Prof. Dr. Ulrich Kalinke

Amurri L., Dumont C., Pelissier R., Reynard O., Mathieu C., Spanier J., Palyi B., Deri D., Karkowski L., Gonzalez C., Skerra J., Kis Z., Kalinke U., ... , Horvat B., Iampietro M. (2024)

Multifaceted activation of STING axis upon Nipah and measles virus-induced syncytia formation

PLoS Pathog., 20 (9 September)

DOI: 10.1371/journal.ppat.1012569 HZI-Repositorium PubMed

Gern O.L., Pavlou A., Mulenge F., Busker L.M., Ghita L., Aringo A., Costa B., Spanier J., Waltl I., ... , Stangel M., Kalinke U. (2024)

MAVS signaling shapes microglia responses to neurotropic virus infection

J.Neuroinflamm., 21 (1)

DOI: 10.1186/s12974-024-03258-6 HZI-Repositorium PubMed

Ehlers C., Thiele T., Biermann H., Traidl S., Bruns L., Ziegler A., Schefzyk M., Bartsch L.M., Kalinke U., ... , Witte T., Graalmann T. (2024)

Toll-Like Receptor 8 is Expressed in Monocytes in Contrast to Plasmacytoid Dendritic Cells and Mediates Aberrant Interleukin-10 Responses in Patients With Systemic Sclerosis

Arthritis and Rheumatology

DOI: 10.1002/art.42964 HZI-Repositorium PubMed

Innocenti G., Obara M., Costa B., Jacobsen H., Katzmarzyk M., Cicin-Sain L., ... , Kalinke U., Galardini M. (2024)

Real-time identification of epistatic interactions in SARS-CoV-2 from large genome collections

Genome Biology, 25 (1)

DOI: 10.1186/s13059-024-03355-y HZI-Repositorium PubMed

Mulenge F., Gern O.L., Busker L.M., Aringo A., Ghita L., Waltl I., ... , Pavlou A., Kalinke U. (2024)

Transcriptomic analysis unveils bona fide molecular signatures of microglia under conditions of homeostasis and viral encephalitis

Journal of Neuroinflammation, 21 (1)

DOI: 10.1186/s12974-024-03197-2 HZI-Repositorium PubMed

Buhre J.S., Pongracz T., Geisen U.M., Schubert M., Wang W., Nouta J., Obara M., Lehrian S., Rahmöller J., Petry J., Tran F., Schreiber S., Sümbül M., Berner D., Gerdes S., Schirmer J., Longardt A.C., Hoff P., Kalinke U., Ludwig R.J., Bartsch Y.C., Hoyer B.F., ... , Wuhrer M., Ehlers M. (2024)

Anti-TNF therapy impairs both short- and long-term IgG responses after repeated vaccination

Allergy: European Journal of Allergy and Clinical Immunology

DOI: 10.1111/all.16241 HZI-Repositorium PubMed

Pavlou A., Mulenge F., Gern O.L., Busker L.M., Greimel E., ... , Waltl I., Kalinke U. (2024)

Orchestration of antiviral responses within the infected central nervous system

Cellular and Molecular Immunology

DOI: 10.1038/s41423-024-01181-7 HZI-Repositorium PubMed

Riedl A., Bojkova D., Tan J., Jeney C., Larsen P.K., Jeney C., Full F., ... , Kalinke U., Ruzsics Z. (2024)

Construction and Characterization of a High-Capacity Replication-Competent Murine Cytomegalovirus Vector for Gene Delivery

Vaccines, 12 (7)

DOI: 10.3390/vaccines12070791 HZI-Repositorium PubMed

Fneish Z., Becker J., Mulenge F., Fneish F., Costa B., Traidl-Hoffmann C., ... , Gilles S., Kalinke U. (2024)

Birch pollen-induced signatures in dendritic cells are maintained upon additional cytomegalovirus exposure

Gene, 927

DOI: 10.1016/j.gene.2024.148649 HZI-Repositorium PubMed

Santamorena M.M., Tischer-Zimmermann S., Bonifacius A., Mireisz C.N.-M., Costa B., Khan F., Kulkarni U., Lauruschkat C.D., Sampaio K.L., Stripecke R., Blasczyk R., Maecker-Kolhoff B., Kraus S., Schlosser A., Cicin-Sain L., ... , Kalinke U., Eiz-Vesper B. (2024)

Engineered HCMV-infected APCs enable the identification of new immunodominant HLA-restricted epitopes of anti-HCMV T-cell immunity

HLA, 103 (6)

DOI: 10.1111/tan.15541 HZI-Repositorium PubMed

Bruhn M., Obara M., Salam A., Costa B., Ziegler A., Waltl I., Pavlou A., Hoffmann M., Graalmann T., Pöhlmann S., ... , Schambach A., Kalinke U. (2024)

Diversification of the VH3-53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS-CoV-2 virus variants

European Journal of Immunology

DOI: 10.1002/eji.202451056 HZI-Repositorium PubMed

Bruhn M., Spatz M., Kalinke U. (2024)

MORITS: An improved method to predict peptides from heterologous proteins that are recognized by the same T-cell receptor

Scientific Reports, 14 (1)

DOI: 10.1038/s41598-024-58350-x HZI-Repositorium PubMed

Krueger M.B., Bonifacius A., Dragon A.C., Santamorena M.M., Nashan B., Taubert R., Kalinke U., Maecker-Kolhoff B., ... , Blasczyk R., Eiz-Vesper B. (2024)

In Vitro Profiling of Commonly Used Post-transplant Immunosuppressants Reveals Distinct Impact on Antiviral T-cell Immunity Towards CMV

Transplant International, 37

DOI: 10.3389/ti.2024.12720 HZI-Repositorium PubMed

Passos V., Henkel L.M., Wang J., Zapatero-Belinchon F.J., Möller R., Sun G., Waltl I., Schneider T., Wachs A., Ritter B., Kropp K.A., Zhu S., Deleidi M., Kalinke U., Schulz T.F., Höglinger G., Gerold G., ... , Wegner F., Viejo-Borbolla A. (2024)

Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons

Journal of Medical Virology, 96 (2)

DOI: 10.1002/jmv.29455 HZI-Repositorium PubMed

Costa B., Becker J., Krammer T., Mulenge F., Duran V., Pavlou A., Gern O.L., Chu X., Li Y., Cicin-Sain L., Eiz-Vesper B., Messerle M., Dölken L., Saliba A.E., ... , Erhard F., Kalinke U. (2024)

Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells

Nat.Commun., 15 (1)

DOI: 10.1038/s41467-024-45614-3 HZI-Repositorium PubMed

Chiyyeadu A., Asgedom G., Bruhn M., Rocha C., Schlegel T.U., Neumann T., Galla M., Barbosa P.V., Hoffmann M., Ehrhardt K., Ha T.C., Morgan M., Schoeder C.T., Pöhlmann S., ... , Kalinke U., Schambach A. (2024)

A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants

Clin.Immunol.

DOI: 10.1016/j.clim.2024.109902 HZI-Repositorium PubMed

Manoharan J., Rana R., Kuenze G., Gupta D., Elwakiel A., Ambreen S., Wang H., Banerjee K., Zimmermann S., Singh K., Gupta A., Fatima S., Kretschmer S., Schaefer L., Zeng-Brouwers J., Schwab C., Al-Dabet M.M., Gadi I., Altmann H., Koch T., Poitz D.M., Baber R., Kohli S., Shahzad K., Geffers R., Lee-Kirsch M.A., Kalinke U., Meiler J., ... , Mackman N., Isermann B. (2024)

Tissue factor binds to and inhibits interferon-a[alpha] receptor 1 signaling

Immunity., 57 (1)

DOI: 10.1016/j.immuni.2023.11.017 HZI-Repositorium PubMed

Bruhn M., Obara M., Chiyyeadu A., Costa B., Salam A., Ziegler A., Waltl I., Pavlou A., Bonifacius A., Hoffmann M., Graalmann T., Pöhlmann S., Eiz-Vesper B., ... , Schambach A., Kalinke U. (2024)

Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation

J.Infect.

DOI: 10.1016/S1473-3099(23)00690-4 HZI-Repositorium PubMed

Camarao A.A.R., Gern O.L., Stegmann F., Mulenge F., Costa B., Saremi B., Jung K., Lepenies B., ... , Kalinke U., Steffen I. (2023)

Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions

Microbiol.Spectr.

