Ausgewählte Publikationen

Chen FF#, Lukat P#, Iqbal AA, Saile K, Kaever V, van den Heuvel J, Blankenfeldt W, Büssow K*, Pessler F* (2019). Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc Natl Acad Sci, doi: 10.1073/pnas.1908770116; #equal contribution; *corresponding authors

Witzgall F, Depke T, Hoffmann M, Empting M, Brönstrup M, Müller R, Blankenfeldt W (2018). The Alkylquinolone Repertoire of Pseudomonas aeruginosa is linked to Structural Flexibility of the FabH-like PQS Biosynthesis Enzyme PqsBC. Chembiochem 19:1531-44

Diederich C#, Leypold M#, Culka M#, Weber HJ, Breinbauer R*, Ullmann GM* & Blankenfeldt W* (2017). Mechanisms and specificity of phenazine biosynthesis protein PhzF. Sci Rep. 7:6272. #equal contribution; *corresponding authors

Bock T, Luxenburger E, Hoffmann J, Schütza V, Feiler C, Müller R & Blankenfeldt W (2017). AibA/AibB induces an intramolecular decarboxylation in de novo isovalerate biosynthesis of Myxococcus xanthus. Angew Chem Int Ed Engl. 56:9986-9

Zender M, Witzgall F, Drees SL, Weidel E, Maurer CK, Fetzner S, Blankenfeldt W, Empting M* & Hartmann RW* (2016). Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds. ACS Chem Biol 11:1755-63; * corresponding authors

Publikationen

Research Papers

Truthe S., Klassert T.E., Schmelz S., Jonigk D., Blankenfeldt W., Slevogt H. (2024)
Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions
Journal of Innate Immunity, 16 (1)

Mingers T., Barthels S., Mass V., Acuna J.M.B., Biedendieck R., Cooke A., Dailey T.A., Gerdes S., Blankenfeldt W., Dailey H.A., Warren M.J., ... , Jahn M., Jahn D. (2024)
The alternative coproporphyrinogen III oxidase (CgoN) catalyzes the oxygen-independent conversion of coproporphyrinogen III into coproporphyrin III
Front.Microbiol., 15

Ajay A.K., Gasser M., Hsiao L.L., Böldicke T., Waaga-Gasser A.M. (2024)
TLR2 and TLR9 Blockade Using Specific Intrabodies Inhibits Inflammation-Mediated Pancreatic Cancer Cell Growth
Antibodies (Basel), 13 (1)

Storm A., Köster J., Ghorbani-Asl M., Kretschmer S., Gorelik T.E., ... , Krasheninnikov A.V., Kaiser U. (2023)
Structural Transformations in Few-Layer MnPSe3 Stimulated by Thermal Annealing and Electron Irradiation
Journal of Physical Chemistry C, 127 (51)

Hiller M., Diwo M., Wamp S., Gutsmann T., Lang C., ... , Blankenfeldt W., Flieger A. (2023)
Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA
Mol.Microbiol.

Gorelik T.E., Lukat P., Kleeberg C., Blankenfeldt W., Mueller R. (2023)
Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution
Acta Crystallogr.A Found.Adv., 79 (6)

Gorelik T.E., Beko S.L., Teteruk J., Heyse W., Schmidt M.U. (2023)
Analysis of diffuse scattering in electron diffraction data for the crystal structure determination of Pigment Orange 13, C32H24Cl2N8O2
Acta Crystallogr.Sect.B Struct.Sci.Crys.Eng.Mater., 79 (2)

Kirchenwitz M., Halfen J., von Peinen K., Prettin S., Kollasser J., Zur Lage S., Blankenfeldt W., Brakebusch C., Rottner K., ... , Steffen A., Stradal T.E.B. (2023)
RhoB promotes Salmonella survival by regulating autophagy
Eur.J.Cell Biol., 102 (4)

Gorelik T.E., Ulmer A., Schleper A.L., Kuehne A.J.C. (2023)
Crystal structure of 9,10-bis-((perchloro-phenyl)-ethynyl)anthracene determined from three-dimensional electron diffraction data
Z.Kristallogr., Cryst.mater.

