Prof. Dr. Till Strowig

Prof. Dr. Till Strowig
Forschungsgruppenleiter
+49 531 6181-4700

Till Strowig studierte „Medizinische Biotechnologie“ an der Technischen Universität Berlin und promovierte 2009 in „Viraler Immunbiologie“ an der Rockefeller University in New York. Nach einem vierjährigen Aufenthalt als Postdoc an der Yale University in New Haven, USA, kam er 2013 als Leiter der Nachwuchsgruppe „Mikrobielle Immunregulation“ ans HZI. Seit 2019 ist er Leiter der gleichnamigen Abteilung und bekam außerdem eine W3-Professur an der Medizinischen Hochschule Hannover (MHH).

Publikationen
el Mouali Y., Tawk C., Huang K.D., Amend L., Lesker T.R., Ponath F., ... , Vogel J., Strowig T. (2024)
The RNA landscape of the human commensal Segatella copri reveals a small RNA essential for gut colonization
Cell Host.Microbe
DOI: 10.1016/j.chom.2024.09.008 HZI-Repositorium PubMed
Roesner L.M., Gupta M.K., Kopfnagel V., van Unen N., Kemmling Y., Heise J., Castell S., Jiang X., Riemann L., Traidl S., Lange B., Sühs K., Illig T., Strowig T., Li Y., Förster R., Huehn J., Schulz T.F., ... , Werfel T., RESIST SI Cohort Investigators (2024)
Correction to: The RESIST Senior Individuals Cohort: Design, participant characteristics and aims (GeroScience, (2024), 10.1007/s11357-024-01299-6)
GeroScience
DOI: 10.1007/s11357-024-01380-0 HZI-Repositorium PubMed
Essex M., Pascual-Leone B.M., Löber U., Kuhring M., Zhang B., Brüning U., Fritsche-Guenther R., Krzanowski M., Fiocca Vernengo F., Brumhard S., Röwekamp I., Bielecka A., Lesker T.R., Wyler E., Landthaler M., Mantei A., Meisel C., Caesar S., Thibeault C., Corman V.M., Marko L., Suttorp N., Strowig T., Kurth F., Sander L.E., Li Y., Kirwan J.A., ... , Forslund S.K., Opitz B. (2024)
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19
npj Biofilms and Microbiomes, 10 (1)
DOI: 10.1038/s41522-024-00538-0 HZI-Repositorium PubMed
Roesner L.M., Gupta M.K., Kopfnagel V., van Unen N., Kemmling Y., Heise J.K., Castell S., Jiang X., Riemann L., Traidl S., Lange B., Sühs K.W., Illig T., Strowig T., Li Y., Förster R., Huehn J., Schulz T.F., ... , Werfel T., RESIST SI Cohort Investigators (2024)
The RESIST Senior Individuals Cohort: Design, participant characteristics and aims
GeroScience
DOI: 10.1007/s11357-024-01299-6 HZI-Repositorium PubMed
Osbelt L., Almasi E.D.H., Wende M., Kienesberger S., Voltz A., Lesker T.R., Muthukumarasamy U., Knischewski N., Nordmann E., Bielecka A.A., Giralt-Zuniga M., Kaganovitch E., Kühne C., Baier C., Pietsch M., Müsken M., Greweling-Pils M.C., Breinbauer R., Flieger A., Schlüter D., Müller R., Erhardt M., ... , Zechner E.L., Strowig T. (2024)
Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms
Nat.Microbiol.
DOI: 10.1038/s41564-024-01710-0 HZI-Repositorium PubMed
Büssing R., Bublitz A., Karge B., Brönstrup M., Strowig T., Ott I. (2024)
An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile
J.Biol.Inorg.Chem.
DOI: 10.1007/s00775-024-02064-y HZI-Repositorium PubMed
Neumann C., Blume J., Roy U., Teh P.P., Vasanthakumar A., Beller A., Liao Y., Heinrich F., Arenzana T.L., Hackney J.A., Eidenschenk C., G+ílvez E.J.C., Stehle C., Heinz G.A., Maschmeyer P., Sidwell T., Hu Y., Amsen D., Romagnani C., Chang H.D., Kruglov A., Mashreghi M.F., Shi W., Strowig T., Rutz S., ... , Kallies A., Scheffold A. (2024)
Correction to: c-Maf-dependent T(reg) cell control of intestinal T(H)17 cells and IgA establishes host-microbiota homeostasis (Nature Immunology, (2019), 20, 4, (471-481), 10.1038/s41590-019-0316-2)
Nature Immunology
DOI: 10.1038/s41590-024-01863-4 PubMed
Vialetto E., Miele S., Goren M.G., Yu J., Yu Y., Collias D., Beamud B., Osbelt L., Lourenco M., Strowig T., Brisse S., Barquist L., Qimron U., ... , Bikard D., Beisel C.L. (2024)
Systematic interrogation of CRISPR antimicrobials in Klebsiella pneumoniae reveals nuclease-, guide-and strain-dependent features influencing antimicrobial activity
Nucleic Acids Res.