DOI: 10.1128/spectrum.02192-23 HZI-Repositorium PubMed

Harit K., Bhattacharjee R., Matuschewski K., Becker J., Kalinke U., ... , Schlüter D., Nishanth G. (2023)

The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2

Cell Death Dis., 14 (7)

DOI: 10.1038/s41419-023-06014-5 HZI-Repositorium PubMed

Schröder L.J., Mulenge F., Pavlou A., Skripuletz T., Stangel M., ... , Gudi V., Kalinke U. (2023)

Dynamics of reactive astrocytes fosters tissue regeneration after cuprizone-induced demyelination

Glia

DOI: 10.1002/glia.24440 HZI-Repositorium PubMed

Barends M., Koller N., Schölz C., Duran V., Bosnjak B., Becker J., Döring M., Blees H., Förster R., ... , Kalinke U., Tampe R. (2023)

Dynamic interactome of the MHC I peptide loading complex in human dendritic cells

Proc.Natl.Acad.Sci.U.S.A, 120 (25)

DOI: 10.1073/pnas.2219790120 HZI-Repositorium PubMed

Angelova A., Pierrard K., Detje C.N., Santiago E., Grewenig A.l, Nüesch J.P.F., Kalinke U., Ungerechts G., ... , Rommelaere J., Daeffler L. (2023)

Oncolytic Rodent Protoparvoviruses Evade a TLR- and RLR-Independent Antiviral Response in Transformed Cells

Pathogens., 12 (4)

DOI: 10.3390/pathogens12040607 HZI-Repositorium PubMed

Tischer-Zimmermann S., Bonifacius A., Santamorena M.M., Mausberg P., Stoll S., Döring M., Kalinke U., Blasczyk R., ... , Maecker-Kolhoff B., Eiz-Vesper B. (2023)

Reinforcement of cell-mediated immunity driven by tumor-associated Epstein-Barr virus (EBV)-specific T cells during targeted B-cell therapy with rituximab

Frontiers in Immunology, 14

DOI: 10.3389/fimmu.2023.878953 HZI-Repositorium PubMed

Bühler M., Li D., Li L., Runft S., Waltl I., Pavlou A., Kalinke U., Ciurkiewicz M., Huehn J., Floess S., Beineke A., ... , Baumgärtner W., Gerhauser I. (2023)

IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL/6 mice infected with Theiler's murine encephalomyelitis virus

J.Neuroinflamm., 20 (1)

DOI: 10.1186/s12974-023-02737-6 HZI-Repositorium PubMed

Schwerk J., Kemper L., Bussey K.A., Lienenklaus S., Weiss S., Cicin-Sain L., Kröger A., Kalinke U., Collins C.M., Speck S.H., Messerle M., Wirth D., Brinkmann M.M., ... , Hauser H., Köster M. (2022)

Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo

Pathogens, 11 (12)

DOI: 10.3390/pathogens11121554 HZI-Repositorium PubMed

Michaely L.M., Schuwerk L., Allnoch L., Schön K., Waltl I., Larsen P.K., Pavlou A., Prajeeth C.K., Rimmelzwaan G.F., Becker S.C., Kalinke U., ... , Baumgärtner W., Gerhauser I. (2022)

Intact Type I Interferon Receptor Signaling Prevents Hepatocellular Necrosis but Not Encephalitis in a Dose-Dependent Manner in Rift Valley Fever Virus Infected Mice

Int.J.Mol.Sci., 23 (20)

DOI: 10.3390/ijms232012492 HZI-Repositorium PubMed

Koller N., Höllthaler P., Barends M., Döring M., Spahn C., Durán V., Costa B., Becker J., Heilemann M., ... , Kalinke U., Tampé R. (2022)

Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells

Cell.Mol.Life Sci., 79 (9)

DOI: 10.1007/s00018-022-04472-2 HZI-Repositorium PubMed

Fneish Z., Becker J., Mulenge F., Costa B., Krajewski L., Duran V., Ziegler A., Sommer V., Traidl-Hoffmann C., ... , Gilles S., Kalinke U. (2022)

Birch pollen extract enhances human cytomegalovirus replication in monocyte-derived dendritic cells

Allergy

DOI: 10.1111/all.15497 HZI-Repositorium PubMed

Pais T.F., Ali H., Moreira da Silva J., Duarte N., Neres R., Chhatbar C., Acúrcio R.C., Guedes R.C., Strano Moraes M.C., Costa-Silva B., ... , Kalinke U., Penha-Goncalves C. (2022)

Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response

Proc.Natl.Acad.Sci.U.S.A, 119 (36)

DOI: 10.1073/pnas.2206327119 HZI-Repositorium PubMed

Lu D., Chatterjee S., Xiao K., Riedel I., Huang C.K., Costa A., Cushman S., Neufeldt D., Rode L., Schmidt A., Juchem M., Leonardy J., Büchler G., Blume J., Gern O.L., Kalinke U., Tan W.L.W., Foo R., Vink A., van Laake L.W., van der Meer P., ... , Bär C., Thum T. (2022)

A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity

Eur.Heart J.

DOI: 10.1093/eurheartj/ehac337 HZI-Repositorium PubMed

Tsay H.C., Yuan Q., Balakrishnan A., Kaiser M., Möbus S., Kozdrowska E., Farid M., Tegtmeyer P.K., Borst K., Vondran F.W.R., Kalinke U., Kispert A., Manns M.P., ... , Ott M., Sharma A.D. (2022)

Corrigendum to: Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis [J Hepatol (2019) 722-734] (Journal of Hepatology (2019) 722-734, (S0168827818326357), (10.1016/j.jhep.2018.12.016))

Journal of Hepatology

DOI: 10.1016/j.jhep.2022.03.022 HZI-Repositorium PubMed

Knop L., Spanier J., Larsen P.K., Witte A., Bank U., Dunay I.R., ... , Kalinke U., Schüler T. (2022)

IFNAR signaling in fibroblastic reticular cells can modulate CD8+ memory fate decision

European Journal of Immunology

DOI: 10.1002/eji.202149760 HZI-Repositorium PubMed

Yang X., Ali S., Zhao M., Richter L., Schäfer V., Schliehe-Diecks J., Frank M., Qi J., Larsen P.K., Skerra J., Islam H., Wachtmeister T., Alter C., Huang A., Bhatia S., Köhrer K., Kirschning C., Weighardt H., Kalinke U., Kalscheuer R., ... , Uhrberg M., Scheu S. (2022)

The Mycotoxin Beauvericin Exhibits Immunostimulatory Effects on Dendritic Cells via Activating the TLR4 Signaling Pathway

Front Immunol., 13

DOI: 10.3389/fimmu.2022.856230 HZI-Repositorium PubMed

Becker J., Kalinke U. (2022)

Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19

EMBO J.

DOI: 10.15252/embj.2022111208 HZI-Repositorium PubMed

Kalinke U., Barouch D.H., Rizzi R., Lagkadinou E., Türeci Ö, ... , Pather S., Neels P. (2022)

Clinical development and approval of COVID-19 vaccines

Expert.Rev.Vaccines.

DOI: 10.1080/14760584.2022.2042257 HZI-Repositorium PubMed

Bühler M., Runft S., Li D., Götting J., Detje C.N., Nippold V., Stoff M., Beineke A., Schulz T., Kalinke U., ... , Baumgärtner W., Gerhauser I. (2022)

IFN- b

Front.Immunol., 13

DOI: 10.3389/fimmu.2022.786940 HZI-Repositorium PubMed

Waltl I., Kalinke U. (2022)

Beneficial and detrimental functions of microglia during viral encephalitis

Trends Neurosci., 45 (2)

DOI: 10.1016/j.tins.2021.11.004 HZI-Repositorium PubMed

Demoulins T., Baron M.L., Gauchat D., Kettaf N., Reed S.J., Charpentier T., Kalinke U., Lamarre A., Ahmed R., Sékaly R.P., ... , Sarkar S., Kalia V. (2022)

Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection

Virology, 567 (2)

DOI: 10.1016/j.virol.2021.12.007 HZI-Repositorium PubMed

Pezoldt J., Wiechers C., Erhard F., Rand U., Bulat T., Beckstette M., Brendolan A., Hühn J., Kalinke U., Mueller M., Strobl B., Deplancke B., ... , Cicin-Sain L., Sitnik K.M. (2021)

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Commun.Biolog., 4 (1)

DOI: 10.1038/s42003-021-02882-9 HZI-Repositorium PubMed

Gussarow D., Bonifacius A., Cossmann A., Stankov M.V., Mausberg P., Tischer-Zimmermann S., Gödecke N., Kalinke U., Behrens G.M.N., ... , Blasczyk R., Eiz-Vesper B. (2021)

Long-Lasting Immunity Against SARS-CoV-2: Dream or Reality?

Front Med.(Lausanne), 8

DOI: 10.3389/fmed.2021.770381 HZI-Repositorium PubMed

Gern O.L., Mulenge F., Pavlou A., Ghita L., Steffen I., ... , Stangel M., Kalinke U. (2021)

Toll-like receptors in viral encephalitis

Viruses, 13 (10)

DOI: 10.3390/v13102065 HZI-Repositorium PubMed

Ghita L., Breitkopf V., Mulenge F., Pavlou A., Gern O.L., Durán V., Prajeeth C.K., Kohls M., Jung K., Stangel M., ... , Steffen I., Kalinke U. (2021)

Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes

J.Neurosci.Res.