Wichmann J., Mayer J., Hintmann M., Lukat P., Blankenfeldt W., Biedendieck R. (2023)
Multistep Engineering of a Penicillin G Acylase for Systematic Improvement of Crystallization Efficiency
Crystal Growth and Design, 23 (5)

Hamed M.M., Abdelsamie A.S., Rox K., Schütz C., Kany A.M., Röhrig T., Schmelz S., Blankenfeldt W., Arce-Rodriguez A., Borrero-de Acuna J.M., Jahn D., Rademacher J., Ringshausen F.C., Cramer N., Tümmler B., Hirsch A.K.H., ... , Hartmann R.W., Empting M. (2023)
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle
Adv.Sci.

Borgert S.R., Henke S., Witzgall F., Schmelz S., Zur Lage S., Hotop S.K., Stephen S., Lübken D., Krüger J., Gomez N.O., Van Ham M., Jänsch L., Kalesse M., Pich A., Brönstrup M., ... , Häußler S., Blankenfeldt W. (2022)
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa
Nat.Commun., 13 (1)

Gorelik T.E. (2022)
Towards a new level of quantitative treatment of 3D electron diffraction data - in-pattern optical distortions
IUCrJ., 9 (Pt 6)

Gorelik T.E., Tehrani K.H.M.E., Gruene T., Monecke T., Niessing D., Kaiser U., ... , Blankenfeldt W., Müller R. (2022)
Crystal structure of natural product argyrin-D determined by 3D electron diffraction
Environ.Sci.Atmos.

Böldicke T. (2022)
Therapeutic Potential of Intrabodies for Cancer Immunotherapy: Current Status and Future Directions
Antibodies (Basel), 11 (3)

Chen F., Elgaher W.A.M., Winterhoff M., Büssow K., Waqas F.H., Graner E., Pires-Afonso Y., Casares Perez L., La Vega L., Sahini N., Czichon L., Zobl W., Zillinger T., Shehata M., Pleschka S., Bähre H., Falk C., Michelucci A., Schuchardt S., Blankenfeldt W., ... , Hirsch A.K.H., Pessler F. (2022)
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
Nat.Metab, 4 (5)

Gisdon F.J., Feiler C.G., Kempf O., Foerster J.M., Haiss J., Blankenfeldt W., ... , Ullmann G.M., Bombarda E. (2022)
Structural and Biophysical Analysis of the Phytochelatin-Synthase-Like Enzyme from Nostoc sp. Shows That Its Protease Activity is Sensitive to the Redox State of the Substrate
ACS Chemical Biology, 17 (4)

Staar M., Henke S., Blankenfeldt W., Schallmey A. (2022)
Biocatalytically Active and Stable Cross-Linked Enzyme Crystals of Halohydrin Dehalogenase HheG by Protein Engineering
ChemCatChem

Schütz C., Hodzic A., Hamed M., Abdelsamie A.S., Kany A.M., Bauer M., Röhrig T., Schmelz S., Scrima A., ... , Blankenfeldt W., Empting M. (2021)
Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR
Eur.J.Med.Chem., 226

Höfler S., Lukat P., Blankenfeldt W., Carlomagno T. (2021)
Eukaryotic Box C/D methylation machinery has two non-symmetric protein assembly sites
Sci.Rep., 11 (1)

Schotte C., Lukat P., Deuschmann A., Blankenfeldt W., Cox R.J. (2021)
Understanding and Engineering the Stereoselectivity of Humulene Synthase
Angew.Chem.Int.Ed Engl., 60

Diwo M., Michel W., Aurass P., Kuhle-Keindorf K., Pippel J., Krausze J., Wamp S., Lang C., ... , Blankenfeldt W., Flieger A. (2021)
NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB
Proc.Natl.Acad.Sci.U.S.A, 118 (23)

Schubert M., Nimtz M., Bertoglio F., Schmelz S., Lukat P., van den Heuvel J. (2021)
Reproducible and Easy Production of Mammalian Proteins by Transient Gene Expression in High Five Insect Cells
, 3 (6)

Singh K.S., Anand S., Dholpuria S., Sharma J.K., Blankenfeldt W., Shouche Y. (2021)
Antimicrobial resistance dynamics and the one-health strategy: a review
Environ.Chem.Lett.