DOI: 10.1093/nar/gkae281 HZI-Repositorium PubMed
Klee B., Diexer S., Horn J., Langer S., Wende M., Ortiz D., Bielecka A., Strowig T., ... , Mikolajczyk R., Gottschick C. (2024)
The impact of non-pharmaceutical interventions on community non-SARS-CoV-2 respiratory infections in preschool children
BMC Pediatrics, 24 (1)
DOI: 10.1186/s12887-024-04686-2 HZI-Repositorium PubMed
Zou M., Pezoldt J., Mohr J., Philipsen L., Leufgen A., Cerovic V., Wiechers C., Pils M., Ortiz D., Hao L., Yang J., Beckstette M., Dupont A., Hornef M., Dersch P., Strowig T., Müller A.J., ... , Raila J., Huehn J. (2024)
Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes
Cell Reports, 43 (5)
DOI: 10.1016/j.celrep.2024.114153 HZI-Repositorium PubMed
Almasi E.D.H., Knischewski N., Osbelt L., Muthukumarasamy U., el Mouali Y., Vialetto E., ... , Beisel C.L., Strowig T. (2024)
An adapted method for Cas9-mediated editing reveals the species-specific role of b
J.Bacteriol.
DOI: 10.1128/jb.00317-23 PubMed
Huang K.D., Amend L., Galvez E.J.C., Lesker T.R., de Oliveira R., Bielecka A., Blanco-Miguez A., Valles-Colomer M, Ruf I, Pasolli E, Buer J, Segata N, Esser S, ... , Strowig T, Kehrmann J (2024)
Establishment of a non-Westernized gut microbiota in men who have sex with men is associated with sexual practices
Cell Rep.Med.
DOI: 10.1016/j.xcrm.2024.101426 HZI-Repositorium PubMed
Kerlikowsky F., Müller M., Greupner T., Amend L., Strowig T., Hahn A. (2023)
Distinct Microbial Taxa Are Associated with LDL-Cholesterol Reduction after 12 Weeks of Lactobacillus plantarum Intake in Mild Hypercholesterolemia: Results of a Randomized Controlled Study
Probiotics Antimicrob.Proteins
DOI: 10.1007/s12602-023-10191-2 HZI-Repositorium PubMed
Tsakmaklis A., Farowski F., Zenner R., Lesker T.R., Strowig T., Schlößer H., Lehmann J., von Bergwelt-Baildon M., Mauch C., Schlaak M., Knuever J., Schweinsberg V., ... , Heinzerling L.M., Vehreschild M.J.G.T. (2023)
TIGIT+ NK cells in combination with specific gut microbiota features predict response to checkpoint inhibitor therapy in melanoma patients
BMC Cancer, 23 (1)
DOI: 10.1186/s12885-023-11551-5 HZI-Repositorium PubMed
Blanco-Miguez A., Galvez E.J.C., Pasolli E., De Filippis F., Amend L., Huang K.D., Manghi P., Lesker T.R., Riedel T., Cova L., Puncoochar M., Thomas A.M., Valles-Colomer M., Schober I., Hitch T.C.A., Clavel T., Berry S.E., Davies R., Wolf J., Spector T.D., Overmann J., Tett A., Ercolini D., ... , Segata N., Strowig T. (2023)
Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions
Cell Host.Microbe, 31 (11)
DOI: 10.1016/j.chom.2023.09.013 HZI-Repositorium PubMed
Ma J., Urgard E., Runge S., Classon C.H., Mathä L., Stark J.M., Cheng L., Alvarez J.A., von Zedtwitz S., Baleviciute A., Martinez Hoyer S., Li M., Gernand A.M., Osbelt L., Bielecka A.A., Lesker T.R., Huang H.J., Vrtala S., Boon L., Beyaert R., Adner M., Martinez Gonzalez I., Strowig T., Du J., Nylen S., ... , Rosshart S.P., Coquet J.M. (2023)
Laboratory mice with a wild microbiota generate strong allergic immune responses
Sci Immunol, 8 (87)
DOI: 10.1126/sciimmunol.adf7702 HZI-Repositorium PubMed
Hamad I., Van Broeckhoven J., Cardilli A., Hellings N., Strowig T., Lemmens S., ... , Hendrix S., Kleinewietfeld M. (2023)
Effects of Recombinant IL-13 Treatment on Gut Microbiota Composition and Functional Recovery after Hemisection Spinal Cord Injury in Mice
Nutrients, 15 (19)
DOI: 10.3390/nu15194184 HZI-Repositorium PubMed
Siracusa F., Schaltenberg N., Kumar Y., Lesker T.R., Steglich B., Liwinski T., Cortesi F., Frommann L., Diercks B.P., B+Ânisch F., Fischer A.W., Scognamiglio P., Pauly M.J., Casar C., Cohen Y., Pelczar P., Agalioti T., Delfs F., Worthmann A., Wahib R., Jagemann B., Mittr++cker H.W., Kretz O., Guse A.H., Izbicki J.R., Lassen K.G., Strowig T., Schweizer M., Villablanca E.J., Elinav E., Huber S., ... , Heeren J., Gagliani N. (2023)
Short-term dietary changes can result in mucosal and systemic immune depression
Nat.Immunol., 24 (9)
DOI: 10.1038/s41590-023-01587-x HZI-Repositorium PubMed
Essex M., Rios Rodriguez V, Rademacher J., Proft F., Löber U., Marko L., Pleyer U., Strowig T., Marchand J., Kirwan J.A., Siegmund B., ... , Forslund S.K., Poddubnyy D. (2023)
Spondyloarthritis, acute anterior uveitis, and Crohn's disease have both shared and distinct gut microbiota
Arthritis Rheumatol.
