or CD55 by Hepatitis C Virus

PLoS ONE, 7 (9)

DOI: 10.1371/journal.pone.0045770 HZI-Repositorium PubMed

Menzel N., Fischl W., Hueging K., Bankwitz D., Frentzen A., Haid S., Gentzsch J., Kaderali L., ... , Bartenschlager R., Pietschmann Thomas* (2012)

MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles1

PLoS Pathogens, 8 (7)

DOI: 10.1371/journal.ppat.1002829 HZI-Repositorium PubMed

Sandmann L., Wilson M., Back D., Wedemeyer H., Manns M.P., Steinmann E., Pietschmann Thomas*, ... , von Hahn T., Ciesek S. (2012)

Antiretroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro

Antiviral Research, 96 (1)

Barbier J., Wegner J., Benson S., Gentzsch J., Pietschmann Thomas*, Kirschning A. (2012)

Total synthesis of a noricumazole a library and evaluation of HCV inhibition1

Chemistry, 18 (29)

von Hahn T., Schiene-Fischer C., Van N.D., Pfaender S., Karavul B., Steinmann E., Potthoff A., Strassburg C., Hamdi N., Abdelaziz A.I., Sarrazin C., Muller T., Berg T., Trepo E., Wedemeyer H., Manns M.P., ... , Pietschmann Thomas*, Ciesek S. (2012)

Hepatocytes that express variants of cyclophilin a are resistant to HCV infection and replication1

Gastroenterology, 143 (2)

DOI: 10.1053/j.gastro.2012.04.053 PubMed

Stegmann K.A., Bjorkstrom N.K., Ciesek S., Lunemann S., Jaroszewicz J., Wiegand J., Malinski P., Dustin L.B., Rice C.M., Manns M.P., Pietschmann T., Cornberg M., ... , Ljunggren H.G., Wedemeyer H. (2012)

Interferon a[alpha]-stimulated natural killer cells from patients with acute hepatitis C virus (HCV) infection recognize HCV-infected and uninfected hepatoma cells via DNAX accessory molecule-11

Journal of Infectious Diseases, 205 (9)

DOI: 10.1093/infdis/jis210 HZI-Repositorium PubMed

Steinmann E., Ciesek S., Friesland M., Erichsen T.J., Pietschmann Thomas* (2011)

Prolonged survival of hepatitis C virus in the anesthetic propofol2

Clinical Infectious Diseases, 53 (9)

Haybaeck J., Zeller N., Wolf M.J., Weber A., Wagner U., Kurrer M.O., Bremer J., Iezzi G., Graf R., Clavien P.A., Thimme R., Blum H., Nedospasov S.A., Zatloukal K., Ramzan M., Ciesek S., Pietschmann Thomas*, Marche P.N., Karin M., Kopf M., Browning J.L., ... , Aguzzi A., Heikenwalder M. (2009)

Erratum: A lymphotoxin-driven pathway to hepatocellular carcinoma3

Cancer Cell, 16 (5)

Chhatwal P., Bankwitz D., Grentzsch J., Frenzen A., Schult Ph., ... , Lohmann V., Pietschmann Thomas* (2012)

Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication

PLoS ONE, 7 (4)

DOI: 10.1371/journal.pone.0036029 HZI-Repositorium PubMed

Haid S., Novodomska A., Gentzsch J., Grethe C., Geuenich S., Bankwitz D., Chhatwal P., Jannack B., Hennebelle T., Bailleul F., Keppler O.T., Ponisch M., Bartenschlager R., Hernandez C., Lemasson M., Rosenberg A., Wong-Staal F., ... , vioud-Charvet E., Pietschmann Thomas* (2012)

A Plant-Derived Flavonoid Inhibits Entry of All HCV Genotypes into Human Hepatocytes

Gastroenterology, 143 (1)

DOI: 10.1053/j.gastro.2012.03.036 HZI-Repositorium PubMed

Ruhl M., Chhatwal P., Strathmann H., Kuntzen T., Bankwitz D., Skibbe K., Walker A., Heinemann F.M., Horn P.A., Allen T.M., Hoffmann D., ... , Pietschmann Thomas*, Timm J. (2012)

Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope1

Journal of Virology, 86 (2)

DOI: 10.1128/JVI.05603-11 HZI-Repositorium PubMed

Ciesek S., von Hahn T., Colpitts C.C., Schang L.M., Friesland M., Steinmann J., Manns M.P., Ott M., Wedemeyer H., Meuleman P., ... , Pietschmann Thomas*, Steinmann E. (2011)

The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry

Hepatology, 54 (6)

DOI: 10.1002/hep.24610 HZI-Repositorium PubMed

Doerrbecker J., Friesland M., Ciesek S., Erichsen T.J., Mateu-Gelabert P., Steinmann J., Steinmann J., ... , Pietschmann Thomas*, Steinmann E. (2011)

Inactivation and survival of hepatitis C virus on inanimate surfaces

Journal of Infectious Diseases, 204 (12)