Hendry S., Steinke S., Wittstein K., Stadler M., Harmrolfs K., Adewunmi Y., Sahukhal G., Elasri M., Thomashow L., Weller D., Mavrodi O., ... , Blankenfeldt W., Mavrodi D. (2021)
Functional Analysis of Phenazine Biosynthesis Genes in Burkholderia spp
Appl.Environ.Microbiol., 87 (11)

Singh K.S., Singh B.P., Rokana N., Singh N., Kaur J., ... , Singh A., Panwar H. (2021)
Bio-therapeutics from human milk: prospects and perspectives
J.Appl.Microbiol.

Schütz C., Ho D.K., Hamed M.M., Abdelsamie A.S., Röhrig T., Herr C., Kany A.M., Rox K., Schmelz S., Siebenbürger L., Wirth M., Börger C., Yahiaoui S., Bals R., Scrima A., Blankenfeldt W., Horstmann J.C., Christmann R., Murgia X., Koch M., Berwanger A., Loretz B., Hirsch A.K.H., Hartmann R.W., ... , Lehr C.M., Empting M. (2021)
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms
Adv.Sci.

Höfler S., Lukat P., Blankenfeldt W., Carlomagno T. (2021)
High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain
RNA, 27 (4)

Böldicke T. (2021)
Immunotherapy with antibodies: Tumor development, immune defense and therapeutic antibodies [/ Immuntherapie mit Antikörpern: Tumorentwicklung, Immunabwehr und therapeutische Antikörper]
Onkologe, 27 (4)

Scheithauer L., Thiem S., Schmelz S., Dellmann A., Büssow K., Brouwer R.M.H.J., Ünal C.M., ... , Blankenfeldt W., Steinert M. (2021)
Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation
Cell Microbiol.

Chaoprasid P., Lukat P., Mühlen S., Heidler T., Gazdag E.M., Dong S., Bi W., Rüter C., Kirchenwitz M., Steffen A., Jänsch L., Stradal T.E.B., ... , Dersch P., Blankenfeldt W. (2021)
Crystal structure of bacterial cytotoxic necrotizing factor CNF g
EMBO J, 40 (4)

Feiler C.G., Weiss M.S., Blankenfeldt W. (2020)
The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure
Acta Crystallogr F Struct Biol Commun, 76

Bracco P., Wijma H.J., Nicolai B., Rodriguez Buitrago J.A., Klünemann T., Vila A., Schrepfer P., Blankenfeldt W., ... , Janssen D.B., Schallmey A. (2021)
CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering
Chembiochem.

Panwar H., Rokana N., Sudhakaran V.A., Kaur J., Singh A., Singh J., Singh K.S., ... , Chaudhary V., Puniya A.K. (2020)
Gastrointestinal stress as innate defense against microbial attack
J.Appl.Microbiol., 130 (4)

Rodriguez Buitrago J.A., Klünemann T., Blankenfeldt W., Schallmey A. (2020)
Expression, purification and crystal structure determination of a ferredoxin reductase from the actinobacterium Thermobifida fusca
Acta Crystallogr F Struct Biol Commun, 76

Klünemann T., Blankenfeldt W. (2020)
Structure of heme d1-free cd1 nitrite reductase NirS
Acta Crystallogr.Sect.F.Struct.Biol.Cryst.Commun., 76

Mancini F., Unver M.Y., Elgaher W.A.M., Jumde V.R., Alhayek A., Lukat P., Herrmann J., Witte M.D., Köck M., Blankenfeldt W., ... , Müller R., Hirsch A.K.H. (2020)
Protein-Templated Hit Identification via an Ugi Four-Component Reaction
Chemistry., 26 (64)