DOI: 10.1002/art.42658 PubMed
Harnack C., Berger H., Liu L., Mollenkopf H.J., Strowig T., Sigal M. (2023)
Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis
Gut Microbes, 15 (1)
DOI: 10.1080/19490976.2023.2233689 HZI-Repositorium PubMed
Liu X., Khalil A.E.M.M., Muthukumarasamy U., Onogi Y., Yan X., Singh I., Lopez-Gonzales E., Israel A., Serrano A.C., ... , Strowig T., Ussar S. (2023)
Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice
BMC Biol., 21 (1)
DOI: 10.1186/s12915-023-01629-8 HZI-Repositorium PubMed
Li D., Bühler M., Runft S., Gerold G., Marek K., Baumgärtner W., ... , Strowig T., Gerhauser I. (2023)
ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler's murine encephalomyelitis virus
Sci.Rep., 13 (1)
DOI: 10.1038/s41598-023-38152-3 HZI-Repositorium PubMed
Saleh D.O., Horstmann J.A., Giralt-Zuniga M., Weber W., Kaganovitch E., Durairaj A.C., Klotzsch E., ... , Strowig T., Erhardt M. (2023)
SPI-1 virulence gene expression modulates motility of Salmonella Typhimurium in a proton motive force- and adhesins-dependent manner
PLoS.Pathog., 19 (6)
DOI: 10.1371/journal.ppat.1011451 HZI-Repositorium PubMed
Lourenco M., Osbelt L., Passet V., Gravey F., Megrian D., Strowig T., ... , Rodrigues C., Brisse S. (2023)
Phages against Noncapsulated Klebsiella pneumoniae: Broader Host range, Slower Resistance
Microbiol.Spectr.
DOI: 10.1128/spectrum.04812-22 HZI-Repositorium PubMed
Gui W., Hole M.J., Molinaro A., Edlund K., Jorgensen K.K., Su H., Begher-Tibbe B., Gaßler N., Schneider C.V., Muthukumarasamy U., Mohs A., Liao L., Jaeger J., Mertens C.J., Bergheim I., Strowig T., Hengstler J.G., Hov J.R., Marschall H.U., ... , Trautwein C., Schneider K.M. (2023)
Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
Nat.Commun., 14 (1)
DOI: 10.1038/s41467-023-38840-8 HZI-Repositorium PubMed
Paschold L., Gottschick C., Langer S., Klee B., Diexer S., Aksentijevich I., Schultheiß C., Purschke O., Riese P., Trittel S., Haase R., Dressler F., Eberl W., Hübner J., Strowig T., Guzman C.A., ... , Mikolajczyk R., Binder M. (2023)
T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort
Sci.Rep., 13 (1)
DOI: 10.1038/s41598-023-36144-x HZI-Repositorium
Zhao B., Osbelt L., Lesker T.R., Wende M., Galvez E.J.C., Hönicke L., Bublitz A., Greweling-Pils M.C., Grassl G.A., ... , Neumann-Schaal M., Strowig T. (2023)
Helicobacter spp. are prevalent in wild mice and protect from lethal Citrobacterrodentium infection in the absence of adaptive immunity
Cell Rep., 42 (6)
DOI: 10.1016/j.celrep.2023.112549 HZI-Repositorium PubMed
Fuchs M., Lamm-Schmidt V., Lence T., Sulzer J., Bublitz A., Wackenreuter J., Gerovac M., ... , Strowig T., Faber F. (2023)
A network of small RNAs regulates sporulation initiation in Clostridioides difficile
EMBO J
DOI: 10.15252/embj.2022112858 HZI-Repositorium PubMed
Manghi P., Blanco-Miguez A., Manara S., NabiNejad A., Cumbo F., Beghini F., Armanini F., Golzato D., Huang K.D., Thomas A.M., Piccinno G., Puncochar M., Zolfo M., Lesker T.R., Bredon M., Planchais J., Glodt J., Valles-Colomer M., Koren O., Pasolli E., Asnicar F., Strowig T., ... , Sokol H., Segata N. (2023)
MetaPhlAn 4 profiling of unknown species-level genome bins improves the characterization of diet-associated microbiome changes in mice
Cell Rep., 42 (5)
DOI: 10.1016/j.celrep.2023.112464 HZI-Repositorium PubMed
Bublitz A., Brauer M., Wagner S., Hofer W., Müsken M., Deschner F., Lesker T.R., Neumann-Schaal M., Paul L., Nübel U., Bartel J., Kany A.M., Zühlke D., Bernecker S., Jansen R., Sievers S., Riedel K., Herrmann J., Müller R., ... , Fuchs T.M., Strowig T. (2023)
The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection
Cell Host.Microbe
DOI: 10.1016/j.chom.2023.04.003 HZI-Repositorium PubMed
Su H., Haque M., Becker S., Edlund K., Duda J., Wang Q., Marschall H.U., Candels L.S., Mohamed M., Sj+Âland W., Liao L., Drexler S.A., Strowig T., Rahnenführer J., ... , Hengstler J.G., Hatting M. (2023)
Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals
Liver International
DOI: 10.1111/liv.15587 HZI-Repositorium PubMed
Gilbert B.T.P., Lamacchia C., Amend L., Strowig T., Rodriguez E., ... , Palmer G., Finckh A. (2023)
Brief report: Assessment of mucosal barrier integrity using serological biomarkers in preclinical stages of rheumatoid arthritis
Front.Immunol., 14
DOI: 10.3389/fimmu.2023.1117742 HZI-Repositorium PubMed
Tintelnot J., Xu Y., Lesker T.R., Schönlein M., Konczalla L., Giannou A.D., Pelczar P., Kylies D., Puelles V.G., Bielecka A.A., Peschka M., Cortesi F., Riecken K., Jung M., Amend L., Bröring T.S., Trajkovic-Arsic M., Siveke J.T., Renné T., Zhang D., Boeck S., Strowig T., Uzunoglu F.G., Güngör C., Stein A., Izbicki J.R., Bokemeyer C., Sinn M., Kimmelman A.C., ... , Huber S., Gagliani N. (2023)
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Nature