DOI: 10.1002/jnr.24923 HZI-Repositorium PubMed

Graalmann T., Borst K., Manchanda H., Vaas L., Bruhn M., Graalmann L., Köster M., Verboom M., Hallensleben M., Guzmán C.A., Sutter G., Schmidt R.E., ... , Witte T., Kalinke U. (2021)

B cell depletion impairs vaccination-induced CD8+T cell responses in a type i interferon-dependent manner

Annals of the Rheumatic Diseases

DOI: 10.1136/annrheumdis-2021-220435 HZI-Repositorium PubMed

Ghita L., Spanier J., Chhatbar C., Mulenge F., Pavlou A., Larsen P.K., Waltl I., Lueder Y., Kohls M., Jung K., Best S.M., Forster R., Stangel M., ... , Schreiner D., Kalinke U. (2021)

MyD88 signaling by neurons induces chemokines that recruit protective leukocytes to the virus-infected CNS

Science Immunology, 6 (60)

DOI: 10.1126/sciimmunol.abc9165 HZI-Repositorium PubMed

Iampietro M., Dumont C., Mathieu C., Spanier J., Robert J., Charpenay A., Dupichaud S., Dhondt K.P., Aurine N., Pelissier R., Ferren M., Mely S., Gerlier D., ... , Kalinke U., Horvat B. (2021)

Activation of cGAS/STING pathway upon paramyxovirus infection

iScience, 24 (6)

DOI: 10.1016/j.isci.2021.102519 HZI-Repositorium PubMed

Duran V., Grabski E., Hozsa C., Becker J., Yasar H., Monteiro J.T., Costa B., Koller N., Lueder Y., Wiegmann B., Brandes G., Kaever V., Lehr C.M., Lepenies B., Tampé R., Förster R., Bosnjak B., Furch M., ... , Graalmann T., Kalinke U. (2021)

Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells

J.Control Release, 334

DOI: 10.1016/j.jconrel.2021.04.012 HZI-Repositorium PubMed

Krenn V., Bosone C., Burkard T.R., Spanier J., Kalinke U., Calistri A., Salata C., Rilo Christoff R., Pestana Garcez P., ... , Mirazimi A., Knoblich J.A. (2021)

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Cell Stem Cell

DOI: 10.1016/j.stem.2021.03.004 HZI-Repositorium PubMed

Seelbinder B., Wallstabe J., Marischen L., Weiss E., Wurster S., Page L., Löffler C., Bussemer L., Schmitt A.L., Wolf T., Linde J., Cicin-Sain L., Becker J., Kalinke U., Vogel J., Panagiotou G., Einsele H., Westermann A.J., ... , Schäuble S., Loeffler J. (2020)

Triple RNA-Seq Reveals Synergy in a Human Virus-Fungus Co-infection Model

Cell Rep., 33 (7)

DOI: 10.1016/j.celrep.2020.108389 HZI-Repositorium PubMed

Vardi A., Ben-Dor S., Cho S.M., Kalinke U., Spanier J., Futerman A.H. (2020)

Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease

J Neuroinflammation, 17 (1)

DOI: 10.1186/s12974-020-01934-x HZI-Repositorium PubMed

Elsner C., Ponnurangam A., Kazmierski J., Zillinger T., Jansen J., Todt D., Döhner K., Xu S., Ducroux A., Kriedemann N., Malassa A., Larsen P.K., Hartmann G., Barchet W., Steinmann E., Kalinke U., ... , Sodeik B., Goffinet C. (2020)

Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells

Proc.Natl.Acad.Sci.U.S.A, 117 (32)

DOI: 10.1073/pnas.2002481117 HZI-Repositorium PubMed

Gamrekelashvili J., Kapanadze T., Sablotny S., Ratiu C., Dastagir K., Lochner M., Karbach S., Wenzel P., Sitnow A., Fleig S., Sparwasser T., Kalinke U., Holzmann B., ... , Haller H., Limbourg F.P. (2020)

Notch and TLR signaling coordinate monocyte cell fate and inflammation

eLife, 9

DOI: 10.7554/eLife.57007 HZI-Repositorium PubMed

Hosseini S., Michaelsen-Preusse K., Grigoryan G., Chhatbar C., Kalinke U., Korte M. (2020)

Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS

Cell Rep., 31 (7)

DOI: 10.1016/j.celrep.2020.107666 HZI-Repositorium PubMed

Schaupp L., Muth S., Rogell L., Kofoed-Branzk M., Melchior F., Lienenklaus S., Ganal-Vonarburg S.C., Klein M., Guendel F., Hain T., Schütze K., Grundmann U., Schmitt V., Dorsch M., Spanier J., Larsen P.K., Schwanz T., Jäckel S., Reinhardt C., Bopp T., Danckwardt S., Mahnke K., Heinz G.A., Mashreghi M.F., Durek P., Kalinke U., Kretz O., Huber T.B., Weiss S., Wilhelm C., Macpherson A.J., Schild H., ... , Diefenbach A., Probst H.C. (2020)

Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

Cell, 181 (5)

DOI: 10.1016/j.cell.2020.04.022 PubMed

Haake K., Neehus A.L., Buchegger T., Kühnel M.P., Blank P., Philipp F., Oleaga-Quintas C., Schulz A., Grimley M., Goethe R., Jonigk D., Kalinke U., Boisson-Dupuis S., Casanova J.L., ... , Bustamante J., Lachmann N. (2020)

Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-gamma Responsive Pathway

Cells, 9 (2)

DOI: 10.3390/cells9020483 HZI-Repositorium PubMed

Borst K., Flindt S., Blank P., Larsen P.K., Chhatbar C., Skerra J., Spanier J., Hirche C., König M., Alanentalo T., Hafner M., Waibler Z., Pfeffer K., Sexl V., Sutter G., Müller W., ... , Graalmann T., Kalinke U. (2020)

Selective reconstitution of IFNgamma gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection

PLoS.Pathog., 16 (2)

DOI: 10.1371/journal.ppat.1008279 HZI-Repositorium PubMed

Knop L., Deiser K., Bank U., Witte A., Mohr J., Philipsen L., Fehling H.J., Müller A.J., ... , Kalinke U., Schüler T. (2020)

IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival

Eur.J.Immunol., 50 (6)

DOI: 10.1002/eji.201948368 HZI-Repositorium PubMed

Mulas F., Wang X., Song S., Nishanth G., Yi W., Brunn A., Larsen P.K., Isermann B., Kalinke U., Barragan A., Naumann M., ... , Deckert M., Schlüter D. (2020)

The deubiquitinase OTUB1 augments NF-k[kappa]B-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13

Cell.Mol.Immunol

DOI: 10.1038/s41423-020-0362-6 HZI-Repositorium PubMed

Forster D., Schwarz J.H., Brosinski K., Kalinke U., Sutter G., Volz A. (2020)

Obstetric ultrasonography to detect fetal abnormalities in a mouse model for Zika virus infection

Viruses, 12 (1)

DOI: 10.3390/v12010072 HZI-Repositorium PubMed

Namineni S., O'Connor T., Faure-Dupuy S., Johansen P., Riedl T., Liu K., Xu H., Singh I., Shinde P., Li F., Pandyra A., Sharma P., Ringelhan M., Muschaweckh A., Borst K., Blank P., Lampl S., Durantel D., Farhat R., Weber A., Lenggenhager D., Kündig T.M., Staeheli P., Protzer U., Wohlleber D., Holzmann B., Binder M., Breuhahn K., Assmus L.M., Nattermann J., Abdullah Z., Rolland M., Dejardin E., Lang P.A., Lang K.S., Karin M., Lucifora J., Kalinke U., ... , Knolle P.A., Heikenwalder M. (2020)

A dual role for hepatocyte-intrinsic canonical NF-kappaB signaling in virus control

J.Hepatol., 72 (5)

DOI: 10.1016/j.jhep.2019.12.019 HZI-Repositorium PubMed

Kalodimou G., Veit S., Jany S., Kalinke U., Broder C.C., ... , Sutter G., Volz A. (2019)

A Soluble Version of Nipah Virus Glycoprotein G Delivered by Vaccinia Virus MVA Activates Specific CD8 and CD4 T Cells in Mice

Viruses., 12 (1)

DOI: 10.3390/v12010026 HZI-Repositorium PubMed

Iampietro M., Aurine N., Dhondt K.P., Dumont C., Pelissier R., Spanier J., Vallve A., Raoul H., ... , Kalinke U., Horvat B. (2020)

Control of Nipah Virus Infection in Mice by the Host Adaptors Mitochondrial Antiviral Signaling Protein (MAVS) and Myeloid Differentiation Primary Response 88 (MyD88)

J.Infect.Dis., 221 (Supplement_4)

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Hensel N., Raker V., Forthmann B., Detering N.T., Kubinski S., Buch A., Katzilieris-Petras G., Spanier J., Gudi V., Wagenknecht S., Kopfnagel V., Werfel T.A., Stangel M., Beineke A., Kalinke U., Paludan S.R., ... , Sodeik B., Claus P. (2019)