Hollmann T., Berkhan G., Wagner L., Sung K.H., Kolb S., ... , Geise H., Hahn F. (2020)
Biocatalysts from Biosynthetic Pathways: Enabling Stereoselective, Enzymatic Cycloether Formation on a Gram Scale
ACS Catal., 10 (9)

Stampfli A.R., Blankenfeldt W., Seebeck F.P. (2020)
Structural basis of ergothioneine biosynthesis
Curr.Opin.Struct.Biol., 65 (December)

Klünemann T., Henke S., Blankenfeldt W. (2020)
The crystal structure of the heme d1 biosynthesis-associated small c-type cytochrome NirC reveals mixed oligomeric states in crystallo
Acta Crystallogr.D.Struct.Biol., 76 (Pt 4)

Klünemann T., Nimtz M., Jänsch L., Layer G., Blankenfeldt W. (2021)
Crystal structure of NirF: Insights into its role in heme d1 biosynthesis
FEBS J., 188 (1)

Hercher T.W., Krausze J., Hoffmeister S., Zwerschke D., Lindel T., Blankenfeldt W., ... , Mendel R.R., Kruse T. (2020)
Insights into the Cnx1E catalyzed MPT-AMP hydrolysis
Biosci.Rep., 40 (1)

Zender M., Witzgall F., Kiefer A.F., Kirsch B., Maurer C.K., Kany A.M., Xu N., Schmelz S., Börger C., ... , Blankenfeldt W., Empting M. (2020)
Flexible Fragment Growing Boosts Potency of Quorum Sensing Inhibitors against Pseudomonas aeruginosa Virulence
ChemMedChem., 15 (2)

Chen F., Lukat P., Iqbal A.A., Saile K., Kaever V., van den Heuvel J., Blankenfeldt W., ... , Büssow K., Pessler F. (2019)
Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis
Proc.Natl.Acad.Sci.U.S.A, 116 (41)

Schaks M., Döring H., Kage F., Steffen A., Klünemann T., Blankenfeldt W., ... , Stradal T., Rottner K. (2021)
RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding
Small Gtpases., 12 (2)

Juettner N.E., Schmelz S., Anderl A., Colin F., Classen M., Pfeifer F., ... , Scrima A., Fuchsbauer H.L. (2020)
The N-terminal peptide of the transglutaminase-activating metalloprotease inhibitor from Streptomyces mobaraensis accommodates both inhibition and glutamine cross-linking sites
FEBS J., 287 (4)

Mayer J., Pippel J., Günther G., Müller C., Lauermann A., Knuuti T., Blankenfeldt W., ... , Jahn D., Biedendieck R. (2019)
Crystal structures and protein engineering of three different penicillin G acylases from Gram-positive bacteria with different thermostability
Appl.Microbiol.Biotechnol., 103 (18)

Klünemann T., Preuss A., Adamczack J., Rosa L.F.M., Harnisch F., ... , Layer G., Blankenfeldt W. (2019)
Crystal Structure of Dihydro-Heme d1 Dehydrogenase NirN from Pseudomonas aeruginosa Reveals Amino Acid Residues Essential for Catalysis
J.Mol.Biol., 431 (17)

Leisinger F., Burn R., Meury M., Lukat P., Seebeck F.P. (2019)
Structural and Mechanistic Basis for Anaerobic Ergothioneine Biosynthesis
J.Am.Chem.Soc., 141 (17)

Büssow K., Themann P., Luu S., Pentrowski P., Harting C., Majewski M., Vollmer V., Köster M., Grashoff M., Zawatzky R., van den Heuvel J., ... , Kröger A., Böldicke T. (2019)
ER intrabody-mediated inhibition of interferon a secretion by mouse macrophages and dendritic cells
PLoS ONE, 14 (4)

Solarczek J., Klünemann T., Brandt F., Schrepfer P., Wolter M., Jacob C.R., ... , Blankenfeldt W., Schallmey A. (2019)
Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity
Sci.Rep., 9 (1)

