Prof. Dr. Susanne Engelmann

Prof. Dr. Susanne Engelmann
Arbeitsgruppenleiterin

Susanne Engelmann studierte Biologie an der Universität Greifswald und promovierte dort am Institut für Mikrobiologie. Im Jahr 2001 übernahm sie die Leitung der Arbeitsgruppe „Pathogenomik“ am Greifswalder Institut für Mikrobiologie und folgte im Jahr 2013 dem Ruf der TU Braunschweig auf die Professur für Mikrobielle Proteomforschung. Gleichzeitig übernahm sie die Leitung der Arbeitsgruppe „Mikrobielle Proteomik“ am HZI.

Publikationen
Müller-Langhans K., Oberberger L., Zablotski Y., Engelmann S., Hoedemaker M., Kühn C., Schuberth H.J., Zerbe H., ... , Petzl W., Meyerholz-Wohllebe M.M. (2024)
Cows with diverging haplotypes show differences in differential milk cell count, milk parameters and vaginal temperature after S. aureus challenge but not after E. coli challenge
BMC Veterinary Research, 20 (1)

Fuchs S., Engelmann S. (2023)
Small proteins in bacteria - Big challenges in prediction and identification
Proteomics.

Seffer M.T., Weinert M., Molinari G., Rohde M., Gröbe L., ... , Kielstein J.T., Engelmann S. (2023)
Staphylococcus aureus binding to Seraph- â
PLoS ONE, 18 (3)

Becker D., Weikard R., Heimes A., Hadlich F., Hammon H.M., Meyerholz M.M., Petzl W., Zerbe H., Schuberth H.J., Hoedemaker M., Schmicke M., ... , Engelmann S., Kühn C. (2022)
Allele-biased expression of the bovine APOB gene associated with the cholesterol deficiency defect suggests cis-regulatory enhancer effects of the LTR retrotransposon insertion
Sci.Rep., 12 (1)

Thunberg U., Hugosson S., Fredlund H., Cai Y., Ehricht R., Monnecke S., Müller E., ... , Engelmann S., Söderquist B. (2019)
Anti-Staphyloccocal humoral immune response in patients with chronic rhinosinusitis
Rhinology online, 2019 (2)

Mayer K., Kucklick M., Marbach H., Ehling-Schulz M., Engelmann S., Grunert T. (2021)
Within-host adaptation of staphylococcus aureus in a bovine mastitis infection is associated with increased cytotoxicity
Int.J.Mol.Sci., 22 (16)

Bartholomäus A., Kolte B., Mustafayeva A., Goebel I., Fuchs S., Benndorf D., ... , Engelmann S., Ignatova Z. (2021)
smORFer: a modular algorithm to detect small ORFs in prokaryotes
Nucleic Acids Res.

Fuchs S., Kucklick M., Lehmann E., Beckmann A., Wilkens M., Kolte B., Mustafayeva A., Ludwig T., Diwo M., Wissing J., Jänsch L., Ahrens C.H., ... , Ignatova Z., Engelmann S. (2021)
Towards the characterization of the hidden world of small proteins in Staphylococcus aureus, a proteogenomics approach
PLoS.Genet., 17 (6)

Beier N., Kucklick M., Fuchs S., Mustafayeva A., Behringer M., Hürtig E., ... , Jahn D., Engelmann S. (2021)
Adaptation of Dinoroseobacter shibae to oxidative stress and the specific role of RirA
PLoS ONE, 16 (3)

Wang H., Beier N., Boedeker C., Sztajer H., Henke P., Neumann-Schaal M., Mansky J., Rohde M., Overmann J., Petersen J., Klawonn F., Kucklick M., Engelmann S., ... , Tomasch J., Wagner-Döbler I. (2021)
Dinoroseobacter shibae outer membrane vesicles are enriched for the chromosome dimer resolution site dif
mSystems., 6 (1)

Seffer M.T., Eden G., Engelmann S., Kielstein J.T. (2020)
Elimination of Staphylococcus aureus from the bloodstream using a novel biomimetic sorbent haemoperfusion device
BMJ Case.Rep., 13 (8)

Heimes A., Brodhagen J., Weikard R., Seyfert H.M., Becker D., Meyerholz M.M., Petzl W., Zerbe H., Hoedemaker M., Rohmeier L., Schuberth H.J., Schmicke M., ... , Engelmann S., Kühn C. (2020)
Hepatic Transcriptome Analysis Identifies Divergent Pathogen-Specific Targeting-Strategies to Modulate the Innate Immune System in Response to Intramammary Infection
Front.Immunol., 11

Heimes A., Brodhagen J., Weikard R., Becker D., Meyerholz M.M., Petzl W., Zerbe H., Schuberth H.J., Hoedemaker M., Schmicke M., ... , Engelmann S., Kühn C. (2020)
Cows selected for divergent mastitis susceptibility display a differential liver transcriptome profile after experimental Staphylococcus aureus mammary gland inoculation
J.Dairy Sci., 103 (7)