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

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Lercher A., Bhattacharya A., Popa A.M., Caldera M., Schlapansky M.F., Baazim H., Agerer B., Gurtl B., Kosack L., Majek P., Brunner J.S., Vitko D., Pinter T., Genger J.W., Orlova A., Pikor N., Reil D., Ozsvar-Kozma M., Kalinke U., Ludewig B., Moriggl R., Bennett K.L., Menche J., Cheng P.N., Schabbauer G., Trauner M., ... , Klavins K., Bergthaler A. (2019)

Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

Immunity., 51 (6)

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Ziegler A., Hinz T., Kalinke U. (2019)

RNA-based adjuvants: Immunoenhancing effect on antiviral vaccines and regulatory considerations

Crit.Rev.Immunol., 39 (1)

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Durán V., Yasar H., Becker J., Thiyagarajan D., Loretz B., ... , Kalinke U., Lehr C.M. (2019)

Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells

Nanomed.Nanotechnol.Biol.Med., 21

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Tegtmeyer P.K., Spanier J., Borst K., Becker J., Riedl A., Hirche C., Ghita L., Skerra J., Baumann K., Lienenklaus S., Doering M., ... , Ruzsics Z., Kalinke U. (2019)

STING induces early IFN-b[beta] in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

Nat.Commun., 10 (1)

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Borst K., Graalmann T., Kalinke U. (2019)

Reply to: "Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers"

J.Hepatol., 71 (3)

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Ruangkiattikul N., Rys D., Abdissa K., Rohde M., Semmler T., Tegtmeyer P.K., Kalinke U., Schwarz C., ... , Lewin A., Goethe R. (2019)

Type I interferon induced by TLR2-TLR4-MyD88-TRIF-IRF3 controls Mycobacterium abscessus subsp. abscessus persistence in murine macrophages via nitric oxide

Int.J.Med.Microbiol., 309 (5)

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Solmaz G., Puttur F., Francozo M., Lindenberg M., Guderian M., Swallow M., Duhan V., Khairnar V., Kalinke U., Ludewig B., Clausen B.E., Wagner H., ... , Lang K.S., Sparwasser T.D. (2019)

TLR7 Controls VSV Replication in CD169 + SCS Macrophages and Associated Viral Neuroinvasion

Front Immunol, 10

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Heidegger S., Kreppel D., Bscheider M., Stritzke F., Nedelko T., Wintges A., Bek S., Fischer J.C., Graalmann T., Kalinke U., Bassermann F., ... , Haas T., Poeck H. (2019)

RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade

EBioMedicine, 41 (March)

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Döring M., Blees H., Koller N., Tischer-Zimmermann S., Müsken M., Henrich F., Becker J., Grabski E., Wang J., Janssen H., Zuschratter W., Neefjes J., Klawonn F., Eiz-Vesper B., ... , Tampe R., Kalinke U. (2019)

Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation

Blood Adv., 3 (6)

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Knop L., Frommer C., Stoycheva D., Deiser K., Kalinke U., Blankenstein T., Kammertoens T., ... , Dunay I.R., Schuler T. (2019)

Interferon-gamma Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4(+) T Cells in Chronic Lymphopenic Mice

Front Immunol, 10

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Gawish R., Bulat T., Biaggio M., Lassnig C., Bago-Horvath Z., Macho-Maschler S., Poelzl A., Simonovic N., Prchal-Murphy M., Rom R., Amenitsch L., Ferrarese L., Kornhoff J., Lederer T., Svinka J., Eferl R., Bosmann M., Kalinke U., Stoiber D., Sexl V., Krmpotic A., Jonjic S., ... , Müller M., Strobl B. (2019)

Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1

Cell Rep., 26 (9)

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Borst K., Graalmann T., Kalinke U. (2019)

Reply to: "Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation"

J.Hepatol., 70 (4)

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Tsay H.C., Yuan Q., Balakrishnan A., Kaiser M., Möbus S., Kozdrowska E., Farid M., Tegtmeyer P.K., Borst K., Vondran F.W.R., Kalinke U., Kispert A., Manns M.P., ... , Ott M., Sharma A.D. (2019)

Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis

J.Hepatol., 70 (4)

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Becker J., Kinast V., Döring M., Lipps C., Duran V., Spanier J., Tegtmeyer P.K., Wirth D., Cicin-Sain L., ... , Alcami A., Kalinke U. (2018)

Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines

Virulence., 9 (1)

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Pägelow D., Chhatbar C., Beineke A., Liu X., Nerlich A., van Vorst K., Rohde M., Kalinke U., Förster R., Halle S., Valentin-Weigand P., ... , Hornef M.W., Fulde M. (2018)

The olfactory epithelium as a port of entry in neonatal neurolisteriosis

Nat Commun, 9 (1)

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Tappe K.A., Budida R., Stankov M.V., Frenz T., Shah H., Volz A., Sutter G., ... , Kalinke U., Behrens G.M.N. (2018)

Immunogenic cell death of dendritic cells following modified vaccinia virus Ankara infection enhances CD8(+) T cell proliferation

Eur.J.Immunol.

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Waltl I., Käufer C., Gerhauser I., Chhatbar C., Ghita L., ... , Kalinke U., Löscher W. (2018)

Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage

Brain Behav.Immun., 74

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Käufer C., Chhatbar C., Bröer S., Waltl I., Ghita L., Gerhauser I., ... , Kalinke U., Löscher W. (2018)

Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures

Proc.Natl.Acad.Sci.U.S.A, 115 (38)

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Koestner W., Spanier J., Klause T., Tegtmeyer P.K., Becker J., Herder V., Borst K., Todt D., Lienenklaus S., Gerhauser I., Detje C.N., Geffers R., Langereis M.A., Vondran F.W.R., Yuan Q., van Kuppeveld F.J.M., Ott M., Staeheli P., Steinmann E., Baumgärtner W., ... , Wacker F., Kalinke U. (2018)

Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice

PLoS.Pathog., 14 (8)

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Paijo J., Kaever V., Kalinke U. (2017)

cGAMP quantification in virus-infected human monocyte-derived cells by HPLC-coupled tandem mass spectroscopy

Methods in Molecular Biology, 1656 (chapter 9)

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Herzmann C., Dallenga T., Kalinke U. (2018)

Pulmonale Immunität bei Tuberkulose [Pulmonary Immune Mechanisms in Tuberculosis]

Pneumologie, 72 (7)

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Vendelova E., Ashour D., Blank P., Erhard F., Saliba A.E., ... , Kalinke U., Lutz M.B. (2018)

Tolerogenic transcriptional signatures of steady-state and pathogen-induced dendritic cells

Front.Immunol., 9 (FEB)

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Schleicher U., Liese J., Justies N., Mischke T., Haeberlein S., Sebald H., Kalinke U., ... , Weiss S., Bogdan C. (2018)

Type I interferon signaling is required for CpG-oligodesoxynucleotide-induced control of Leishmania major, but not for spontaneous cure of subcutaneous primary or secondary L. major infection

Front.Immunol., 9 (FEB)

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Narendra S.C., Chalise J.P., Biggs S., Kalinke U., Magnusson M. (2018)

Regulatory T-cells mediate IFN-a-induced resistance against antigen-induced arthritis

Front.Immunol., 9 (FEB)

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Mzinza D.T., Fleige H., Laarmann K., Willenzon S., Ristenpart J., Spanier J., Sutter G., Kalinke U., ... , Valentin-Weigand P., Förster R. (2018)

Application of light sheet microscopy for qualitative and quantitative analysis of bronchus-associated lymphoid tissue in mice

Cell Mol.Immunol., 15 (10)

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Bieling M., Tischer S., Kalinke U., Blasczyk R., Buus S., ... , Maecker-Kolhoff B., Eiz-Vesper B. (2018)

Personalized adoptive immunotherapy for patients with EBVassociated tumors and complications: Evaluation of novel naturally processed and presented EBV-derived T-cell epitopes

Oncotarget, 9 (4)

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Neehus A.-L., Lam J., Haake K., Merkert S., Schmidt N., Mucci A., Ackermann M., Schubert M., Happle C., Kühnel M.P., Blank P., Philipp F., Goethe R., Jonigk D., Martin U., Kalinke U., Baumann U., Schambach A., ... , Roesler J., Lachmann N. (2017)

Impaired IFNg[gamma]-Signaling and Mycobacterial Clearance in IFNg[gamma]R1-Deficient Human iPSC-Derived Macrophages

Stem Cell Reports, 10 (1)

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Waltl I., Br÷er S., Chhatbar C., Ghita L., Gerhauser I., ... , Anjum M., Kalinke U. (2018)

Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis

Neurobiol.Dis., 110

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Borst K., Frenz T., Spanier J., Tegtmeyer P.K., Chhatbar C., Skerra J., Ghita L., Namineni S., Lienenklaus S., Köster M., Heikenwaelder M., ... , Sutter G., Kalinke U. (2017)

Type I interferon receptor-signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis

J.Hepatol., 68 (4)