Friedel K., Popp M.A., Matern J.C.J., Gazdag E., Thiel I.V., Volkmann G., ... , Blankenfeldt W., Mootz H.D. (2019)
A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine
Chem.Sci., 10 (1)

Schaks M., Singh S.P., Kage F., Thomason P., Klünemann T., Steffen A., Blankenfeldt W., Stradal T.E., ... , Insall R.H., Rottner K. (2018)
Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo
Curr.Biol., 28 (11)

Juettner N.E., Schmelz S., Kraemer A., Knapp S., Becker B., Kolmar H., ... , Scrima A., Fuchsbauer H.L. (2018)
Structure of a glutamine donor mimicking inhibitory peptide shaped by the catalytic cleft of microbial transglutaminase
FEBS J.

Poppe J., Reichelt J., Blankenfeldt W. (2018)
Pseudomonas aeruginosa pyoverdine maturation enzyme PvdP has a noncanonical domain architecture and affords insight into a new subclass of tyrosinases
J.Biol.Chem., 293 (38)

Sung K.H., Josewski J., Dübel S., Blankenfeldt W., Rau U. (2018)
Structural insights into antigen recognition of an anti-beta-(1,6)-beta-(1,3)-D-glucan antibody
Sci.Rep., 8 (1)

Fiebig D., Storka J., Roeder M., Meyners C., Schmelz S., Blankenfeldt W., Scrima A., ... , Kolmar H., Fuchsbauer H.L. (2018)
Destructive twisting of neutral metalloproteases: the catalysis mechanism of the Dispase autolysis-inducing protein from Streptomyces mobaraensis DSM 40487
FEBS J., 285 (22)

Schwemmlein N., Pippel J., Gazdag E.M., Blankenfeldt W. (2018)
Crystal structures of R-type bacteriocin sheath and tube proteins CD1363 and CD1364 from Clostridium difficile in the pre-assembled state
Front.Microbiol., 9 (AUG)

Weiner J., Zieger K., Pippel J., Heiker J.T. (2018)
Molecular Mechanisms of Vaspin Action - From Adipose Tissue to Skin and Bone, from Blood Vessels to the Brain
Adv.Exp.Med.Biol., 1111

Witzgall F., Depke T., Hoffmann M., Empting M., Brönstrup M., ... , Müller R., Blankenfeldt W. (2018)
The Alkylquinolone Repertoire of Pseudomonas aeruginosa is linked to Structural Flexibility of the FabH-like PQS Biosynthesis Enzyme PqsBC
Chembiochem.

Krausze J., Hercher T.W., Zwerschke D., Kirk M.L., Blankenfeldt W., ... , Mendel R.R., Kruse T. (2018)
The functional principle of eukaryotic molybdenum insertases
Biochem.J., 475 (10)

Misson L., Burn R., Vit A., Hildesheim J., Beliaeva M.A., ... , Blankenfeldt W., Seebeck F.P. (2018)
Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtD
ACS Chem.Biol., 13 (5)

Juettner N.E., Schmelz S., Bogen J.P., Happel D., Fessner W.D., Pfeifer F., ... , Fuchsbauer H.L., Scrima A. (2018)
Illuminating structure and acyl donor sites of a physiological transglutaminase substrate from Streptomyces mobaraensis
Protein Sci., 27 (5)

Sung K.H., Berkhan G., Hollmann T., Wagner L., Blankenfeldt W., Hahn F. (2018)
Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain
Angew.Chem.Int.Ed., 57 (1)

Koopmeiners J., Diederich C., Solarczek J., Voß H., Mayer J., ... , Blankenfeldt W., Schallmey A. (2017)
HheG, a halohydrin dehalogenase with activity on cyclic epoxides
ACS Catal., 7 (10)

Von Tesmar A., Hoffmann M., Pippel J., Fayad A.A., Dausend-Werner S., Bauer A., ... , Blankenfeldt W., Müller R. (2017)
Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System
Cell Chem.Biol., 24 (10)