DOI: 10.1038/s41586-023-05728-y HZI-Repositorium PubMed
Amend L., Gilbert B.T.P., Pelczar P., Böttcher M., Huber S., Witte T., ... , Finckh A., Strowig T. (2023)
Characterization of serum biomarkers and antibody responses against Prevotella spp. in preclinical and new-onset phase of rheumatic diseases
Front.Cell.Infect.Microbiol., 12
DOI: 10.3389/fcimb.2022.1096211 HZI-Repositorium PubMed
Collias D., Vialetto E., Yu J., Co K., Almasi E., Rüttiger A.S., Achmedov T., ... , Strowig T., Beisel C.L. (2023)
Systematically attenuating DNA targeting enables CRISPR-driven editing in bacteria
Nat.Commun., 14 (1)
DOI: 10.1038/s41467-023-36283-9 HZI-Repositorium PubMed
Giannou A.D., Kempski J., Shiri A.M., Lücke J., Zhang T., Zhao L., Zazara D.E., Cortesi F., Riecken K., Amezcua Vesely M.C., Low J.S., Xu H., Kaffe E., Garcia-Perez L., Agalioti T., Yamada Y., Jungraithmayr W., Zigmond E., Karstens K.F., Steglich B., Wagner J., Konczalla L., Carambia A., Schulze K., von Felden J., May P., Briukhovetska D., Bedke T., Brockmann L., Starzonek S., Lange T., Koch C., Riethdorf S., Pelczar P., Böttcher M., Sabihi M., Huber F.J., Reeh M., Grass J.K., Wahib R., Seese H., Stüben B.O., Fard-Aghaie M., Duprée A., Scognamiglio P., Plitzko G., Meiners J., Soukou S., Wittek A., Manthey C., Maroulis I.C., Arck P.C., Perez D., Gao B., Zarogiannis S.G., Strowig T., Pasqualini R., Arap W., Gosálvez J.S., Kobold S., Prinz I., Guse A.H., Tachezy M., Ghadban T., Heumann A., Li J., Melling N., Mann O., Izbicki J.R., Pantel K., Schumacher U., Lohse A.W., Flavell R.A., ... , Gagliani N., Huber S. (2023)
Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22
Immunity, 56 (1)
DOI: 10.1016/j.immuni.2022.12.014 HZI-Repositorium PubMed
Hankel J., Sander S., Muthukumarasamy U., Strowig T., Kamphues J., ... , Jung K., Visscher C. (2022)
Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection
Front.Vet.Sci., 9
DOI: 10.3389/fvets.2022.1004506 HZI-Repositorium PubMed
Thriene K., Stanislas V., Amend L., Strowig T., Michels K.B. (2022)
Assessment of the Gut Microbiota during Juice Fasting with and without Inulin Supplementation: A Feasibility Study in Healthy Volunteers
Foods, 11 (22)
DOI: 10.3390/foods11223673 HZI-Repositorium PubMed
Riese P., Trittel S., Akmatov M.K., May M., Prokein J., Illig T., Schindler C., Sawitzki B., Elfaki Y., Floess S., Huehn J., Blazejewski A.J., Strowig T., Hernandez-Vargas E.A., Geffers R., Zhang B., Li Y., ... , Pessler F., Guzmán C.A. (2022)
Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly
Nat.Commun., 13 (1)
DOI: 10.1038/s41467-022-34487-z HZI-Repositorium PubMed
Hankel J., Kittler S., Chuppava B., Galvez E., Strowig T., Becker A., Von Köckritz-Blickwede M., ... , Plötz M., Visscher C. (2022)
Luminal and mucosa-associated caecal microbiota of chickens after experimental Campylobacter jejuni infection in the absence of Campylobacter-specific phages of group II and III
Microb.Genomics, 8 (10)
DOI: 10.1099/mgen.0.000874 HZI-Repositorium PubMed
Afrizal A., Jennings S.A.V., Hitch T.C.A., Riedel T., Basic M., Panyot A., Treichel N., Hager F.T., Wong E.O., Wolter B., Viehof A., von Strempel A., Eberl C., Buhl E.M., Abt B., Bleich A., Tolba R., Blank L.M., Navarre W.W., Kiessling F., Horz H.P., Torow N., Cerovic V., Stecher B., Strowig T., ... , Overmann J., Clavel T. (2022)
Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities
Cell Host.Microbe
DOI: 10.1016/j.chom.2022.09.011 HZI-Repositorium PubMed
Hankel J., Chuppava B., Wilke V., Hartung C.B., Muthukumarasamy U., Strowig T., Bach Knudsen K.E., ... , Kamphues J., Visscher C. (2022)
High Dietary Intake of Rye Affects Porcine Gut Microbiota in a Salmonella Typhimurium Infection Study
Plants, 11 (17)
DOI: 10.3390/plants11172232 HZI-Repositorium PubMed
Hitch T.C.A., Bisdorf K., Afrizal A., Riedel T., Overmann J., ... , Strowig T., Clavel T. (2022)
A taxonomic note on the genus Prevotella: Description of four novel genera and emended description of the genera Hallella and Xylanibacter
Syst.Appl.Microbiol., 45 (6)
DOI: 10.1016/j.syapm.2022.126354 HZI-Repositorium PubMed
Pausder A., Mras P., Hoenicke L., Waldburg N., Lesker T.R., Schreiber J., Strowig T., ... , Boehme J.D., Bruder D. (2022)
Altered nasal microbiota in asthmatic patients is not related to changes in secretory immunity in the nasopharynx
Clin.Exp.Allergy
DOI: 10.1111/cea.14200 HZI-Repositorium PubMed
French T., Steffen J., Glas A., Osbelt L., Strowig T., Schott B.H., ... , Schüler T., Dunay I.R. (2022)
Persisting Microbiota and Neuronal Imbalance Following T. gondii Infection Reliant on the Infection Route
Front.Immunol., 13
DOI: 10.3389/fimmu.2022.920658 HZI-Repositorium PubMed
Melcher C., Yu J., Duong V.H.H., Westphal K., Helmi Siasi Farimany N., Shaverskyi A., Zhao B., Strowig T., Glage S., Brand K., Chan A.C., ... , Föger N., Lee K.H. (2022)
B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation
Cell Rep., 40 (2)
DOI: 10.1016/j.celrep.2022.111051 HZI-Repositorium PubMed
Schneider K.M., Mohs A., Gui W., Galvez E.J.C., Candels L.S., Hoenicke L., Muthukumarasamy U., Holland C.H., Elfers C., Kilic K., Schneider C.V., Schierwagen R., Strnad P., Wirtz T.H., Marschall H.U., Latz E., Lelouvier B., Saez-Rodriguez J., de Vos W., Strowig T., ... , Trebicka J., Trautwein C. (2022)
Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment
Nat.Commun., 13 (1)
DOI: 10.1038/s41467-022-31312-5 HZI-Repositorium PubMed
Lucassen A., Hankel J., Finkler-Schade C., Osbelt L., Strowig T., ... , Visscher C., Schuberth H.J. (2022)
Feeding a Saccharomyces cerevisiae Fermentation Product (Olimond BB) Does Not Alter the Fecal Microbiota of Thoroughbred Racehorses
Animals.(Basel), 12 (12)
DOI: 10.3390/ani12121496 HZI-Repositorium PubMed
Meyer F., Fritz A., Deng Z.L., Koslicki D., Lesker T.R., Gurevich A., Robertson G., Alser M., Antipov D., Beghini F., Bertrand D., Brito J.J., Brown C.T., Buchmann J., Buluc A., Chen B., Chikhi R., Clausen P.T.L.C., Cristian A., Dabrowski P.W., Darling A.E., Egan R., Eskin E., Georganas E., Goltsman E., Gray M.A., Hansen L.H., Hofmeyr S., Huang P., Irber L., Jia H., Jorgensen T.S., Kieser S.D., Klemetsen T., Kola A., Kolmogorov M., Korobeynikov A., Kwan J., LaPierre N., Lemaitre C., Li C., Limasset A., Malcher-Miranda F., Mangul S., Marcelino V.R., Marchet C., Marijon P., Meleshko D., Mende D.R., Milanese A., Nagarajan N., Nissen J., Nurk S., Oliker L., Paoli L., Peterlongo P., Piro V.C., Porter J.S., Rasmussen S., Rees E.R., Reinert K., Renard B., Robertsen E.M., Rosen G.L., Ruscheweyh H.J., Sarwal V., Segata N., Seiler E., Shi L., Sun F., Sunagawa S., Sorensen S.J., Thomas A., Tong C., Trajkovski M., Tremblay J., Uritskiy G., Vicedomini R., Wang Z., Warren A., Willassen N.P., Yelick K., You R., Zeller G., Zhao Z., Zhu S., Zhu J., Garrido-Oter R., Gastmeier P., Hacquard S., Häussler S., Khaledi A., Maechler F., Mesny F., Radutoiu S., Schulze-Lefert P., Smit N., Strowig T., Bremges A., ... , Sczyrba A., McHardy A.C. (2022)
Critical Assessment of Metagenome Interpretation: the second round of challenges
Nature Methods, 19 (4)
DOI: 10.1038/s41592-022-01431-4 HZI-Repositorium PubMed
Kini A., Zhao B., Basic M., Roy U., Iljazovic A., Odak I., Ye Z., Riederer B., Di Stefano G., Römermann D., Koenecke C., Bleich A., ... , Strowig T., Seidler U. (2022)
Upregulation of antimicrobial peptide expression in slc26a3-/- mice with colonic dysbiosis and barrier defect
Gut Microbes, 14 (1)
DOI: 10.1080/19490976.2022.2041943 HZI-Repositorium PubMed
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A versatile genetic toolbox for Prevotella copri enables studying polysaccharide utilization systems
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Muschaweck M., Kopplin L., Ticconi F., Schippers A., Iljazovic A., Galvez E.J.C., Abdallah A.T., Wagner N., Costa I.G., ... , Strowig T., Pabst O. (2021)
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Klebsiella oxytoca causes colonization resistance against multidrug-resistant K. pneumoniae in the gut via cooperative carbohydrate competition
Cell Host.Microbe
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Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
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Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells
Front.Immunol., 12
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A Central Role for Atg5 in Microbiota-Dependent Foxp3(+) RORg[gamma]t(+) Treg Cell Preservation to Maintain Intestinal Immune Homeostasis
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Hankel J., Bodmann B., Todte M., Galvez E., Strowig T., Radko D., ... , Antakli A., Visscher C. (2021)
Comparison of Chicken Cecal Microbiota after Metaphylactic Treatment or Following Administration of Feed Additives in a Broiler Farm with Enterococcal Spondylitis History
Pathogens., 10 (8)
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Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
Immunity, 54 (4)
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Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients
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Cell Mol.Immunol., 18 (5)
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Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury
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IL-17 controls central nervous system autoimmunity through the intestinal microbiome
Sci.Immunol., 6 (56)
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Iljazovic A., Amend L., Galvez E.J.C., de Oliveira R., Strowig T. (2021)
Modulation of inflammatory responses by gastrointestinal Prevotella spp. - From associations to functional studies
Int.J.Med.Microbiol., 311 (2)