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Hetzel M., Mucci A., Blank P., Nguyen A.H.H., Schiller J., Halle O., Kuhnel M.P., Billig S., Meineke R., Brand D., Herder V., Baumgartner W., Bange F.C., Goethe R., Jonigk D., Forster R., Gentner B., Casanova J.L., Bustamante J., Schambach A., ... , Kalinke U., Lachmann N. (2017)

Hematopoietic stem cell gene therapy for IFNg[gamma]R1 deficiency protects mice from mycobacterial infections

Blood, 131 (5)

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Speth M.T., Repnik U., Müller E., Spanier J., Kalinke U., ... , Corthay A., Griffiths G. (2017)

Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Gu q

Mol.Pharm., 14 (11)

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Ivin M., Dumigan A., de Vasconcelos F.N., Ebner F., Borroni M., Kavirayani A., Przybyszewska K.N., Ingram R.J., Lienenklaus S., Kalinke U., Stoiber D., ... , Bengoechea J.A., Kovarik P. (2017)

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection

PLoS.Pathog., 13 (11)

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Selvakumar T.A., Bhushal S., Kalinke U., Wirth D., Hauser H., ... , Köster M., Hornef M.W. (2017)

Identification of a Predominantly Interferon-lambda-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells

Front Immunol., 8

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Hinz T., Kallen K., Britten C.M., Flamion B., Granzer U., Hoos A., Huber C., Khleif S., Kreiter S., Rammensee H.G., Sahin U., Singh-Jasuja H., ... , Türeci Ö, Kalinke U. (2017)

The European regulatory environment of rna-based vaccines

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Lirussi D., Ebensen T., Schulze K., Trittel S., Duran V., Liebich I., ... , Kalinke U., Guzmán C.A. (2017)

Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway

EBioMedicine., 22

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Hirche C., Frenz T., Haas S.F., Doring M., Borst K., Tegtmeyer P.K., Brizic I., Jordan S., Keyser K., Chhatbar C., Pronk E., Lin S., Messerle M., Jonjic S., Falk C.S., Trumpp A., ... , Essers M.A.G., Kalinke U. (2017)

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo

Cell Rep., 19 (11)

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Thiemann S., Smit N., Roy U., Lesker T.R., Galvez E.J.C., Helmecke J., Basic M., Bleich A., Goodman A.L., Kalinke U., Flavell R.A., ... , Erhardt M., Strowig T. (2017)

Enhancement of IFNgamma Production by Distinct Commensals Ameliorates Salmonella-Induced Disease

Cell Host.Microbe, 21 (6)

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Matschulla T., Berry R., Gerke C., Doring M., Busch J., Paijo J., Kalinke U., Momburg F., ... , Hengel H., Halenius A. (2017)

A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle

Sci.Rep., 7 (1)

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Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration

PLoS Pathog., 13 (5)

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Ruangkiattikul N., Nerlich A., Abdissa K., Lienenklaus S., Suwandi A., Janze N., Laarmann K., Spanier J., Kalinke U., ... , Weiss S., Goethe R. (2017)

cGAS-STING-TBK1-IRF3/7 Induced Interferon-b[beta] Contributes to the Clearing of Non Tuberculous Mycobacterial Infection in Mice

Virulence., 8 (7)

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Fischer J.C., Bscheider M., Eisenkolb G., Lin C.C., Wintges A., Otten V., Lindemans C.A., Heidegger S., Rudelius M., Monette S., Porosnicu Rodriguez K.A., Calafiore M., Liebermann S., Liu C., Lienenklaus S., Weiss S., Kalinke U., Ruland J., Peschel C., Shono Y., Docampo M., Velardi E., Jenq R.R., Hanash A.M., Dudakov J.A., Haas T., ... , van den Brink M.R.M., Poeck H. (2017)

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

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Hoffmann M., Crone L., Dietzel E., Paijo J., Nehlmeier I., ... , Kalinke U., Becker S. (2017)

A polymorphism within the internal fusion loop of the Ebola virus glycoprotein modulates host cell entry

J.Virol., 91 (9)

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Pfaender S., Walter S., Grabski E., Todt D., Bruening J., Romero-Brey I., Gather T., Brown R.J., Hahn K., Puff C., Pfankuche V.M., Hansmann F., Postel A., Becher P., Thiel V., Kalinke U., Wagner B., Bartenschlager R., Baumgartner W., Feige K., Pietschmann T., ... , Cavalleri J.M., Steinmann E. (2017)

Immune protection against reinfection with nonprimate hepacivirus

Proc.Natl.Acad.Sci U.S A, 114 (12)

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Ziegler A., Soldner C., Lienenklaus S., Spanier J., Trittel S., Riese P., Kramps T., Weiss S., Heidenreich R., Jasny E., Guzmán C.A., Kallen K.J., ... , Fotin-Mleczek M., Kalinke U. (2017)

A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects

J Immunol., 198 (4)

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Kindler E., Gil-Cruz C., Spanier J., Li Y., Wilhelm J., Rabouw H.H., Zust R., Hwang M., V'kovski P., Stalder H., Marti S., Habjan M., Cervantes-Barragan L., Elliot R., Karl N., Gaughan C., van Kuppeveld F.J., Silverman R.H., Keller M., Ludewig B., Bergmann C.C., Ziebuhr J., Weiss S.R., ... , Kalinke U., Thiel V. (2017)

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

PLoS Pathog., 13 (2)

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Maier B.B., Hladik A., Lakovits K., Korosec A., Martins R., Kral J.B., Mesteri I., Strobl B., Müller M., Kalinke U., ... , Merad M., Knapp S. (2016)

Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice

Eur.J.Immunol., 46 (9)

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Pfaender S., Grabski E., Detje C.N., Riebesehl N., Lienenklaus S., Steinmann E., ... , Kalinke U., Pietschmann T. (2016)

Hepatitis C Virus Stimulates Murine CD8a[alpha]-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner

PLoS Pathog., 12 (7)

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Frenz T., Grabski E., Buschjager D., Vaas L.A., Burgdorf N., Schmidt R.E., ... , Witte T., Kalinke U. (2016)

CD4 T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion

J Allergy Clin.Immunol., 138 (2)

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Luckoff A., Caramoy A., Scholz R., Prinz M., Kalinke U., Langmann T. (2016)

Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization

EMBO Mol.Med., 8 (6)

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Blank T., Detje C.N., Spiess A., Hagemeyer N., Brendecke S.M., Wolfart J., Staszewski O., Zoller T., Papageorgiou I., Schneider J., Paricio-Montesinos R., Eisel U.L., Manahan-Vaughan D., Jansen S., Lienenklaus S., Lu B., Imai Y., Muller M., Goelz S.E., Baker D.P., Schwaninger M., Kann O., Heikenwalder M., ... , Kalinke U., Prinz M. (2016)

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

Immunity, 44 (4)

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Andzinski L., Spanier J., Kasnitz N., Kroger A., Jin L., Brinkmann M.M., Kalinke U., Weiss S., ... , Jablonska J., Lienenklaus S. (2016)

Growing tumors induce a local STING dependent type I IFN response in dendritic cells

Int.J Cancer, 139 (6)

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Paijo J., Doring M., Spanier J., Grabski E., Nooruzzaman M., Schmidt T., Witte G., Messerle M., Hornung V., ... , Kaever V., Kalinke U. (2016)

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

PLoS Pathog., 12 (4)

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Weissmuller S., Kronhart S., Kreuz D., Schnierle B., Kalinke U., Kirberg J., ... , Hanschmann K.M., Waibler Z. (2016)

TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model

PLoS ONE, 11 (3)

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Castiglia V., Piersigilli A., Ebner F., Janos M., Goldmann O., Dambock U., Kroger A., Weiss S., Knapp S., Jamieson A.M., Kirschning C., Kalinke U., Strobl B., Muller M., Stoiber D., ... , Lienenklaus S., Kovarik P. (2016)

Type I Interferon Signaling Prevents IL-1b[beta]-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue

Cell Host.Microbe, 19 (3)

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Pfefferkorn C., Kallfass C., Lienenklaus S., Spanier J., Kalinke U., Rieder M., Conzelmann K.K., ... , Michiels T., Staeheli P. (2016)

Abortively infected astrocytes appear to represent the main source of interferon beta in the virus-infected brain

J.Virol., 90 (4)

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Vogel S., Grabski E., Buschjager D., Klawonn F., Doring M., Wang J., Fletcher E., Bechmann I., Witte T., Durisin M., Schraven B., Mangsbo S.M., Schonfeld K., ... , Czeloth N., Kalinke U. (2015)

Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells

Sci Rep., 5

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Waffarn E.E., Hastey C.J., Dixit N., Soo Choi Y., Cherry S., Kalinke U., ... , Simon S.I., Baumgarth N. (2015)

Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation

Nat.Commun., 6

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Skripuletz T., Tejedor L.S., Prajeeth C.K., Hansmann F., Chhatbar C., Kucman V., Zhang N., Raddatz B.B., Detje C.N., Sühs K.W., Pul R., Gudi V., Kalinke U., ... , Baumgärtner W., Stangel M. (2015)