Witzgall F., Ewert W., Blankenfeldt W. (2017)
Structures of the N-terminal domain of PqsA in complex with anthraniloyl- and 6-fluoroanthraniloyl-AMP: substrate activation in Pseudomonas Quinolone Signal (PQS) biosynthesis
Chembiochem., 18 (20)

Backhaus O., Böldicke T. (2016)
ER-targeted intrabodies mediating specific in vivo knockdown of transitory proteins in comparison to RNAi
(7)

Diederich C., Leypold M., Culka M., Weber H., Breinbauer R., ... , Ullmann G.M., Blankenfeldt W. (2017)
Mechanisms and Specificity of Phenazine Biosynthesis Protein PhzF
Sci.Rep., 7 (1)

Bock T., Luxenburger E., Hoffmann J., Schutza V., Feiler C., ... , Müller R., Blankenfeldt W. (2017)
AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus
Angew.Chem.Int.Ed Engl.

Somplatzki S., Muhlenhoff M., Kröger A., Gerardy-Schahn R., Böldicke T. (2017)
Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells
BMC Biotechnol., 17 (1)

Dolan S.K., Bock T., Hering V., Owens R.A., Jones G.W., ... , Blankenfeldt W., Doyle S. (2017)
Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus
Open Biol., 7 (2)

Guttenberger N., Blankenfeldt W., Breinbauer R. (2017)
Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products
Bioorg.Med.Chem., 25 (22)

Bock T., Volz C., Hering V., Scrima A., Müller R., Blankenfeldt W. (2016)
The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus
Nucleic Acids Res, 45 (4)

Krausze J., Probst C., Curth U., Reichelt J., Saha S., Schafflick D., Heinz D.W., ... , Mendel R.R., Kruse T. (2016)
Dimerization of the plant molybdenum insertase Cnx1E is required for synthesis of the molybdenum cofactor
Biochem.J., 474 (1)

Kayser H., Nimtz M. (2016)
Farnesyl biliverdins IXa are novel ligands of biliproteins from moths of the Noctuoidea superfamily: A chemosystematic view of the Lepidoptera
Insect Biochem.Mol.Biol., 78

Bock T., Müller R., Blankenfeldt W. (2016)
Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus
Acta Crystallogr.F Struct.Biol.Commun., 72 (Pt 8)

Füller J.J., Röpke R., Krausze J., Rennhack K.E., Daniel N.P., Blankenfeldt W., Schulz S., ... , Jahn D., Moser J. (2016)
Biosynthesis of Violacein: Structure and Function of L-Tryptophan Oxidase VioA from Chromobacterium violaceum
J Biol.Chem., 291 (38)

Bock T., Reichelt J., Müller R., Blankenfeldt W. (2016)
The structure of LiuC, a 3-hydroxy-3-methylglutaconyl CoA dehydratase involved in isovaleryl CoA biosynthesis in Myxococcus xanthus, reveals insights into specificity and catalysis
ChemBioChem, 17

Hartmann T., Schrapers P., Utesch T., Nimtz M., Rippers Y., Dau H., Mroginski M.A., ... , Haumann M., Leimkühler S. (2016)
The Molybdenum Active Site of Formate Dehydrogenase Is Capable of Catalyzing C-H Bond Cleavage and Oxygen Atom Transfer Reactions
Biochemistry, 55 (16)

Bock T., Kasten J., Müller R., Blankenfeldt W. (2016)
Crystal structure of the HMG-CoA synthase MvaS from the Gram-negative bacterium Myxococcus xanthus
ChemBioChem, 17 (13)

Zender M., Witzgall F., Drees S.L., Weidel E., Maurer C.K., Fetzner S., Blankenfeldt W., ... , Empting M., Hartmann R.W. (2016)
Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds
ACS Chem.Biol., 11 (6)

Diederich C., Leypold M., Breinbauer R., Blankenfeldt W. (2016)
Aus zwei mach eins: die Biosynthese der Phenazine
Biospektrum, 22 (2)

Reichelt J. (2016)
In silico prediction of target-inhibitor interaction
(1)

