Prof. Dr. Ulrich Kalinke

Prof. Dr. Ulrich Kalinke
Forschungsgruppenleiter

Ulrich Kalinke studierte Biologie in Hannover und promovierte am Deutschen Krebsforschungszentrum in Heidelberg (DKFZ). Während seiner PostDoc-Zeit forschte er – gefördert von einem DFG-Stipendium – in der Schweiz bei Rolf Zinkernagel am Institut für Experimentelle Immunologie des Universitätshospitals Zürich. Im Jahr 1998 wechselte Ulrich Kalinke an das European Molecular Biology Laboratory (EMBL) im italienischen Monterontondo bei Rom und leitete dort die „Anti-Viral Defense Group“.

Im Jahr 2002 erhielt er einen Ruf als Professor und Direktor der Abteilung Immunologie am Paul-Ehrlich-Institut in Langen. Dort war für alle regulatorischen Aspekte therapeutischer Impfstoffe sowie monoklonaler- und polyklonaler Antikörper verantwortlich. Weiterhin leitete er eine Forschergruppe, die sich mit anti-viralen Immunantworten beschäftigte.

Seit 2008 ist er Geschäftsführender Direktor des TWINCORE und leitet dort das Institut für Experimentelle Infektionsforschung. Ziel von TWINCORE ist es, zusammen mit Forschern des HZI in Braunschweig und der MHH in Hannover ein translationales Forschungsprogramm zu etablieren.

Publikationen
Fneish Z., Becker J., Mulenge F., Fneish F., Costa B., Traidl-Hoffmann C., ... , Gilles S., Kalinke U. (2024)
Birch pollen-induced signatures in dendritic cells are maintained upon additional cytomegalovirus exposure
Gene, 927

Santamorena M.M., Tischer-Zimmermann S., Bonifacius A., Mireisz C.N.-M., Costa B., Khan F., Kulkarni U., Lauruschkat C.D., Sampaio K.L., Stripecke R., Blasczyk R., Maecker-Kolhoff B., Kraus S., Schlosser A., Cicin-Sain L., ... , Kalinke U., Eiz-Vesper B. (2024)
Engineered HCMV-infected APCs enable the identification of new immunodominant HLA-restricted epitopes of anti-HCMV T-cell immunity
HLA, 103 (6)

Bruhn M., Obara M., Salam A., Costa B., Ziegler A., Waltl I., Pavlou A., Hoffmann M., Graalmann T., Pöhlmann S., ... , Schambach A., Kalinke U. (2024)
Diversification of the VH3-53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS-CoV-2 virus variants
European Journal of Immunology

Bruhn M., Spatz M., Kalinke U. (2024)
MORITS: An improved method to predict peptides from heterologous proteins that are recognized by the same T-cell receptor
Scientific Reports, 14 (1)

Krueger M.B., Bonifacius A., Dragon A.C., Santamorena M.M., Nashan B., Taubert R., Kalinke U., Maecker-Kolhoff B., ... , Blasczyk R., Eiz-Vesper B. (2024)
In Vitro Profiling of Commonly Used Post-transplant Immunosuppressants Reveals Distinct Impact on Antiviral T-cell Immunity Towards CMV
Transplant International, 37

Passos V., Henkel L.M., Wang J., Zapatero-Belinchon F.J., Möller R., Sun G., Waltl I., Schneider T., Wachs A., Ritter B., Kropp K.A., Zhu S., Deleidi M., Kalinke U., Schulz T.F., Höglinger G., Gerold G., ... , Wegner F., Viejo-Borbolla A. (2024)
Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons
Journal of Medical Virology, 96 (2)

Costa B., Becker J., Krammer T., Mulenge F., Duran V., Pavlou A., Gern O.L., Chu X., Li Y., Cicin-Sain L., Eiz-Vesper B., Messerle M., Dölken L., Saliba A.E., ... , Erhard F., Kalinke U. (2024)
Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells
Nat.Commun., 15 (1)

Chiyyeadu A., Asgedom G., Bruhn M., Rocha C., Schlegel T.U., Neumann T., Galla M., Barbosa P.V., Hoffmann M., Ehrhardt K., Ha T.C., Morgan M., Schoeder C.T., Pöhlmann S., ... , Kalinke U., Schambach A. (2024)
A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants
Clin.Immunol.

Manoharan J., Rana R., Kuenze G., Gupta D., Elwakiel A., Ambreen S., Wang H., Banerjee K., Zimmermann S., Singh K., Gupta A., Fatima S., Kretschmer S., Schaefer L., Zeng-Brouwers J., Schwab C., Al-Dabet M.M., Gadi I., Altmann H., Koch T., Poitz D.M., Baber R., Kohli S., Shahzad K., Geffers R., Lee-Kirsch M.A., Kalinke U., Meiler J., ... , Mackman N., Isermann B. (2024)
Tissue factor binds to and inhibits interferon-a[alpha] receptor 1 signaling
Immunity., 57 (1)

Bruhn M., Obara M., Chiyyeadu A., Costa B., Salam A., Ziegler A., Waltl I., Pavlou A., Bonifacius A., Hoffmann M., Graalmann T., Pöhlmann S., Eiz-Vesper B., ... , Schambach A., Kalinke U. (2024)
Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation
J.Infect.

Camarao A.A.R., Gern O.L., Stegmann F., Mulenge F., Costa B., Saremi B., Jung K., Lepenies B., ... , Kalinke U., Steffen I. (2023)
Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions
Microbiol.Spectr.

Harit K., Bhattacharjee R., Matuschewski K., Becker J., Kalinke U., ... , Schlüter D., Nishanth G. (2023)
The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2
Cell Death Dis., 14 (7)

Schröder L.J., Mulenge F., Pavlou A., Skripuletz T., Stangel M., ... , Gudi V., Kalinke U. (2023)
Dynamics of reactive astrocytes fosters tissue regeneration after cuprizone-induced demyelination
Glia

Barends M., Koller N., Schölz C., Duran V., Bosnjak B., Becker J., Döring M., Blees H., Förster R., ... , Kalinke U., Tampe R. (2023)
Dynamic interactome of the MHC I peptide loading complex in human dendritic cells
Proc.Natl.Acad.Sci.U.S.A, 120 (25)

Angelova A., Pierrard K., Detje C.N., Santiago E., Grewenig A.l, Nüesch J.P.F., Kalinke U., Ungerechts G., ... , Rommelaere J., Daeffler L. (2023)
Oncolytic Rodent Protoparvoviruses Evade a TLR- and RLR-Independent Antiviral Response in Transformed Cells
Pathogens., 12 (4)

Tischer-Zimmermann S., Bonifacius A., Santamorena M.M., Mausberg P., Stoll S., Döring M., Kalinke U., Blasczyk R., ... , Maecker-Kolhoff B., Eiz-Vesper B. (2023)
Reinforcement of cell-mediated immunity driven by tumor-associated Epstein-Barr virus (EBV)-specific T cells during targeted B-cell therapy with rituximab
Frontiers in Immunology, 14

Bühler M., Li D., Li L., Runft S., Waltl I., Pavlou A., Kalinke U., Ciurkiewicz M., Huehn J., Floess S., Beineke A., ... , Baumgärtner W., Gerhauser I. (2023)
IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL/6 mice infected with Theiler's murine encephalomyelitis virus
J.Neuroinflamm., 20 (1)

Schwerk J., Kemper L., Bussey K.A., Lienenklaus S., Weiss S., Cicin-Sain L., Kröger A., Kalinke U., Collins C.M., Speck S.H., Messerle M., Wirth D., Brinkmann M.M., ... , Hauser H., Köster M. (2022)
Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo
Pathogens, 11 (12)

Michaely L.M., Schuwerk L., Allnoch L., Schön K., Waltl I., Larsen P.K., Pavlou A., Prajeeth C.K., Rimmelzwaan G.F., Becker S.C., Kalinke U., ... , Baumgärtner W., Gerhauser I. (2022)
Intact Type I Interferon Receptor Signaling Prevents Hepatocellular Necrosis but Not Encephalitis in a Dose-Dependent Manner in Rift Valley Fever Virus Infected Mice
Int.J.Mol.Sci., 23 (20)