The antiviral drug ganciclovir does not inhibit microglial proliferation and activation

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A highly immunogenic and protective MERS-Coronavirus vaccine based on recombinant MV vaccine platform

J Virol., 89

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Wang H., El Maadidi S., Fischer J., Grabski E., Dickhöfer S., Klimosch S., Flannery S.M., Filomena A., Wolz O.O., Schneiderhan-Marra N., Löffler M.W., Wiese M., Pichulik T., Mullhaupt B., Semela D., Dufour J.F., Bochud P.Y., East-German and Swiss Hepatitis C Virus Study Groups, Bowie A.G., Kalinke U., ... , Berg T., Weber A.N. (2015)

A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance

Hepatology, 62

DOI: 10.1002/hep.28105 PubMed

Brinkmann M.M., Daq F., Hengel H., Messerle M., Kalinke U., Cicin-Sain L. (2015)

Cytomegalovirus immune evasion of myeloid lineage cells

Med.Microbiol.Immunol., 204

Crouse J., Kalinke U., Oxenius A. (2015)

Regulation of antiviral T cell responses by type i interferons

Nat.Rev.Immunol., 15 (4)

Fischbach H., Doring M., Nikles D., Lehnert E., Baldauf C., ... , Kalinke U., Tampe R. (2015)

Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets

Nat.Commun., 6

DOI: 10.1038/ncomms7199 HZI-Repositorium PubMed

Detje C.N., Lienenklaus Stefan, Chhatbar C., Spanier Julia, Prajeeth C.K., Soldner C., Tovey M.G., Schluter D., Weiss Siegfried, ... , Stangel M., Kalinke Ulrich (2014)

Upon intranasal VSV infection astrocytes in the olfactory bulb are important interferon Beta producers that protect from lethal encephalitis

Journal of Virology, 89 (5)

DOI: 10.1128/JVI.02044-14 HZI-Repositorium PubMed

Grabski E., Wappler I., Pfaender S., Steinmann E., Haid S., Dzionek A., ... , Pietschmann T., Kalinke U. (2014)

Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus induced interferon-alpha responses of plasmacytoid dendritic cells

Journal of Virology, 89

DOI: 10.1128/JVI.03229-14 HZI-Repositorium PubMed

Gabaev I., Elbasani E., Ameres S., Steinbruck L., Stanton R., Doring M., Lenac Rovis T., Kalinke Ulrich, Jonjic S., ... , Moosmann A., Messerle M. (2014)

Expression of the Human Cytomegalovirus UL11 Glycoprotein in Viral Infection and Evaluation of its Effect on Virus-Specific CD8 T Cells

Journal of Virology, 88 (24)

Döring M., Lessin I., Frenz T., Spanier J., Kessler A., Tegtmeyer P., Dag F., Thiel N., Trilling M., Lienenklaus S., Weiss S., Scheu S., Messerle M., Cicin-Sain L., ... , Hengel H., Kalinke U. (2014)

M27 expressed by cytomegalovirus counteracts effective type I IFN induction of myeloid cells, but not of plasmacytoid dendritic cells

Journal of Virology, 88 (23)

PubMed

Weber E., Finsterbusch Katja, Lindquist R., Nair S., Lienenklaus S., Gekara N.O.*, Janik D., Weiss S., Kalinke U., ... , Overby A.K., Kröger A. (2014)

Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local anti-viral response

Journal of Virology, 88

PubMed

Spanier J., Lienenklaus Stefan, Paijo J., Kessler A., Borst K., Heindorf Sabrina, Baker D.P., Kröger Andrea, Weiss Siegfried, Detje C.N., ... , Staeheli P., Kalinke Ulrich (2014)

Concomitant TLR/RLH Signaling of Radioresistant and Radiosensitive Cells Is Essential for Protection against Vesicular Stomatitis Virus Infection

Journal of Immunology, 193 (6)

Frenz T., Graalmann L., Detje C.N., Doring M., Grabski E., ... , Scheu S., Kalinke Ulrich (2014)

Independent of Plasmacytoid Dendritic Cell (pDC) infection, pDC Triggered by Virus-Infected Cells Mount Enhanced Type I IFN Responses of Different Composition as Opposed to pDC Stimulated with Free Virus

Journal of Immunology, 193

Bald T., Landsberg J., Lopez-Ramos D., Renn M., Glodde N., Jansen P., Gaffal E., Steitz J., Tolba R., Kalinke Ulrich, Limmer A., Jönsson G., ... , Hölzel M., Tüting T. (2014)

Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation

Cancer Discovery, 4 (6)

Zheng L.S., Hitoshi S., Kaneko N., Takao K., Miyakawa T., Tanaka Y., Xia H., Kalinke Ulrich, Kudo K., Kanba S., ... , Ikenaka K., Sawamoto K. (2014)

Mechanisms for interferon-?-induced depression and neural stem cell dysfunction

Stem Cell Reports, 3 (1)

DOI: 10.1016/j.stemcr.2014.05.015 HZI-Repositorium PubMed

Volz A., Langenmayer M., Jany S., Kalinke Ulrich, Sutter G. (2014)

Rapid expansion of CD8+ T cells in wildtype and type I interferon receptor deficient mice correlates with protection after low-dose emergency immunization with Modified Vaccinia virus Ankara

Journal of Virology, 88

Züst R., Toh Y.X., Cerny D., Heinrich J., Hermida L., Marcos E., Guillén G., ... , Kalinke Ulrich, Shi P.Y. (2014)

Type I interferon signals in macrophages and dendritic cells control dengue virus infection: Implications for a new mouse model to test dengue vaccines

Journal of Virology, 88 (13)

DOI: 10.1128/JVI.03827-13 HZI-Repositorium PubMed

Haque A., Best S.E., De Oca M.M., James K.R., Ammerdorffer A., Edwards C.L., bastida Rivera F., Amante F.H., Bunn P.T., Sheel M., Sebina I., Koyama M., Varelias A., Hertzog P.J., Kalinke Ulrich, Gun S.Y., Rénia L., Ruedl C., MacDonald K.P.A., ... , Hill G.R., Engwerda C.R. (2014)

Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity

Journal of Clinical Investigation, 124 (6)

DOI: 10.1172/JCI70698 HZI-Repositorium PubMed

Crouse J., Bedenikovic G., Wiesel M., Ibberson M., Xenarios I., Von Laer D., Kalinke Ulrich, Vivier E., ... , Jonjic S., Oxenius A. (2014)

Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1

Immunity, 40

Fleige H., Ravens S., Moschovakis G.L., Bölter J., Willenzon S., Sutter G., Häußler Susanne, Kalinke Ulrich, ... , Prinz I., Förster R. (2014)

IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs

Journal of Experimental Medicine, 211 (4)

Nair Sharmila, Michaelsen-Preusse K., Finsterbusch Katja, Stegemann-Koniszewski Sabine, Bruder Dunja, Grashoff Martina, Korte Martin, Köster Mario, Kalinke Ulrich, ... , Hauser Hansjörg, Kröger Andrea (2014)

Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons

PLoS Pathogens, 10 (3)

DOI: 10.1371/journal.ppat.1003999 HZI-Repositorium PubMed

Conrad E., Resch T.K., Gogesch P., Kalinke Ulrich, Bechmann I., ... , Bogdan C., Waibler Z. (2014)

Protection against RNA-induced liver damage by myeloid cells requires type I interferon and IL-1 receptor antagonist in mice

Hepatology, 59 (4)

Bartholomaeus P., Semmler L.Y., Bukur T., Boisguerin V., Romer P.S., Tabares P., Chuvpilo S., Tyrsin D.Y., Matske Victoriah A., Hengel H., Castle J., ... , Hunig T., Kalinke Ulrich (2014)

Cell contact-dependent priming and FC interaction with CD32+ immune cells contribute to the TGN1412-triggered cytokine response

Journal of Immunology, 192 (5)

Lebel M.E., Daudelin J.F., Chartrand K., Tarrab E., Kalinke Ulrich, Savard P., Labrecque N., ... , Leclerc D., Lamarre A. (2014)

Nanoparticle adjuvant sensing by tlr7 enhances cd8+ t cell-mediated protection from listeria monocytogenes infection

Journal of Immunology, 192 (3)

Svitek N., Gerhauser I., Goncalves C., Grabski E., Döring M., Kalinke Ulrich, Anderson D.E., ... , Cattaneo R., Von Messling V. (2014)

Morbillivirus control of the interferon response: Relevance of STAT2 and mda5 but not STAT1 for canine distemper virus virulence in ferrets

Journal of Virology, 88 (5)

Bunse C.E., Borchers S., Varanasi P.R., Tischer S., Figueiredo C., Immenschuh S., Kalinke Ulrich, Köhl U., Goudeva L., Maecker-Kolhoff B., Ganser A., Blasczyk R., ... , Weissinger E.M., Eiz-Vesper B. (2013)