Kayser H., Nimtz M., Ringler P., Müller S.A. (2016)
Very high-density lipoprotein and vitellin as carriers of novel biliverdins IXa[alpha] with a farnesyl side-chain presumably derived from heme A in Spodoptera littoralis
Insect Biochem.Mol.Biol., 68

Gumz F., Krausze J., Eisenschmidt D., Backenkohler A., Barleben L., ... , Brandt W., Wittstock U. (2015)
The crystal structure of the thiocyanate-forming protein from Thlaspi arvense, a kelch protein involved in glucosinolate breakdown
Plant Mol.Biol., 89 (1-2)

Hebecker S., Krausze J., Hasenkampf T., Schneider J., Groenewold M., Reichelt J., Jahn D., ... , Heinz D.W., Moser J. (2015)
Structures of two bacterial resistance factors mediating tRNA-dependent aminoacylation of phosphatidylglycerol with lysine or alanine
Proc.Natl.Acad.Sci.U.S.A., 112 (34)

Vit A., Mashabela G.T., Blankenfeldt W., Seebeck F.P. (2015)
Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC
ChemBioChem, 16 (10)

Castelle C.J., Roger M., Bauzan M., Brugna M., Lignon S., Nimtz M., Golyshina O.V., ... , Giudici-Orticoni M.T., Guiral M. (2015)
The aerobic respiratory chain of the acidophilic archaeon Ferroplasma acidiphilum: A membrane-bound complex oxidizing ferrous iron
Biochim.Biophys.Acta, 1847 (8)

Seele J., Beineke A., Hillermann L.M., Jaschok-Kentner B., Von Pawel-Rammingen U., ... , Valentin-Weigand P., Baums C.G. (2015)
The immunoglobulin M-degrading enzyme of Streptococcus suis, Ide <inf>Ssuis</inf>, is involved in complement evasion
Vet.Res., 46 (1)

Lanfermann I., Linke D., Nimtz M., Berger R.G. (2015)
Manganese Peroxidases from Ganoderma applanatum Degrade b[beta]-Carotene Under Alkaline Conditions
Appl.Biochem.Biotechnol., 175 (8)

Linke D., Leonhardt R., Eisele N., Petersen L.M., Riemer S., ... , Nimtz M., Berger R.G. (2015)
Carotene-degrading activities from Bjerkandera adusta possess an application in detergent industries
Bioprocess.Biosyst.Eng, 38 (6)

Goncharenko K.V., Vit A., Blankenfeldt W., Seebeck F.P. (2015)
Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway
Angew.Chem.Int.Ed Engl., 54 (9)

Vit A., Misson L., Blankenfeldt W., Seebeck F.P. (2014)
Ergothioneine Biosynthetic Methyltransferase EgtD Reveals the Structural Basis of Aromatic Amino Acid Betaine Biosynthesis
ChemBioChem, 16

Blankenfeldt Wulf, Parsons J.F. (2014)
The structural biology of phenazine biosynthesis
Current Opinion in Structural Biology, 29C

Kuhle K., Krausze Jörn, Curth U., Rössle M., Heuner K., ... , Lang C., Flieger A. (2014)
Oligomerization inhibits legionella pneumophila PlaB phospholipase A activity
Journal of Biological Chemistry, 289 (27)

Bui T.H., Wray Victor, Nimtz Manfred, Fossen T., Preisitsch M., Schröder G., Wende K., ... , Heiden S.E., Mundt S. (2014)
Balticidins A-D, antifungal hassallidin-like lipopeptides from the Baltic Sea cyanobacterium Anabaena cylindrica Bio33
Journal of Natural Products, 77 (6)

Linke D., Lehnert N., Nimtz Manfred, Berger R.G. (2014)
An alcohol oxidase of Phanerochaete chrysosporium with a distinct glycerol oxidase activity
Enzyme Microbial Technology, 61-62

Kayser H., Wray Victor, Nimtz Manfred (2014)
Structure of a novel farnesylated bilin from an insect - Formation by ?-cleavage of heme A of mitochondrial cytochrome c oxidases?
FEBS Journal, 281 (10)