Koller N., Höllthaler P., Barends M., Döring M., Spahn C., Durán V., Costa B., Becker J., Heilemann M., ... , Kalinke U., Tampé R. (2022)
Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells
Cell.Mol.Life Sci., 79 (9)

Fneish Z., Becker J., Mulenge F., Costa B., Krajewski L., Duran V., Ziegler A., Sommer V., Traidl-Hoffmann C., ... , Gilles S., Kalinke U. (2022)
Birch pollen extract enhances human cytomegalovirus replication in monocyte-derived dendritic cells
Allergy

Pais T.F., Ali H., Moreira da Silva J., Duarte N., Neres R., Chhatbar C., Acúrcio R.C., Guedes R.C., Strano Moraes M.C., Costa-Silva B., ... , Kalinke U., Penha-Goncalves C. (2022)
Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response
Proc.Natl.Acad.Sci.U.S.A, 119 (36)

Lu D., Chatterjee S., Xiao K., Riedel I., Huang C.K., Costa A., Cushman S., Neufeldt D., Rode L., Schmidt A., Juchem M., Leonardy J., Büchler G., Blume J., Gern O.L., Kalinke U., Tan W.L.W., Foo R., Vink A., van Laake L.W., van der Meer P., ... , Bär C., Thum T. (2022)
A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity
Eur.Heart J.

Tsay H.C., Yuan Q., Balakrishnan A., Kaiser M., Möbus S., Kozdrowska E., Farid M., Tegtmeyer P.K., Borst K., Vondran F.W.R., Kalinke U., Kispert A., Manns M.P., ... , Ott M., Sharma A.D. (2022)
Corrigendum to: Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis [J Hepatol (2019) 722-734] (Journal of Hepatology (2019) 722-734, (S0168827818326357), (10.1016/j.jhep.2018.12.016))
Journal of Hepatology

Knop L., Spanier J., Larsen P.K., Witte A., Bank U., Dunay I.R., ... , Kalinke U., Schüler T. (2022)
IFNAR signaling in fibroblastic reticular cells can modulate CD8+ memory fate decision
European Journal of Immunology

Yang X., Ali S., Zhao M., Richter L., Schäfer V., Schliehe-Diecks J., Frank M., Qi J., Larsen P.K., Skerra J., Islam H., Wachtmeister T., Alter C., Huang A., Bhatia S., Köhrer K., Kirschning C., Weighardt H., Kalinke U., Kalscheuer R., ... , Uhrberg M., Scheu S. (2022)
The Mycotoxin Beauvericin Exhibits Immunostimulatory Effects on Dendritic Cells via Activating the TLR4 Signaling Pathway
Front Immunol., 13

Becker J., Kalinke U. (2022)
Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19
EMBO J.

Kalinke U., Barouch D.H., Rizzi R., Lagkadinou E., Türeci Ö, ... , Pather S., Neels P. (2022)
Clinical development and approval of COVID-19 vaccines
Expert.Rev.Vaccines.

Bühler M., Runft S., Li D., Götting J., Detje C.N., Nippold V., Stoff M., Beineke A., Schulz T., Kalinke U., ... , Baumgärtner W., Gerhauser I. (2022)
IFN- b
Front.Immunol., 13

Waltl I., Kalinke U. (2022)
Beneficial and detrimental functions of microglia during viral encephalitis
Trends Neurosci., 45 (2)

Demoulins T., Baron M.L., Gauchat D., Kettaf N., Reed S.J., Charpentier T., Kalinke U., Lamarre A., Ahmed R., Sékaly R.P., ... , Sarkar S., Kalia V. (2022)
Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection
Virology, 567 (2)

Pezoldt J., Wiechers C., Erhard F., Rand U., Bulat T., Beckstette M., Brendolan A., Hühn J., Kalinke U., Mueller M., Strobl B., Deplancke B., ... , Cicin-Sain L., Sitnik K.M. (2021)
Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection
Commun.Biolog., 4 (1)

Gussarow D., Bonifacius A., Cossmann A., Stankov M.V., Mausberg P., Tischer-Zimmermann S., Gödecke N., Kalinke U., Behrens G.M.N., ... , Blasczyk R., Eiz-Vesper B. (2021)
Long-Lasting Immunity Against SARS-CoV-2: Dream or Reality?
Front Med.(Lausanne), 8

Gern O.L., Mulenge F., Pavlou A., Ghita L., Steffen I., ... , Stangel M., Kalinke U. (2021)
Toll-like receptors in viral encephalitis
Viruses, 13 (10)

Ghita L., Breitkopf V., Mulenge F., Pavlou A., Gern O.L., Durán V., Prajeeth C.K., Kohls M., Jung K., Stangel M., ... , Steffen I., Kalinke U. (2021)
Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes
J.Neurosci.Res.

Graalmann T., Borst K., Manchanda H., Vaas L., Bruhn M., Graalmann L., Köster M., Verboom M., Hallensleben M., Guzmán C.A., Sutter G., Schmidt R.E., ... , Witte T., Kalinke U. (2021)
B cell depletion impairs vaccination-induced CD8+T cell responses in a type i interferon-dependent manner
Annals of the Rheumatic Diseases

Ghita L., Spanier J., Chhatbar C., Mulenge F., Pavlou A., Larsen P.K., Waltl I., Lueder Y., Kohls M., Jung K., Best S.M., Forster R., Stangel M., ... , Schreiner D., Kalinke U. (2021)
MyD88 signaling by neurons induces chemokines that recruit protective leukocytes to the virus-infected CNS
Science Immunology, 6 (60)

Iampietro M., Dumont C., Mathieu C., Spanier J., Robert J., Charpenay A., Dupichaud S., Dhondt K.P., Aurine N., Pelissier R., Ferren M., Mely S., Gerlier D., ... , Kalinke U., Horvat B. (2021)
Activation of cGAS/STING pathway upon paramyxovirus infection
iScience, 24 (6)

Duran V., Grabski E., Hozsa C., Becker J., Yasar H., Monteiro J.T., Costa B., Koller N., Lueder Y., Wiegmann B., Brandes G., Kaever V., Lehr C.M., Lepenies B., Tampé R., Förster R., Bosnjak B., Furch M., ... , Graalmann T., Kalinke U. (2021)
Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells
J.Control Release, 334

Krenn V., Bosone C., Burkard T.R., Spanier J., Kalinke U., Calistri A., Salata C., Rilo Christoff R., Pestana Garcez P., ... , Mirazimi A., Knoblich J.A. (2021)
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly
Cell Stem Cell

Seelbinder B., Wallstabe J., Marischen L., Weiss E., Wurster S., Page L., Löffler C., Bussemer L., Schmitt A.L., Wolf T., Linde J., Cicin-Sain L., Becker J., Kalinke U., Vogel J., Panagiotou G., Einsele H., Westermann A.J., ... , Schäuble S., Loeffler J. (2020)
Triple RNA-Seq Reveals Synergy in a Human Virus-Fungus Co-infection Model
Cell Rep., 33 (7)

Vardi A., Ben-Dor S., Cho S.M., Kalinke U., Spanier J., Futerman A.H. (2020)
Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease
J Neuroinflammation, 17 (1)

Elsner C., Ponnurangam A., Kazmierski J., Zillinger T., Jansen J., Todt D., Döhner K., Xu S., Ducroux A., Kriedemann N., Malassa A., Larsen P.K., Hartmann G., Barchet W., Steinmann E., Kalinke U., ... , Sodeik B., Goffinet C. (2020)
Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells
Proc.Natl.Acad.Sci.U.S.A, 117 (32)