Rohmeier L., Petzl W., Koy M., Eickhoff T., Hülsebusch A., Jander S., Macias L., Heimes A., Engelmann S., Hoedemaker M., Seyfert H.M., Kühn C., Schuberth H.J., ... , Zerbe H., Meyerholz M.M. (2020)
In vivo model to study the impact of genetic variation on clinical outcome of mastitis in uniparous dairy cows
BMC.Vet.Res., 16 (1)

Kohler C., Proctor R.A., Bayer A.S., Yeaman M.R., Lalk M., ... , Engelmann S., Mishra N.N. (2019)
Proteomic and Membrane Lipid Correlates of Reduced Host Defense Peptide
Antibiotics.(Basel), 8 (4)

Meyerholz M.M., Rohmeier L., Eickhoff T., Hülsebusch A., Jander S., Linden M., Macias L., Koy M., Heimes A., Gorríz-Martín L., Segelke D., Engelmann S., Schmicke M., Hoedemaker M., Petzl W., Zerbe H., ... , Schuberth H.J., Kühn C. (2019)
Genetic selection for bovine chromosome 18 haplotypes associated with divergent somatic cell score affects postpartum reproductive and metabolic performance
J.Dairy Sci., 102 (11)

Heimes A., Brodhagen J., Weikard R., Hammon H.M., Meyerholz M.M., Petzl W., Zerbe H., Engelmann S., Schmicke M., Hoedemaker M., ... , Schuberth H.J., Kühn C. (2019)
Correction to: Characterization of functional traits with focus on udder health in heifers with divergent paternally inherited haplotypes on BTA18 (BMC Vet Res (2019) 15:241 DOI: 10.1186/s12917-019-1988-4)
BMC Vet.Res., 15 (1)

Heimes A., Brodhagen J., Weikard R., Hammon H.M., Meyerholz M.M., Petzl W., Zerbe H., Engelmann S., Schmicke M., Hoedemaker M., ... , Schuberth H.J., Kühn C. (2019)
Characterization of functional traits with focus on udder health in heifers with divergent paternally inherited haplotypes on BTA18
BMC Vet.Res., 15 (1)

Brodhagen J., Weikard R., Thom U., Heimes A., Günther J., Hadlich F., Zerbe H., Petzl W., Meyerholz M.M., Hoedemaker M., Schuberth H.J., ... , Engelmann S., Kühn C. (2019)
Development and evaluation of a milk protein transcript depletion method for differential transcriptome analysis in mammary gland tissue
BMC GENOMICS, 20 (1)

Seiß E.A., Krone A., Formaglio P., Goldmann O., Engelmann S., Schraven B., ... , Medina E., Müller A.J. (2019)
Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils
Sci.Rep., 9 (1)

Lerch M.F., Schoenfelder S.M.K., Marincola G., Wencker F.D.R., Eckart M., Förstner K.U., Sharma C.M., Thormann K.M., Kucklick M., ... , Engelmann S., Ziebuhr W. (2019)
A non-coding RNA from the intercellular adhesin (ica) locus of Staphylococcus epidermidis controls polysaccharide intercellular adhesin (PIA)-mediated biofilm formation
Mol.Microbiol., 111 (6)

Engelmann S., Fuchs S. (2018)
Proteomic Signatures in Staphylococcus aureus
Methods Mol.Biol., 1841 (chapter 9)

Graf A., Lewis R.J., Fuchs S., Pagels M., Engelmann S., ... , Riedel K., Pané-Farré J. (2018)
The hidden lipoproteome of Staphylococcus aureus
Int.J.Med.Microbiol., 308 (6)

Romero Pastrana F., Neef J., Koedijk D.G.A.M., De Graaf D., Duipmans J., Jonkman M.F., Engelmann S., ... , van Dijl J.M., Buist G. (2018)
Human antibody responses against non-covalently cell wall-bound Staphylococcus aureus proteins
Sci.Rep., 8 (1)

Treffon J., Block D., Moche M., Reiss S., Fuchs S., Engelmann S., Becher D., Langhanki L., Mellmann A., ... , Peters G., Kahl B.C. (2018)
Adaptation of Staphylococcus aureus to the airways of cystic fibrosis patients by the up-regulation of superoxide dismutase M and iron-scavenging proteins
J.Infect.Dis., 217 (9)

Boedeker C., Schuler M., Reintjes G., Jeske O., van Teeseling M.C., Jogler M., Rast P., Borchert D., Devos D.P., Kucklick M., Schaffer M., Kolter R., van Niftrik L., Engelmann S., Amann R., Rohde M., ... , Engelhardt H., Jogler C. (2017)
Determining the bacterial cell biology of Planctomycetes
Nat.Commun., 8

Engelmann S., Fuchs S., Hecker M. (2016)
Physiological proteomics of S. aureus - from the protein inventory to stress physiology and in vivo adaption
(7)