DOI: 10.1093/infdis/jir535 HZI-Repositorium PubMed

von Hahn T., Schulze A., Wust I.C., Heidrich B., Becker T., Steinmann E., Helfritz F.A., Rohrmann K., Urban S., Manns M.P., ... , Pietschmann Thomas*, Ciesek S. (2011)

The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitits B or C virus

PLoS ONE, 6 (9)

DOI: 10.1371/journal.pone.0024142 HZI-Repositorium PubMed

Steinmann E., Pietschmann Thomas* (2010)

Hepatitis C virus P7 - a viroporin crucial for virus assembly and an emerging target for antiviral therapy

Viruses, 285 (41)

Ciesek S., Westhaus S., Wicht M., Wappler I., Henschen S., Sarrazin C., Hamdi N., Abdelaziz A.I., Strassburg C.P., Wedemeyer H., Manns M.P., ... , Pietschmann Thomas*, von Hahn T. (2011)

Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles

Journal of Virology, 85 (15)

Frentzen A., Huging K., Bitzegeio J., Friesland M., Haid S., Gentzsch J., Hoffmann M., Lindemann D., Zimmer G., Zielecki F., Weber F., ... , Steinmann E., Pietschmann Thomas* (2011)

Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines

PLoS Pathogens, 7 (4)

DOI: 10.1371/journal.ppat.1002029 HZI-Repositorium PubMed

Lupberger J., Zeisel M.B., Xiao F., Thumann C., Fofana I., Zona L., Davis C., Mee C.J., Turek M., Gorke S., Royer C., Fischer B., Zahid M.N., Lavillette D., Fresquet J., Cosset F.L., Rothenberg S.M., Pietschmann Thomas*, Patel A.H., Pessaux P., Doffoel M., Raffelsberger W., Poch O., McKeating J.A., ... , Brino L., Baumert T.F. (2011)

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

Nature medicine, 17 (5)

Gentzsch J., Hinkelmann B., Kaderali L., Irschik Herbert*, Jansen Rolf*, Sasse Florenz*, ... , Frank Ronald*, Pietschmann Thomas* (2011)

Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity

Antiviral Research, 89 (2)

Burgel B., Friesland M., Koch A., Manns M.P., Wedemeyer H., Weissenborn K., Schulz-Schaeffer W.J., Pietschmann Thomas*, ... , Steinmann E., Ciesek S. (2011)

Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration

Journal of Viral Hepatitis, 18 (8)

Bitzegeio J., Bankwitz D., Hueging K., Haid S., Brohm C., Zeisel M.B., Herrmann E., Iken M., Ott M., ... , Baumert T.F., Pietschmann Thomas* (2010)

Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors

PLoS Pathogens, 6

DOI: 10.1371/journal.ppat.1000978 HZI-Repositorium PubMed

Montserret R., Saint N., Vanbelle C., Salvay A.G., Simorre J.P., Ebel C., Sapay N., Renisio J.G., Bockmann A., Steinmann E., Pietschmann Thomas*, Dubuisson J., ... , Chipot C., Penin F. (2010)

NMR structure and ion channel activity of the p7 protein from hepatitis C virus

Journal of Biological Chemistry, 285 (41)

von Hahn T., Steinmann E., Ciesek S., Pietschmann Thomas* (2010)

Know your enemy: translating insights about the molecular biology of hepatitis C virus into novel therapeutic approaches

Expert Review of Gastroenterology and Hepatology, 4 (1)

Lemon S.M., McKeating J.A., Pietschmann Thomas*, Frick D.N., Glenn J.S., Tellinghuisen T.L., ... , Symons J., Furman P.A. (2010)

Development of novel therapies for hepatitis C

Antiviral Research, 86 (1)

Ciesek S., Steinmann E., Iken M., Ott M., Helfritz F.A., Wappler I., Manns M.P., ... , Wedemeyer H., Pietschmann Thomas* (2010)

Glucocorticosteroids increase cell entry by hepatitis C virus

Gastroenterology, 138 (5)

DOI: 10.1053/j.gastro.2010.02.004 HZI-Repositorium PubMed

Bankwitz D., Steinmann E., Bitzegeio J., Ciesek S., Friesland M., Herrmann E., Zeisel M.B., Baumert T.F., Keck Z.Y., Foung S.K., ... , Pecheur E.I., Pietschmann Thomas* (2010)

Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes

Journal of Virology, 84 (11)

Ciesek S., Friesland M., Steinmann J., Becker B., Wedemeyer H., Manns M.P., Steinmann J., ... , Pietschmann Thomas*, Steinmann E. (2010)

How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides

Journal of Infectious Diseases, 201 (12)

DOI: 10.1086/652803 HZI-Repositorium PubMed

Stegmann K.A., Björkström N.K., Liermann H., Ciesek S., Riese P., Wiegand J., Hadem J., Suneetha P.V., Jaroszewicz J., Wang C., Schlaphoff V., Fytili P., Cornberg M., Manns M.P., Geffers R., Pietschmann T., Guzmán C.A., ... , Ljunggren H.-G., Wedemeyer H. (2010)

Interf alpha-induced TRAIL on human NK cells is associated with control of hepatitis C virus infection