Gamrekelashvili J., Kapanadze T., Sablotny S., Ratiu C., Dastagir K., Lochner M., Karbach S., Wenzel P., Sitnow A., Fleig S., Sparwasser T., Kalinke U., Holzmann B., ... , Haller H., Limbourg F.P. (2020)
Notch and TLR signaling coordinate monocyte cell fate and inflammation
eLife, 9

Hosseini S., Michaelsen-Preusse K., Grigoryan G., Chhatbar C., Kalinke U., Korte M. (2020)
Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS
Cell Rep., 31 (7)

Schaupp L., Muth S., Rogell L., Kofoed-Branzk M., Melchior F., Lienenklaus S., Ganal-Vonarburg S.C., Klein M., Guendel F., Hain T., Schütze K., Grundmann U., Schmitt V., Dorsch M., Spanier J., Larsen P.K., Schwanz T., Jäckel S., Reinhardt C., Bopp T., Danckwardt S., Mahnke K., Heinz G.A., Mashreghi M.F., Durek P., Kalinke U., Kretz O., Huber T.B., Weiss S., Wilhelm C., Macpherson A.J., Schild H., ... , Diefenbach A., Probst H.C. (2020)
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells
Cell, 181 (5)

Haake K., Neehus A.L., Buchegger T., Kühnel M.P., Blank P., Philipp F., Oleaga-Quintas C., Schulz A., Grimley M., Goethe R., Jonigk D., Kalinke U., Boisson-Dupuis S., Casanova J.L., ... , Bustamante J., Lachmann N. (2020)
Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-gamma Responsive Pathway
Cells, 9 (2)

Borst K., Flindt S., Blank P., Larsen P.K., Chhatbar C., Skerra J., Spanier J., Hirche C., König M., Alanentalo T., Hafner M., Waibler Z., Pfeffer K., Sexl V., Sutter G., Müller W., ... , Graalmann T., Kalinke U. (2020)
Selective reconstitution of IFNgamma gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection
PLoS.Pathog., 16 (2)

Knop L., Deiser K., Bank U., Witte A., Mohr J., Philipsen L., Fehling H.J., Müller A.J., ... , Kalinke U., Schüler T. (2020)
IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival
Eur.J.Immunol., 50 (6)

Mulas F., Wang X., Song S., Nishanth G., Yi W., Brunn A., Larsen P.K., Isermann B., Kalinke U., Barragan A., Naumann M., ... , Deckert M., Schlüter D. (2020)
The deubiquitinase OTUB1 augments NF-k[kappa]B-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13
Cell.Mol.Immunol

Forster D., Schwarz J.H., Brosinski K., Kalinke U., Sutter G., Volz A. (2020)
Obstetric ultrasonography to detect fetal abnormalities in a mouse model for Zika virus infection
Viruses, 12 (1)

Namineni S., O'Connor T., Faure-Dupuy S., Johansen P., Riedl T., Liu K., Xu H., Singh I., Shinde P., Li F., Pandyra A., Sharma P., Ringelhan M., Muschaweckh A., Borst K., Blank P., Lampl S., Durantel D., Farhat R., Weber A., Lenggenhager D., Kündig T.M., Staeheli P., Protzer U., Wohlleber D., Holzmann B., Binder M., Breuhahn K., Assmus L.M., Nattermann J., Abdullah Z., Rolland M., Dejardin E., Lang P.A., Lang K.S., Karin M., Lucifora J., Kalinke U., ... , Knolle P.A., Heikenwalder M. (2020)
A dual role for hepatocyte-intrinsic canonical NF-kappaB signaling in virus control
J.Hepatol., 72 (5)

Kalodimou G., Veit S., Jany S., Kalinke U., Broder C.C., ... , Sutter G., Volz A. (2019)
A Soluble Version of Nipah Virus Glycoprotein G Delivered by Vaccinia Virus MVA Activates Specific CD8 and CD4 T Cells in Mice
Viruses., 12 (1)

Iampietro M., Aurine N., Dhondt K.P., Dumont C., Pelissier R., Spanier J., Vallve A., Raoul H., ... , Kalinke U., Horvat B. (2020)
Control of Nipah Virus Infection in Mice by the Host Adaptors Mitochondrial Antiviral Signaling Protein (MAVS) and Myeloid Differentiation Primary Response 88 (MyD88)
J.Infect.Dis., 221 (Supplement_4)

Hensel N., Raker V., Forthmann B., Detering N.T., Kubinski S., Buch A., Katzilieris-Petras G., Spanier J., Gudi V., Wagenknecht S., Kopfnagel V., Werfel T.A., Stangel M., Beineke A., Kalinke U., Paludan S.R., ... , Sodeik B., Claus P. (2019)
HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0
J.Neuroinflammation., 16 (1)

Lercher A., Bhattacharya A., Popa A.M., Caldera M., Schlapansky M.F., Baazim H., Agerer B., Gurtl B., Kosack L., Majek P., Brunner J.S., Vitko D., Pinter T., Genger J.W., Orlova A., Pikor N., Reil D., Ozsvar-Kozma M., Kalinke U., Ludewig B., Moriggl R., Bennett K.L., Menche J., Cheng P.N., Schabbauer G., Trauner M., ... , Klavins K., Bergthaler A. (2019)
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function
Immunity., 51 (6)

Ziegler A., Hinz T., Kalinke U. (2019)
RNA-based adjuvants: Immunoenhancing effect on antiviral vaccines and regulatory considerations
Crit.Rev.Immunol., 39 (1)

Durán V., Yasar H., Becker J., Thiyagarajan D., Loretz B., ... , Kalinke U., Lehr C.M. (2019)
Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells
Nanomed.Nanotechnol.Biol.Med., 21

Tegtmeyer P.K., Spanier J., Borst K., Becker J., Riedl A., Hirche C., Ghita L., Skerra J., Baumann K., Lienenklaus S., Doering M., ... , Ruzsics Z., Kalinke U. (2019)
STING induces early IFN-b[beta] in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
Nat.Commun., 10 (1)

Borst K., Graalmann T., Kalinke U. (2019)
Reply to: "Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers"
J.Hepatol., 71 (3)

Ruangkiattikul N., Rys D., Abdissa K., Rohde M., Semmler T., Tegtmeyer P.K., Kalinke U., Schwarz C., ... , Lewin A., Goethe R. (2019)
Type I interferon induced by TLR2-TLR4-MyD88-TRIF-IRF3 controls Mycobacterium abscessus subsp. abscessus persistence in murine macrophages via nitric oxide
Int.J.Med.Microbiol., 309 (5)

Solmaz G., Puttur F., Francozo M., Lindenberg M., Guderian M., Swallow M., Duhan V., Khairnar V., Kalinke U., Ludewig B., Clausen B.E., Wagner H., ... , Lang K.S., Sparwasser T.D. (2019)
TLR7 Controls VSV Replication in CD169 + SCS Macrophages and Associated Viral Neuroinvasion
Front Immunol, 10

Heidegger S., Kreppel D., Bscheider M., Stritzke F., Nedelko T., Wintges A., Bek S., Fischer J.C., Graalmann T., Kalinke U., Bassermann F., ... , Haas T., Poeck H. (2019)
RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade
EBioMedicine, 41 (March)

Döring M., Blees H., Koller N., Tischer-Zimmermann S., Müsken M., Henrich F., Becker J., Grabski E., Wang J., Janssen H., Zuschratter W., Neefjes J., Klawonn F., Eiz-Vesper B., ... , Tampe R., Kalinke U. (2019)
Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation
Blood Adv., 3 (6)

Knop L., Frommer C., Stoycheva D., Deiser K., Kalinke U., Blankenstein T., Kammertoens T., ... , Dunay I.R., Schuler T. (2019)
Interferon-gamma Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4(+) T Cells in Chronic Lymphopenic Mice
Front Immunol, 10