Impaired functionality of antiviral T cells in G-CSF mobilized stem cell donors: Implications for the selection of CTL donor

PLoS ONE, 8 (12)

DOI: 10.1371/journal.pone.0077925 HZI-Repositorium PubMed

Prete F., Catucci M., Labrada M., Gobessi S., Castiello M.C., Bonomi E., Aiuti A., Vermi W., Cancrini C., Metin A., Hambleton S., Bredius R., Notarangelo L.D., van der Burg M., Kalinke Ulrich, ... , Villa A., Benvenuti F. (2013)

Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells

Journal of Experimental Medicine, 210 (2)

Mizutani T., Neugebauer N., Putz E.M., Moritz N., Simma O., Zebedin-Brandl E., Gotthardt D., Warsch W., Eckelhart E., Kantner H.P., Kalinke U., Lienenklaus Stefan, Weiss Siegfried, Strobl B., Muller M., ... , Sexl V., Stoiber D. (2012)

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

Oncoimmunology, 1 (7)

DOI: 10.4161/onci.21284 HZI-Repositorium PubMed

Hogner K., Wolff T., Pleschka S., Plog S., Gruber A.D., Kalinke U., Walmrath H.D., Bodner J., Gattenlohner S., Lewe-Schlosser P., Matrosovich M., Seeger W., ... , Lohmeyer J., Herold S. (2013)

Macrophage-expressed IFN-b[beta] contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia

PLoS Pathogens, 9 (2)

DOI: 10.1371/journal.ppat.1003188 HZI-Repositorium PubMed

Britten C.M., Singh-Jasuja H., Flamion B., Hoos A., Huber C., Kallen K.J., Khleif S.N., Kreiter S., Nielsen M., Rammensee H.G., Sahin U., ... , Hinz T., Kalinke Ulrich (2013)

The regulatory landscape for actively personalized cancer immunotherapies

Nature Biotechnology, 31 (10)

Siegfried A., Berchtold S., Manncke B., Deuschle E., Reber J., Ott T., Weber M., Kalinke U., Hofer M.J., Hatesuer Bastian, Schughart Klaus, Gailus-Durner V., Fuchs H., Hrabe de Angelis M., Weber F., Hornef M.W., ... , Autenrieth I.B., Bohn E. (2013)

IFIT2 Is an Effector Protein of Type I IFN-Mediated Amplification of Lipopolysaccharide (LPS)-Induced TNF-a[alpha] Secretion and LPS-Induced Endotoxin Shock

Journal of Immunology, 191 (7)

DOI: 10.4049/jimmunol.1203305 PubMed

Frentzen Anne, Kusuma Angga, Guerlevik E., Hueging Kathrin, Knocke S., Ginkel Corinne, Brown Richard J.P., Heim M., Dill M.T., Kröger Andrea, Kalinke Ulrich, Kaderali L., ... , Kuehnel F., Pietschmann Thomas (2013)

Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells

Hepatology

DOI: 10.1002/hep.26626 HZI-Repositorium PubMed

Goulet M.L., Olagnier D., Xu Z., Paz S., Belgnaoui S.M., Lafferty E.I., Janelle V., Arguello M., Paquet M., Ghneim K., Richards S., Smith A., Wilkinson P., Cameron M., Kalinke Ulrich, Qureshi S., Lamarre A., Haddad E.K., Sekaly R.P., Peri S., Balachandran S., ... , Lin R., Hiscott J. (2013)

Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

PLoS Pathogens, 9 (4)

DOI: 10.1371/journal.ppat.1003298 HZI-Repositorium PubMed

Kremer M., Suezer Y., Volz A., Frenz T., Majzoub M., Hanschmann K.M., Lehmann M.H., ... , Kalinke Ulrich*, Sutter G. (2012)

Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox1

PLoS Pathogens, 8 (3)

DOI: 10.1371/journal.ppat.1002557 HZI-Repositorium PubMed

Baranek T., Manh T.P., Alexandre Y., Maqbool M.A., Cabeza J.Z., Tomasello E., Crozat K., Bessou G., Zucchini N., Robbins S.H., Vivier E., Kalinke Ulrich*, ... , Ferrier P., Dalod M. (2012)

Differential responses of immune cells to type I interferon contribute to host resistance to viral infection1

Cell Host and Microbe, 12 (4)

DOI: 10.1016/j.chom.2012.09.002 HZI-Repositorium PubMed

Kernbauer E., Maier V., Stoiber D., Strobl B., Schneckenleithner C., Sexl V., Reichart U., Reizis B., Kalinke Ulrich*, Jamieson A., ... , Muller M., Decker T. (2012)

Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection1

PLoS Pathogens, 8 (6)

DOI: 10.1371/journal.ppat.1002763 HZI-Repositorium PubMed

Weissmuller S., Semmler L.Y., Kalinke Ulrich*, Christians S., Muller-Berghaus J., Waibler Z. (2012)

ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation1

Blood, 119 (26)

Kalinke Ulrich*, Prinz M. (2012)

Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS13777

Immunology and Cell Biology, 90 (5)

DOI: 10.1038/icb.2012.8 HZI-Repositorium PubMed

Arico E., Monque D.M., D'Agostino G., Moschella F., Venditti M., Kalinke U., Allen D.J., Nash A.A., ... , Belardelli F., Ferrantini M. (2012)

Corrigendum to "MHV-68 producing mIFNa[alpha]1 is severely attenuated in vivo and effectively protects mice against challenge with wt MHV-68" [Vaccine 29 (2011) 3935-3944]1

Vaccine, 30 (20)

DOI: 10.1016/j.vaccine.2011.03.09 PubMed

Schwandt T., Schumak B., Gielen G.H., Jungerkes F., Schmidbauer P., Klocke K., Staratschek-Jox A., Van Rooijen N., Kraal G., Ludwig-Portugall I., Franken L., Wehner S., Kalff J.C., Weber O., Kirschning C., Coch C., Kalinke Ulrich*, Wenzel J., Kurts C., Zawatzky R., Holzmann B., Layland L., Schultze J.L., Burgdorf S., den Haan J.M., ... , Knolle P.A., Limmer A. (2011)

Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis

Embo Journal, 31 (1)

Dann A., Poeck H., Croxford A.L., Gaupp S., Kierdorf K., Knust M., Pfeifer D., Maihoefer C., Endres S., Kalinke Ulrich*, Meuth S.G., Wiendl H., Knobeloch K.-P., Akira S., Waisman A., ... , Hartmann G., Prinz M. (2012)

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS

Nature Neuroscience, 15 (1)

Schülke S., Burggraf M., Waibler Z., Wangorsch A., Wolfheimer S., Kalinke Ulrich*, Vieths S., ... , Toda M., Scheurer S. (2011)

A fusion protein of flagellin and ovalbumin suppresses the T(H)2 response and prevents murine intestinal allergy

Journal of Allergy and Clinical Immunology, 128 (6)

Diamond M.S., Kinder M., Matsushita H., Mashayekhi M., Dunn G.P., Archambault J.M., Lee H., Arthur C.D., White J.M., Kalinke Ulrich*, ... , Murphy K.M., Schreiber R.D. (2011)

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

Journal of Experimental Medicine, 208 (10)

Dominguez P.M., Lopez-Bravo M., Kalinke U., Ardavin C. (2011)

Statins inhibit iNOS-mediated microbicidal potential of activated monocyte-derived dendritic cells by an IFN-b[beta]-dependent mechanism

European Journal of Immunology, 41 (11)

DOI: 10.1002/eji.201141674 HZI-Repositorium PubMed

Chopy D., Detje C.N., Lafage M., Kalinke Ulrich*, Lafon M. (2011)

The type I interferon response bridles rabies virus infection and reduces pathogenicity

Journal of NeuroVirology, 17 (4)

Kalinke Ulrich*, Bechmann I., Detje C.N. (2011)

Host strategies against virus entry via the olfactory system

Virulence, 2 (4)

HZI-Repositorium PubMed

Williams S.K., Fairless R., Weise J., Kalinke Ulrich*, Schulz-Schaeffer W., Diem R. (2011)

Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis

American Journal of Pathology, 178 (6)

Arico E., Monque D.M., D'Agostino G., Moschella F., Venditti M., Kalinke U., Allen D.J., Nash A.A., ... , Belardelli F., Ferrantini M. (2011)

MHV-68 producing mIFNa[alpha]1 is severely attenuated in vivo and effectively protects mice against challenge with wt MHV-68

Vaccine, 29 (23)

DOI: 10.1016/j.vaccine.2011.03.092 PubMed

Grabski E., Waibler Z., Schule S., Kloke B.P., Sender L.Y., Panitz S., Cichutek K., ... , Schweizer M., Kalinke Ulrich* (2011)

Comparative Analysis of Transduced Primary Human Dendritic Cells Generated by the Use of Three Different Lentiviral Vector Systems

Molecular Biotechnology, 47 (3)

Gratz M.S., Suezer Y., Kremer M., Volz A., Majzoub M., Hanschmann K.M., Kalinke Ulrich*, ... , Schwantes A., Sutter G. (2011)

