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How the gut microbiome responds to antibiotics
Each person's gut microbiome contains a specific community of microorganisms that normally remains stable for years. However, it can be thrown off balance by factors such as dietary changes, infections or medications. Antibiotics in particular have a strong influence on…
Chemist Jörn Piel receives Inhoffen Medal 2023
The research group of Inhoffen Medal 2023 winner Prof Jörn Piel investigates how structurally complex natural products are produced. “Prof Jörn Piel is an outstanding scientist who has done ground-breaking work on microbial natural products research. His molecular…
A virus lurking in the connective tissue
As part of the new study, Dr Katarzyna Sitnik, then working in the “Viral Immunology” department at the HZI, headed by Prof Luka Cicin-Sain, and her colleagues naturally infected mice with murine CMV (mCMV). This variant of the virus is used because human CMV (HCMV) is…
Small RNA, big impact
How and why do our organs age? To help answer this question, a group of researchers from Saarbrücken and Stanford have been studying some of the molecular mechanisms that underlie ageing. A team led by Andreas Keller, Professor of Clinical Bioinformatics at Saarbrücken…
The folding is the key
Human Immunodeficiency Viruses (HIV) are responsible for millions of infections worldwide. By causing the Acquired Immunodeficiency Syndrome (AIDS), these pathogens have led to nearly 40 million deaths since the outbreak of the HIV pandemic in the 1980s. For decades,…
What leads to severe COVID-19?
The team was able to identify underlying regulators of the malfunction of the innate immune system in COVID-19 patients and confirm that certain already known genetic risk loci play a role in the development of COVID-19. The results have been published in the journal…
Helmholtz Young Investigator Group for Yannic Bartsch
"I will initially focus on the respiratory syncytial virus RSV, which can cause severe respiratory infections, especially in young children," says Bartsch. "How do antibody responses influence the course of the disease? Can such immune responses be therapeutically…
Gérard Krause moves from HZI to WHO
After twelve years as head of the Department of Epidemiology at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Prof Gérard Krause is moving to the World Health Organization (WHO) where he will become the director of a newly established department for…
The fifth anniversary of HIRI
In May 2017, the world's first institution combining research on ribonucleic acids (RNA) with infection biology was founded in Würzburg: the Helmholtz Institute for RNA-based Infection Research (HIRI). Since then, the still young HIRI has gained a global reputation in…
A bright spot for microbiological diagnostics
In view of the increasing threat by antibiotic resistances, diseases should not be treated with antibiotics on suspicion. Antibiotic stewardship therefore requires prior verification that a bacterial infection is indeed present. However, microbiological methods, in…