Li Z., Nimtz M., Rinas U. (2014)
The metabolic potential of Escherichia coli BL21 in defined and rich medium
Microbial Cell Factories, 13 (1)

Vit A., Misson L., Blankenfeldt Wulf, Seebeck F.P. (2014)
Crystallization and preliminary X-ray analysis of the ergothioneine-biosynthetic methyltransferase EgtD
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 70 (Pt 5)

Sztajer H., Szafranski S.P., Tomasch Jürgen, Reck Michael, Nimtz Manfred, ... , Rohde Manfred, Wagner-Döbler Irene (2014)
Cross-feeding and interkingdom communication in dual-species biofilms of Streptococcus mutans and Candida albicans
ISME Journal, 8 (11)

Niggemann Jutta, Bozko P., Bruns Nicole, Wodtke Anne, Gieseler M.T., Thomas K., Jahns C., Nimtz Manfred, Reupke I., Brüser T., Auling G., ... , Malek N., Kalesse Markus (2014)
Baceridin, a cyclic hexapeptide from an epiphytic bacillus strain, inhibits the proteasome
ChemBioChem, 15 (7)

Reviews

9.      Guttenberger N, Blankenfeldt W, Breinbauer R. (2017) Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products. Bioorg Med Chem. 25:6149-66.

8.      Diederich C, Leypold M, Breinbauer R, Blankenfeldt W (2016) Aus zwei mach eins: die Biosynthese der Phenazine, BIOspektrum 22:137-9.

7.      Diederich C, Leypold M, Breinbauer R, Blankenfeldt W (2014) Die Biosynthese der Phenazine, Nachrichten aus der Chemie 62:975-80.

6.      Blankenfeldt W*, Parsons JF* (2014) The structural biology of phenazine biosynthesis. Curr Opin Struct Biol 29:26-33. *corresponding authors

5.      Itzen A, Blankenfeldt, W, Goody RS (2011) Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci 36:221-8

4.      Goody RS, Müller MP, Schoebel S, Oesterlin LK, Blümer J, Peters H, Blankenfeldt, W, Itzen A (2011) The versatile Legionella effector protein DrrA. Commun Integ Biol 4:1-3

3.      Mentel M, Ahuja EG, Mavrodi CV, Breinbauer R, Thomashow LS, Blankenfeldt W (2009) Of Two Make One: The Biosynthesis of Phenazines. ChemBiochem 10:2295-304

2.      Mavrodi DV, Blankenfeldt W, Thomashow LS (2006) Phenazine Compounds in Fluorescent Pseudomonas spp.. Annu Rev Phytochemistry 44:417-45

1.      Dong C, Beis K, Giraud MF, Blankenfeldt W, Allard S, Major LL, Kerr ID, Whitfield C, Naismith JH (2003) A structural perspective on the enzymes that convert dTDP-D-glucose into dTDP-L-rhamnose. Biochem Soc Trans 31:532-6

Book Chapters:

3.      Blankenfeldt W (2013). The Biosynthesis of Phenazines. In: S. Chincholkar, L. Thomashow (eds.). Microbial Phenazines: Biosynthesis, Agriculture and Health. Springer:1-17.

2.      Alexandrov K, Wu YW, Blankenfeldt W, Waldmann H, Goody RS (2011). Organization and Function of the Rab Prenylation and Recycling Machinery. In: F. Tamanoi, C.A. Hrycyna, M.O. Bergo (eds.). The Enzymes, Vol. 29: Protein Prenylation PART A. Academic Press:147-62.

1.      Mavrodi DV, Thomashow L, Blankenfeldt W (2008) Biosynthesis and regulation of phenazine compounds in Pseudomonas spp. In: B. Rehm (ed.). Pseudomonas: Model Organism, Pathogen, Cell Factory. Wiley-VCH. Weinheim:331-52.

Patents:

1.      Blankenfeldt W, Naismith JH (2001) Crystallisation and Functional Analysis of Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa. Patent WO/2002/006509