Vu C.H., Kolata J., Stentzel S., Beyer A., Gesell Salazar M., Steil L., Pane-Farre J., Rühmling V., Engelmann S., Götz F., van Dijl J.M., Hecker M., Mäder U., Schmidt F., ... , Völker U., Bröker B.M. (2016)
Adaptive immune response to lipoproteins of Staphylococcus aureus in healthy subjects
Proteomics, 16 (20)

Zühlke D., Dörries K., Bernhardt J., Maaß S., Muntel J., Liebscher V., Pané-Farré J., Riedel K., Lalk M., Völker U., Engelmann S., Becher D., ... , Fuchs S., Hecker M. (2016)
Costs of life-Dynamics of the protein inventory of Staphylococcus aureus during anaerobiosis
Sci.Rep., 6

Stentzel S., Teufelberger A., Nordengrun M., Kolata J., Schmidt F., van Crombruggen K., Michalik S., Kumpfmuller J., Tischer S., Schweder T., Hecker M., Engelmann S., Volker U., Krysko O., ... , Bachert C., Broker B.M. (2016)
Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus
J Allergy Clin.Immunol., 139 (2)

Selle M., Hertlein T., Oesterreich B., Klemm T., Kloppot P., Muller E., Ehricht R., Stentzel S., Broker B.M., ... , Engelmann S., Ohlsen K. (2016)
Global antibody response to Staphylococcus aureus live-cell vaccination
Sci Rep., 6

Kloppot P., Selle M., Kohler C., Stentzel S., Fuchs S., Liebscher V., Müller E., Kale D., Ohlsen K., Bröker B.M., Zipfel P.F., Kahl B.C., Ehricht R., ... , Hecker M., Engelmann S. (2015)
Microarray-based identification of human antibodies against Staphylococcus aureus antigens
Proteomics Clin.Appl., 9 (11-12)

Bauer I., Gunther J., Wheeler T.T., Engelmann S., Seyfert H.M. (2015)
Extracellular milieu grossly alters pathogen-specific immune response of mammary epithelial cells
BMC Vet.Res, 11

Stentzel S., Sundaramoorthy N., Michalik S., Nordengrun M., Schulz S., Kolata J., Kloppot P., Engelmann S., Steil L., Hecker M., Schmidt F., Volker U., ... , Roghmann M.C., Broker B.M. (2015)
Specific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression
J Proteomics, 128

Hasenberg A., Hasenberg M., Mann L., Neumann F., Borkenstein L., Stecher M., Kraus A., Engel D.R., Klingberg A., Seddigh P., Abdullah Z., Klebow S., Engelmann S., Reinhold A., Brandau S., Seeling M., Waisman A., Schraven B., Gothert J.R., ... , Nimmerjahn F., Gunzer M. (2015)
Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes
Nat.Methods, 12 (5)

Neumann Y., Ohlsen K., Donat S., Engelmann Susanne, Kusch H., Albrecht D., Cartron M., ... , Hurd A., Foster S.J. (2014)
The effect of skin fatty acids on Staphylococcus aureus
Archives of Microbiology, 197

Halbedel S., Reiss S., Hahn B., Albrecht D., Mannala G.K., Chakraborty T., Hain T., ... , Engelmann Susanne, Flieger A. (2014)
A systematic proteomic analysis of listeria monocytogenes house-keeping protein secretion systems
Molecular and Cellular Proteomics, 13 (11)

Müller M., Reiß S., Schlüter R., Mäder U., Beyer A., Reiß W., Marles-Wright J., Lewis R.J., Pförtner H., Völker U., Riedel K., Hecker M., ... , Engelmann Susanne, Pané-Farré J. (2014)
Deletion of membrane-associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus
Molecular Microbiology, 93 (6)

Kusch H., Engelmann Susanne (2013)
Secrets of the secretome in Staphylococcus aureus
International Journal of Medical Microbiology, 304

Engelmann S., Togni M., Thielitz A., Reichardt P., Kliche S., Reinhold D., ... , Schraven Burkhart, Reinhold A. (2013)
T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice
Journal of Immunology, 191 (10)

Togni M., Engelmann S., Reinhold D., Schraven B., Reinhold A. (2012)
The adapter protein ADAP is required for selected dendritic cell functions
Cell Communication and Signalling, 10 (1)

Kusch K., Hanke K., Holtfreter S., Schmudde M., Kohler C., Erck C., Wehland J., Hecker M., Ohlsen K., ... , Broker B., Engelmann S. (2011)
The influence of SaeRS and sigma(B) on the expression of superantigens in different Staphylococcus aureus isolates
International Journal of Medical Microbiology, 301 (6)

Quiel A., Jurgen B., Piechotta G., Le Foll A.P., Ziebandt A.K., Kohler C., Koster D., Engelmann S., Erck C., Hintsche R., Wehland Jürgen*, ... , Hecker M., Schweder T. (2009)
Electrical protein array chips for the detection of staphylococcal virulence factors
Applied Microbiology and Biotechnology, 85 (5)