Gawish R., Bulat T., Biaggio M., Lassnig C., Bago-Horvath Z., Macho-Maschler S., Poelzl A., Simonovic N., Prchal-Murphy M., Rom R., Amenitsch L., Ferrarese L., Kornhoff J., Lederer T., Svinka J., Eferl R., Bosmann M., Kalinke U., Stoiber D., Sexl V., Krmpotic A., Jonjic S., ... , Müller M., Strobl B. (2019)
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1
Cell Rep., 26 (9)

Borst K., Graalmann T., Kalinke U. (2019)
Reply to: "Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation"
J.Hepatol., 70 (4)

Tsay H.C., Yuan Q., Balakrishnan A., Kaiser M., Möbus S., Kozdrowska E., Farid M., Tegtmeyer P.K., Borst K., Vondran F.W.R., Kalinke U., Kispert A., Manns M.P., ... , Ott M., Sharma A.D. (2019)
Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis
J.Hepatol., 70 (4)

Becker J., Kinast V., Döring M., Lipps C., Duran V., Spanier J., Tegtmeyer P.K., Wirth D., Cicin-Sain L., ... , Alcami A., Kalinke U. (2018)
Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines
Virulence., 9 (1)

Pägelow D., Chhatbar C., Beineke A., Liu X., Nerlich A., van Vorst K., Rohde M., Kalinke U., Förster R., Halle S., Valentin-Weigand P., ... , Hornef M.W., Fulde M. (2018)
The olfactory epithelium as a port of entry in neonatal neurolisteriosis
Nat Commun, 9 (1)

Tappe K.A., Budida R., Stankov M.V., Frenz T., Shah H., Volz A., Sutter G., ... , Kalinke U., Behrens G.M.N. (2018)
Immunogenic cell death of dendritic cells following modified vaccinia virus Ankara infection enhances CD8(+) T cell proliferation
Eur.J.Immunol.

Waltl I., Käufer C., Gerhauser I., Chhatbar C., Ghita L., ... , Kalinke U., Löscher W. (2018)
Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage
Brain Behav.Immun., 74

Käufer C., Chhatbar C., Bröer S., Waltl I., Ghita L., Gerhauser I., ... , Kalinke U., Löscher W. (2018)
Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures
Proc.Natl.Acad.Sci.U.S.A, 115 (38)

Koestner W., Spanier J., Klause T., Tegtmeyer P.K., Becker J., Herder V., Borst K., Todt D., Lienenklaus S., Gerhauser I., Detje C.N., Geffers R., Langereis M.A., Vondran F.W.R., Yuan Q., van Kuppeveld F.J.M., Ott M., Staeheli P., Steinmann E., Baumgärtner W., ... , Wacker F., Kalinke U. (2018)
Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice
PLoS.Pathog., 14 (8)

Paijo J., Kaever V., Kalinke U. (2017)
cGAMP quantification in virus-infected human monocyte-derived cells by HPLC-coupled tandem mass spectroscopy
Methods in Molecular Biology, 1656 (chapter 9)

Herzmann C., Dallenga T., Kalinke U. (2018)
Pulmonale Immunität bei Tuberkulose [Pulmonary Immune Mechanisms in Tuberculosis]
Pneumologie, 72 (7)

Vendelova E., Ashour D., Blank P., Erhard F., Saliba A.E., ... , Kalinke U., Lutz M.B. (2018)
Tolerogenic transcriptional signatures of steady-state and pathogen-induced dendritic cells
Front.Immunol., 9 (FEB)

Schleicher U., Liese J., Justies N., Mischke T., Haeberlein S., Sebald H., Kalinke U., ... , Weiss S., Bogdan C. (2018)
Type I interferon signaling is required for CpG-oligodesoxynucleotide-induced control of Leishmania major, but not for spontaneous cure of subcutaneous primary or secondary L. major infection
Front.Immunol., 9 (FEB)

Narendra S.C., Chalise J.P., Biggs S., Kalinke U., Magnusson M. (2018)
Regulatory T-cells mediate IFN-a-induced resistance against antigen-induced arthritis
Front.Immunol., 9 (FEB)

Mzinza D.T., Fleige H., Laarmann K., Willenzon S., Ristenpart J., Spanier J., Sutter G., Kalinke U., ... , Valentin-Weigand P., Förster R. (2018)
Application of light sheet microscopy for qualitative and quantitative analysis of bronchus-associated lymphoid tissue in mice
Cell Mol.Immunol., 15 (10)

Bieling M., Tischer S., Kalinke U., Blasczyk R., Buus S., ... , Maecker-Kolhoff B., Eiz-Vesper B. (2018)
Personalized adoptive immunotherapy for patients with EBVassociated tumors and complications: Evaluation of novel naturally processed and presented EBV-derived T-cell epitopes
Oncotarget, 9 (4)

Neehus A.-L., Lam J., Haake K., Merkert S., Schmidt N., Mucci A., Ackermann M., Schubert M., Happle C., Kühnel M.P., Blank P., Philipp F., Goethe R., Jonigk D., Martin U., Kalinke U., Baumann U., Schambach A., ... , Roesler J., Lachmann N. (2017)
Impaired IFNg[gamma]-Signaling and Mycobacterial Clearance in IFNg[gamma]R1-Deficient Human iPSC-Derived Macrophages
Stem Cell Reports, 10 (1)

Waltl I., Br÷er S., Chhatbar C., Ghita L., Gerhauser I., ... , Anjum M., Kalinke U. (2018)
Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis
Neurobiol.Dis., 110

Borst K., Frenz T., Spanier J., Tegtmeyer P.K., Chhatbar C., Skerra J., Ghita L., Namineni S., Lienenklaus S., Köster M., Heikenwaelder M., ... , Sutter G., Kalinke U. (2017)
Type I interferon receptor-signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis
J.Hepatol., 68 (4)

Hetzel M., Mucci A., Blank P., Nguyen A.H.H., Schiller J., Halle O., Kuhnel M.P., Billig S., Meineke R., Brand D., Herder V., Baumgartner W., Bange F.C., Goethe R., Jonigk D., Forster R., Gentner B., Casanova J.L., Bustamante J., Schambach A., ... , Kalinke U., Lachmann N. (2017)
Hematopoietic stem cell gene therapy for IFNg[gamma]R1 deficiency protects mice from mycobacterial infections
Blood, 131 (5)

Speth M.T., Repnik U., Müller E., Spanier J., Kalinke U., ... , Corthay A., Griffiths G. (2017)
Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Gu q
Mol.Pharm., 14 (11)

Ivin M., Dumigan A., de Vasconcelos F.N., Ebner F., Borroni M., Kavirayani A., Przybyszewska K.N., Ingram R.J., Lienenklaus S., Kalinke U., Stoiber D., ... , Bengoechea J.A., Kovarik P. (2017)
Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection
PLoS.Pathog., 13 (11)

Selvakumar T.A., Bhushal S., Kalinke U., Wirth D., Hauser H., ... , Köster M., Hornef M.W. (2017)
Identification of a Predominantly Interferon-lambda-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells
Front Immunol., 8

Hinz T., Kallen K., Britten C.M., Flamion B., Granzer U., Hoos A., Huber C., Khleif S., Kreiter S., Rammensee H.G., Sahin U., Singh-Jasuja H., ... , Türeci Ö, Kalinke U. (2017)
The European regulatory environment of rna-based vaccines
, 1499

Lirussi D., Ebensen T., Schulze K., Trittel S., Duran V., Liebich I., ... , Kalinke U., Guzmán C.A. (2017)
Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway
EBioMedicine., 22

Hirche C., Frenz T., Haas S.F., Doring M., Borst K., Tegtmeyer P.K., Brizic I., Jordan S., Keyser K., Chhatbar C., Pronk E., Lin S., Messerle M., Jonjic S., Falk C.S., Trumpp A., ... , Essers M.A.G., Kalinke U. (2017)
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
Cell Rep., 19 (11)

Thiemann S., Smit N., Roy U., Lesker T.R., Galvez E.J.C., Helmecke J., Basic M., Bleich A., Goodman A.L., Kalinke U., Flavell R.A., ... , Erhardt M., Strowig T. (2017)
Enhancement of IFNgamma Production by Distinct Commensals Ameliorates Salmonella-Induced Disease
Cell Host.Microbe, 21 (6)