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Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
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A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity
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Associations between gut microbiota and genetic risk for rheumatoid arthritis in the absence of disease: a cross-sectional study
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Galvez E.J.C., Iljazovic A., Amend L., Lesker T.R., Renault T., Thiemann S., Hao L., Roy U., Gronow A., ... , Charpentier E., Strowig T. (2020)
Distinct Polysaccharide Utilization Determines Interspecies Competition between Intestinal Prevotella spp
Cell Host.Microbe, 28 (6)
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Dürholz K., Hofmann J., Iljazovic A., Häger J., Lucas S., Sarter K., Strowig T., Bang H., Rech J., ... , Schett G., Zaiss M.M. (2020)
Dietary short-term fiber interventions in arthritis patients increase systemic scfa levels and regulate inflammation
Nutrients, 12 (10)
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Wilharm A., Brigas H.C., Sandrock I., Ribeiro M., Amado T., Reinhardt A., Demera A., Hoenicke L., Strowig T., Carvalho T., ... , Prinz I., Ribot J.C. (2020)
Correction: Microbiota-dependent expansion of testicular IL-17-producing Vg[gamma]6(+) g[gamma]d[delta]T cells upon puberty promotes local tissue immune surveillance
Mucosal.Immunol., 14 (1)
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Hankel J., El-Wahab A.A., Grone R., Keller B., Galvez E., ... , Strowig T., Visscher C. (2020)
Faecal microbiota of dogs offered a vegetarian diet with or without the supplementation of feather meal and either cornmeal, rye or fermented rye: A preliminary study
Microorg., 8 (9)
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Wilharm A., Brigas H.C., Sandrock I., Ribeiro M., Amado T., Reinhardt A., Demera A., Hoenicke L., Strowig T., Carvalho T., ... , Prinz I., Ribot J.C. (2020)
Microbiota-dependent expansion of testicular IL-17-producing Vg[gamma]6+ g[gamma]d[delta] T cells upon puberty promotes local tissue immune surveillance
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IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans
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Regulating T cell differentiation through the polyamine spermidine
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Intestinal microbiota of fattening pigs offered non-fermented and fermented liquid feed with and without the supplementation of non-fermented coarse cereals
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Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis
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Roje B., Elek A., Palada V., Bom J., Iljazovic A., Simic A., Susak L., Vilovic K., Strowig T., ... , Vlahovicek K., Terzic J. (2020)
Microbiota Alters Urinary Bladder Weight and Gene Expression
Microorganisms., 8 (3)
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Osbelt L., Thiemann S., Smit N., Lesker T.R., Schröter M., Galvez E.J.C., Schmidt-Hohagen K., Pils M.C., Mühlen S., Dersch P., Hiller K., Schluter D., ... , Neumann-Schaal M., Strowig T. (2020)
Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production
PLoS.Pathog., 16 (3)
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Lesker T.R., Durairaj A.C., Gálvez E.J.C., Lagkouvardos I., Baines J.F., Clavel T., Sczyrba A., ... , McHardy A.C., Strowig T. (2020)
An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome
Cell Rep., 30 (9)
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Bank U., Deiser K., Plaza-Sirvent C., Osbelt L., Witte A., Knop L., Labrenz R., Jänsch R., Richter F., Biswas A., Zenclussen A.C., Vivier E., Romagnani C., Kühl A.A., Dunay I.R., Strowig T., ... , Schmitz I., Schüler T. (2020)
c-FLIP is crucial for IL-7/IL-15-dependent NKp46(+) ILC development and protection from intestinal inflammation in mice
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Al-Kershi S., Bhayadia R., Ng M., Verboon L., Emmrich S., Gack L., Schwarzer A., Strowig T., ... , Heckl D., Klusmann J.H. (2019)
The stem cell-specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia
Blood Adv., 3 (24)
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Alpizar Rodriguez D., Lesker T.R., Gilbert B., Strowig T., Finckh A. (2021)
Response to: 'Non-causal association of gut microbiome on the risk of rheumatoid arthritis: a Mendelian randomisation study' by Inamo
Ann.Rheum.Dis., 80 (7)
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Wiesenborn D.S., Galvez E.J.C., Spinel L., Victoria B., Allen B., Schneider A., Gesing A., Al-Regaiey K.A., Strowig T., ... , Schäfer K.H., Masternak M.M. (2020)
The role of Ames dwarfism and calorie restriction on gut microbiota
J.Gerontol.A Biol.Sci.Med.Sci., 75 (7)