N1L Is an Ectromelia Virus Virulence Factor and Essential for In Vivo Spread upon Respiratory Infection

Journal of Virology, 85 (7)

Murikinati S., Juttler E., Keinert T., Ridder D.A., Muhammad S., Waibler Z., Ledent C., Zimmer A., ... , Kalinke Ulrich*, Schwaninger M. (2010)

Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment

FASEB journal, 24 (3)

Ilchmann A., Burgdorf S., Scheurer S., Waibler Z., Nagai R., Wellner A., Yamamoto Y., Yamamoto H., Henle T., Kurts C., Kalinke Ulrich*, ... , Vieths S., Toda M. (2010)

Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II

Journal of Allergy and Clinical Immunology, 125 (1)

Goossens P., Gijbels M.J., Zernecke A., Eijgelaar W., Vergouwe M.N., van der Made I, Vanderlocht J., Beckers L., Buurman W.A., Daemen M.J., Kalinke Ulrich*, Weber C., ... , Lutgens E., de Winther M.P. (2010)

Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions

Cell Metabolism, 12 (2)

Sender L.Y., Gibbert K., Suezer Y., Radeke H.H., Kalinke Ulrich*, Waibler Z. (2010)

CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals

Molecular immunology, 47 (6)

Kochs G., Bauer S., Vogt C., Frenz T., Tschopp J., ... , Kalinke Ulrich*, Waibler Z. (2010)

Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells

Journal of Virology, 84 (23)

DOI: 10.1128/JVI.00931-10 HZI-Repositorium PubMed

Frenz T., Waibler Z., Hofmann J., Hamdorf M., Lantermann M., Reizis B., Tovey M.G., Aichele P., ... , Sutter G., Kalinke Ulrich* (2010)

Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion

European Journal of Immunology, 40 (10)

Prinz M., Kalinke Ulrich* (2010)

New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS

Trends in Molecular Medicine, 16 (8)

Lang P.A., Recher M., Honke N., Scheu S., Borkens S., Gailus N., Krings C., Meryk A., Kulawik A., Cervantes-Barragan L., Van Rooijen N., Kalinke Ulrich*, Ludewig B., Hengartner H., Harris N., Haussinger D., Ohashi P.S., ... , Zinkernagel R.M., Lang K.S. (2010)

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice

Hepatology, 52 (1)

Waibler Z., Sender L.Y., Merten C., Hartig R., Kliche S., Gunzer M., Reichardt P., ... , Kalinke Ulrich*, Schraven B. (2008)

Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies

PLoS ONE, 3 (3)

Waibler Z., Anzaghe M., Konur A., Akira S., Müller W., Kalinke U. (2008)

Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC

European Journal of Immunology, 38 (11)

DOI: 10.1002/eji.200838184 HZI-Repositorium PubMed

Detje C.N., Meyer T., Schmidt H., Kreuz D., Rose J.K., Bechmann I., ... , Prinz M., Kalinke Ulrich* (2009)

Local type I IFN receptor signaling protects against virus spread within the central nervous system

Journal of Immunology, 182 (4)

DOI: 10.4049/jimmunol.0800596 HZI-Repositorium

Stockinger S., Kastner R., Kernbauer E., Pilz A., Westermayer S., Reutterer B., Soulat D., Stengl G., Vogl C., Frenz T., Waibler Z., Taniguchi T., Rulicke T., Kalinke Ulrich*, ... , Muller M., Decker T. (2009)

Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes

PLoS Pathogens, 5 (3)

DOI: 10.1371/journal.ppat.1000355 HZI-Repositorium PubMed

Anz D., Thaler R., Stephan N., Waibler Z., Trauscheid M.J., Scholz C., Kalinke Ulrich*, Barchet W., ... , Endres S., Bourquin C. (2009)

Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus

Journal of Immunology, 182 (10)

Bach P., Tschape J.A., Kopietz F., Braun G., Baade J.K., Wiederhold K.H., Staufenbiel M., Prinz M., Deller T., Kalinke U., ... , Buchholz C.J., Muller U.C. (2009)

Vaccination with Abeta-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice

Journal of Immunology, 182 (12)

DOI: 10.4049/jimmunol.0803366 PubMed

Pilz A., Kratky W., Stockinger S., Simma O., Kalinke Ulrich*, Lingnau K., von Gabain A., Stoiber D., Sexl V., Kolbe T., Rulicke T., ... , Muller M., Decker T. (2009)

Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL

Journal of Immunology, 183 (4)

Kern M., Popov A., Scholz K., Schumak B., Djandji D., Limmer A., Eggle D., Sacher T., Zawatzky R., Holtappels R., Reddehase M.J., Hartmann G., bey-Pascher S., Diehl L., Kalinke Ulrich*, Koszinowski U., ... , Schultze J., Knolle P.A. (2010)

Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity

Gastroenterology, 138 (1)

Al Moussawi K., Ghigo E., Kalinke Ulrich*, Alexopoulou L., Mege J.L., Desnues B. (2010)

Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei

PLoS Pathogens, 6 (1)

DOI: 10.1371/journal.ppat.1000722 HZI-Repositorium PubMed

Essers M.A., Offner S., Blanco-Bose W.E., Waibler Z., Kalinke U., ... , Duchosal M.A., Trumpp A. (2009)

IFNalpha activates dormant haematopoietic stem cells in vivo

Nature, 458 (7240)

DOI: 10.1038/nature0781 PubMed

Cucak H., Yrlid U., Reizis B., Kalinke Ulrich*, Johansson-Lindbom B. (2009)

Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells

Immunity, 31 (3)

DOI: 10.1016/j.immuni.2009.07.005 HZI-Repositorium

Waibler Z., Anzaghe M., Frenz T., Schwantes A., Pohlmann C., Ludwig H., Palomo-Otero M., Alcami A., ... , Sutter G., Kalinke Ulrich* (2009)

Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components

Journal of Virology, 83 (4)

Waibler Z., Sender L.Y., Kamp C., Muller-Berghaus J., Liedert B., Schneider C.K., ... , Lower J., Kalinke Ulrich* (2008)

Toward experimental assessment of receptor occupancy: TGN1412 revisited

Journal of Allergy and Clinical Immunology, 122 (5)

Schneider C.K., Kalinke Ulrich* (2008)

Toward biosimilar monoclonal antibodies

Nature Biotechnology, 26 (9)

Waibler Z., Anzaghe M., Ludwig H., Akira S., Weiss Siegfried*, ... , Sutter G., Kalinke U. (2007)

Modified vaccinia virus Ankara induces toll-like receptor-independent type I interferon responses

Journal of Virology, 81 (22)

Schleicher U., Liese J., Knippertz I., Kurzmann C., Hesse A., Heit A., Fischer J.A.A., Weiss Siegfried*, Kalinke U., ... , Kunz S., Bogdan C. (2007)

NK cell activation in visceral Leishmaniasis requires

Journal of Experimental Medicine, 204

DOI: 10.1084/jem.20061293 HZI-Repositorium PubMed

Blakqori G., Delhaye S., Habjan M., Blair C.D., Sanchez-Vargas I., Olson K.E., Attarzadeh-Yazdi G., Fragkoudis R., Kohl A., Kalinke U., Weiss Siegfried*, Michiels T., ... , Staeheli P., Weber F. (2007)

La Crosse bunyavirus

Journal of Virology, 81 (10)

DOI: 10.1128/JVI.01933-06. HZI-Repositorium

Koerner I., Kochs G., Kalinke U., Weiss S., Staeheli P. (2007)

Protective role of beta interferon in host defense against influenza a virus

Journal of Virology, 81 (4)

DOI: 10.1128/JVI.01718-06 HZI-Repositorium PubMed

Osterloh A., Kalinke U., Weiss Siegfried*, Fleischer B., Breloer M. (2007)

Synergistic and differential modulation of immune responses by HSP60 and Lipopolysaccharide

The Journal of Biological Chemistry, 282

DOI: 10.1074/jbc.M608666200 HZI-Repositorium PubMed

Gerlach N., Schimmer S., Weiss Siegfried*, Kalinke U., Dittmer U. (2006)

Effects of type I interferons on friend retrovirus infection

Journal of Virology, 80

DOI: 10.1128/JVI.80.7.3438-3444.2006 HZI-Repositorium PubMed

Liehl P., Zuzarte-Luis V., Chan J., Zillinger T., Baptista F., Carapau D., Konert M., Hanson K.K., Carret C., Lassnig C., Muller M., Kalinke Ulrich, Saeed M., Chora A.F., Golenbock D.T., Strobl B., Prudencio M., Coelho L.P., Kappe S.H., Superti-Furga G., Pichlmair A., Vigario A.M., Rice C.M., Fitzgerald K.A., ... , Barchet W., Mota M.M. (2014)

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Nature medicine, 20 (1)

DOI: 10.1038/nm.3424 HZI-Repositorium PubMed

Prof. Dr. Ulrich Kalinke

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