Matschulla T., Berry R., Gerke C., Doring M., Busch J., Paijo J., Kalinke U., Momburg F., ... , Hengel H., Halenius A. (2017)
A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle
Sci.Rep., 7 (1)

Gonzalez-Motos V., Jürgens C., Ritter B., Kropp K.A., Durán V., Larsen O., Binz A., Ouwendijk W.J.D., Lenac Rovis T., Jonjic S., Verjans G.M.G.M., Sodeik B., Krey T., Bauerfeind R., Schulz T.F., Kaufer B.B., Kalinke U., Proudfoot A.E.I., ... , Rosenkilde M.M., Viejo-Borbolla A. (2017)
Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration
PLoS Pathog., 13 (5)

Ruangkiattikul N., Nerlich A., Abdissa K., Lienenklaus S., Suwandi A., Janze N., Laarmann K., Spanier J., Kalinke U., ... , Weiss S., Goethe R. (2017)
cGAS-STING-TBK1-IRF3/7 Induced Interferon-b[beta] Contributes to the Clearing of Non Tuberculous Mycobacterial Infection in Mice
Virulence., 8 (7)

Fischer J.C., Bscheider M., Eisenkolb G., Lin C.C., Wintges A., Otten V., Lindemans C.A., Heidegger S., Rudelius M., Monette S., Porosnicu Rodriguez K.A., Calafiore M., Liebermann S., Liu C., Lienenklaus S., Weiss S., Kalinke U., Ruland J., Peschel C., Shono Y., Docampo M., Velardi E., Jenq R.R., Hanash A.M., Dudakov J.A., Haas T., ... , van den Brink M.R.M., Poeck H. (2017)
RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury
Sci.Transl.Med., 9 (386)

Hoffmann M., Crone L., Dietzel E., Paijo J., Nehlmeier I., ... , Kalinke U., Becker S. (2017)
A polymorphism within the internal fusion loop of the Ebola virus glycoprotein modulates host cell entry
J.Virol., 91 (9)

Pfaender S., Walter S., Grabski E., Todt D., Bruening J., Romero-Brey I., Gather T., Brown R.J., Hahn K., Puff C., Pfankuche V.M., Hansmann F., Postel A., Becher P., Thiel V., Kalinke U., Wagner B., Bartenschlager R., Baumgartner W., Feige K., Pietschmann T., ... , Cavalleri J.M., Steinmann E. (2017)
Immune protection against reinfection with nonprimate hepacivirus
Proc.Natl.Acad.Sci U.S A, 114 (12)

Ziegler A., Soldner C., Lienenklaus S., Spanier J., Trittel S., Riese P., Kramps T., Weiss S., Heidenreich R., Jasny E., Guzmán C.A., Kallen K.J., ... , Fotin-Mleczek M., Kalinke U. (2017)
A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects
J Immunol., 198 (4)

Kindler E., Gil-Cruz C., Spanier J., Li Y., Wilhelm J., Rabouw H.H., Zust R., Hwang M., V'kovski P., Stalder H., Marti S., Habjan M., Cervantes-Barragan L., Elliot R., Karl N., Gaughan C., van Kuppeveld F.J., Silverman R.H., Keller M., Ludewig B., Bergmann C.C., Ziebuhr J., Weiss S.R., ... , Kalinke U., Thiel V. (2017)
Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication
PLoS Pathog., 13 (2)

Maier B.B., Hladik A., Lakovits K., Korosec A., Martins R., Kral J.B., Mesteri I., Strobl B., Müller M., Kalinke U., ... , Merad M., Knapp S. (2016)
Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice
Eur.J.Immunol., 46 (9)

Pfaender S., Grabski E., Detje C.N., Riebesehl N., Lienenklaus S., Steinmann E., ... , Kalinke U., Pietschmann T. (2016)
Hepatitis C Virus Stimulates Murine CD8a[alpha]-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner
PLoS Pathog., 12 (7)

Frenz T., Grabski E., Buschjager D., Vaas L.A., Burgdorf N., Schmidt R.E., ... , Witte T., Kalinke U. (2016)
CD4 T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion
J Allergy Clin.Immunol., 138 (2)

Luckoff A., Caramoy A., Scholz R., Prinz M., Kalinke U., Langmann T. (2016)
Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization
EMBO Mol.Med., 8 (6)

Blank T., Detje C.N., Spiess A., Hagemeyer N., Brendecke S.M., Wolfart J., Staszewski O., Zoller T., Papageorgiou I., Schneider J., Paricio-Montesinos R., Eisel U.L., Manahan-Vaughan D., Jansen S., Lienenklaus S., Lu B., Imai Y., Muller M., Goelz S.E., Baker D.P., Schwaninger M., Kann O., Heikenwalder M., ... , Kalinke U., Prinz M. (2016)
Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment
Immunity, 44 (4)

Andzinski L., Spanier J., Kasnitz N., Kroger A., Jin L., Brinkmann M.M., Kalinke U., Weiss S., ... , Jablonska J., Lienenklaus S. (2016)
Growing tumors induce a local STING dependent type I IFN response in dendritic cells
Int.J Cancer, 139 (6)

Paijo J., Doring M., Spanier J., Grabski E., Nooruzzaman M., Schmidt T., Witte G., Messerle M., Hornung V., ... , Kaever V., Kalinke U. (2016)
cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells
PLoS Pathog., 12 (4)

Weissmuller S., Kronhart S., Kreuz D., Schnierle B., Kalinke U., Kirberg J., ... , Hanschmann K.M., Waibler Z. (2016)
TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model
PLoS ONE, 11 (3)

Castiglia V., Piersigilli A., Ebner F., Janos M., Goldmann O., Dambock U., Kroger A., Weiss S., Knapp S., Jamieson A.M., Kirschning C., Kalinke U., Strobl B., Muller M., Stoiber D., ... , Lienenklaus S., Kovarik P. (2016)
Type I Interferon Signaling Prevents IL-1b[beta]-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue
Cell Host.Microbe, 19 (3)

Pfefferkorn C., Kallfass C., Lienenklaus S., Spanier J., Kalinke U., Rieder M., Conzelmann K.K., ... , Michiels T., Staeheli P. (2016)
Abortively infected astrocytes appear to represent the main source of interferon beta in the virus-infected brain
J.Virol., 90 (4)

Vogel S., Grabski E., Buschjager D., Klawonn F., Doring M., Wang J., Fletcher E., Bechmann I., Witte T., Durisin M., Schraven B., Mangsbo S.M., Schonfeld K., ... , Czeloth N., Kalinke U. (2015)
Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells
Sci Rep., 5

Waffarn E.E., Hastey C.J., Dixit N., Soo Choi Y., Cherry S., Kalinke U., ... , Simon S.I., Baumgarth N. (2015)
Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation
Nat.Commun., 6

Skripuletz T., Tejedor L.S., Prajeeth C.K., Hansmann F., Chhatbar C., Kucman V., Zhang N., Raddatz B.B., Detje C.N., Sühs K.W., Pul R., Gudi V., Kalinke U., ... , Baumgärtner W., Stangel M. (2015)
The antiviral drug ganciclovir does not inhibit microglial proliferation and activation
Sci.Rep., 5

Malczyk A.H., Kupke A., Prufer S., Scheuplein V.A., Hutzler S., Kreuz D., Beissert T., Bauer S., Hubich-Rau S., Tondera C., Shams Eldin H., Schmidt J., Vergara-Alert J., Suzer Y., Seifried J., Hanschmann K.M., Kalinke U., Herold S., Sahin U., Cichutek K., Waibler Z., Eickmann M., ... , Becker S., Muhlebach M.D. (2015)
A highly immunogenic and protective MERS-Coronavirus vaccine based on recombinant MV vaccine platform
J Virol., 89