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Hankel J., Jung K., Kuder H., Keller B., Keller C., Galvez E., ... , Strowig T., Visscher C. (2019)
Caecal Microbiota of Experimentally Campylobacter jejuni-Infected Chickens at Different Ages
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Lipinski S., Pfeuffer S., Arnold P., Treitz C., Aden K., Ebsen H., Falk-Paulsen M., Gisch N., Fazio A., Kuiper J., Luzius A., Billmann-Born S., Schreiber S., Nunez G., Beer H.D., Strowig T., Lamkanfi M., ... , Tholey A., Rosenstiel P. (2019)
Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles
EMBO J., 38 (20)
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Strowig T., Thiemann S., Diefenbach A. (2018)
Microbiome and gut immunity: Innate immune cells
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Liao L., Schneider K.M., Galvez E.J.C., Frissen M., Marschall H.U., Su H., Hatting M., Wahlström A., Haybaeck J., Puchas P., Mohs A., Peng J., Bergheim I., Nier A., Hennings J., Reissing J., Zimmermann H.W., Longerich T., Strowig T., Liedtke C., ... , Cubero F.J., Trautwein C. (2019)
Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis
GUT, 68 (8)
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Visscher C., Hankel J., Nies A., Keller B., Galvez E., Strowig T., ... , Keller C., Breves G. (2019)
Performance, Fermentation Characteristics and Composition of the Microbiome in the Digest of Piglets Kept on a Feed With Humic Acid-Rich Peat
Front Vet.Sci., 6 (Febrary)
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Mamareli P., Kruse F., Friedrich C., Smit N., Strowig T., ... , Sparwasser T., Lochner M. (2019)
Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile
Eur.J.Immunol, 49 (5)
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Neumann C., Blume J., Roy U., Teh P.P., Vasanthakumar A., Beller A., Liao Y., Heinrich F., Arenzana T.L., Hackney J.A., Eidenschenk C., Gálvez E.J.C., Stehle C., Heinz G.A., Maschmeyer P., Sidwell T., Hu Y., Amsen D., Romagnani C., Chang H.D., Kruglov A., Mashreghi M.F., Shi W., Strowig T., Rutz S., ... , Kallies A., Scheffold A. (2019)
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Lagkouvardos I., Lesker T.R., Hitch T.C.A., Gálvez E.J.C., Smit N., Neuhaus K., Wang J., Baines J.F., Abt B., Stecher B., Overmann J., ... , Strowig T., Clavel T. (2019)
Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family
Microbiome, 7 (1)
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Alpizar-Rodriguez D., Lesker T.R., Gronow A., Gilbert B., Raemy E., Lamacchia C., Gabay C., ... , Finckh A., Strowig T. (2019)
Prevotella copri in individuals at risk for rheumatoid arthritis
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Mathies F., Steffens N., Kleinschmidt D., Stuhlmann F., Huber F.J., Roy U., Meyer T., Luetgehetmann M., von Petersdorff M., Seiz O., Herkel J., Schramm C., Flavell R.A., Gagliani N., Krebs C., Panzer U., Abdullah Z., Strowig T., ... , Bedke T., Huber S. (2018)
Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3(+) Regulatory T Cells
J.Immunol., 201 (12)
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Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes
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The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice
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Chronic D-serine supplementation impairs insulin secretion
Molecular Metabolism, 15 (September)
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Just S., Mondot S., Ecker J., Wegner K., Rath E., Gau L., Streidl T., Hery-Arnaud G., Schmidt S., Lesker T.R., Bieth V., Dunkel A., Strowig T., Hofmann T., Haller D., Liebisch G., ... , Rohn S., Lepage P. (2018)
The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism
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Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation
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Elinav E., Henao-Mejia J., Strowig T., Flavell R. (2018)
NLRP6 and Dysbiosis: Avoiding the Luring Attraction of Over-Simplification
Immunity, 48 (4)
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Heine W., Beckstette M., Heroven A.K., Thiemann S., Heise U., Nuss A.M., Pisano F., ... , Strowig T., Dersch P. (2018)
Loss of CNFY toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency
PLoS.Pathog., 14 (2)
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Galvez E.J.C., Iljazovic A., Gronow A., Flavell R., Strowig T. (2017)
Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure
Cell Rep., 21 (13)
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Lucas S., Omata Y., Hofmann J., Bottcher M., Iljazovic A., Sarter K., Albrecht O., Schulz O., Krishnacoumar B., Kronke G., Herrmann M., Mougiakakos D., Strowig T., ... , Schett G., Zaiss M.M. (2018)
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