Gastroenterology, 138 (5)

DOI: 10.1053/j.gastro.2010.01.051 PubMed

Brohm C., Steinmann E., Friesland M., Lorenz I.C., Patel A., Penin F., ... , Bartenschlager R., Pietschmann Thomas* (2009)

Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation

Journal of Virology, 83 (22)

Haid S., Windisch M.P., Bartenschlager R., Pietschmann Thomas* (2010)

Mouse-specific residues of claudin-1 limit hepatitis C virus genotype 2a infection in a human hepatocyte cell line

Journal of Virology, 84 (2)

Steinmann J., Becker B., Bischoff B., Paulmann D., Friesland M., Pietschmann Thomas*, ... , Steinmann J., Steinmann E. (2009)

Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization

American Journal of Infection Control, 38 (1)

Ciesek S., Steinmann E., Wedemeyer H., Manns M.P., Neyts J., Tautz N., Madan V., Bartenschlager R., ... , von Hahn T., Pietschmann Thomas* (2009)

Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A

Hepatology, 50 (5)

DOI: 10.1002/hep.23281 HZI-Repositorium

Haybaeck J., Zeller N., Wolf M.J., Weber A., Wagner U., Kurrer M.O., Bremer J., Iezzi G., Graf R., Clavien P.A., Thimme R., Blum H., Nedospasov S.A., Zatloukal K., Ramzan M., Ciesek S., Pietschmann Thomas*, Marche P.N., Karin M., Kopf M., Browning J.L., ... , Aguzzi A., Heikenwalder M. (2009)

A lymphotoxin-driven pathway to hepatocellular carcinoma

Cancer Cell, 16 (4)

Schaller T., Appel N., Koutsoudakis G., Kallis S., Lohmann V., ... , Pietschmann Thomas*, Bartenschlager R. (2007)

Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes

Journal of Virology, 81 (9)

Steinmann E., Whitfield T., Kallis S., Dwek R.A., Zitzmann N., ... , Pietschmann Thomas*, Bartenschlager R. (2007)

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus

Hepatology, 46 (2)

Pietschmann Thomas* (2009)

Full-length infectious HCV chimeras

Methods in Molecular Biology, 510

Witteveldt J., Evans M.J., Bitzegeio J., Koutsoudakis G., Owsianka A.M., Angus A.G., Keck Z.Y., Foung S.K., Pietschmann Thomas*, ... , Rice C.M., Patel A.H. (2009)

CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells

Journal of General Virology, 90 (Pt 1)

Pietschmann Thomas*, Zayas M., Meuleman P., Long G., Appel N., Koutsoudakis G., Kallis S., Leroux-Roels G., ... , Lohmann V., Bartenschlager R. (2009)

Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations

PLoS Pathogens, 5 (6)

DOI: 10.1371/journal.ppat.1000475 HZI-Repositorium PubMed

Haid S., Pietschmann Thomas*., Pecheur E.I. (2009)

Low pH-dependent Hepatitis C Virus Membrane Fusion Depends on E2 Integrity, Target Lipid Composition, and Density of Virus Particles

Journal of Biological Chemistry, 284 (26)

DOI: 10.1074/jbc.M109.014647 HZI-Repositorium PubMed

Pietschmann Thomas* (2009)

Virology: Final entry key for hepatitis C

Nature, 457 (7231)

Pietschmann Thomas* (2008)

Regulation of hepatitis C virus replication by microRNAs

Journal of Hepatology, 50 (3)

Jirasko V., Montserret R., Appel N., Janvier A., Eustachi L., Brohm C., Steinmann E., Pietschmann Thomas*, ... , Penin F., Bartenschlager R. (2008)

Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly

Journal of Biological Chemistry, 283 (42)

Steinmann E., Brohm C., Kallis S., Bartenschlager R., Pietschmann Thomas* (2008)

Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles

Journal of Virology, 82 (14)

Pietschmann Thomas*, Steinmann E., Ciesek S. (2008)

[Hepatitis C virus cell culture models--new perspectives for research and clinic]

Deutsche Medizinische Wochenschrift, 133 (30)

Ciesek S., Steinmann E., Manns M.P., Wedemeyer H., Pietschmann Thomas* (2008)

The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase

Journal of Infectious Diseases, 198 (7)

DOI: 10.1086/591463 HZI-Repositorium

Steinmann E., Penin F., Kallis S., Patel A.H., Bartenschlager R., Pietschmann Thomas* (2007)

Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions

PLoS Pathogens, 3 (7)

DOI: 10.3390/v2092078 HZI-Repositorium PubMed

Zeisel M.B., Koutsoudakis G., Schnober E.K., Haberstroh A., Blum H.E., Cosset F.L., Wakita T., Jaeck D., Doffoel M., Royer C., Soulier E., Schvoerer E., Schuster C., Stoll-Keller F., Bartenschlager R., Pietschmann Thomas*, ... , Barth H., Baumert T.F. (2007)

Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81

Hepatology, 46 (6)

Prof. Dr. Thomas Pietschmann

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