Wang H., El Maadidi S., Fischer J., Grabski E., Dickhöfer S., Klimosch S., Flannery S.M., Filomena A., Wolz O.O., Schneiderhan-Marra N., Löffler M.W., Wiese M., Pichulik T., Mullhaupt B., Semela D., Dufour J.F., Bochud P.Y., East-German and Swiss Hepatitis C Virus Study Groups, Bowie A.G., Kalinke U., ... , Berg T., Weber A.N. (2015)
A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance
Hepatology, 62

Brinkmann M.M., Daq F., Hengel H., Messerle M., Kalinke U., Cicin-Sain L. (2015)
Cytomegalovirus immune evasion of myeloid lineage cells
Med.Microbiol.Immunol., 204

Crouse J., Kalinke U., Oxenius A. (2015)
Regulation of antiviral T cell responses by type i interferons
Nat.Rev.Immunol., 15 (4)

Fischbach H., Doring M., Nikles D., Lehnert E., Baldauf C., ... , Kalinke U., Tampe R. (2015)
Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets
Nat.Commun., 6

Detje C.N., Lienenklaus Stefan, Chhatbar C., Spanier Julia, Prajeeth C.K., Soldner C., Tovey M.G., Schluter D., Weiss Siegfried, ... , Stangel M., Kalinke Ulrich (2014)
Upon intranasal VSV infection astrocytes in the olfactory bulb are important interferon Beta producers that protect from lethal encephalitis
Journal of Virology, 89 (5)

Grabski E., Wappler I., Pfaender S., Steinmann E., Haid S., Dzionek A., ... , Pietschmann T., Kalinke U. (2014)
Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus induced interferon-alpha responses of plasmacytoid dendritic cells
Journal of Virology, 89

Gabaev I., Elbasani E., Ameres S., Steinbruck L., Stanton R., Doring M., Lenac Rovis T., Kalinke Ulrich, Jonjic S., ... , Moosmann A., Messerle M. (2014)
Expression of the Human Cytomegalovirus UL11 Glycoprotein in Viral Infection and Evaluation of its Effect on Virus-Specific CD8 T Cells
Journal of Virology, 88 (24)

Döring M., Lessin I., Frenz T., Spanier J., Kessler A., Tegtmeyer P., Dag F., Thiel N., Trilling M., Lienenklaus S., Weiss S., Scheu S., Messerle M., Cicin-Sain L., ... , Hengel H., Kalinke U. (2014)
M27 expressed by cytomegalovirus counteracts effective type I IFN induction of myeloid cells, but not of plasmacytoid dendritic cells
Journal of Virology, 88 (23)

Weber E., Finsterbusch Katja, Lindquist R., Nair S., Lienenklaus S., Gekara N.O.*, Janik D., Weiss S., Kalinke U., ... , Overby A.K., Kröger A. (2014)
Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local anti-viral response
Journal of Virology, 88

Spanier J., Lienenklaus Stefan, Paijo J., Kessler A., Borst K., Heindorf Sabrina, Baker D.P., Kröger Andrea, Weiss Siegfried, Detje C.N., ... , Staeheli P., Kalinke Ulrich (2014)
Concomitant TLR/RLH Signaling of Radioresistant and Radiosensitive Cells Is Essential for Protection against Vesicular Stomatitis Virus Infection
Journal of Immunology, 193 (6)

Frenz T., Graalmann L., Detje C.N., Doring M., Grabski E., ... , Scheu S., Kalinke Ulrich (2014)
Independent of Plasmacytoid Dendritic Cell (pDC) infection, pDC Triggered by Virus-Infected Cells Mount Enhanced Type I IFN Responses of Different Composition as Opposed to pDC Stimulated with Free Virus
Journal of Immunology, 193

Bald T., Landsberg J., Lopez-Ramos D., Renn M., Glodde N., Jansen P., Gaffal E., Steitz J., Tolba R., Kalinke Ulrich, Limmer A., Jönsson G., ... , Hölzel M., Tüting T. (2014)
Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation
Cancer Discovery, 4 (6)

Zheng L.S., Hitoshi S., Kaneko N., Takao K., Miyakawa T., Tanaka Y., Xia H., Kalinke Ulrich, Kudo K., Kanba S., ... , Ikenaka K., Sawamoto K. (2014)
Mechanisms for interferon-?-induced depression and neural stem cell dysfunction
Stem Cell Reports, 3 (1)

Volz A., Langenmayer M., Jany S., Kalinke Ulrich, Sutter G. (2014)
Rapid expansion of CD8+ T cells in wildtype and type I interferon receptor deficient mice correlates with protection after low-dose emergency immunization with Modified Vaccinia virus Ankara
Journal of Virology, 88

Züst R., Toh Y.X., Cerny D., Heinrich J., Hermida L., Marcos E., Guillén G., ... , Kalinke Ulrich, Shi P.Y. (2014)
Type I interferon signals in macrophages and dendritic cells control dengue virus infection: Implications for a new mouse model to test dengue vaccines
Journal of Virology, 88 (13)

Haque A., Best S.E., De Oca M.M., James K.R., Ammerdorffer A., Edwards C.L., bastida Rivera F., Amante F.H., Bunn P.T., Sheel M., Sebina I., Koyama M., Varelias A., Hertzog P.J., Kalinke Ulrich, Gun S.Y., Rénia L., Ruedl C., MacDonald K.P.A., ... , Hill G.R., Engwerda C.R. (2014)
Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity
Journal of Clinical Investigation, 124 (6)

Crouse J., Bedenikovic G., Wiesel M., Ibberson M., Xenarios I., Von Laer D., Kalinke Ulrich, Vivier E., ... , Jonjic S., Oxenius A. (2014)
Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1
Immunity, 40

Fleige H., Ravens S., Moschovakis G.L., Bölter J., Willenzon S., Sutter G., Häußler Susanne, Kalinke Ulrich, ... , Prinz I., Förster R. (2014)
IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs
Journal of Experimental Medicine, 211 (4)

Nair Sharmila, Michaelsen-Preusse K., Finsterbusch Katja, Stegemann-Koniszewski Sabine, Bruder Dunja, Grashoff Martina, Korte Martin, Köster Mario, Kalinke Ulrich, ... , Hauser Hansjörg, Kröger Andrea (2014)
Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons
PLoS Pathogens, 10 (3)

Conrad E., Resch T.K., Gogesch P., Kalinke Ulrich, Bechmann I., ... , Bogdan C., Waibler Z. (2014)
Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice
Hepatology, 59 (4)

Bartholomaeus P., Semmler L.Y., Bukur T., Boisguerin V., Romer P.S., Tabares P., Chuvpilo S., Tyrsin D.Y., Matske Victoriah A., Hengel H., Castle J., ... , Hunig T., Kalinke Ulrich (2014)
Cell contact-dependent priming and FC interaction with CD32+ immune cells contribute to the TGN1412-triggered cytokine response
Journal of Immunology, 192 (5)

Lebel M.E., Daudelin J.F., Chartrand K., Tarrab E., Kalinke Ulrich, Savard P., Labrecque N., ... , Leclerc D., Lamarre A. (2014)
Nanoparticle adjuvant sensing by tlr7 enhances cd8+ t cell-mediated protection from listeria monocytogenes infection
Journal of Immunology, 192 (3)

Svitek N., Gerhauser I., Goncalves C., Grabski E., Döring M., Kalinke Ulrich, Anderson D.E., ... , Cattaneo R., Von Messling V. (2014)
Morbillivirus control of the interferon response: Relevance of STAT2 and mda5 but not STAT1 for canine distemper virus virulence in ferrets
Journal of Virology, 88 (5)

Bunse C.E., Borchers S., Varanasi P.R., Tischer S., Figueiredo C., Immenschuh S., Kalinke Ulrich, Köhl U., Goudeva L., Maecker-Kolhoff B., Ganser A., Blasczyk R., ... , Weissinger E.M., Eiz-Vesper B. (2013)
Impaired functionality of antiviral T cells in G-CSF mobilized stem cell donors: Implications for the selection of CTL donor
PLoS ONE, 8 (12)