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Herndler-Brandstetter D., Shan L., Yao Y., Stecher C., Plajer V., Lietzenmayer M., Strowig T., de Zoete M.R., Palm N.W., Chen J., Blish C.A., Frleta D., Gurer C., Macdonald L.E., Murphy A.J., Yancopoulos G.D., ... , Montgomery R.R., Flavell R.A. (2017)
Humanized mouse model supports development, function, and tissue residency of human natural killer cells
Proc.Natl.Acad.Sci.U.S.A., 114 (45)
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Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells
Cell Reports, 21 (4)
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Fabiani F.D., Renault T.T., Peters B., Dietsche T., Galvez E.J.C., Guse A., Freier K., Charpentier E., Strowig T., Franz-Wachtel M., Macek B., Wagner S., ... , Hensel M., Erhardt M. (2017)
A flagellum-specific chaperone facilitates assembly of the core type III export apparatus of the bacterial flagellum
PLoS Biol., 15 (8)
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Blazejewski A.J., Thiemann S., Schenk A., Pils M.C., Galvez E.J.C., Roy U., Heise U., de Zoete M.R., ... , Flavell R.A., Strowig T. (2017)
Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation
Cell Rep., 19 (11)
DOI: 10.1016/j.celrep.2017.05.058 HZI-Repositorium PubMed
Thiemann S., Smit N., Roy U., Lesker T.R., Galvez E.J.C., Helmecke J., Basic M., Bleich A., Goodman A.L., Kalinke U., Flavell R.A., ... , Erhardt M., Strowig T. (2017)
Enhancement of IFNgamma Production by Distinct Commensals Ameliorates Salmonella-Induced Disease
Cell Host.Microbe, 21 (6)
DOI: 10.1016/j.chom.2017.05.005 HZI-Repositorium PubMed
Friedrich C., Mamareli P., Thiemann S., Kruse F., Wang Z., Holzmann B., Strowig T., ... , Sparwasser T., Lochner M. (2017)
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium
PLoS Pathog., 13 (5)
DOI: 10.1371/journal.ppat.1006357 HZI-Repositorium PubMed
Rueckert C., Rand U., Roy U., Kasmapour B., Strowig T., Guzmán C.A. (2017)
Cyclic dinucleotides modulate induced type I IFN responses in innate immune cells by degradation of STING
FASEB J., 31 (7)
DOI: 10.1096/fj.201601093R PubMed
Yu H., Borsotti C., Schickel J.N., Zhu S., Strowig T., Eynon E.E., Frleta D., Gurer C., Murphy A.J., Yancopoulos G.D., Meffre E., ... , Manz M.G., Flavell R.A. (2017)
A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production
Blood, 129 (8)
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Horstmann J.A., Zschieschang E., Truschel T., de Diego J., Lunelli M., Rohde M., May T., Strowig T., Stradal T., ... , Kolbe M., Erhardt M. (2017)
Flagellin phase-dependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonization
Cell Microbiol., 19 (8)
DOI: 10.1111/cmi.12739 HZI-Repositorium PubMed
Hu B., Jin C., Li H.B., Tong J., Ouyang X., Cetinbas N.M., Zhu S., Strowig T., Lam F.C., Zhao C., Henao-Mejia J., Yilmaz O., Fitzgerald K.A., Eisenbarth S.C., ... , Elinav E., Flavell R.A. (2016)
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
Science, 354 (6313)
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Pelczar P., Witkowski M., Perez L.G., Kempski J., Hammel A.G., Brockmann L., Kleinschmidt D., Wende S., Haueis C., Bedke T., Witkowski M., Krasemann S., Steurer S., Booth C.J., Busch P., König A., Rauch U., Benten D., Izbicki J.R., Rösch T., Lohse A.W., Strowig T., Gagliani N., ... , Flavell R.A., Huber S. (2016)
A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease
Science, 354 (6310)
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Thiemann S., Smit N., Strowig T. (2016)
Antibiotics and the Intestinal Microbiome : Individual Responses, Resilience of the Ecosystem, and the Susceptibility to Infections
Curr Top.Microbiol.Immunol., 398 (6)
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Rausch P., Basic M., Batra A., Bischoff S.C., Blaut M., Clavel T., Glasner J., Gopalakrishnan S., Grassl G.A., Gunther C., Haller D., Hirose M., Ibrahim S., Loh G., Mattner J., Nagel S., Pabst O., Schmidt F., Siegmund B., Strowig T., Volynets V., Wirtz S., Zeissig S., Zeissig Y., ... , Bleich A., Baines J.F. (2016)
Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities
Int.J Med.Microbiol., 306 (5)
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Finethy R., Jorgensen I., Haldar A.K., de Zoete M.R., Strowig T., Flavell R.A., Yamamoto M., Nagarajan U.M., ... , Miao E.A., Coers J. (2015)
Guanylate Binding Proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages
Infect.Immun., 83
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Wynosky-Dolfi M.A., Snyder A.G., Philip N.H., Doonan P.J., Poffenberger M.C., Avizonis D., Zwack E.E., Riblett A.M., Hu B., Strowig Till, Flavell R.A., Jones R.G., ... , Freedman B.D., Brodsky I.E. (2014)
Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome
Journal of Experimental Medicine, 211 (4)

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