Prete F., Catucci M., Labrada M., Gobessi S., Castiello M.C., Bonomi E., Aiuti A., Vermi W., Cancrini C., Metin A., Hambleton S., Bredius R., Notarangelo L.D., van der Burg M., Kalinke Ulrich, ... , Villa A., Benvenuti F. (2013)
Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells
Journal of Experimental Medicine, 210 (2)

Mizutani T., Neugebauer N., Putz E.M., Moritz N., Simma O., Zebedin-Brandl E., Gotthardt D., Warsch W., Eckelhart E., Kantner H.P., Kalinke U., Lienenklaus Stefan, Weiss Siegfried, Strobl B., Muller M., ... , Sexl V., Stoiber D. (2012)
Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance
Oncoimmunology, 1 (7)

Hogner K., Wolff T., Pleschka S., Plog S., Gruber A.D., Kalinke U., Walmrath H.D., Bodner J., Gattenlohner S., Lewe-Schlosser P., Matrosovich M., Seeger W., ... , Lohmeyer J., Herold S. (2013)
Macrophage-expressed IFN-b[beta] contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia
PLoS Pathogens, 9 (2)

Britten C.M., Singh-Jasuja H., Flamion B., Hoos A., Huber C., Kallen K.J., Khleif S.N., Kreiter S., Nielsen M., Rammensee H.G., Sahin U., ... , Hinz T., Kalinke Ulrich (2013)
The regulatory landscape for actively personalized cancer immunotherapies
Nature Biotechnology, 31 (10)

Siegfried A., Berchtold S., Manncke B., Deuschle E., Reber J., Ott T., Weber M., Kalinke U., Hofer M.J., Hatesuer Bastian, Schughart Klaus, Gailus-Durner V., Fuchs H., Hrabe de Angelis M., Weber F., Hornef M.W., ... , Autenrieth I.B., Bohn E. (2013)
IFIT2 Is an Effector Protein of Type I IFN-Mediated Amplification of Lipopolysaccharide (LPS)-Induced TNF-a[alpha] Secretion and LPS-Induced Endotoxin Shock
Journal of Immunology, 191 (7)

Frentzen Anne, Kusuma Angga, Guerlevik E., Hueging Kathrin, Knocke S., Ginkel Corinne, Brown Richard J.P., Heim M., Dill M.T., Kröger Andrea, Kalinke Ulrich, Kaderali L., ... , Kuehnel F., Pietschmann Thomas (2013)
Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells
Hepatology

Goulet M.L., Olagnier D., Xu Z., Paz S., Belgnaoui S.M., Lafferty E.I., Janelle V., Arguello M., Paquet M., Ghneim K., Richards S., Smith A., Wilkinson P., Cameron M., Kalinke Ulrich, Qureshi S., Lamarre A., Haddad E.K., Sekaly R.P., Peri S., Balachandran S., ... , Lin R., Hiscott J. (2013)
Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity
PLoS Pathogens, 9 (4)

Kremer M., Suezer Y., Volz A., Frenz T., Majzoub M., Hanschmann K.M., Lehmann M.H., ... , Kalinke Ulrich*, Sutter G. (2012)
Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox1
PLoS Pathogens, 8 (3)

Baranek T., Manh T.P., Alexandre Y., Maqbool M.A., Cabeza J.Z., Tomasello E., Crozat K., Bessou G., Zucchini N., Robbins S.H., Vivier E., Kalinke Ulrich*, ... , Ferrier P., Dalod M. (2012)
Differential responses of immune cells to type I interferon contribute to host resistance to viral infection1
Cell Host and Microbe, 12 (4)

Kernbauer E., Maier V., Stoiber D., Strobl B., Schneckenleithner C., Sexl V., Reichart U., Reizis B., Kalinke Ulrich*, Jamieson A., ... , Muller M., Decker T. (2012)
Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection1
PLoS Pathogens, 8 (6)

Weissmuller S., Semmler L.Y., Kalinke Ulrich*, Christians S., Muller-Berghaus J., Waibler Z. (2012)
ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation1
Blood, 119 (26)

Kalinke Ulrich*, Prinz M. (2012)
Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS13777
Immunology and Cell Biology, 90 (5)

Arico E., Monque D.M., D'Agostino G., Moschella F., Venditti M., Kalinke U., Allen D.J., Nash A.A., ... , Belardelli F., Ferrantini M. (2012)
Corrigendum to "MHV-68 producing mIFNa[alpha]1 is severely attenuated in vivo and effectively protects mice against challenge with wt MHV-68" [Vaccine 29 (2011) 3935-3944]1
Vaccine, 30 (20)

Schwandt T., Schumak B., Gielen G.H., Jungerkes F., Schmidbauer P., Klocke K., Staratschek-Jox A., Van Rooijen N., Kraal G., Ludwig-Portugall I., Franken L., Wehner S., Kalff J.C., Weber O., Kirschning C., Coch C., Kalinke Ulrich*, Wenzel J., Kurts C., Zawatzky R., Holzmann B., Layland L., Schultze J.L., Burgdorf S., den Haan J.M., ... , Knolle P.A., Limmer A. (2011)
Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis
Embo Journal, 31 (1)

Dann A., Poeck H., Croxford A.L., Gaupp S., Kierdorf K., Knust M., Pfeifer D., Maihoefer C., Endres S., Kalinke Ulrich*, Meuth S.G., Wiendl H., Knobeloch K.-P., Akira S., Waisman A., ... , Hartmann G., Prinz M. (2012)
Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS
Nature Neuroscience, 15 (1)

Schülke S., Burggraf M., Waibler Z., Wangorsch A., Wolfheimer S., Kalinke Ulrich*, Vieths S., ... , Toda M., Scheurer S. (2011)
A fusion protein of flagellin and ovalbumin suppresses the T(H)2 response and prevents murine intestinal allergy
Journal of Allergy and Clinical Immunology, 128 (6)

Diamond M.S., Kinder M., Matsushita H., Mashayekhi M., Dunn G.P., Archambault J.M., Lee H., Arthur C.D., White J.M., Kalinke Ulrich*, ... , Murphy K.M., Schreiber R.D. (2011)
Type I interferon is selectively required by dendritic cells for immune rejection of tumors
Journal of Experimental Medicine, 208 (10)

Dominguez P.M., Lopez-Bravo M., Kalinke U., Ardavin C. (2011)
Statins inhibit iNOS-mediated microbicidal potential of activated monocyte-derived dendritic cells by an IFN-b[beta]-dependent mechanism
European Journal of Immunology, 41 (11)

Chopy D., Detje C.N., Lafage M., Kalinke Ulrich*, Lafon M. (2011)
The type I interferon response bridles rabies virus infection and reduces pathogenicity
Journal of NeuroVirology, 17 (4)

Kalinke Ulrich*, Bechmann I., Detje C.N. (2011)
Host strategies against virus entry via the olfactory system
Virulence, 2 (4)

Williams S.K., Fairless R., Weise J., Kalinke Ulrich*, Schulz-Schaeffer W., Diem R. (2011)
Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis
American Journal of Pathology, 178 (6)

Arico E., Monque D.M., D'Agostino G., Moschella F., Venditti M., Kalinke U., Allen D.J., Nash A.A., ... , Belardelli F., Ferrantini M. (2011)
MHV-68 producing mIFNa[alpha]1 is severely attenuated in vivo and effectively protects mice against challenge with wt MHV-68
Vaccine, 29 (23)

Grabski E., Waibler Z., Schule S., Kloke B.P., Sender L.Y., Panitz S., Cichutek K., ... , Schweizer M., Kalinke Ulrich* (2011)
Comparative Analysis of Transduced Primary Human Dendritic Cells Generated by the Use of Three Different Lentiviral Vector Systems
Molecular Biotechnology, 47 (3)

Gratz M.S., Suezer Y., Kremer M., Volz A., Majzoub M., Hanschmann K.M., Kalinke Ulrich*, ... , Schwantes A., Sutter G. (2011)
N1L Is an Ectromelia Virus Virulence Factor and Essential for In Vivo Spread upon Respiratory Infection
Journal of Virology, 85 (7)

Murikinati S., Juttler E., Keinert T., Ridder D.A., Muhammad S., Waibler Z., Ledent C., Zimmer A., ... , Kalinke Ulrich*, Schwaninger M. (2010)
Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment
FASEB journal, 24 (3)

Ilchmann A., Burgdorf S., Scheurer S., Waibler Z., Nagai R., Wellner A., Yamamoto Y., Yamamoto H., Henle T., Kurts C., Kalinke Ulrich*, ... , Vieths S., Toda M. (2010)
Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II
Journal of Allergy and Clinical Immunology, 125 (1)

Goossens P., Gijbels M.J., Zernecke A., Eijgelaar W., Vergouwe M.N., van der Made I, Vanderlocht J., Beckers L., Buurman W.A., Daemen M.J., Kalinke Ulrich*, Weber C., ... , Lutgens E., de Winther M.P. (2010)
Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions
Cell Metabolism, 12 (2)

Sender L.Y., Gibbert K., Suezer Y., Radeke H.H., Kalinke Ulrich*, Waibler Z. (2010)
CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals
Molecular immunology, 47 (6)

Kochs G., Bauer S., Vogt C., Frenz T., Tschopp J., ... , Kalinke Ulrich*, Waibler Z. (2010)
Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells
Journal of Virology, 84 (23)

Frenz T., Waibler Z., Hofmann J., Hamdorf M., Lantermann M., Reizis B., Tovey M.G., Aichele P., ... , Sutter G., Kalinke Ulrich* (2010)
Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion
European Journal of Immunology, 40 (10)

Prinz M., Kalinke Ulrich* (2010)
New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS
Trends in Molecular Medicine, 16 (8)

Lang P.A., Recher M., Honke N., Scheu S., Borkens S., Gailus N., Krings C., Meryk A., Kulawik A., Cervantes-Barragan L., Van Rooijen N., Kalinke Ulrich*, Ludewig B., Hengartner H., Harris N., Haussinger D., Ohashi P.S., ... , Zinkernagel R.M., Lang K.S. (2010)
Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice
Hepatology, 52 (1)

Waibler Z., Sender L.Y., Merten C., Hartig R., Kliche S., Gunzer M., Reichardt P., ... , Kalinke Ulrich*, Schraven B. (2008)
Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies
PLoS ONE, 3 (3)

Waibler Z., Anzaghe M., Konur A., Akira S., Müller W., Kalinke U. (2008)
Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC
European Journal of Immunology, 38 (11)

Detje C.N., Meyer T., Schmidt H., Kreuz D., Rose J.K., Bechmann I., ... , Prinz M., Kalinke Ulrich* (2009)
Local type I IFN receptor signaling protects against virus spread within the central nervous system
Journal of Immunology, 182 (4)

Stockinger S., Kastner R., Kernbauer E., Pilz A., Westermayer S., Reutterer B., Soulat D., Stengl G., Vogl C., Frenz T., Waibler Z., Taniguchi T., Rulicke T., Kalinke Ulrich*, ... , Muller M., Decker T. (2009)
Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes
PLoS Pathogens, 5 (3)

Anz D., Thaler R., Stephan N., Waibler Z., Trauscheid M.J., Scholz C., Kalinke Ulrich*, Barchet W., ... , Endres S., Bourquin C. (2009)
Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus
Journal of Immunology, 182 (10)

Bach P., Tschape J.A., Kopietz F., Braun G., Baade J.K., Wiederhold K.H., Staufenbiel M., Prinz M., Deller T., Kalinke U., ... , Buchholz C.J., Muller U.C. (2009)
Vaccination with Abeta-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice
Journal of Immunology, 182 (12)

Pilz A., Kratky W., Stockinger S., Simma O., Kalinke Ulrich*, Lingnau K., von Gabain A., Stoiber D., Sexl V., Kolbe T., Rulicke T., ... , Muller M., Decker T. (2009)
Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL
Journal of Immunology, 183 (4)

Kern M., Popov A., Scholz K., Schumak B., Djandji D., Limmer A., Eggle D., Sacher T., Zawatzky R., Holtappels R., Reddehase M.J., Hartmann G., bey-Pascher S., Diehl L., Kalinke Ulrich*, Koszinowski U., ... , Schultze J., Knolle P.A. (2010)
Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity
Gastroenterology, 138 (1)

Al Moussawi K., Ghigo E., Kalinke Ulrich*, Alexopoulou L., Mege J.L., Desnues B. (2010)
Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei
PLoS Pathogens, 6 (1)

Essers M.A., Offner S., Blanco-Bose W.E., Waibler Z., Kalinke U., ... , Duchosal M.A., Trumpp A. (2009)
IFNalpha activates dormant haematopoietic stem cells in vivo
Nature, 458 (7240)

Cucak H., Yrlid U., Reizis B., Kalinke Ulrich*, Johansson-Lindbom B. (2009)
Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells
Immunity, 31 (3)

Waibler Z., Anzaghe M., Frenz T., Schwantes A., Pohlmann C., Ludwig H., Palomo-Otero M., Alcami A., ... , Sutter G., Kalinke Ulrich* (2009)
Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components
Journal of Virology, 83 (4)

Waibler Z., Sender L.Y., Kamp C., Muller-Berghaus J., Liedert B., Schneider C.K., ... , Lower J., Kalinke Ulrich* (2008)
Toward experimental assessment of receptor occupancy: TGN1412 revisited
Journal of Allergy and Clinical Immunology, 122 (5)

Schneider C.K., Kalinke Ulrich* (2008)
Toward biosimilar monoclonal antibodies
Nature Biotechnology, 26 (9)

Waibler Z., Anzaghe M., Ludwig H., Akira S., Weiss Siegfried*, ... , Sutter G., Kalinke U. (2007)
Modified vaccinia virus Ankara induces toll-like receptor-independent type I interferon responses
Journal of Virology, 81 (22)

Schleicher U., Liese J., Knippertz I., Kurzmann C., Hesse A., Heit A., Fischer J.A.A., Weiss Siegfried*, Kalinke U., ... , Kunz S., Bogdan C. (2007)
NK cell activation in visceral Leishmaniasis requires
Journal of Experimental Medicine, 204

Blakqori G., Delhaye S., Habjan M., Blair C.D., Sanchez-Vargas I., Olson K.E., Attarzadeh-Yazdi G., Fragkoudis R., Kohl A., Kalinke U., Weiss Siegfried*, Michiels T., ... , Staeheli P., Weber F. (2007)
La Crosse bunyavirus
Journal of Virology, 81 (10)

Koerner I., Kochs G., Kalinke U., Weiss S., Staeheli P. (2007)
Protective role of beta interferon in host defense against influenza a virus
Journal of Virology, 81 (4)

Osterloh A., Kalinke U., Weiss Siegfried*, Fleischer B., Breloer M. (2007)
Synergistic and differential modulation of immune responses by HSP60 and Lipopolysaccharide
The Journal of Biological Chemistry, 282

Gerlach N., Schimmer S., Weiss Siegfried*, Kalinke U., Dittmer U. (2006)
Effects of type I interferons on friend retrovirus infection
Journal of Virology, 80

Liehl P., Zuzarte-Luis V., Chan J., Zillinger T., Baptista F., Carapau D., Konert M., Hanson K.K., Carret C., Lassnig C., Muller M., Kalinke Ulrich, Saeed M., Chora A.F., Golenbock D.T., Strobl B., Prudencio M., Coelho L.P., Kappe S.H., Superti-Furga G., Pichlmair A., Vigario A.M., Rice C.M., Fitzgerald K.A., ... , Barchet W., Mota M.M. (2014)
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection
Nature medicine, 20 (1)